StarFunc result for job id P00533

User Input

>input (1210 residues)
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A0R4IFV9	0.334	0.338	0.000	1191	0.619	0.629	A0A0R4IFV9.pdb.gz
2	AFDB:F1N7F3	0.499	0.512	0.000	1179	0.860	0.883	F1N7F3.pdb.gz	F1N7F3_BOVIN Receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=EGFR PE=3 SV=3
3	AFDB:F1R5S1	0.274	0.261	0.000	1275	0.489	0.464	F1R5S1.pdb.gz
4	AFDB:P00533	1.000	1.000	0.000	1210	1.000	1.000	P00533.pdb.gz	EGFR_HUMAN Epidermal growth factor receptor OS=Homo sapiens OX=9606 GN=EGFR PE=1 SV=2
5	AFDB:P21860	0.509	0.466	0.000	1342	0.426	0.384	P21860.pdb.gz	ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 OS=Homo sapiens OX=9606 GN=ERBB3 PE=1 SV=1
6	AFDB:Q15303	0.466	0.434	0.000	1308	0.520	0.481	Q15303.pdb.gz	ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1
7	AFDB:Q504U8	0.484	0.537	0.000	1091	0.869	0.963	Q504U8.pdb.gz	Q504U8_HUMAN Receptor protein-tyrosine kinase OS=Homo sapiens OX=9606 GN=EGFR PE=1 SV=1
8	AFDB:P04412	0.383	0.333	9.945E-99	1426	0.386	0.327	P04412.pdb.gz	EGFR_DROME Epidermal growth factor receptor OS=Drosophila melanogaster OX=7227 GN=Egfr PE=1 SV=3
9	AFDB:Q9ESE0	0.274	0.666	2.926E-68	478	0.322	0.816	Q9ESE0.pdb.gz	Q9ESE0_RAT receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=2 SV=2
10	PDB:7mn8B	0.249	0.501	4.332E-59	579	0.212	0.444	7mn8B.pdb.gz
11	AFDB:F1QNX5	0.254	0.230	8.278E-46	1353	0.217	0.194	F1QNX5.pdb.gz
12	PDB:4fl2A	0.208	0.446	1.853E-21	555	0.089	0.195	4fl2A.pdb.gz	Structural and biophysical characterization of the syk activation switch.
13	PDB:4k2rA	0.203	0.437	4.227E-20	551	0.075	0.165	4k2rA.pdb.gz	Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker.
14	PDB:1k9aB	0.203	0.544	5.172E-20	441	0.078	0.213	1k9aB.pdb.gz
15	PDB:6pxvA	0.184	0.261	8.143E-20	823	0.097	0.142	6pxvA.pdb.gz
16	PDB:2h8hA	0.203	0.535	8.715E-19	445	0.079	0.216	2h8hA.pdb.gz	N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
17	PDB:8dtlA	0.267	0.415	7.249E-18	741	0.103	0.169	8dtlA.pdb.gz
18	PDB:7bwaA	0.175	0.297	9.492E-17	674	0.102	0.184	7bwaA.pdb.gz
19	PDB:6pyhD	0.177	0.256	2.930E-15	798	0.092	0.139	6pyhD.pdb.gz
20	PDB:3nynA	0.202	0.425	8.887E-15	554	0.056	0.123	3nynA.pdb.gz	Molecular basis for activation of G protein-coupled receptor kinases.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A8I5ZMJ2	739	492	0.296	0.728	A0A8I5ZMJ2_RAT receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=1 SV=1
2	A0A8I5ZQB9	2120	1170	0.855	0.885	A0A8I5ZQB9_RAT Receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=1 SV=1
3	A6QR62	971	1336	0.397	0.359	A6QR62_BOVIN Receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=ERBB3 PE=2 SV=1
4	B4DTR1	919	979	0.404	0.499	B4DTR1_HUMAN Erb-b2 receptor tyrosine kinase 2 OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1
5	B8LFF6	1176	1414	0.490	0.419	B8LFF6_DANRE Receptor protein-tyrosine kinase OS=Danio rerio OX=7955 GN=erbb4 PE=2 SV=1
6	E7CXR8	2244	1209	0.907	0.907	E7CXR8_RAT Receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=2 SV=1
7	E7CXR9	2243	1209	0.906	0.907	E7CXR9_RAT Receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=2 SV=1
8	F1N7F3	2150	1179	0.861	0.884	F1N7F3_BOVIN Receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=EGFR PE=3 SV=3
9	F5H1T4	548	603	0.219	0.439	F5H1T4_HUMAN receptor protein-tyrosine kinase OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1
10	G3V6K6	2236	1208	0.905	0.906	G3V6K6_RAT Receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=1 SV=2
11	J3QLU9	1143	1055	0.461	0.529	J3QLU9_HUMAN Receptor protein-tyrosine kinase OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1
12	P00533	2523	1210	1.000	1.000	EGFR_HUMAN Epidermal growth factor receptor OS=Homo sapiens OX=9606 GN=EGFR PE=1 SV=2
13	P04626	1175	1255	0.510	0.492	ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1
14	P06494	1165	1257	0.524	0.504	ERBB2_RAT Receptor tyrosine-protein kinase erbB-2 OS=Rattus norvegicus OX=10116 GN=Erbb2 PE=1 SV=3
15	P21860	978	1342	0.393	0.354	ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 OS=Homo sapiens OX=9606 GN=ERBB3 PE=1 SV=1
16	P70424	1160	1256	0.517	0.498	ERBB2_MOUSE Receptor tyrosine-protein kinase erbB-2 OS=Mus musculus OX=10090 GN=Erbb2 PE=1 SV=3
17	Q01279	2272	1210	0.905	0.905	EGFR_MOUSE Epidermal growth factor receptor OS=Mus musculus OX=10090 GN=Egfr PE=1 SV=1
18	Q15303	1256	1308	0.536	0.496	ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1
19	Q153D9	1244	1299	0.534	0.497	Q153D9_XENLA Receptor protein-tyrosine kinase OS=Xenopus laevis OX=8355 GN=erbb4.L PE=2 SV=1
20	Q4PLA5	1259	1292	0.531	0.497	Q4PLA5_CHICK Receptor protein-tyrosine kinase OS=Gallus gallus OX=9031 GN=ERBB4 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	4.5e+02	11.3	ABC1 atypical kinase-like domain
2	PF01636 APH	1.7e+02	13.4	Phosphotransferase enzyme family
3	PF00757 Furin-like	1.6e-31	120.6	Furin-like cysteine rich region
4	PF11770 GAPT	4.1e+02	12.1	GRB2-binding adapter (GAPT)
5	PF14843 GF_recep_IV	6.3e-48	173.3	Growth factor receptor domain IV
6	PF06293 Kdo	5.5e+02	11.3	Lipopolysaccharide kinase (Kdo/WaaP) family
7	PF14531 Kinase-like	1.5e+02	13.1	Kinase-like
8	PF00069 Pkinase	8.2e-36	135.3	Protein kinase domain
9	PF07714 PK_Tyr_Ser-Thr	1.7e-84	294.8	Protein tyrosine and serine/threonine kinase
10	PF01030 Recep_L_domain	1.4e-57	204.0	Receptor L domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000275493

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000230990	0.999	Proheparin-binding EGF-like growth factor
2	9606.ENSP00000244007	0.999	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
3	9606.ENSP00000244869	0.999	Proepiregulin
4	9606.ENSP00000261769	0.999	Cadherin-1
5	9606.ENSP00000264033	0.999	E3 ubiquitin-protein ligase CBL
6	9606.ENSP00000264657	0.999	Signal transducer and activator of transcription 3
7	9606.ENSP00000265171	0.999	Pro-epidermal growth factor
8	9606.ENSP00000274376	0.999	Ras GTPase-activating protein 1
9	9606.ENSP00000295400	0.999	Protransforming growth factor alpha
10	9606.ENSP00000335153	0.999	Heat shock protein HSP 90-alpha
11	9606.ENSP00000339191	0.999	Caveolin-1
12	9606.ENSP00000340944	0.999	Tyrosine-protein phosphatase non-receptor type 11
13	9606.ENSP00000344456	0.999	Catenin beta-1
14	9606.ENSP00000360683	0.999	Tyrosine-protein phosphatase non-receptor type 1
15	9606.ENSP00000360798	0.999	Epidermal growth factor receptor substrate 15
16	9606.ENSP00000366702	0.999	ERBB receptor feedback inhibitor 1
17	9606.ENSP00000376345	0.999	Growth factor receptor-bound protein 2
18	9606.ENSP00000379092	0.999	Probetacellulin
19	9606.ENSP00000379097	0.999	Amphiregulin
20	9606.ENSP00000384620	0.999	Pro-neuregulin-1, membrane-bound isoform

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0044877	1.000	protein-containing complex binding
GO:0050839	1.000	cell adhesion molecule binding
GO:0005102	1.000	signaling receptor binding
GO:0019903	1.000	protein phosphatase binding
GO:0004714	1.000	transmembrane receptor protein tyrosine kinase activity
GO:0042562	0.999	hormone binding
GO:0019838	0.999	growth factor binding
GO:0019901	0.998	protein kinase binding
GO:0005516	0.984	calmodulin binding
GO:0005178	0.983	integrin binding
GO:0042802	0.969	identical protein binding
GO:0140677	0.943	molecular function activator activity
GO:0030234	0.920	enzyme regulator activity
GO:0030296	0.900	protein tyrosine kinase activator activity
GO:0044389	0.544	ubiquitin-like protein ligase binding
GO:0005006	0.542	epidermal growth factor receptor activity
GO:0031625	0.516	ubiquitin protein ligase binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0048522	0.990	positive regulation of cellular process
GO:0051716	0.989	cellular response to stimulus
GO:0007154	0.987	cell communication
GO:0007165	0.983	signal transduction
GO:0019222	0.981	regulation of metabolic process
GO:0032501	0.980	multicellular organismal process
GO:0071704	0.979	organic substance metabolic process
GO:0038127	0.974	ERBB signaling pathway
GO:0023051	0.973	regulation of signaling
GO:0010646	0.973	regulation of cell communication
GO:0044238	0.971	primary metabolic process
GO:0048583	0.967	regulation of response to stimulus
GO:0007173	0.962	epidermal growth factor receptor signaling pathway
GO:0044237	0.959	cellular metabolic process
GO:0009966	0.958	regulation of signal transduction
GO:0032502	0.957	developmental process
GO:0018212	0.955	peptidyl-tyrosine modification
GO:0042221	0.954	response to chemical
GO:0018108	0.954	peptidyl-tyrosine phosphorylation
GO:0048856	0.953	anatomical structure development
GO:0023056	0.951	positive regulation of signaling
GO:0043408	0.951	regulation of MAPK cascade
GO:0031323	0.949	regulation of cellular metabolic process
GO:0010647	0.949	positive regulation of cell communication
GO:0048584	0.943	positive regulation of response to stimulus
GO:0046777	0.943	protein autophosphorylation
GO:0048519	0.940	negative regulation of biological process
GO:0060341	0.939	regulation of cellular localization
GO:0042303	0.938	molting cycle
GO:0048731	0.938	system development
GO:0008284	0.937	positive regulation of cell population proliferation
GO:0006950	0.933	response to stress
GO:0043410	0.932	positive regulation of MAPK cascade
GO:0051049	0.926	regulation of transport
GO:1903829	0.926	positive regulation of protein localization
GO:0048523	0.923	negative regulation of cellular process
GO:0009893	0.923	positive regulation of metabolic process
GO:0051222	0.923	positive regulation of protein transport
GO:0022404	0.921	molting cycle process
GO:0048513	0.911	animal organ development
GO:2000377	0.909	regulation of reactive oxygen species metabolic process
GO:0009719	0.907	response to endogenous stimulus
GO:0098773	0.900	skin epidermis development
GO:2000379	0.891	positive regulation of reactive oxygen species metabolic process
GO:0042633	0.883	hair cycle
GO:0010033	0.882	response to organic substance
GO:0009653	0.873	anatomical structure morphogenesis
GO:0071840	0.870	cellular component organization or biogenesis
GO:1901700	0.865	response to oxygen-containing compound
GO:0009611	0.861	response to wounding
GO:0080134	0.857	regulation of response to stress
GO:0051094	0.852	positive regulation of developmental process
GO:0032355	0.848	response to estradiol
GO:0030154	0.841	cell differentiation
GO:0065008	0.839	regulation of biological quality
GO:0016043	0.838	cellular component organization
GO:0071495	0.834	cellular response to endogenous stimulus
GO:0007399	0.832	nervous system development
GO:0060548	0.825	negative regulation of cell death
GO:0022405	0.823	hair cycle process
GO:0060255	0.801	regulation of macromolecule metabolic process
GO:0051173	0.800	positive regulation of nitrogen compound metabolic process
GO:0080090	0.791	regulation of primary metabolic process
GO:0043069	0.780	negative regulation of programmed cell death
GO:0043066	0.771	negative regulation of apoptotic process
GO:0051726	0.768	regulation of cell cycle
GO:0051239	0.749	regulation of multicellular organismal process
GO:0051179	0.739	localization
GO:0009991	0.738	response to extracellular stimulus
GO:0010604	0.722	positive regulation of macromolecule metabolic process
GO:0051592	0.708	response to calcium ion
GO:0007417	0.707	central nervous system development
GO:0009058	0.696	biosynthetic process
GO:0051240	0.695	positive regulation of multicellular organismal process
GO:0070887	0.689	cellular response to chemical stimulus
GO:0051046	0.653	regulation of secretion
GO:0071310	0.623	cellular response to organic substance
GO:0045595	0.609	regulation of cell differentiation
GO:1901576	0.589	organic substance biosynthetic process
GO:1901701	0.587	cellular response to oxygen-containing compound
GO:0051246	0.584	regulation of protein metabolic process
GO:0048699	0.575	generation of neurons
GO:0065009	0.568	regulation of molecular function
GO:0044249	0.567	cellular biosynthetic process
GO:0044260	0.564	cellular macromolecule metabolic process
GO:0031175	0.558	neuron projection development
GO:0048732	0.541	gland development
GO:0000902	0.528	cell morphogenesis
GO:0034641	0.527	cellular nitrogen compound metabolic process
GO:0044093	0.495	positive regulation of molecular function
GO:0010468	0.490	regulation of gene expression
GO:0010467	0.477	gene expression
GO:0035295	0.475	tube development
GO:0007346	0.453	regulation of mitotic cell cycle
GO:0009628	0.448	response to abiotic stimulus
GO:0071407	0.425	cellular response to organic cyclic compound
GO:0051247	0.425	positive regulation of protein metabolic process
GO:0051174	0.403	regulation of phosphorus metabolic process
GO:0006979	0.398	response to oxidative stress
GO:0019220	0.386	regulation of phosphate metabolic process
GO:0050790	0.383	regulation of catalytic activity
GO:0031399	0.372	regulation of protein modification process
GO:0019219	0.352	regulation of nucleobase-containing compound metabolic process
GO:0031326	0.348	regulation of cellular biosynthetic process
GO:0010556	0.347	regulation of macromolecule biosynthetic process
GO:0042325	0.343	regulation of phosphorylation
GO:0051234	0.328	establishment of localization
GO:0071466	0.308	cellular response to xenobiotic stimulus
GO:0051252	0.306	regulation of RNA metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0031410	0.995	cytoplasmic vesicle
GO:0005634	0.994	nucleus
GO:0012505	0.992	endomembrane system
GO:0030054	0.991	cell junction
GO:0009925	0.976	basal plasma membrane
GO:0016323	0.958	basolateral plasma membrane
GO:0098857	0.938	membrane microdomain
GO:0045121	0.924	membrane raft
GO:0009986	0.919	cell surface
GO:0005768	0.897	endosome
GO:0005829	0.895	cytosol
GO:0030139	0.884	endocytic vesicle
GO:0032991	0.419	protein-containing complex
GO:0045202	0.375	synapse
GO:0045177	0.357	apical part of cell
GO:0016324	0.345	apical plasma membrane
GO:0031090	0.300	organelle membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.10.1	1.000	receptor protein-tyrosine kinase.

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