StarFunc result for job id P01213

User Input

>input (254 residues)
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWE
RCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKEN
TLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLR
KYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRS
QEDPNAYSGELFDA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P01213	1.000	1.000	1.017E-41	254	1.000	1.000	P01213.pdb.gz	PDYN_HUMAN Proenkephalin-B OS=Homo sapiens OX=9606 GN=PDYN PE=1 SV=1
2	AFDB:P06300	0.272	0.277	3.869E-20	248	0.638	0.653	P06300.pdb.gz	PDYN_RAT Proenkephalin-B OS=Rattus norvegicus OX=10116 GN=Pdyn PE=1 SV=2
3	AFDB:F1R4H8	0.298	0.299	3.870E-12	253	0.386	0.387	F1R4H8.pdb.gz
4	AFDB:P04094	0.248	0.237	5.830E-6	269	0.307	0.290	P04094.pdb.gz	PENK_RAT Proenkephalin-A OS=Rattus norvegicus OX=10116 GN=Penk PE=1 SV=1
5	AFDB:Q95Q34	0.099	0.052	6.432E-2	529	0.114	0.055	Q95Q34.pdb.gz	RIOK2_CAEEL Serine/threonine-protein kinase RIO2 OS=Caenorhabditis elegans OX=6239 GN=riok-2 PE=2 SV=2
6	AFDB:O45995	0.082	0.040	1.610E-1	701	0.094	0.034	O45995.pdb.gz	O45995_CAEEL SET domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=CELE_ZK1053.4 PE=1 SV=2
7	AFDB:E9QA62	0.096	0.049	1.720E-1	571	0.154	0.068	E9QA62.pdb.gz	LMOD3_MOUSE Leiomodin-3 OS=Mus musculus OX=10090 GN=Lmod3 PE=1 SV=1
8	AFDB:Q7Z4S6	0.134	0.026	2.093E-1	1674	0.114	0.017	Q7Z4S6.pdb.gz	KI21A_HUMAN Kinesin-like protein KIF21A OS=Homo sapiens OX=9606 GN=KIF21A PE=1 SV=2
9	AFDB:P29536	0.093	0.048	2.235E-1	600	0.150	0.063	P29536.pdb.gz	LMOD1_HUMAN Leiomodin-1 OS=Homo sapiens OX=9606 GN=LMOD1 PE=1 SV=3
10	AFDB:Q8L8A5	0.110	0.106	2.235E-1	210	0.157	0.190	Q8L8A5.pdb.gz	GIF1_ARATH GRF1-interacting factor 1 OS=Arabidopsis thaliana OX=3702 GN=GIF1 PE=1 SV=1
11	PDB:3j4qB	0.094	0.076	1.227	382	0.079	0.052	3j4qB.pdb.gz
12	PDB:6dv9F	0.129	0.175	2.694	174	0.079	0.115	6dv9F.pdb.gz	Structural basis of ECF-sigma-factor-dependent transcription initiation.
13	PDB:7oleC	0.113	0.074	3.501	427	0.059	0.035	7oleC.pdb.gz	Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone.
14	PDB:6tm5N	0.092	0.047	3.739	676	0.094	0.036	6tm5N.pdb.gz	A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
15	PDB:1bcfA	0.109	0.164	3.992	158	0.039	0.063	1bcfA.pdb.gz	Structure of a unique twofold symmetric haem-binding site.
16	PDB:6jq0E	0.105	0.060	4.551	577	0.079	0.035	6jq0E.pdb.gz	Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone.
17	PDB:7d4iRQ	0.107	0.088	4.551	339	0.079	0.059	7d4iRQ.pdb.gz	Cryo-EM structure of 90S small ribosomal precursors complex with Dhr1
18	PDB:7dvqR	0.114	0.118	4.551	241	0.157	0.166	7dvqR.pdb.gz	Structure of the activated human minor spliceosome.
19	PDB:5z56L	0.080	0.064	4.859	342	0.071	0.053	5z56L.pdb.gz	Structure of the human activated spliceosome in three conformational states.
20	PDB:6elzm	0.083	0.039	4.859	645	0.134	0.053	6elzm.pdb.gz	Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P01213	0.0	517	254	1.000	1.000	PDYN_HUMAN Proenkephalin-B OS=Homo sapiens OX=9606 GN=PDYN PE=1 SV=1
2	P06300	4.72e-101	296	248	0.638	0.653	PDYN_RAT Proenkephalin-B OS=Rattus norvegicus OX=10116 GN=Pdyn PE=1 SV=2
3	Q6JT77	1.06e-45	155	252	0.421	0.425	Q6JT77_DANRE Proenkephalin-B OS=Danio rerio OX=7955 GN=fj38c03 PE=2 SV=1
4	P04094	6.48e-19	85.5	269	0.319	0.301	PENK_RAT Proenkephalin-A OS=Rattus norvegicus OX=10116 GN=Penk PE=1 SV=1
5	P01210	6.76e-18	82.8	267	0.311	0.296	PENK_HUMAN Proenkephalin-A OS=Homo sapiens OX=9606 GN=PENK PE=1 SV=1
6	P22005	1.05e-17	82.0	268	0.311	0.295	PENK_MOUSE Proenkephalin-A OS=Mus musculus OX=10090 GN=Penk PE=1 SV=2
7	Q5RIC2	1.18e-05	47.4	233	0.209	0.227	Q5RIC2_DANRE Prepronociceptin OS=Danio rerio OX=7955 GN=pnoc PE=2 SV=1
8	Q62923	0.12	35.0	181	0.091	0.127	PNOC_RAT Prepronociceptin OS=Rattus norvegicus OX=10116 GN=Pnoc PE=1 SV=1
9	D6XEJ9	1.2	33.1	1244	0.071	0.014	D6XEJ9_TRYB2 ATP pyrophosphate-lyase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb04.3I12.1110 PE=4 SV=1
10	Q581G5	1.2	33.1	1244	0.071	0.014	Q581G5_9TRYP ATP pyrophosphate-lyase OS=Trypanosoma brucei OX=5691 GN=Tb04.30K5.1120 PE=4 SV=1
11	Q583C9	1.2	33.1	1247	0.071	0.014	Q583C9_TRYB2 ATP pyrophosphate-lyase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb04.3I12.1080 PE=4 SV=1
12	Q13519	1.3	32.0	176	0.094	0.136	PNOC_HUMAN Prepronociceptin OS=Homo sapiens OX=9606 GN=PNOC PE=1 SV=1
13	Q583D2	2.5	32.0	1271	0.075	0.015	Q583D2_TRYB2 ATP pyrophosphate-lyase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb04.3I12.1040 PE=4 SV=1
14	P07293	3.5	31.6	1873	0.110	0.015	CAC1S_RABIT Voltage-dependent L-type calcium channel subunit alpha-1S OS=Oryctolagus cuniculus OX=9986 GN=CACNA1S PE=1 SV=1
15	A0A0B4KG50	4.5	31.2	4976	0.091	0.005	A0A0B4KG50_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform B OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=1
16	A0A0B4KH36	4.5	31.2	4852	0.091	0.005	A0A0B4KH36_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform C OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=1
17	A0A0B4KGR9	4.6	31.2	4875	0.091	0.005	A0A0B4KGR9_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform D OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=1
18	Q9VH01	4.6	31.2	4876	0.091	0.005	Q9VH01_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform A OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=3
19	A0A0B4KFQ0	4.9	31.2	4865	0.091	0.005	A0A0B4KFQ0_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform E OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=1
20	Q02789	5.8	30.8	1852	0.106	0.015	CAC1S_MOUSE Voltage-dependent L-type calcium channel subunit alpha-1S OS=Mus musculus OX=10090 GN=Cacna1s PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01160 Opiods_neuropep	7.2e-14	62.9	Vertebrate endogenous opioids neuropeptide

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000440185

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000265572	0.984	Kappa-type opioid receptor
2	9606.ENSP00000384092	0.974	Pro-opiomelanocortin
3	9606.ENSP00000394624	0.948	Mu-type opioid receptor
4	9606.ENSP00000477455	0.902	Glutamate receptor ionotropic, NMDA 2B
5	9606.ENSP00000356162	0.891	Metastasis-suppressor KiSS-1
6	9606.ENSP00000324248	0.889	Proenkephalin-A
7	9606.ENSP00000379818	0.888	Glutamate receptor ionotropic, NMDA 2A
8	9606.ENSP00000321106	0.881	Protachykinin-1
9	9606.ENSP00000336764	0.877	Nociceptin receptor
10	9606.ENSP00000483110	0.875	Tachykinin-3
11	9606.ENSP00000360608	0.870	Glutamate receptor ionotropic, NMDA 1
12	9606.ENSP00000234961	0.853	Delta-type opioid receptor
13	9606.ENSP00000355155	0.847	Glutamate receptor ionotropic, NMDA 3A
14	9606.ENSP00000293190	0.841	Glutamate receptor ionotropic, NMDA 2C
15	9606.ENSP00000384364	0.841	Pro-neuropeptide Y
16	9606.ENSP00000263269	0.833	Glutamate receptor ionotropic, NMDA 2D
17	9606.ENSP00000234389	0.818	Glutamate receptor ionotropic, NMDA 3B
18	9606.ENSP00000276571	0.815	Corticoliberin
19	9606.ENSP00000276414	0.802	Progonadoliberin-1
20	9606.ENSP00000256010	0.796	Neurotensin/neuromedin N

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0005102	0.510	signaling receptor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.989	regulation of cellular process
GO:0065008	0.978	regulation of biological quality
GO:0023051	0.890	regulation of signaling
GO:0010646	0.890	regulation of cell communication
GO:0032879	0.786	regulation of localization
GO:0051049	0.780	regulation of transport
GO:0009987	0.771	cellular process
GO:0099177	0.725	regulation of trans-synaptic signaling
GO:0001505	0.724	regulation of neurotransmitter levels
GO:0023052	0.702	signaling
GO:0050804	0.690	modulation of chemical synaptic transmission
GO:0051046	0.684	regulation of secretion
GO:0051588	0.681	regulation of neurotransmitter transport
GO:0050896	0.675	response to stimulus
GO:0007154	0.656	cell communication
GO:1903530	0.637	regulation of secretion by cell
GO:0046928	0.599	regulation of neurotransmitter secretion
GO:0051716	0.576	cellular response to stimulus
GO:0007165	0.552	signal transduction
GO:0032501	0.327	multicellular organismal process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0045202	0.999	synapse
GO:0005886	0.999	plasma membrane
GO:0098992	0.998	neuronal dense core vesicle
GO:0005576	0.996	extracellular region
GO:0070013	0.844	intracellular organelle lumen
GO:0098984	0.634	neuron to neuron synapse
GO:0005615	0.540	extracellular space
GO:0098686	0.515	hippocampal mossy fiber to CA3 synapse
GO:0044297	0.367	cell body
GO:0036477	0.353	somatodendritic compartment
GO:0098793	0.353	presynapse
GO:0030133	0.332	transport vesicle
GO:0034774	0.330	secretory granule lumen
GO:0070382	0.314	exocytic vesicle
GO:0043025	0.303	neuronal cell body

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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