StarFunc result for job id P00451

User Input

>input (2351 residues)
MQIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFN
TSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV
GVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSH
VDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRD
AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH
RQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNE
EAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLA
PDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTL
LIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGP
TKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDE
NRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILS
IGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRG
MTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTI
PENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPS
PGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSST
SNNLISTIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEE
NNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTN
KTSNNSATNRKTHIDGPSLLIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRL
NHMSNKTTSSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSG
QGPSPKQLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDN
LHENNTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYD
GAYAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNT
SQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNEKE
KGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLPAASY
RKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKVENTVLP
KPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAIKWNEANRP
GKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPEKTAFKKKDTILSL
NACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQREITRTTLQSDQEE
IDYDDTISVEMKKEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNR
AQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASR
PYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDV
DLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRA
PCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGH
VFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKC
QTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMII
HGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFN
PPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFA
TWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFL
ISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRM
EVLGCEAQDLY

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:4bxsV	0.483	0.875	0.000	1262	0.229	0.426	4bxsV.pdb.gz	Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
2	PDB:7kveB	0.513	0.861	0.000	1374	0.245	0.419	7kveB.pdb.gz
3	AFDB:D3ZEB1	0.603	0.627	0.000	2257	0.536	0.558	D3ZEB1.pdb.gz	D3ZEB1_RAT Coagulation factor VIII OS=Rattus norvegicus OX=10116 GN=F8 PE=3 SV=4
4	AFDB:O88783	0.529	0.569	0.000	2183	0.298	0.321	O88783.pdb.gz	FA5_MOUSE Coagulation factor V OS=Mus musculus OX=10090 GN=F5 PE=1 SV=1
5	AFDB:P00451	1.000	1.000	0.000	2351	1.000	1.000	P00451.pdb.gz	FA8_HUMAN Coagulation factor VIII OS=Homo sapiens OX=9606 GN=F8 PE=1 SV=1
6	AFDB:Q90X47	0.531	0.592	0.000	2101	0.299	0.334	Q90X47.pdb.gz
7	PDB:5n4lA	0.385	0.850	4.179E-82	1034	0.157	0.358	5n4lA.pdb.gz	Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic.
8	PDB:1kcwA	0.380	0.858	9.266E-82	1017	0.155	0.358	1kcwA.pdb.gz	The X-ray structure of human serum ceruloplasmin at 3.1 angstrom: Nature of the copper centres.
9	PDB:2dv6A	0.100	0.497	8.693E-21	422	0.034	0.190	2dv6A.pdb.gz	Structure and function of a hexameric copper-containing nitrite reductase.
10	PDB:5lwxA	0.090	0.346	7.067E-16	554	0.027	0.116	5lwxA.pdb.gz	Structure and function of Aspergillus niger laccase McoG
11	PDB:2uxtA	0.096	0.468	1.837E-15	422	0.025	0.137	2uxtA.pdb.gz
12	PDB:6im9A	0.098	0.410	1.937E-15	490	0.024	0.114	6im9A.pdb.gz
13	PDB:3qqxA	0.093	0.407	3.863E-15	474	0.023	0.112	3qqxA.pdb.gz	CueO E506D Mutant: Crystal Structure of Reduced Native Intermediate, Kinetics, and Impairment of Product Release
14	PDB:3divA	0.094	0.399	2.903E-14	499	0.028	0.132	3divA.pdb.gz	Crystal Structure of laccase from Cerrena maxima at 1.76A resolution.
15	AFDB:E7F5U2	0.047	0.045	6.910E-8	2497	0.102	0.096	E7F5U2.pdb.gz
16	AFDB:Q6WRI0	0.041	0.039	1.453E-7	2623	0.107	0.096	Q6WRI0.pdb.gz	IGS10_HUMAN Immunoglobulin superfamily member 10 OS=Homo sapiens OX=9606 GN=IGSF10 PE=1 SV=1
17	AFDB:Q6WRH9	0.041	0.038	8.830E-7	2597	0.098	0.089	Q6WRH9.pdb.gz	IGS10_RAT Immunoglobulin superfamily member 10 OS=Rattus norvegicus OX=10116 GN=Igsf10 PE=1 SV=1
18	AFDB:Q3V1M1	0.044	0.040	3.329E-6	2594	0.102	0.092	Q3V1M1.pdb.gz	IGS10_MOUSE Immunoglobulin superfamily member 10 OS=Mus musculus OX=10090 GN=Igsf10 PE=2 SV=2
19	AFDB:Q8TEP8	0.047	0.045	3.903E-6	2537	0.103	0.096	Q8TEP8.pdb.gz	CE192_HUMAN Centrosomal protein of 192 kDa OS=Homo sapiens OX=9606 GN=CEP192 PE=1 SV=3
20	AFDB:A2VDJ0	0.038	0.052	1.255E-5	1609	0.085	0.125	A2VDJ0.pdb.gz	T131L_HUMAN Transmembrane protein 131-like OS=Homo sapiens OX=9606 GN=TMEM131L PE=1 SV=2

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	D3ZEB1	0.0	2461	2258	0.541	0.563	D3ZEB1_RAT Coagulation factor VIII OS=Rattus norvegicus OX=10116 GN=F8 PE=3 SV=4
2	P00451	0.0	4920	2351	1.000	1.000	FA8_HUMAN Coagulation factor VIII OS=Homo sapiens OX=9606 GN=F8 PE=1 SV=1
3	Q7TN96	0.0	2461	2258	0.541	0.563	Q7TN96_RAT Factor VIII OS=Rattus norvegicus OX=10116 GN=F8 PE=2 SV=1
4	Q58L91	5.75e-166	555	1459	0.120	0.193	FA5V_OXYSU Venom prothrombin activator oscutarin-C non-catalytic subunit OS=Oxyuranus scutellatus OX=8668 PE=1 SV=1
5	Q7SZN0	1.24e-165	554	1460	0.119	0.191	FA5V_PSETE Venom prothrombin activator pseutarin-C non-catalytic subunit OS=Pseudonaja textilis OX=8673 PE=1 SV=1
6	Q58L90	5.76e-163	546	1460	0.119	0.192	FA5V_OXYMI Venom prothrombin activator omicarin-C non-catalytic subunit OS=Oxyuranus microlepidotus OX=111177 PE=2 SV=1
7	B7ZVT7	4.19e-162	556	2087	0.117	0.132	B7ZVT7_DANRE Coagulation factor V OS=Danio rerio OX=7955 GN=si:bz20i5.3 PE=2 SV=1
8	A0A0G2K3W2	7.33e-162	558	2259	0.119	0.124	A0A0G2K3W2_RAT Coagulation factor V OS=Rattus norvegicus OX=10116 GN=F5 PE=1 SV=2
9	P12259	3.92e-158	546	2224	0.123	0.130	FA5_HUMAN Coagulation factor V OS=Homo sapiens OX=9606 GN=F5 PE=1 SV=4
10	O88783	4.82e-157	542	2183	0.116	0.125	FA5_MOUSE Coagulation factor V OS=Mus musculus OX=10090 GN=F5 PE=1 SV=1
11	Q6MZM0	4.17e-141	475	1159	0.120	0.244	HPHL1_HUMAN Ferroxidase HEPHL1 OS=Homo sapiens OX=9606 GN=HEPHL1 PE=1 SV=2
12	Q9Z0Z4	3.60e-130	443	1157	0.111	0.226	HEPH_MOUSE Hephaestin OS=Mus musculus OX=10090 GN=Heph PE=1 SV=3
13	Q7ZU12	5.88e-129	437	1087	0.111	0.240	Q7ZU12_DANRE Ceruloplasmin OS=Danio rerio OX=7955 GN=wu:fi23f10 PE=1 SV=1
14	Q920H8	1.04e-127	436	1157	0.108	0.220	HEPH_RAT Hephaestin OS=Rattus norvegicus OX=10116 GN=Heph PE=1 SV=1
15	Q1L857	2.09e-127	431	1006	0.111	0.259	Q1L857_HUMAN Ceruloplasmin (Fragment) OS=Homo sapiens OX=9606 PE=3 SV=1
16	A5PL27	7.94e-127	431	1065	0.111	0.245	A5PL27_HUMAN CP protein OS=Homo sapiens OX=9606 GN=CP PE=2 SV=1
17	P00450	7.94e-127	431	1065	0.111	0.245	CERU_HUMAN Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1
18	A8K5A4	4.63e-126	429	1065	0.111	0.246	A8K5A4_HUMAN cDNA FLJ76826, highly similar to Homo sapiens ceruloplasmin (ferroxidase) (CP), mRNA OS=Homo sapiens OX=9606 PE=2 SV=1
19	P13635	1.25e-124	424	1059	0.111	0.247	CERU_RAT Ceruloplasmin OS=Rattus norvegicus OX=10116 GN=Cp PE=1 SV=3
20	Q61147	1.56e-122	418	1061	0.114	0.252	CERU_MOUSE Ceruloplasmin OS=Mus musculus OX=10090 GN=Cp PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00394 Cu-oxidase	8.6e-07	40.7	Multicopper oxidase
2	PF07731 Cu-oxidase_2	1e-11	56.1	Multicopper oxidase
3	PF07732 Cu-oxidase_3	1.1e-12	59.4	Multicopper oxidase
4	PF00754 F5_F8_type_C	2.7e-51	184.4	F5/8 type C domain
5	PF07738 Sad1_UNC	1.1e+02	14.2	Sad1 / UNC-like C-terminal

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000353393

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000261405	0.999	Von Willebrand factor
2	9606.ENSP00000218099	0.996	Coagulation factor IX
3	9606.ENSP00000308541	0.992	Prothrombin
4	9606.ENSP00000364709	0.992	Coagulation factor X
5	9606.ENSP00000356671	0.985	Antithrombin-III
6	9606.ENSP00000234071	0.971	Vitamin K-dependent protein C
7	9606.ENSP00000251047	0.970	Protein ERGIC-53
8	9606.ENSP00000386651	0.961	Multiple coagulation factor deficiency protein 2
9	9606.ENSP00000384957	0.956	Coagulation factor XI
10	9606.ENSP00000215727	0.936	Heparin cofactor 2
11	9606.ENSP00000333203	0.916	Plasma serine protease inhibitor
12	9606.ENSP00000415786	0.915	Glia-derived nexin
13	9606.ENSP00000302413	0.913	Protein-tyrosine sulfotransferase 1
14	9606.ENSP00000243077	0.909	Prolow-density lipoprotein receptor-related protein 1
15	9606.ENSP00000339813	0.909	Protein-tyrosine sulfotransferase 2
16	9606.ENSP00000222547	0.900	BET1 homolog
17	9606.ENSP00000259400	0.900	Syntaxin-17
18	9606.ENSP00000390783	0.900	Sec1 family domain-containing protein 1
19	9606.ENSP00000329380	0.895	Platelet glycoprotein Ib alpha chain
20	9606.ENSP00000334145	0.870	Tissue factor

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0003824	0.691	catalytic activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0065007	0.996	biological regulation
GO:0050896	0.988	response to stimulus
GO:0009611	0.979	response to wounding
GO:0050878	0.978	regulation of body fluid levels
GO:1901564	0.971	organonitrogen compound metabolic process
GO:0043170	0.968	macromolecule metabolic process
GO:0007596	0.959	blood coagulation
GO:0044238	0.953	primary metabolic process
GO:0019538	0.939	protein metabolic process
GO:0006508	0.933	proteolysis

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0012505	1.000	endomembrane system
GO:0005576	1.000	extracellular region
GO:0031410	0.995	cytoplasmic vesicle
GO:0070013	0.993	intracellular organelle lumen
GO:0005783	0.985	endoplasmic reticulum
GO:0032991	0.984	protein-containing complex
GO:0005886	0.980	plasma membrane
GO:0030135	0.978	coated vesicle
GO:0030141	0.974	secretory granule
GO:0030134	0.960	COPII-coated ER to Golgi transport vesicle
GO:0005794	0.949	Golgi apparatus
GO:0005615	0.913	extracellular space
GO:0031090	0.895	organelle membrane
GO:0031091	0.886	platelet alpha granule
GO:0098588	0.881	bounding membrane of organelle
GO:0005793	0.819	endoplasmic reticulum-Golgi intermediate compartment
GO:0031983	0.696	vesicle lumen
GO:0005788	0.691	endoplasmic reticulum lumen
GO:0031093	0.689	platelet alpha granule lumen
GO:0033116	0.687	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0005796	0.467	Golgi lumen
GO:0030659	0.423	cytoplasmic vesicle membrane
GO:1903561	0.321	extracellular vesicle
GO:0098827	0.319	endoplasmic reticulum subcompartment
GO:0070062	0.310	extracellular exosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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