StarFunc result for job id O95602

User Input

>input (1720 residues)
MLISKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADS
KEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLL
LCQLRVLEVGALQAVYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQGAH
VKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDS
EPLGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFNPSVFFLD
FLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTT
DEEKDSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQI
LEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL
RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCR
HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQ
SELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRG
LTDKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKET
PRSVPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTC
LARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYD
EVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQS
GAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIK
PPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYG
EDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHP
NTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAA
ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKW
QRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIK
TPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQ
FLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNA
GELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEEN
DDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMER
RVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGIT
RCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRV
IEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQF
LKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPLR

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:4c3hA	0.782	0.879	0.000	1523	0.363	0.410	4c3hA.pdb.gz	Crystal Structure of the 14-Subunit RNA Polymerase I
2	PDB:4ym7BA	0.781	0.915	0.000	1462	0.359	0.423	4ym7BA.pdb.gz	An alternative RNA polymerase I structure reveals a dimer hinge.
3	PDB:5g5lA	0.791	0.916	0.000	1480	0.358	0.416	5g5lA.pdb.gz	RNA Polymerase I-Rrn3 Complex at 4.8 A Resolution
4	PDB:5m3fA	0.782	0.919	0.000	1459	0.358	0.422	5m3fA.pdb.gz	Structure of RNA polymerase I transcribing ribosomal DNA genes.
5	PDB:5m5wA	0.793	0.910	0.000	1493	0.361	0.416	5m5wA.pdb.gz	Molecular Structures of Transcribing RNA Polymerase I.
6	PDB:6hlsA	0.773	0.925	0.000	1431	0.351	0.421	6hlsA.pdb.gz	The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2.
7	PDB:6rqlA	0.802	0.890	0.000	1542	0.367	0.409	6rqlA.pdb.gz	Molecular insight into RNA polymerase I promoter recognition and promoter melting.
8	PDB:7aoeA	0.759	0.927	0.000	1401	0.373	0.458	7aoeA.pdb.gz	Conserved strategies of RNA polymerase I hibernation and activation.
9	PDB:7obaA	0.843	0.949	0.000	1522	0.883	0.997	7obaA.pdb.gz	Cryo-EM structures of human RNA polymerase I.
10	PDB:7vbcA	0.823	0.955	0.000	1477	0.856	0.997	7vbcA.pdb.gz	Structure of the human RNA polymerase I elongation complex.
11	AFDB:A0A0R4I9V4	0.937	0.951	0.000	1693	0.672	0.683	A0A0R4I9V4.pdb.gz	A0A0R4I9V4_DANRE DNA-directed RNA polymerase subunit OS=Danio rerio OX=7955 GN=polr1a PE=1 SV=1
12	AFDB:O35134	0.972	0.974	0.000	1717	0.865	0.866	O35134.pdb.gz	RPA1_MOUSE DNA-directed RNA polymerase I subunit RPA1 OS=Mus musculus OX=10090 GN=Polr1a PE=1 SV=2
13	AFDB:O95602	1.000	1.000	0.000	1720	1.000	1.000	O95602.pdb.gz	RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2
14	AFDB:P10964	0.831	0.858	0.000	1664	0.373	0.386	P10964.pdb.gz	RPA1_YEAST DNA-directed RNA polymerase I subunit RPA190 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPA190 PE=1 SV=2
15	AFDB:P15398	0.828	0.843	0.000	1689	0.394	0.401	P15398.pdb.gz	RPA1_SCHPO DNA-directed RNA polymerase I subunit rpa1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rpa1 PE=1 SV=2
16	AFDB:Q9SVY0	0.796	0.819	0.000	1670	0.331	0.341	Q9SVY0.pdb.gz	NRPA1_ARATH DNA-directed RNA polymerase I subunit 1 OS=Arabidopsis thaliana OX=3702 GN=NRPA1 PE=3 SV=1
17	AFDB:Q57UI1	0.708	0.684	9.477E-91	1781	0.269	0.259	Q57UI1.pdb.gz	Q57UI1_TRYB2 DNA-directed RNA polymerase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.5H5.740 PE=3 SV=1
18	AFDB:P04051	0.657	0.768	3.695E-84	1460	0.244	0.287	P04051.pdb.gz	RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPO31 PE=1 SV=1
19	AFDB:A8JUY3	0.653	0.802	1.225E-83	1383	0.236	0.294	A8JUY3.pdb.gz	A8JUY3_DROME DNA-directed RNA polymerase subunit OS=Drosophila melanogaster OX=7227 GN=Polr3A PE=1 SV=2
20	AFDB:A0A1D8PUA6	0.647	0.644	4.846E-83	1728	0.234	0.233	A0A1D8PUA6.pdb.gz	A0A1D8PUA6_CANAL DNA-directed RNA polymerase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=RPO21 PE=3 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0R4I9V4	0.0	2371	1693	0.673	0.683	A0A0R4I9V4_DANRE DNA-directed RNA polymerase subunit OS=Danio rerio OX=7955 GN=polr1a PE=1 SV=1
2	O35134	0.0	3049	1717	0.866	0.868	RPA1_MOUSE DNA-directed RNA polymerase I subunit RPA1 OS=Mus musculus OX=10090 GN=Polr1a PE=1 SV=2
3	O54889	0.0	3057	1716	0.876	0.878	RPA1_RAT DNA-directed RNA polymerase I subunit RPA1 OS=Rattus norvegicus OX=10116 GN=Polr1a PE=1 SV=1
4	O95602	0.0	3590	1720	1.000	1.000	RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2
5	P10964	0.0	1099	1664	0.383	0.395	RPA1_YEAST DNA-directed RNA polymerase I subunit RPA190 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPA190 PE=1 SV=2
6	P15398	0.0	1157	1689	0.409	0.417	RPA1_SCHPO DNA-directed RNA polymerase I subunit rpa1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rpa1 PE=1 SV=2
7	Q9SVY0	0.0	678	1670	0.241	0.249	NRPA1_ARATH DNA-directed RNA polymerase I subunit 1 OS=Arabidopsis thaliana OX=3702 GN=NRPA1 PE=3 SV=1
8	P18616	1.31e-124	434	1839	0.186	0.174	NRPB1_ARATH DNA-directed RNA polymerase II subunit RPB1 OS=Arabidopsis thaliana OX=3702 GN=NRPB1 PE=1 SV=3
9	B2RXC6	7.98e-124	426	1390	0.177	0.219	B2RXC6_MOUSE DNA-directed RNA polymerase subunit OS=Mus musculus OX=10090 GN=Polr3a PE=1 SV=1
10	O14802	4.10e-122	421	1390	0.177	0.219	RPC1_HUMAN DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2
11	Q980R2	4.85e-122	408	880	0.189	0.369	RPO1N_SACS2 DNA-directed RNA polymerase subunit Rpo1N OS=Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) OX=273057 GN=rpo1N PE=1 SV=1
12	B8YB53	9.25e-121	405	880	0.188	0.367	RPO1N_SACSH DNA-directed RNA polymerase subunit Rpo1N OS=Saccharolobus shibatae OX=2286 GN=rpo1N PE=1 SV=1
13	A0A8I6ASE2	1.69e-117	414	1956	0.232	0.204	A0A8I6ASE2_RAT DNA-directed RNA polymerase subunit OS=Rattus norvegicus OX=10116 GN=Polr2a PE=1 SV=1
14	D4A5A6	1.80e-117	414	1970	0.232	0.203	D4A5A6_RAT DNA-directed RNA polymerase subunit OS=Rattus norvegicus OX=10116 GN=Polr2a PE=1 SV=1
15	P24928	2.34e-117	414	1970	0.232	0.203	RPB1_HUMAN DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2
16	P08775	2.42e-117	414	1970	0.232	0.203	RPB1_MOUSE DNA-directed RNA polymerase II subunit RPB1 OS=Mus musculus OX=10090 GN=Polr2a PE=1 SV=3
17	G3MZY8	2.51e-117	414	1970	0.232	0.203	G3MZY8_BOVIN DNA-directed RNA polymerase subunit OS=Bos taurus OX=9913 GN=POLR2A PE=1 SV=2
18	P11512	6.22e-117	394	880	0.178	0.348	RPO1N_SULAC DNA-directed RNA polymerase subunit Rpo1N OS=Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) OX=330779 GN=rpo1N PE=1 SV=2
19	P04052	2.60e-115	407	1887	0.172	0.157	RPB1_DROME DNA-directed RNA polymerase II subunit RPB1 OS=Drosophila melanogaster OX=7227 GN=RpII215 PE=3 SV=4
20	P16355	2.26e-114	403	1744	0.187	0.185	RPA1_TRYBB DNA-directed RNA polymerase I subunit RPA1 OS=Trypanosoma brucei brucei OX=5702 GN=TRP11 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF06524 NOA36	8.5e+02	10.6	NOA36 protein
2	PF04997 RNA_pol_Rpb1_1	1.9e-19	81.8	RNA polymerase Rpb1, domain 1
3	PF00623 RNA_pol_Rpb1_2	1.1e-67	238.9	RNA polymerase Rpb1, domain 2
4	PF04983 RNA_pol_Rpb1_3	5.9e-33	125.5	RNA polymerase Rpb1, domain 3
5	PF05000 RNA_pol_Rpb1_4	2.3e-22	90.4	RNA polymerase Rpb1, domain 4
6	PF04998 RNA_pol_Rpb1_5	4.2e-101	349.5	RNA polymerase Rpb1, domain 5

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000263857

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000222567	0.999	DNA-directed RNA polymerase I subunit RPA43
2	9606.ENSP00000302478	0.999	DNA-directed RNA polymerases I and III subunit RPAC2
3	9606.ENSP00000361465	0.999	DNA-directed RNA polymerases I and III subunit RPAC1
4	9606.ENSP00000367029	0.999	DNA-directed RNA polymerase I subunit RPA49
5	9606.ENSP00000415536	0.999	DNA-directed RNA polymerases I, II, and III subunit RPABC3
6	9606.ENSP00000444136	0.999	DNA-directed RNA polymerase I subunit RPA2
7	9606.ENSP00000478303	0.999	DNA-directed RNA polymerases I, II, and III subunit RPABC1
8	9606.ENSP00000324124	0.998	DNA-directed RNA polymerases I, II, and III subunit RPABC5
9	9606.ENSP00000403852	0.998	DNA-directed RNA polymerases I, II, and III subunit RPABC2
10	9606.ENSP00000198767	0.996	RNA polymerase I-specific transcription initiation factor RRN3
11	9606.ENSP00000331111	0.996	DNA-directed RNA polymerase I subunit RPA12
12	9606.ENSP00000228347	0.993	DNA-directed RNA polymerase III subunit RPC2
13	9606.ENSP00000361446	0.986	DNA-directed RNA polymerase III subunit RPC1
14	9606.ENSP00000385410	0.983	Nucleolar and coiled-body phosphoprotein 1
15	9606.ENSP00000370968	0.978	Myb-binding protein 1A
16	9606.ENSP00000342889	0.977	DNA-directed RNA polymerases I, II, and III subunit RPABC4
17	9606.ENSP00000302640	0.973	Nucleolar transcription factor 1
18	9606.ENSP00000370625	0.965	DNA-directed RNA polymerase II subunit RPB2
19	9606.ENSP00000334564	0.964	DNA-directed RNA polymerase III subunit RPC3
20	9606.ENSP00000264279	0.955	Nucleolar protein 58

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0003899	1.000	DNA-directed 5'-3' RNA polymerase activity
GO:0003682	0.916	chromatin binding
GO:0003676	0.417	nucleic acid binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0044238	0.997	primary metabolic process
GO:0043170	0.996	macromolecule metabolic process
GO:0034641	0.995	cellular nitrogen compound metabolic process
GO:0016072	0.994	rRNA metabolic process
GO:0098781	0.993	ncRNA transcription
GO:0009303	0.955	rRNA transcription
GO:0065007	0.895	biological regulation
GO:0050789	0.892	regulation of biological process
GO:0050794	0.857	regulation of cellular process
GO:0048519	0.407	negative regulation of biological process
GO:0048523	0.394	negative regulation of cellular process
GO:0019222	0.384	regulation of metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0032991	0.998	protein-containing complex
GO:0043232	0.998	intracellular non-membrane-bounded organelle
GO:0005654	0.996	nucleoplasm
GO:1902494	0.978	catalytic complex
GO:0140535	0.973	intracellular protein-containing complex
GO:1990234	0.956	transferase complex
GO:0140513	0.948	nuclear protein-containing complex
GO:0000428	0.946	DNA-directed RNA polymerase complex
GO:0005730	0.903	nucleolus
GO:0055029	0.805	nuclear DNA-directed RNA polymerase complex
GO:0005737	0.687	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.7.6	1.000	DNA-directed RNA polymerase.

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