StarFunc result for job id P04083

User Input

>input (346 residues)
MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGV
DEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDA
DELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNAL
LSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKY
TKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIM
VSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P04083	1.000	1.000	2.938E-52	346	1.000	1.000	P04083.pdb.gz	ANXA1_HUMAN Annexin A1 OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=2
2	AFDB:P07150	0.998	0.998	7.203E-48	346	0.890	0.890	P07150.pdb.gz	ANXA1_RAT Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=2
3	AFDB:P19619	0.999	0.999	2.107E-47	346	0.887	0.887	P19619.pdb.gz	ANXA1_PIG Annexin A1 OS=Sus scrofa OX=9823 GN=ANXA1 PE=1 SV=3
4	PDB:1hm6A	0.980	0.989	1.198E-44	343	0.887	0.895	1hm6A.pdb.gz
5	PDB:1ainA	0.887	0.976	1.796E-40	314	0.908	1.000	1ainA.pdb.gz
6	AFDB:Q7T3A8	0.921	0.937	3.629E-35	340	0.639	0.650	Q7T3A8.pdb.gz
7	AFDB:P17785	0.880	0.898	1.217E-30	339	0.500	0.510	P17785.pdb.gz	ANXA2_CHICK Annexin A2 OS=Gallus gallus OX=9031 GN=ANXA2 PE=1 SV=2
8	AFDB:A6NMY6	0.884	0.902	5.091E-30	339	0.488	0.499	A6NMY6.pdb.gz	AXA2L_HUMAN Putative annexin A2-like protein OS=Homo sapiens OX=9606 GN=ANXA2P2 PE=5 SV=2
9	AFDB:P14669	0.887	0.946	9.106E-30	324	0.448	0.478	P14669.pdb.gz	ANXA3_RAT Annexin A3 OS=Rattus norvegicus OX=10116 GN=Anxa3 PE=1 SV=4
10	AFDB:P20072	0.882	0.663	1.041E-29	463	0.419	0.313	P20072.pdb.gz	ANXA7_BOVIN Annexin A7 OS=Bos taurus OX=9913 GN=ANXA7 PE=1 SV=2
11	AFDB:P50995	0.887	0.611	1.191E-29	505	0.442	0.303	P50995.pdb.gz	ANX11_HUMAN Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1
12	AFDB:P20073	0.878	0.627	1.862E-29	488	0.410	0.291	P20073.pdb.gz	ANXA7_HUMAN Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3
13	PDB:7p70A	0.879	0.749	2.312E-29	407	0.491	0.418	7p70A.pdb.gz	Quantitative fragmentomics allow affinity mapping of interactomes.
14	PDB:5n7dA	0.882	0.723	2.418E-29	423	0.491	0.402	5n7dA.pdb.gz	Dynamic control of RSK complexes by phosphoswitch-based regulation.
15	PDB:7p73A	0.879	0.726	4.945E-29	420	0.491	0.405	7p73A.pdb.gz	Quantitative fragmentomics allow affinity mapping of interactomes.
16	PDB:1axnA	0.870	0.930	1.978E-28	323	0.451	0.483	1axnA.pdb.gz	The high-resolution crystal structure of human annexin III shows subtle differences with annexin V.
17	PDB:7qqnC	0.863	0.724	2.829E-28	414	0.497	0.415	7qqnC.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
18	PDB:7pcbA	0.847	0.708	6.328E-28	415	0.483	0.402	7pcbA.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
19	PDB:7pc3A	0.865	0.741	6.617E-28	405	0.491	0.420	7pc3A.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
20	PDB:7qqmA	0.858	0.721	9.464E-28	413	0.491	0.412	7qqmA.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P04083	0.0	715	346	1.000	1.000	ANXA1_HUMAN Annexin A1 OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=2
2	P07150	0.0	644	346	0.890	0.890	ANXA1_RAT Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=2
3	P10107	0.0	634	346	0.876	0.876	ANXA1_MOUSE Annexin A1 OS=Mus musculus OX=10090 GN=Anxa1 PE=1 SV=2
4	P19619	0.0	637	346	0.887	0.887	ANXA1_PIG Annexin A1 OS=Sus scrofa OX=9823 GN=ANXA1 PE=1 SV=3
5	P46193	0.0	649	346	0.905	0.905	ANXA1_BOVIN Annexin A1 OS=Bos taurus OX=9913 GN=ANXA1 PE=1 SV=2
6	Q5TZZ9	0.0	715	346	1.000	1.000	Q5TZZ9_HUMAN Annexin OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=1
7	Q804H2	4.77e-147	420	340	0.642	0.653	Q804H2_DANRE Annexin OS=Danio rerio OX=7955 GN=anx1a PE=1 SV=1
8	Q5T3N1	1.13e-139	396	204	0.558	0.946	Q5T3N1_HUMAN Annexin (Fragment) OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=1
9	P17785	6.40e-117	343	339	0.512	0.522	ANXA2_CHICK Annexin A2 OS=Gallus gallus OX=9031 GN=ANXA2 PE=1 SV=2
10	P07355	8.49e-117	343	339	0.506	0.516	ANXA2_HUMAN Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2
11	P07356	1.58e-116	342	339	0.500	0.510	ANXA2_MOUSE Annexin A2 OS=Mus musculus OX=10090 GN=Anxa2 PE=1 SV=2
12	Q07936	2.55e-116	342	339	0.503	0.513	ANXA2_RAT Annexin A2 OS=Rattus norvegicus OX=10116 GN=Anxa2 PE=1 SV=2
13	P04272	1.74e-115	340	339	0.503	0.513	ANXA2_BOVIN Annexin A2 OS=Bos taurus OX=9913 GN=ANXA2 PE=1 SV=2
14	Q6TEQ7	5.40e-115	338	339	0.500	0.510	ANXA2_CANLF Annexin A2 OS=Canis lupus familiaris OX=9615 GN=ANXA2 PE=1 SV=1
15	P19620	1.62e-114	337	339	0.497	0.507	ANXA2_PIG Annexin A2 OS=Sus scrofa OX=9823 GN=ANXA2 PE=1 SV=4
16	A6NMY6	4.87e-113	333	339	0.494	0.504	AXA2L_HUMAN Putative annexin A2-like protein OS=Homo sapiens OX=9606 GN=ANXA2P2 PE=5 SV=2
17	P14669	2.52e-104	311	324	0.448	0.478	ANXA3_RAT Annexin A3 OS=Rattus norvegicus OX=10116 GN=Anxa3 PE=1 SV=4
18	O35639	2.62e-101	303	323	0.457	0.489	ANXA3_MOUSE Annexin A3 OS=Mus musculus OX=10090 GN=Anxa3 PE=1 SV=4
19	P12429	5.36e-101	302	323	0.454	0.486	ANXA3_HUMAN Annexin A3 OS=Homo sapiens OX=9606 GN=ANXA3 PE=1 SV=3
20	P50995	5.48e-98	301	505	0.465	0.319	ANX11_HUMAN Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00191 Annexin	2.6e-90	307.8	Annexin
2	PF15963 Myb_DNA-bind_7	0.03	25.5	Myb DNA-binding like

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000366109

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000271638	0.998	Protein S100-A11
2	9606.ENSP00000471493	0.997	fMet-Leu-Phe receptor
3	9606.ENSP00000468897	0.996	N-formyl peptide receptor 2
4	9606.ENSP00000341821	0.995	N-formyl peptide receptor 3
5	9606.ENSP00000386881	0.992	Dysferlin
6	9606.ENSP00000346839	0.944	Fibronectin type III domain containing
7	9606.ENSP00000357801	0.944	Protein S100-A10
8	9606.ENSP00000231509	0.936	Glucocorticoid receptor
9	9606.ENSP00000346032	0.931	Annexin A2
10	9606.ENSP00000231449	0.929	Interleukin-4
11	9606.ENSP00000297268	0.924	Collagen alpha-2(I) chain
12	9606.ENSP00000304915	0.922	Interleukin-13
13	9606.ENSP00000312675	0.921	Tripartite motif-containing protein 72
14	9606.ENSP00000264870	0.919	Coagulation factor XIII A chain
15	9606.ENSP00000252999	0.909	Laminin subunit alpha-5
16	9606.ENSP00000219235	0.906	C-C motif chemokine 22
17	9606.ENSP00000482604	0.881	Hematopoietic SH2 domain-containing protein
18	9606.ENSP00000483825	0.865	NF-kappa-B essential modulator
19	9606.ENSP00000341940	0.851	Caveolin-3
20	9606.ENSP00000346550	0.819	Annexin A6

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0005544	0.998	calcium-dependent phospholipid binding
GO:0043167	0.943	ion binding
GO:0046872	0.889	metal ion binding
GO:0005509	0.878	calcium ion binding
GO:0098772	0.554	molecular function regulator activity
GO:0042802	0.509	identical protein binding
GO:1901363	0.458	heterocyclic compound binding
GO:0005102	0.450	signaling receptor binding
GO:0097159	0.380	organic cyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.988	cellular process
GO:0050896	0.981	response to stimulus
GO:0050794	0.980	regulation of cellular process
GO:0048518	0.958	positive regulation of biological process
GO:0051179	0.951	localization
GO:0048522	0.945	positive regulation of cellular process
GO:0051234	0.923	establishment of localization
GO:0051716	0.918	cellular response to stimulus
GO:0019222	0.910	regulation of metabolic process
GO:0048519	0.905	negative regulation of biological process
GO:0006810	0.889	transport
GO:0060255	0.886	regulation of macromolecule metabolic process
GO:0032502	0.844	developmental process
GO:0022407	0.843	regulation of cell-cell adhesion
GO:0045785	0.840	positive regulation of cell adhesion
GO:0002682	0.819	regulation of immune system process
GO:1903037	0.816	regulation of leukocyte cell-cell adhesion
GO:0051249	0.814	regulation of lymphocyte activation
GO:0006950	0.809	response to stress
GO:0022409	0.807	positive regulation of cell-cell adhesion
GO:0048523	0.804	negative regulation of cellular process
GO:0032501	0.803	multicellular organismal process
GO:0002684	0.803	positive regulation of immune system process
GO:0050867	0.801	positive regulation of cell activation
GO:0050870	0.788	positive regulation of T cell activation
GO:0048856	0.773	anatomical structure development
GO:0002376	0.770	immune system process
GO:0007162	0.763	negative regulation of cell adhesion
GO:0002683	0.758	negative regulation of immune system process
GO:0042221	0.746	response to chemical
GO:0010468	0.744	regulation of gene expression
GO:0040012	0.742	regulation of locomotion
GO:0050866	0.742	negative regulation of cell activation
GO:1902105	0.734	regulation of leukocyte differentiation
GO:2000145	0.733	regulation of cell motility
GO:1902107	0.707	positive regulation of leukocyte differentiation
GO:0048583	0.695	regulation of response to stimulus
GO:0002695	0.693	negative regulation of leukocyte activation
GO:0007154	0.672	cell communication
GO:0046634	0.672	regulation of alpha-beta T cell activation
GO:0030334	0.665	regulation of cell migration
GO:2000514	0.653	regulation of CD4-positive, alpha-beta T cell activation
GO:0046637	0.652	regulation of alpha-beta T cell differentiation
GO:0046635	0.640	positive regulation of alpha-beta T cell activation
GO:0010721	0.620	negative regulation of cell development
GO:0022408	0.612	negative regulation of cell-cell adhesion
GO:0051250	0.603	negative regulation of lymphocyte activation
GO:0045621	0.602	positive regulation of lymphocyte differentiation
GO:0009719	0.557	response to endogenous stimulus
GO:0023052	0.540	signaling
GO:0045620	0.539	negative regulation of lymphocyte differentiation
GO:0045582	0.539	positive regulation of T cell differentiation
GO:1903038	0.535	negative regulation of leukocyte cell-cell adhesion
GO:0043370	0.534	regulation of CD4-positive, alpha-beta T cell differentiation
GO:0071840	0.529	cellular component organization or biogenesis
GO:0051171	0.528	regulation of nitrogen compound metabolic process
GO:0010604	0.519	positive regulation of macromolecule metabolic process
GO:0008152	0.517	metabolic process
GO:0080090	0.514	regulation of primary metabolic process
GO:0032879	0.512	regulation of localization
GO:0071704	0.507	organic substance metabolic process
GO:0031323	0.507	regulation of cellular metabolic process
GO:0023051	0.501	regulation of signaling
GO:0065009	0.498	regulation of molecular function
GO:0007165	0.496	signal transduction
GO:0051049	0.492	regulation of transport
GO:0010646	0.485	regulation of cell communication
GO:0016043	0.480	cellular component organization
GO:0010033	0.466	response to organic substance
GO:0048584	0.464	positive regulation of response to stimulus
GO:0050868	0.456	negative regulation of T cell activation
GO:0070887	0.455	cellular response to chemical stimulus
GO:0046638	0.455	positive regulation of alpha-beta T cell differentiation
GO:0016192	0.424	vesicle-mediated transport
GO:0065008	0.399	regulation of biological quality
GO:0009966	0.398	regulation of signal transduction
GO:0071310	0.382	cellular response to organic substance
GO:0044238	0.362	primary metabolic process
GO:0042127	0.362	regulation of cell population proliferation
GO:0040017	0.351	positive regulation of locomotion
GO:0001817	0.348	regulation of cytokine production
GO:2000147	0.337	positive regulation of cell motility
GO:0030335	0.333	positive regulation of cell migration
GO:0051173	0.329	positive regulation of nitrogen compound metabolic process
GO:0009892	0.323	negative regulation of metabolic process
GO:0009889	0.321	regulation of biosynthetic process
GO:0031325	0.318	positive regulation of cellular metabolic process
GO:0010941	0.315	regulation of cell death
GO:0006807	0.310	nitrogen compound metabolic process
GO:0031326	0.304	regulation of cellular biosynthetic process
GO:0019219	0.300	regulation of nucleobase-containing compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071944	0.999	cell periphery
GO:0016020	0.999	membrane
GO:0005737	0.999	cytoplasm
GO:0043231	0.999	intracellular membrane-bounded organelle
GO:0005829	0.986	cytosol
GO:0070013	0.985	intracellular organelle lumen
GO:0005886	0.984	plasma membrane
GO:0005634	0.962	nucleus
GO:0005576	0.950	extracellular region
GO:0031982	0.941	vesicle
GO:0005615	0.911	extracellular space
GO:0070062	0.891	extracellular exosome
GO:0012505	0.843	endomembrane system
GO:0031981	0.801	nuclear lumen
GO:0005654	0.730	nucleoplasm
GO:0097708	0.390	intracellular vesicle
GO:0031410	0.312	cytoplasmic vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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