StarFunc result for job id O95633

User Input

>input (263 residues)
MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAE
CCASGNIDTAWSNLTHPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCE
CAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLSVMYRGRCRKSCEHVVCPRPQ
SCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHA
GSCAGTPEEPPGGESAEEEENFV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A024R1Y8	0.841	0.841	1.210E-53	263	1.000	1.000	A0A024R1Y8.pdb.gz
2	AFDB:Q99PW7	0.797	0.818	5.136E-46	256	0.821	0.844	Q99PW7.pdb.gz	FSTL3_RAT Follistatin-related protein 3 OS=Rattus norvegicus OX=10116 GN=Fstl3 PE=2 SV=1
3	PDB:3b4vD	0.787	0.967	4.253E-42	213	0.810	1.000	3b4vD.pdb.gz
4	AFDB:Q9YHV4	0.756	0.622	8.267E-29	322	0.395	0.323	Q9YHV4.pdb.gz	FSTA_DANRE Follistatin-A OS=Danio rerio OX=7955 GN=fsta PE=2 SV=2
5	AFDB:Q90844	0.758	0.587	2.363E-28	343	0.384	0.294	Q90844.pdb.gz	FST_CHICK Follistatin OS=Gallus gallus OX=9031 GN=FST PE=2 SV=1
6	AFDB:P19883	0.764	0.591	6.011E-28	344	0.384	0.294	P19883.pdb.gz	FST_HUMAN Follistatin OS=Homo sapiens OX=9606 GN=FST PE=1 SV=2
7	PDB:2p6aD	0.732	0.661	3.959E-22	292	0.373	0.336	2p6aD.pdb.gz	Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions.
8	AFDB:Q86NV3	0.680	0.251	4.124E-14	767	0.346	0.119	Q86NV3.pdb.gz	Q86NV3_DROME Follistatin, isoform A OS=Drosophila melanogaster OX=7227 GN=Fs PE=2 SV=1
9	AFDB:G5EG68	0.200	0.049	7.035E-10	1473	0.179	0.032	G5EG68.pdb.gz	G5EG68_CAEEL AGRin (Synaptic protein) homolog family member OS=Caenorhabditis elegans OX=6239 GN=agr-1 PE=1 SV=1
10	AFDB:F1R074	0.221	0.053	1.897E-9	2026	0.251	0.033	F1R074.pdb.gz
11	AFDB:O00468	0.220	0.056	3.604E-9	2068	0.240	0.030	O00468.pdb.gz	AGRIN_HUMAN Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6
12	AFDB:P31696	0.211	0.048	6.848E-9	2081	0.171	0.022	P31696.pdb.gz	AGRIN_CHICK Agrin OS=Gallus gallus OX=9031 GN=AGRN PE=1 SV=3
13	PDB:1yu6C	0.145	0.656	2.597E-2	51	0.057	0.294	1yu6C.pdb.gz	Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations.
14	PDB:3t5oA	0.225	0.091	8.342E-2	871	0.141	0.042	3t5oA.pdb.gz	Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).
15	PDB:2leoA	0.152	0.543	9.375E-2	66	0.057	0.227	2leoA.pdb.gz
16	PDB:4e0sB	0.234	0.092	1.054E-1	898	0.125	0.037	4e0sB.pdb.gz	Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
17	PDB:7qe9C	0.143	0.571	1.255E-1	60	0.049	0.217	7qe9C.pdb.gz
18	PDB:2xrcB	0.163	0.096	4.531E-1	485	0.057	0.031	2xrcB.pdb.gz	Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms.
19	PDB:2xrcC	0.148	0.092	8.121E-1	454	0.068	0.040	2xrcC.pdb.gz	Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms.
20	PDB:7q3nU	0.109	0.103	1.026	292	0.076	0.068	7q3nU.pdb.gz	Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O95633	0.0	529	263	1.000	1.000	FSTL3_HUMAN Follistatin-related protein 3 OS=Homo sapiens OX=9606 GN=FSTL3 PE=1 SV=1
2	Q99PW7	5.34e-153	428	256	0.821	0.844	FSTL3_RAT Follistatin-related protein 3 OS=Rattus norvegicus OX=10116 GN=Fstl3 PE=2 SV=1
3	Q9EQC7	1.69e-152	427	256	0.821	0.844	FSTL3_MOUSE Follistatin-related protein 3 OS=Mus musculus OX=10090 GN=Fstl3 PE=1 SV=1
4	Q9YHV4	1.12e-67	214	322	0.414	0.339	FSTA_DANRE Follistatin-A OS=Danio rerio OX=7955 GN=fsta PE=2 SV=2
5	P21674	1.98e-66	211	344	0.388	0.297	FST_RAT Follistatin OS=Rattus norvegicus OX=10116 GN=Fst PE=1 SV=1
6	P19883	2.25e-66	211	344	0.388	0.297	FST_HUMAN Follistatin OS=Homo sapiens OX=9606 GN=FST PE=1 SV=2
7	P47931	2.95e-66	211	344	0.388	0.297	FST_MOUSE Follistatin OS=Mus musculus OX=10090 GN=Fst PE=2 SV=1
8	Q90844	7.46e-64	205	343	0.392	0.300	FST_CHICK Follistatin OS=Gallus gallus OX=9031 GN=FST PE=2 SV=1
9	Q86NV3	1.14e-15	78.6	767	0.194	0.066	Q86NV3_DROME Follistatin, isoform A OS=Drosophila melanogaster OX=7227 GN=Fs PE=2 SV=1
10	G5EG68	1.26e-14	75.9	1473	0.194	0.035	G5EG68_CAEEL AGRin (Synaptic protein) homolog family member OS=Caenorhabditis elegans OX=6239 GN=agr-1 PE=1 SV=1
11	B3GQ72	1.11e-11	67.0	2028	0.209	0.027	B3GQ72_DANRE Agrin OS=Danio rerio OX=7955 GN=wu:fb57e07 PE=1 SV=1
12	A0A0R4IJ40	2.15e-11	66.2	1926	0.190	0.026	A0A0R4IJ40_DANRE Agrin OS=Danio rerio OX=7955 GN=hm:gc12 PE=1 SV=1
13	P31696	1.36e-09	60.8	2081	0.186	0.024	AGRIN_CHICK Agrin OS=Gallus gallus OX=9031 GN=AGRN PE=1 SV=3
14	P25304	3.19e-09	59.7	1959	0.179	0.024	AGRIN_RAT Agrin OS=Rattus norvegicus OX=10116 GN=Agrn PE=1 SV=2
15	A2ASQ1	4.12e-09	59.3	1950	0.183	0.025	AGRIN_MOUSE Agrin OS=Mus musculus OX=10090 GN=Agrn PE=1 SV=1
16	Q8IYR6	2.99e-08	56.2	380	0.160	0.111	TEFF1_HUMAN Tomoregulin-1 OS=Homo sapiens OX=9606 GN=TMEFF1 PE=1 SV=1
17	O00468	3.90e-08	56.2	2068	0.179	0.023	AGRIN_HUMAN Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6
18	P24054	1.53e-07	54.3	634	0.118	0.049	SPRL1_RAT SPARC-like protein 1 OS=Rattus norvegicus OX=10116 GN=Sparcl1 PE=1 SV=1
19	Q14515	1.22e-06	51.6	664	0.114	0.045	SPRL1_HUMAN SPARC-like protein 1 OS=Homo sapiens OX=9606 GN=SPARCL1 PE=1 SV=2
20	O96790	3.51e-06	49.7	351	0.133	0.100	DPGN_DIPMA Serine protease inhibitor dipetalogastin (Fragment) OS=Dipetalogaster maximus OX=72496 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF09289 FOLN	0.29	22.6	Follistatin/Osteonectin-like EGF domain
2	PF00050 Kazal_1	2.8e-05	35.3	Kazal-type serine protease inhibitor domain
3	PF07648 Kazal_2	2.8e-20	83.5	Kazal-type serine protease inhibitor domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000166139

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000260950	0.996	Growth/differentiation factor 8
2	9606.ENSP00000242208	0.970	Inhibin beta A chain
3	9606.ENSP00000295228	0.795	Inhibin beta B chain
4	9606.ENSP00000357668	0.793	Disintegrin and metalloproteinase domain-containing protein 12
5	9606.ENSP00000295633	0.694	Follistatin-related protein 1
6	9606.ENSP00000311184	0.690	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
7	9606.ENSP00000340361	0.690	Activin receptor type-2B
8	9606.ENSP00000324763	0.682	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
9	9606.ENSP00000292363	0.675	E3 ubiquitin-protein ligase RNF126
10	9606.ENSP00000305334	0.663	Follistatin-related protein 5
11	9606.ENSP00000257868	0.662	Growth/differentiation factor 11
12	9606.ENSP00000295379	0.657	Bone morphogenetic protein 10
13	9606.ENSP00000301873	0.651	Latent-transforming growth factor beta-binding protein 3
14	9606.ENSP00000265342	0.633	Follistatin-related protein 4
15	9606.ENSP00000336762	0.624	Angiogenin
16	9606.ENSP00000465759	0.572	DNA-directed RNA polymerase, mitochondrial
17	9606.ENSP00000320434	0.539	Alpha-catulin
18	9606.ENSP00000442656	0.537	Activin receptor type-1B
19	9606.ENSP00000243786	0.524	Inhibin alpha chain

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0048185	1.000	activin binding
GO:0001968	0.990	fibronectin binding
GO:0098772	0.744	molecular function regulator activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0048519	0.997	negative regulation of biological process
GO:0048583	0.996	regulation of response to stimulus
GO:0023051	0.996	regulation of signaling
GO:0010646	0.996	regulation of cell communication
GO:0090287	0.994	regulation of cellular response to growth factor stimulus
GO:0090092	0.988	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0048523	0.987	negative regulation of cellular process
GO:0009987	0.984	cellular process
GO:0048856	0.965	anatomical structure development
GO:0048585	0.925	negative regulation of response to stimulus
GO:0009968	0.906	negative regulation of signal transduction
GO:0090101	0.890	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0048518	0.882	positive regulation of biological process
GO:0048522	0.851	positive regulation of cellular process
GO:0019222	0.847	regulation of metabolic process
GO:0050896	0.834	response to stimulus
GO:0051239	0.832	regulation of multicellular organismal process
GO:0050793	0.812	regulation of developmental process
GO:0030510	0.782	regulation of BMP signaling pathway
GO:0090288	0.777	negative regulation of cellular response to growth factor stimulus
GO:0080090	0.770	regulation of primary metabolic process
GO:0060255	0.766	regulation of macromolecule metabolic process
GO:0051171	0.719	regulation of nitrogen compound metabolic process
GO:0030514	0.702	negative regulation of BMP signaling pathway
GO:0031323	0.700	regulation of cellular metabolic process
GO:0051716	0.646	cellular response to stimulus
GO:0045595	0.613	regulation of cell differentiation
GO:0032501	0.612	multicellular organismal process
GO:0010468	0.590	regulation of gene expression
GO:0007275	0.584	multicellular organism development
GO:0045596	0.578	negative regulation of cell differentiation
GO:0051241	0.571	negative regulation of multicellular organismal process
GO:0009893	0.532	positive regulation of metabolic process
GO:2000026	0.529	regulation of multicellular organismal development
GO:0010604	0.502	positive regulation of macromolecule metabolic process
GO:0051173	0.480	positive regulation of nitrogen compound metabolic process
GO:0006355	0.476	regulation of DNA-templated transcription
GO:0031325	0.462	positive regulation of cellular metabolic process
GO:0048731	0.451	system development
GO:0048513	0.436	animal organ development
GO:0045893	0.392	positive regulation of DNA-templated transcription
GO:0023052	0.351	signaling
GO:0002682	0.335	regulation of immune system process
GO:0007154	0.321	cell communication
GO:0051094	0.316	positive regulation of developmental process
GO:0006357	0.313	regulation of transcription by RNA polymerase II
GO:0060284	0.300	regulation of cell development

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043231	0.999	intracellular membrane-bounded organelle
GO:0005615	0.995	extracellular space
GO:0070013	0.995	intracellular organelle lumen
GO:0005654	0.993	nucleoplasm
GO:0012505	0.992	endomembrane system
GO:0005737	0.935	cytoplasm
GO:0005783	0.342	endoplasmic reticulum
GO:0031982	0.315	vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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