StarFunc result for job id P04085

User Input

>input (211 residues)
MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD
TSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIW
PPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACA
TTSLNPDYREEDTGRPRESGKKRKRKRLKPT

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P04085	1.000	1.000	2.636E-34	211	1.000	1.000	P04085.pdb.gz	PDGFA_HUMAN Platelet-derived growth factor subunit A OS=Homo sapiens OX=9606 GN=PDGFA PE=1 SV=1
2	AFDB:Q90WK1	0.755	0.816	1.917E-27	194	0.730	0.794	Q90WK1.pdb.gz	Q90WK1_CHICK Platelet derived growth factor subunit A OS=Gallus gallus OX=9031 GN=PDGF-A (S2) PE=2 SV=1
3	AFDB:Q9DE50	0.682	0.735	3.022E-21	195	0.550	0.595	Q9DE50.pdb.gz
4	AFDB:P31240	0.622	0.549	9.043E-17	241	0.417	0.365	P31240.pdb.gz	PDGFB_MOUSE Platelet-derived growth factor subunit B OS=Mus musculus OX=10090 GN=Pdgfb PE=2 SV=1
5	AFDB:B1H0W5	0.653	0.578	2.506E-16	241	0.427	0.373	B1H0W5.pdb.gz	B1H0W5_BOVIN PDGFB protein OS=Bos taurus OX=9913 GN=PDGFB PE=2 SV=1
6	AFDB:E7FBB3	0.621	0.289	2.916E-14	482	0.336	0.147	E7FBB3.pdb.gz
7	AFDB:A0A2R8PYF1	0.528	0.255	3.658E-14	463	0.308	0.140	A0A2R8PYF1.pdb.gz
8	AFDB:Q208T6	0.413	0.332	1.510E-7	272	0.227	0.176	Q208T6.pdb.gz	Q208T6_DANRE C-fos induced growth factor OS=Danio rerio OX=7955 GN=figf PE=2 SV=1
9	AFDB:Q9VWP6	0.401	0.268	2.660E-7	325	0.223	0.145	Q9VWP6.pdb.gz	Q9VWP6_DROME LD28763p OS=Drosophila melanogaster OX=7227 GN=Pvf1 PE=2 SV=3
10	AFDB:Q9N413	0.426	0.308	7.371E-7	304	0.194	0.135	Q9N413.pdb.gz	Q9N413_CAEEL Platelet-derived growth factor (PDGF) family profile domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=pvf-1 PE=1 SV=1
11	PDB:1wq8A	0.332	0.632	6.425E-6	100	0.118	0.250	1wq8A.pdb.gz
12	PDB:2k8pA	0.238	0.258	1.199E-2	189	0.142	0.159	2k8pA.pdb.gz
13	PDB:5vqfB	0.224	0.159	1.269E-2	320	0.104	0.069	5vqfB.pdb.gz
14	PDB:7y1rB	0.177	0.133	1.782E-2	308	0.071	0.049	7y1rB.pdb.gz
15	PDB:1m4uA	0.217	0.226	1.996E-2	199	0.076	0.080	1m4uA.pdb.gz
16	PDB:5ffoG	0.192	0.145	2.235E-2	297	0.090	0.064	5ffoG.pdb.gz	Force interacts with macromolecular structure in activation of TGF-beta.
17	PDB:3rjrC	0.191	0.128	2.967E-2	343	0.095	0.058	3rjrC.pdb.gz
18	PDB:7ag0A	0.196	0.264	3.140E-2	140	0.076	0.114	7ag0A.pdb.gz
19	PDB:1hcnB	0.288	0.519	6.556E-2	110	0.085	0.164	1hcnB.pdb.gz
20	PDB:5hk5F	0.253	0.388	1.155E-1	129	0.085	0.140	5hk5F.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P04085	8.86e-153	424	211	1.000	1.000	PDGFA_HUMAN Platelet-derived growth factor subunit A OS=Homo sapiens OX=9606 GN=PDGFA PE=1 SV=1
2	P20033	3.61e-124	351	211	0.924	0.924	PDGFA_MOUSE Platelet-derived growth factor subunit A OS=Mus musculus OX=10090 GN=Pdgfa PE=2 SV=2
3	P28576	6.14e-119	338	204	0.886	0.917	PDGFA_RAT Platelet-derived growth factor subunit A OS=Rattus norvegicus OX=10116 GN=Pdgfa PE=2 SV=2
4	Q90WK1	1.68e-113	323	194	0.730	0.794	Q90WK1_CHICK Platelet derived growth factor subunit A OS=Gallus gallus OX=9031 GN=PDGF-A (S2) PE=2 SV=1
5	A5PMP7	9.01e-76	228	194	0.555	0.603	A5PMP7_DANRE Platelet-derived growth factor alpha a precursor OS=Danio rerio OX=7955 GN=LOC103909601 PE=3 SV=1
6	P31240	8.03e-43	145	241	0.412	0.361	PDGFB_MOUSE Platelet-derived growth factor subunit B OS=Mus musculus OX=10090 GN=Pdgfb PE=2 SV=1
7	P01127	2.55e-42	144	241	0.393	0.344	PDGFB_HUMAN Platelet-derived growth factor subunit B OS=Homo sapiens OX=9606 GN=PDGFB PE=1 SV=1
8	B1H0W5	7.19e-41	140	241	0.384	0.336	B1H0W5_BOVIN PDGFB protein OS=Bos taurus OX=9913 GN=PDGFB PE=2 SV=1
9	Q05028	7.66e-41	140	225	0.389	0.364	PDGFB_RAT Platelet-derived growth factor subunit B (Fragment) OS=Rattus norvegicus OX=10116 GN=Pdgfb PE=2 SV=1
10	Q9VWP6	6.21e-09	57.0	325	0.133	0.086	Q9VWP6_DROME LD28763p OS=Drosophila melanogaster OX=7227 GN=Pvf1 PE=2 SV=3
11	X2JCH3	6.50e-09	56.6	300	0.133	0.093	X2JCH3_DROME PDGF-and VEGF-related factor 1, isoform C OS=Drosophila melanogaster OX=7227 GN=Pvf1 PE=3 SV=1
12	Q9BLX1	6.78e-09	56.6	314	0.133	0.089	Q9BLX1_DROME PDGF-and VEGF-related factor 1, isoform B OS=Drosophila melanogaster OX=7227 GN=Pvf1 PE=2 SV=1
13	Q0QYI0	3.73e-07	50.8	194	0.171	0.186	Q0QYI0_DANRE Vascular endothelial growth factor A isoform 2 precursor (Fragment) OS=Danio rerio OX=7955 GN=fd42e02 PE=2 SV=1
14	Q9N413	7.04e-07	50.8	304	0.223	0.155	Q9N413_CAEEL Platelet-derived growth factor (PDGF) family profile domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=pvf-1 PE=1 SV=1
15	E7EZR4	1.15e-06	50.1	246	0.133	0.114	E7EZR4_DANRE Vascular endothelial growth factor A-like OS=Danio rerio OX=7955 GN=vegfba PE=3 SV=1
16	O35251	1.30e-05	47.0	326	0.261	0.169	VEGFD_RAT Vascular endothelial growth factor D OS=Rattus norvegicus OX=10116 GN=Vegfd PE=1 SV=1
17	O73682	1.37e-05	46.2	188	0.114	0.128	VGFAA_DANRE Vascular endothelial growth factor A-A OS=Danio rerio OX=7955 GN=vegfaa PE=1 SV=1
18	P49766	4.69e-05	45.1	207	0.118	0.121	VEGFB_MOUSE Vascular endothelial growth factor B OS=Mus musculus OX=10090 GN=Vegfb PE=2 SV=2
19	P49765	4.83e-05	45.1	207	0.128	0.130	VEGFB_HUMAN Vascular endothelial growth factor B OS=Homo sapiens OX=9606 GN=VEGFB PE=1 SV=2
20	Q7LAP4	4.83e-05	45.1	207	0.128	0.130	Q7LAP4_HUMAN Vascular endothelial growth factor B OS=Homo sapiens OX=9606 GN=VEGFB PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00341 PDGF	1.4e-18	78.3	PDGF/VEGF domain
2	PF04692 PDGF_N	1.8e-26	104.0	Platelet-derived growth factor, N terminal region
3	PF11089 SyrA	9.3e+02	11.1	Exopolysaccharide production repressor

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000346508

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000257290	0.999	Platelet-derived growth factor receptor alpha
2	9606.ENSP00000261799	0.997	Platelet-derived growth factor receptor beta
3	9606.ENSP00000422464	0.979	Platelet-derived growth factor C
4	9606.ENSP00000376865	0.978	Platelet-derived growth factor D
5	9606.ENSP00000330382	0.944	Platelet-derived growth factor subunit B
6	9606.ENSP00000483552	0.939	Furin
7	9606.ENSP00000407586	0.934	GTPase HRas
8	9606.ENSP00000256078	0.932	GTPase KRas
9	9606.ENSP00000244007	0.929	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
10	9606.ENSP00000263967	0.927	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
11	9606.ENSP00000428056	0.917	Phosphatidylinositol 3-kinase regulatory subunit alpha
12	9606.ENSP00000376345	0.916	Growth factor receptor-bound protein 2
13	9606.ENSP00000313681	0.914	Sphingosine kinase 1
14	9606.ENSP00000401303	0.913	SHC-transforming protein 1
15	9606.ENSP00000358548	0.910	GTPase NRas
16	9606.ENSP00000387784	0.906	Son of sevenless homolog 1
17	9606.ENSP00000274376	0.904	Ras GTPase-activating protein 1
18	9606.ENSP00000302665	0.903	Insulin-like growth factor I
19	9606.ENSP00000343204	0.903	Tyrosine-protein kinase JAK1
20	9606.ENSP00000265171	0.901	Pro-epidermal growth factor

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0008083	1.000	growth factor activity
GO:0070851	0.999	growth factor receptor binding
GO:0042802	0.996	identical protein binding
GO:0044877	0.948	protein-containing complex binding
GO:0019838	0.941	growth factor binding
GO:0046983	0.935	protein dimerization activity
GO:0042803	0.926	protein homodimerization activity
GO:0046982	0.919	protein heterodimerization activity
GO:0005518	0.911	collagen binding
GO:0005161	0.709	platelet-derived growth factor receptor binding
GO:0048407	0.639	platelet-derived growth factor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0042127	0.975	regulation of cell population proliferation
GO:0050896	0.974	response to stimulus
GO:0009987	0.974	cellular process
GO:0048522	0.970	positive regulation of cellular process
GO:0032501	0.969	multicellular organismal process
GO:0048856	0.969	anatomical structure development
GO:0007275	0.956	multicellular organism development
GO:0051716	0.955	cellular response to stimulus
GO:0048731	0.953	system development
GO:0008284	0.938	positive regulation of cell population proliferation
GO:0009893	0.931	positive regulation of metabolic process
GO:0007154	0.926	cell communication
GO:0048513	0.920	animal organ development
GO:0010604	0.902	positive regulation of macromolecule metabolic process
GO:0031325	0.890	positive regulation of cellular metabolic process
GO:0051173	0.886	positive regulation of nitrogen compound metabolic process
GO:0009966	0.879	regulation of signal transduction
GO:0030335	0.874	positive regulation of cell migration
GO:0042221	0.866	response to chemical
GO:0043549	0.866	regulation of kinase activity
GO:0007169	0.865	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0071363	0.861	cellular response to growth factor stimulus
GO:0009611	0.858	response to wounding
GO:0042327	0.856	positive regulation of phosphorylation
GO:0080090	0.854	regulation of primary metabolic process
GO:0031401	0.835	positive regulation of protein modification process
GO:0048584	0.826	positive regulation of response to stimulus
GO:0001934	0.814	positive regulation of protein phosphorylation
GO:0009889	0.791	regulation of biosynthetic process
GO:0045859	0.789	regulation of protein kinase activity
GO:0048519	0.774	negative regulation of biological process
GO:1902531	0.761	regulation of intracellular signal transduction
GO:0008406	0.756	gonad development
GO:0051239	0.753	regulation of multicellular organismal process
GO:0048523	0.745	negative regulation of cellular process
GO:0042060	0.744	wound healing
GO:0032101	0.738	regulation of response to external stimulus
GO:0050793	0.725	regulation of developmental process
GO:0010033	0.724	response to organic substance
GO:0043410	0.715	positive regulation of MAPK cascade
GO:0009887	0.708	animal organ morphogenesis
GO:0051241	0.699	negative regulation of multicellular organismal process
GO:0070887	0.680	cellular response to chemical stimulus
GO:0009888	0.650	tissue development
GO:1901700	0.649	response to oxygen-containing compound
GO:0060429	0.596	epithelium development
GO:0043085	0.567	positive regulation of catalytic activity
GO:0001666	0.567	response to hypoxia
GO:0009410	0.566	response to xenobiotic stimulus
GO:0048145	0.564	regulation of fibroblast proliferation
GO:0014070	0.550	response to organic cyclic compound
GO:0014910	0.550	regulation of smooth muscle cell migration
GO:0048146	0.550	positive regulation of fibroblast proliferation
GO:0048008	0.546	platelet-derived growth factor receptor signaling pathway
GO:0033993	0.525	response to lipid
GO:0080134	0.480	regulation of response to stress
GO:0071840	0.464	cellular component organization or biogenesis
GO:0048585	0.456	negative regulation of response to stimulus
GO:0008152	0.397	metabolic process
GO:0031326	0.387	regulation of cellular biosynthetic process
GO:0065008	0.379	regulation of biological quality
GO:0071900	0.351	regulation of protein serine/threonine kinase activity
GO:0019219	0.343	regulation of nucleobase-containing compound metabolic process
GO:0010468	0.340	regulation of gene expression
GO:0014066	0.335	regulation of phosphatidylinositol 3-kinase signaling
GO:0035295	0.331	tube development
GO:0071704	0.329	organic substance metabolic process
GO:0051128	0.316	regulation of cellular component organization
GO:0044238	0.306	primary metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005576	0.999	extracellular region
GO:0012505	0.997	endomembrane system
GO:0070013	0.997	intracellular organelle lumen
GO:0005615	0.994	extracellular space
GO:0043231	0.987	intracellular membrane-bounded organelle
GO:0005737	0.986	cytoplasm
GO:0016020	0.984	membrane
GO:0071944	0.948	cell periphery
GO:0031410	0.948	cytoplasmic vesicle
GO:0005886	0.924	plasma membrane
GO:0032991	0.826	protein-containing complex
GO:0099503	0.760	secretory vesicle
GO:0031090	0.758	organelle membrane
GO:0005783	0.752	endoplasmic reticulum
GO:0031091	0.726	platelet alpha granule
GO:0034774	0.725	secretory granule lumen
GO:0031093	0.723	platelet alpha granule lumen
GO:0009986	0.721	cell surface
GO:0098588	0.687	bounding membrane of organelle
GO:0005794	0.687	Golgi apparatus
GO:0005788	0.669	endoplasmic reticulum lumen
GO:0000139	0.530	Golgi membrane
GO:0036454	0.391	growth factor complex
GO:1990265	0.371	platelet-derived growth factor complex
GO:0031981	0.363	nuclear lumen
GO:0042995	0.339	cell projection
GO:0005796	0.335	Golgi lumen
GO:0120025	0.313	plasma membrane bounded cell projection

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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