StarFunc result for job id P01112

User Input

>input (189 residues)
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P01112	1.000	1.000	1.036E-39	189	1.000	1.000	P01112.pdb.gz	RASH_HUMAN GTPase HRas OS=Homo sapiens OX=9606 GN=HRAS PE=1 SV=1
2	AFDB:P01111	0.918	0.918	8.128E-36	189	0.852	0.852	P01111.pdb.gz	RASN_HUMAN GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1
3	AFDB:P22981	0.915	0.940	4.626E-34	184	0.735	0.755	P22981.pdb.gz	LET60_CAEEL Ras protein let-60 OS=Caenorhabditis elegans OX=6239 GN=let-60 PE=1 SV=1
4	AFDB:A0A060XMH4	0.911	0.911	1.977E-33	189	0.847	0.847	A0A060XMH4.pdb.gz	A0A060XMH4_ONCMY V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00021867001 PE=3 SV=1
5	AFDB:P08646	0.888	0.888	5.430E-33	189	0.783	0.783	P08646.pdb.gz	RAS1_DROME Ras-like protein 1 OS=Drosophila melanogaster OX=7227 GN=Ras85D PE=1 SV=2
6	AFDB:Q6AZA4	0.894	0.899	2.988E-32	188	0.825	0.830	Q6AZA4.pdb.gz	Q6AZA4_DANRE GTPase KRas OS=Danio rerio OX=7955 GN=K-ras PE=1 SV=1
7	PDB:6zizA	0.888	0.987	3.094E-32	170	0.794	0.882	6zizA.pdb.gz	Drugging all RAS isoforms with one pocket.
8	AFDB:P15064	0.895	0.895	4.515E-31	189	0.677	0.677	P15064.pdb.gz	RASG_DICDI Ras-like protein rasG OS=Dictyostelium discoideum OX=44689 GN=rasG PE=1 SV=1
9	AFDB:P03967	0.902	0.911	6.013E-30	187	0.635	0.642	P03967.pdb.gz	RASD_DICDI Ras-like protein rasD OS=Dictyostelium discoideum OX=44689 GN=rasD PE=1 SV=2
10	AFDB:P62070	0.895	0.830	2.658E-28	204	0.556	0.515	P62070.pdb.gz	RRAS2_HUMAN Ras-related protein R-Ras2 OS=Homo sapiens OX=9606 GN=RRAS2 PE=1 SV=1
11	AFDB:P01120	0.861	0.507	3.016E-28	322	0.582	0.342	P01120.pdb.gz	RAS2_YEAST Ras-like protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RAS2 PE=1 SV=4
12	PDB:7kyzA	0.834	0.838	2.674E-27	188	0.852	0.856	7kyzA.pdb.gz
13	PDB:6kykC	0.848	0.947	1.778E-26	169	0.508	0.568	6kykC.pdb.gz	Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.
14	PDB:7sd0B	0.853	0.925	8.662E-24	174	0.492	0.534	7sd0B.pdb.gz	Structural basis for SHOC2 modulation of RAS signalling.
15	PDB:6zqtA	0.858	0.936	1.017E-22	173	0.466	0.509	6zqtA.pdb.gz	Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
16	PDB:2bovA	0.859	0.936	4.079E-22	173	0.476	0.520	2bovA.pdb.gz	Molecular Recognition of an Adp-Ribosylating Clostridium Botulinum C3 Exoenzyme by Rala Gtpase
17	PDB:1kaoA	0.839	0.946	1.693E-20	167	0.429	0.485	1kaoA.pdb.gz	Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.
18	PDB:7e1tB	0.855	0.926	2.402E-19	174	0.280	0.305	7e1tB.pdb.gz	Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex.
19	PDB:2gf0B	0.780	0.844	4.240E-19	174	0.333	0.362	2gf0B.pdb.gz	The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state
20	PDB:1vg8A	0.827	0.848	1.499E-18	184	0.302	0.310	1vg8A.pdb.gz	Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P01112	1.60e-141	393	189	1.000	1.000	RASH_HUMAN GTPase HRas OS=Homo sapiens OX=9606 GN=HRAS PE=1 SV=1
2	P20171	1.60e-141	393	189	1.000	1.000	RASH_RAT GTPase HRas OS=Rattus norvegicus OX=10116 GN=Hras PE=1 SV=2
3	Q61411	1.60e-141	393	189	1.000	1.000	RASH_MOUSE GTPase HRas OS=Mus musculus OX=10090 GN=Hras PE=1 SV=2
4	X5D945	1.60e-141	393	189	1.000	1.000	X5D945_HUMAN Harvey rat sarcoma viral oncoprotein isoform A (Fragment) OS=Homo sapiens OX=9606 GN=HRAS PE=2 SV=1
5	P08556	1.41e-112	320	189	0.862	0.862	RASN_MOUSE GTPase NRas OS=Mus musculus OX=10090 GN=Nras PE=1 SV=1
6	P01116	5.19e-112	318	189	0.868	0.868	RASK_HUMAN GTPase KRas OS=Homo sapiens OX=9606 GN=KRAS PE=1 SV=1
7	P08644	1.16e-111	318	189	0.868	0.868	RASK_RAT GTPase KRas OS=Rattus norvegicus OX=10116 GN=Kras PE=1 SV=3
8	P32883	1.16e-111	318	189	0.868	0.868	RASK_MOUSE GTPase KRas OS=Mus musculus OX=10090 GN=Kras PE=1 SV=1
9	P01111	1.21e-111	318	189	0.852	0.852	RASN_HUMAN GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1
10	Q04970	4.36e-111	316	189	0.847	0.847	RASN_RAT GTPase NRas OS=Rattus norvegicus OX=10116 GN=Nras PE=1 SV=1
11	A0A2R8Q8S1	2.63e-110	314	189	0.857	0.857	A0A2R8Q8S1_DANRE GTPase KRas isoform X1 OS=Danio rerio OX=7955 GN=wu:fa04e08 PE=1 SV=1
12	A0A060XMH4	6.83e-110	313	189	0.862	0.862	A0A060XMH4_ONCMY V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00021867001 PE=3 SV=1
13	Q6AZA4	3.42e-106	304	188	0.820	0.824	Q6AZA4_DANRE GTPase KRas OS=Danio rerio OX=7955 GN=K-ras PE=1 SV=1
14	P08646	1.11e-96	280	189	0.778	0.778	RAS1_DROME Ras-like protein 1 OS=Drosophila melanogaster OX=7227 GN=Ras85D PE=1 SV=2
15	P22981	2.24e-94	274	184	0.735	0.755	LET60_CAEEL Ras protein let-60 OS=Caenorhabditis elegans OX=6239 GN=let-60 PE=1 SV=1
16	P15064	3.70e-83	246	189	0.656	0.656	RASG_DICDI Ras-like protein rasG OS=Dictyostelium discoideum OX=44689 GN=rasG PE=1 SV=1
17	P03967	1.72e-78	234	187	0.624	0.631	RASD_DICDI Ras-like protein rasD OS=Dictyostelium discoideum OX=44689 GN=rasD PE=1 SV=2
18	Q12526	2.60e-71	216	212	0.624	0.557	RAS_EMENI Ras-like protein OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=rasA PE=2 SV=2
19	P32253	9.10e-71	214	189	0.566	0.566	RASC_DICDI Ras-like protein rasC OS=Dictyostelium discoideum OX=44689 GN=rasC PE=1 SV=1
20	E9QX28	1.76e-70	214	213	0.614	0.545	E9QX28_ASPFU RAS small monomeric GTPase RasA OS=Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) OX=330879 GN=AFUA_5G11230 PE=4 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13191 AAA_16	6.4e+02	12.1	AAA ATPase domain
2	PF13401 AAA_22	4.3e+02	12.6	AAA domain
3	PF13481 AAA_25	6.8e+02	11.2	AAA domain
4	PF00025 Arf	6.5e-06	37.2	ADP-ribosylation factor family
5	PF03029 ATP_bind_1	40	15.4	Conserved hypothetical ATP binding protein
6	PF02421 FeoB_N	1.3	20.0	Ferrous iron transport protein B
7	PF00503 G-alpha	55	14.4	G-protein alpha subunit
8	PF00009 GTP_EFTU	0.0043	28.1	Elongation factor Tu GTP binding domain
9	PF04670 Gtr1_RagA	30	15.5	Gtr1/RagA G protein conserved region
10	PF00056 Ldh_1_N	4.8e+02	12.2	lactate/malate dehydrogenase, NAD binding domain
11	PF01926 MMR_HSR1	0.046	25.2	50S ribosome-binding GTPase
12	PF00071 Ras	3.7e-55	197.4	Ras family
13	PF08477 Roc	5.4e-18	76.8	Ras of Complex, Roc, domain of DAPkinase
14	PF03193 RsgA_GTPase	0.014	26.8	RsgA GTPase
15	PF00735 Septin	91	13.8	Septin

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 1026970.XP_008852607.1

Rank	PPI partner	STRING score	Description
1	1026970.XP_008843731.1	0.999	SOS Ras/Rac guanine nucleotide exchange factor 1
2	1026970.XP_008853131.1	0.999	RAF proto-oncogene serine/threonine-protein kinase isoform X1
3	1026970.XP_008837642.1	0.998	Ras GTPase-activating protein 1
4	1026970.XP_008821740.1	0.997	Serine/threonine-protein kinase B-raf isoform X1
5	1026970.XP_008828950.1	0.996	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
6	1026970.XP_008820481.1	0.995	Ras and Rab interactor 1
7	1026970.XP_008836896.1	0.992	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
8	1026970.XP_008842162.1	0.992	Ral guanine nucleotide dissociation stimulator isoform X1
9	1026970.XP_008826093.1	0.991	Afadin, adherens junction formation factor
10	1026970.XP_008837055.1	0.990	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
11	1026970.XP_008819832.1	0.988	Neurofibromin isoform X1
12	1026970.XP_008840738.1	0.988	A-Raf proto-oncogene, serine/threonine kinase
13	1026970.XP_008828076.1	0.987	SOS Ras/Rho guanine nucleotide exchange factor 2
14	1026970.XP_008851302.1	0.987	Phospholipase C epsilon 1
15	1026970.XP_008853894.1	0.985	SRC proto-oncogene, non-receptor tyrosine kinase
16	1026970.XP_008821512.1	0.984	Ras association domain family member 5
17	1026970.XP_008822143.1	0.984	Mitogen-activated protein kinase 3
18	1026970.XP_008834447.1	0.984	GTPase KRas
19	1026970.XP_008822511.1	0.981	Ral guanine nucleotide dissociation stimulator-like 1 isoform X1
20	1026970.XP_008834567.1	0.980	Mitogen-activated protein kinase kinase 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0044877	0.999	protein-containing complex binding
GO:0003924	0.999	GTPase activity
GO:0097367	0.996	carbohydrate derivative binding
GO:0036094	0.995	small molecule binding
GO:0043168	0.995	anion binding
GO:0032561	0.987	guanyl ribonucleotide binding
GO:0035639	0.976	purine ribonucleoside triphosphate binding
GO:0005525	0.972	GTP binding
GO:0098772	0.763	molecular function regulator activity
GO:0019003	0.539	GDP binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.994	regulation of cellular process
GO:0051716	0.992	cellular response to stimulus
GO:0007154	0.988	cell communication
GO:0048518	0.987	positive regulation of biological process
GO:0035556	0.982	intracellular signal transduction
GO:0032502	0.980	developmental process
GO:0007264	0.974	small GTPase mediated signal transduction
GO:0048856	0.970	anatomical structure development
GO:0090398	0.970	cellular senescence
GO:0019222	0.965	regulation of metabolic process
GO:0048522	0.961	positive regulation of cellular process
GO:0007265	0.952	Ras protein signal transduction
GO:0060255	0.951	regulation of macromolecule metabolic process
GO:0032501	0.943	multicellular organismal process
GO:0023051	0.926	regulation of signaling
GO:0010646	0.926	regulation of cell communication
GO:0048583	0.922	regulation of response to stimulus
GO:1902531	0.901	regulation of intracellular signal transduction
GO:0042127	0.885	regulation of cell population proliferation
GO:0007275	0.851	multicellular organism development
GO:0043410	0.849	positive regulation of MAPK cascade
GO:0008284	0.810	positive regulation of cell population proliferation
GO:0070372	0.806	regulation of ERK1 and ERK2 cascade
GO:0048513	0.800	animal organ development
GO:0051171	0.800	regulation of nitrogen compound metabolic process
GO:0070374	0.800	positive regulation of ERK1 and ERK2 cascade
GO:0050678	0.779	regulation of epithelial cell proliferation
GO:0031323	0.777	regulation of cellular metabolic process
GO:0080090	0.775	regulation of primary metabolic process
GO:0048731	0.769	system development
GO:0042221	0.747	response to chemical
GO:0010468	0.741	regulation of gene expression
GO:0050679	0.735	positive regulation of epithelial cell proliferation
GO:0010033	0.734	response to organic substance
GO:0048519	0.732	negative regulation of biological process
GO:0000165	0.732	MAPK cascade
GO:0009893	0.731	positive regulation of metabolic process
GO:0010604	0.724	positive regulation of macromolecule metabolic process
GO:0006915	0.698	apoptotic process
GO:0045935	0.698	positive regulation of nucleobase-containing compound metabolic process
GO:0050793	0.697	regulation of developmental process
GO:0007166	0.692	cell surface receptor signaling pathway
GO:0051246	0.686	regulation of protein metabolic process
GO:0009605	0.583	response to external stimulus
GO:0051239	0.569	regulation of multicellular organismal process
GO:0048869	0.511	cellular developmental process
GO:0048523	0.489	negative regulation of cellular process
GO:0030154	0.476	cell differentiation
GO:0051174	0.358	regulation of phosphorus metabolic process
GO:0051247	0.302	positive regulation of protein metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	1.000	membrane
GO:0005622	0.996	intracellular anatomical structure
GO:0005886	0.990	plasma membrane
GO:0043226	0.989	organelle
GO:0043227	0.976	membrane-bounded organelle
GO:0005737	0.973	cytoplasm
GO:0043229	0.958	intracellular organelle
GO:0043231	0.900	intracellular membrane-bounded organelle
GO:0012505	0.561	endomembrane system
GO:0031974	0.429	membrane-enclosed lumen
GO:0043233	0.420	organelle lumen
GO:0070013	0.385	intracellular organelle lumen
GO:0031981	0.362	nuclear lumen
GO:0005829	0.320	cytosol

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:19669	0.999	GTP + H2O = GDP + H(+) + phosphate

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