StarFunc result for job id P02749

User Input

>input (345 residues)
MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGG
MRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD
SAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAM
FGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL
DGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC
KNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P02749	1.000	1.000	3.591E-66	345	1.000	1.000	P02749.pdb.gz	APOH_HUMAN Beta-2-glycoprotein 1 OS=Homo sapiens OX=9606 GN=APOH PE=1 SV=3
2	PDB:1c1zA	0.862	0.909	1.885E-58	326	0.942	0.997	1c1zA.pdb.gz
3	AFDB:Q01339	0.914	0.914	2.532E-57	345	0.765	0.765	Q01339.pdb.gz	APOH_MOUSE Beta-2-glycoprotein 1 OS=Mus musculus OX=10090 GN=Apoh PE=1 SV=1
4	AFDB:P26644	0.784	0.907	2.562E-47	297	0.707	0.822	P26644.pdb.gz	APOH_RAT Beta-2-glycoprotein 1 OS=Rattus norvegicus OX=10116 GN=Apoh PE=2 SV=2
5	AFDB:Q22328	0.433	0.262	1.496E-22	622	0.249	0.138	Q22328.pdb.gz	LEV9_CAEEL Protein lev-9 OS=Caenorhabditis elegans OX=6239 GN=lev-9 PE=1 SV=3
6	AFDB:P05160	0.284	0.177	3.294E-22	661	0.241	0.126	P05160.pdb.gz	F13B_HUMAN Coagulation factor XIII B chain OS=Homo sapiens OX=9606 GN=F13B PE=1 SV=3
7	AFDB:P04003	0.482	0.308	3.819E-22	597	0.235	0.136	P04003.pdb.gz	C4BPA_HUMAN C4b-binding protein alpha chain OS=Homo sapiens OX=9606 GN=C4BPA PE=1 SV=2
8	AFDB:Q63514	0.509	0.346	1.248E-21	558	0.241	0.149	Q63514.pdb.gz	C4BPA_RAT C4b-binding protein alpha chain OS=Rattus norvegicus OX=10116 GN=C4bpa PE=2 SV=1
9	AFDB:Q07968	0.253	0.150	1.447E-21	669	0.232	0.120	Q07968.pdb.gz	F13B_MOUSE Coagulation factor XIII B chain OS=Mus musculus OX=10090 GN=F13b PE=1 SV=2
10	AFDB:Q7TSY4	0.555	0.357	2.747E-21	577	0.226	0.135	Q7TSY4.pdb.gz	ZP3R_RAT Zona pellucida sperm-binding protein 3 receptor OS=Rattus norvegicus OX=10116 GN=Zp3r PE=2 SV=1
11	AFDB:P08607	0.569	0.434	3.032E-21	469	0.220	0.162	P08607.pdb.gz	C4BPA_MOUSE C4b-binding protein OS=Mus musculus OX=10090 GN=C4bpa PE=1 SV=3
12	PDB:2gsxA	0.291	0.134	1.759E-16	951	0.217	0.079	2gsxA.pdb.gz
13	PDB:2q7zA	0.190	0.049	9.565E-15	1931	0.217	0.039	2q7zA.pdb.gz
14	PDB:1haqA	0.231	0.101	1.021E-13	1213	0.212	0.060	1haqA.pdb.gz
15	PDB:8a7eC	0.294	0.109	7.464E-12	1524	0.180	0.041	8a7eC.pdb.gz	Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
16	PDB:2xwbF	0.243	0.131	8.794E-11	714	0.128	0.062	2xwbF.pdb.gz	Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
17	PDB:8a7dQ	0.196	0.238	9.538E-9	273	0.113	0.143	8a7dQ.pdb.gz	Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
18	PDB:3t5oA	0.218	0.107	5.104E-8	871	0.113	0.045	3t5oA.pdb.gz	Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).
19	PDB:4e0sB	0.206	0.090	2.731E-7	898	0.122	0.047	4e0sB.pdb.gz	Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
20	PDB:7nycC	0.253	0.126	3.919E-6	809	0.145	0.062	7nycC.pdb.gz	Structural basis of soluble membrane attack complex packaging for clearance.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P02749	0.0	711	345	1.000	1.000	APOH_HUMAN Beta-2-glycoprotein 1 OS=Homo sapiens OX=9606 GN=APOH PE=1 SV=3
2	P26644	0.0	504	297	0.707	0.822	APOH_RAT Beta-2-glycoprotein 1 OS=Rattus norvegicus OX=10116 GN=Apoh PE=2 SV=2
3	Q01339	0.0	577	345	0.765	0.765	APOH_MOUSE Beta-2-glycoprotein 1 OS=Mus musculus OX=10090 GN=Apoh PE=1 SV=1
4	Q63514	1.22e-28	118	558	0.246	0.152	C4BPA_RAT C4b-binding protein alpha chain OS=Rattus norvegicus OX=10116 GN=C4bpa PE=2 SV=1
5	Q22328	4.27e-28	117	622	0.267	0.148	LEV9_CAEEL Protein lev-9 OS=Caenorhabditis elegans OX=6239 GN=lev-9 PE=1 SV=3
6	A0A1D5NSM8	2.38e-25	109	3615	0.206	0.020	A0A1D5NSM8_DANRE Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1 OS=Danio rerio OX=7955 GN=svep1 PE=4 SV=1
7	P16109	2.15e-24	106	830	0.214	0.089	LYAM3_HUMAN P-selectin OS=Homo sapiens OX=9606 GN=SELP PE=1 SV=3
8	A2AVA0	7.63e-24	105	3567	0.203	0.020	SVEP1_MOUSE Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus OX=10090 GN=Svep1 PE=1 SV=1
9	Q00690	8.50e-24	104	612	0.188	0.106	LYAM2_MOUSE E-selectin OS=Mus musculus OX=10090 GN=Sele PE=2 SV=1
10	P08607	1.01e-23	103	469	0.241	0.177	C4BPA_MOUSE C4b-binding protein OS=Mus musculus OX=10090 GN=C4bpa PE=1 SV=3
11	Q4LDE5	3.24e-23	103	3571	0.206	0.020	SVEP1_HUMAN Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SVEP1 PE=1 SV=3
12	A8JUT1	8.54e-23	101	755	0.246	0.113	A8JUT1_DROME Furrowed, isoform B OS=Drosophila melanogaster OX=7227 GN=fw PE=4 SV=1
13	Q9VYR4	9.62e-23	101	1174	0.246	0.072	Q9VYR4_DROME Furrowed, isoform A OS=Drosophila melanogaster OX=7227 GN=fw PE=2 SV=2
14	P91658	1.12e-22	101	974	0.246	0.087	P91658_DROME Furrowed OS=Drosophila melanogaster OX=7227 GN=fw PE=4 SV=1
15	Q9DEG0	1.87e-22	99.8	451	0.246	0.188	Q9DEG0_CHICK Complement regulatory membrane protein OS=Gallus gallus OX=9031 GN=Cremp PE=2 SV=1
16	Q01102	2.45e-22	100	768	0.212	0.095	LYAM3_MOUSE P-selectin OS=Mus musculus OX=10090 GN=Selp PE=1 SV=1
17	P05160	2.65e-22	100	661	0.243	0.127	F13B_HUMAN Coagulation factor XIII B chain OS=Homo sapiens OX=9606 GN=F13B PE=1 SV=3
18	Q923L3	3.82e-22	100	3564	0.217	0.021	CSMD1_MOUSE CUB and sushi domain-containing protein 1 OS=Mus musculus OX=10090 GN=Csmd1 PE=1 SV=2
19	O02839	4.32e-22	97.8	363	0.212	0.201	MCP_PIG Membrane cofactor protein OS=Sus scrofa OX=9823 GN=CD46 PE=1 SV=1
20	A0A024CBD6	4.86e-22	97.8	363	0.209	0.198	A0A024CBD6_PIG Membrane cofactor protein OS=Sus scrofa OX=9823 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF12662 cEGF	57	15.1	Complement Clr-like EGF-like
2	PF00084 Sushi	1.3e-38	142.6	Sushi repeat (SCR repeat)
3	PF09014 Sushi_2	1.1e-32	123.1	Beta-2-glycoprotein-1 fifth domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000205948

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000236850	0.989	Apolipoprotein A-I
2	9606.ENSP00000356969	0.982	Apolipoprotein A-II
3	9606.ENSP00000227667	0.980	Apolipoprotein C-III
4	9606.ENSP00000233242	0.977	Apolipoprotein B-100
5	9606.ENSP00000308541	0.975	Prothrombin
6	9606.ENSP00000393887	0.974	Alpha-2-HS-glycoprotein
7	9606.ENSP00000303634	0.963	Low-density lipoprotein receptor-related protein 8
8	9606.ENSP00000265132	0.956	Protein AMBP
9	9606.ENSP00000336829	0.951	Fibrinogen gamma chain
10	9606.ENSP00000356671	0.946	Antithrombin-III
11	9606.ENSP00000321334	0.945	Apolipoprotein(a)
12	9606.ENSP00000252486	0.923	Apolipoprotein E
13	9606.ENSP00000348170	0.909	Haptoglobin
14	9606.ENSP00000350425	0.904	Apolipoprotein A-IV
15	9606.ENSP00000295897	0.898	Serum albumin
16	9606.ENSP00000465356	0.891	Apolipoprotein C-I
17	9606.ENSP00000351190	0.884	Inter-alpha-trypsin inhibitor heavy chain H2
18	9606.ENSP00000445002	0.884	Apolipoprotein A-V
19	9606.ENSP00000466775	0.882	Apolipoprotein C-II
20	9606.ENSP00000381133	0.879	Fibrinogen-like protein 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0008289	1.000	lipid binding
GO:0005515	1.000	protein binding
GO:0005543	0.976	phospholipid binding
GO:0042802	0.973	identical protein binding
GO:0098772	0.897	molecular function regulator activity
GO:0030234	0.890	enzyme regulator activity
GO:0008047	0.743	enzyme activator activity
GO:0060229	0.703	lipase activator activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0065007	0.996	biological regulation
GO:0050789	0.992	regulation of biological process
GO:0050896	0.990	response to stimulus
GO:0032501	0.948	multicellular organismal process
GO:0050794	0.933	regulation of cellular process
GO:0048518	0.913	positive regulation of biological process
GO:0009987	0.904	cellular process
GO:0006950	0.885	response to stress
GO:0050878	0.876	regulation of body fluid levels
GO:0048583	0.872	regulation of response to stimulus
GO:0071704	0.861	organic substance metabolic process
GO:0044238	0.790	primary metabolic process
GO:0030193	0.766	regulation of blood coagulation
GO:0007596	0.758	blood coagulation
GO:0048519	0.695	negative regulation of biological process
GO:0006807	0.561	nitrogen compound metabolic process
GO:1901564	0.480	organonitrogen compound metabolic process
GO:0043170	0.437	macromolecule metabolic process
GO:0044237	0.423	cellular metabolic process
GO:0048523	0.400	negative regulation of cellular process
GO:0019222	0.396	regulation of metabolic process
GO:0048522	0.391	positive regulation of cellular process
GO:0051241	0.386	negative regulation of multicellular organismal process
GO:0051179	0.385	localization
GO:0048585	0.369	negative regulation of response to stimulus
GO:0080090	0.356	regulation of primary metabolic process
GO:0048584	0.339	positive regulation of response to stimulus
GO:0065009	0.314	regulation of molecular function

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005615	0.997	extracellular space
GO:0005737	0.966	cytoplasm
GO:0071944	0.965	cell periphery
GO:0043227	0.948	membrane-bounded organelle
GO:0043231	0.921	intracellular membrane-bounded organelle
GO:0070062	0.889	extracellular exosome
GO:0032991	0.884	protein-containing complex
GO:0016020	0.833	membrane
GO:0012505	0.833	endomembrane system
GO:0043233	0.806	organelle lumen
GO:0070013	0.746	intracellular organelle lumen
GO:0009986	0.741	cell surface
GO:0005886	0.612	plasma membrane
GO:0030141	0.559	secretory granule
GO:0062023	0.549	collagen-containing extracellular matrix
GO:0031983	0.521	vesicle lumen
GO:0034774	0.494	secretory granule lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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