StarFunc result for job id P04626

User Input

>input (1255 residues)
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA
LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG
AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV
NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ
GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P04626	1.000	1.000	0.000	1255	1.000	1.000	P04626.pdb.gz	ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1
2	AFDB:P06494	0.760	0.759	0.000	1257	0.881	0.880	P06494.pdb.gz	ERBB2_RAT Receptor tyrosine-protein kinase erbB-2 OS=Rattus norvegicus OX=10116 GN=Erbb2 PE=1 SV=3
3	PDB:7mn8B	0.450	0.960	1.533E-94	579	0.457	0.991	7mn8B.pdb.gz
4	AFDB:Q9UK79	0.267	0.782	1.968E-54	419	0.273	0.816	Q9UK79.pdb.gz	Q9UK79_HUMAN receptor protein-tyrosine kinase OS=Homo sapiens OX=9606 GN=HER-2 PE=2 SV=2
5	AFDB:B0R0Q2	0.197	0.180	9.658E-38	1380	0.217	0.197	B0R0Q2.pdb.gz
6	AFDB:D3ZDH4	0.221	0.282	1.882E-28	977	0.096	0.123	D3ZDH4.pdb.gz	D3ZDH4_RAT receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Epha1 PE=1 SV=1
7	AFDB:P70600	0.216	0.267	3.283E-28	1009	0.099	0.123	P70600.pdb.gz	FAK2_RAT Protein-tyrosine kinase 2-beta OS=Rattus norvegicus OX=10116 GN=Ptk2b PE=1 SV=1
8	AFDB:P21709	0.222	0.283	7.372E-28	976	0.095	0.122	P21709.pdb.gz	EPHA1_HUMAN Ephrin type-A receptor 1 OS=Homo sapiens OX=9606 GN=EPHA1 PE=1 SV=4
9	AFDB:P30530	0.209	0.292	1.131E-26	894	0.111	0.155	P30530.pdb.gz	UFO_HUMAN Tyrosine-protein kinase receptor UFO OS=Homo sapiens OX=9606 GN=AXL PE=1 SV=4
10	AFDB:E9PSX9	0.209	0.295	1.316E-26	879	0.101	0.144	E9PSX9.pdb.gz	E9PSX9_RAT receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Axl PE=1 SV=2
11	AFDB:Q0E917	0.216	0.225	1.783E-26	1200	0.104	0.108	Q0E917.pdb.gz	Q0E917_DROME FI18818p1 OS=Drosophila melanogaster OX=7227 GN=Fak PE=2 SV=1
12	PDB:4fl2A	0.199	0.441	9.969E-21	555	0.084	0.189	4fl2A.pdb.gz	Structural and biophysical characterization of the syk activation switch.
13	PDB:1k9aB	0.198	0.551	2.023E-20	441	0.073	0.209	1k9aB.pdb.gz
14	PDB:4k2rA	0.202	0.448	3.905E-20	551	0.075	0.171	4k2rA.pdb.gz	Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker.
15	PDB:2h8hA	0.196	0.535	1.530E-19	445	0.081	0.229	2h8hA.pdb.gz	N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
16	PDB:6pxvA	0.178	0.261	3.179E-18	823	0.099	0.151	6pxvA.pdb.gz
17	PDB:8dtlA	0.184	0.296	7.899E-18	741	0.099	0.167	8dtlA.pdb.gz
18	PDB:8eyyA	0.163	0.246	2.787E-15	775	0.084	0.135	8eyyA.pdb.gz
19	PDB:7bwaA	0.176	0.308	2.931E-15	674	0.096	0.178	7bwaA.pdb.gz
20	PDB:6pjxA	0.195	0.432	1.479E-14	543	0.056	0.129	6pjxA.pdb.gz	Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A8I5ZQB9	1098	1170	0.474	0.509	A0A8I5ZQB9_RAT Receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=1 SV=1
2	A6QR62	910	1336	0.382	0.359	A6QR62_BOVIN Receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=ERBB3 PE=2 SV=1
3	B4DTR1	1966	979	0.760	0.974	B4DTR1_HUMAN Erb-b2 receptor tyrosine kinase 2 OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1
4	B8LFF6	1048	1414	0.439	0.390	B8LFF6_DANRE Receptor protein-tyrosine kinase OS=Danio rerio OX=7955 GN=erbb4 PE=2 SV=1
5	E7CXR8	1179	1209	0.495	0.514	E7CXR8_RAT Receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=2 SV=1
6	E7CXR9	1177	1209	0.493	0.512	E7CXR9_RAT Receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=2 SV=1
7	F1N7F3	1148	1179	0.456	0.485	F1N7F3_BOVIN Receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=EGFR PE=3 SV=3
8	F5H1T4	1258	603	0.480	1.000	F5H1T4_HUMAN receptor protein-tyrosine kinase OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1
9	G3V6K6	1172	1208	0.494	0.513	G3V6K6_RAT Receptor protein-tyrosine kinase OS=Rattus norvegicus OX=10116 GN=Egfr PE=1 SV=2
10	J3QLU9	2180	1055	0.839	0.998	J3QLU9_HUMAN Receptor protein-tyrosine kinase OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1
11	P00533	1160	1210	0.493	0.512	EGFR_HUMAN Epidermal growth factor receptor OS=Homo sapiens OX=9606 GN=EGFR PE=1 SV=2
12	P04626	2585	1255	1.000	1.000	ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1
13	P06494	2230	1257	0.881	0.880	ERBB2_RAT Receptor tyrosine-protein kinase erbB-2 OS=Rattus norvegicus OX=10116 GN=Erbb2 PE=1 SV=3
14	P21860	917	1342	0.379	0.355	ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 OS=Homo sapiens OX=9606 GN=ERBB3 PE=1 SV=1
15	P70424	2217	1256	0.877	0.877	ERBB2_MOUSE Receptor tyrosine-protein kinase erbB-2 OS=Mus musculus OX=10090 GN=Erbb2 PE=1 SV=3
16	Q01279	1183	1210	0.496	0.515	EGFR_MOUSE Epidermal growth factor receptor OS=Mus musculus OX=10090 GN=Egfr PE=1 SV=1
17	Q15303	1124	1308	0.481	0.462	ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1
18	Q153D9	1137	1299	0.480	0.463	Q153D9_XENLA Receptor protein-tyrosine kinase OS=Xenopus laevis OX=8355 GN=erbb4.L PE=2 SV=1
19	Q4PLA5	1141	1292	0.482	0.468	Q4PLA5_CHICK Receptor protein-tyrosine kinase OS=Gallus gallus OX=9031 GN=ERBB4 PE=2 SV=1
20	Q504U8	1087	1091	0.450	0.518	Q504U8_HUMAN Receptor protein-tyrosine kinase OS=Homo sapiens OX=9606 GN=EGFR PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	2.7e+02	12.1	ABC1 atypical kinase-like domain
2	PF01636 APH	63	14.9	Phosphotransferase enzyme family
3	PF00757 Furin-like	5.1e-25	99.6	Furin-like cysteine rich region
4	PF14843 GF_recep_IV	7.7e-41	150.4	Growth factor receptor domain IV
5	PF12330 Haspin_kinase	78	13.7	Haspin like kinase domain
6	PF14531 Kinase-like	5e+02	11.4	Kinase-like
7	PF00069 Pkinase	3e-33	126.9	Protein kinase domain
8	PF07714 PK_Tyr_Ser-Thr	9.6e-83	289.0	Protein tyrosine and serine/threonine kinase
9	PF01030 Recep_L_domain	8.5e-52	185.3	Receptor L domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000269571

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000265171	0.999	Pro-epidermal growth factor
2	9606.ENSP00000335153	0.999	Heat shock protein HSP 90-alpha
3	9606.ENSP00000344456	0.999	Catenin beta-1
4	9606.ENSP00000376345	0.999	Growth factor receptor-bound protein 2
5	9606.ENSP00000384620	0.999	Pro-neuregulin-1, membrane-bound isoform
6	9606.ENSP00000398632	0.999	CD44 antigen
7	9606.ENSP00000401303	0.999	SHC-transforming protein 1
8	9606.ENSP00000403459	0.999	Growth factor receptor-bound protein 7
9	9606.ENSP00000426632	0.999	Erbin
10	9606.ENSP00000275493	0.998	Epidermal growth factor receptor
11	9606.ENSP00000340944	0.998	Tyrosine-protein phosphatase non-receptor type 11
12	9606.ENSP00000417498	0.996	Mucin-4
13	9606.ENSP00000428056	0.996	Phosphatidylinositol 3-kinase regulatory subunit alpha
14	9606.ENSP00000219548	0.994	E3 ubiquitin-protein ligase CHIP
15	9606.ENSP00000264033	0.994	E3 ubiquitin-protein ligase CBL
16	9606.ENSP00000407586	0.994	GTPase HRas
17	9606.ENSP00000264657	0.993	Signal transducer and activator of transcription 3
18	9606.ENSP00000256078	0.992	GTPase KRas
19	9606.ENSP00000267101	0.992	Receptor tyrosine-protein kinase erbB-3
20	9606.ENSP00000351338	0.991	Plexin-B1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004713	0.999	protein tyrosine kinase activity
GO:0019899	0.998	enzyme binding
GO:0004888	0.986	transmembrane signaling receptor activity
GO:0004714	0.984	transmembrane receptor protein tyrosine kinase activity
GO:0042802	0.955	identical protein binding
GO:0019903	0.936	protein phosphatase binding
GO:0005102	0.887	signaling receptor binding
GO:0019838	0.873	growth factor binding
GO:0044877	0.573	protein-containing complex binding
GO:0070063	0.553	RNA polymerase binding
GO:0043175	0.508	RNA polymerase core enzyme binding
GO:0140677	0.444	molecular function activator activity
GO:0046983	0.401	protein dimerization activity
GO:0019900	0.391	kinase binding
GO:0050839	0.333	cell adhesion molecule binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.989	cellular process
GO:0050794	0.988	regulation of cellular process
GO:0050896	0.986	response to stimulus
GO:0051716	0.970	cellular response to stimulus
GO:0007154	0.952	cell communication
GO:0023052	0.946	signaling
GO:0048518	0.936	positive regulation of biological process
GO:0048522	0.928	positive regulation of cellular process
GO:0038127	0.925	ERBB signaling pathway
GO:0048583	0.914	regulation of response to stimulus
GO:0044237	0.879	cellular metabolic process
GO:0019222	0.830	regulation of metabolic process
GO:0042127	0.820	regulation of cell population proliferation
GO:0071704	0.816	organic substance metabolic process
GO:0010604	0.815	positive regulation of macromolecule metabolic process
GO:0043408	0.811	regulation of MAPK cascade
GO:0031401	0.809	positive regulation of protein modification process
GO:0044238	0.791	primary metabolic process
GO:0048519	0.789	negative regulation of biological process
GO:0001932	0.782	regulation of protein phosphorylation
GO:1902533	0.780	positive regulation of intracellular signal transduction
GO:0048523	0.777	negative regulation of cellular process
GO:0071495	0.775	cellular response to endogenous stimulus
GO:0032502	0.769	developmental process
GO:0006793	0.767	phosphorus metabolic process
GO:0032501	0.757	multicellular organismal process
GO:0048856	0.754	anatomical structure development
GO:0044093	0.744	positive regulation of molecular function
GO:0043549	0.743	regulation of kinase activity
GO:0006807	0.739	nitrogen compound metabolic process
GO:0043085	0.734	positive regulation of catalytic activity
GO:0031325	0.734	positive regulation of cellular metabolic process
GO:0043170	0.712	macromolecule metabolic process
GO:1901564	0.678	organonitrogen compound metabolic process
GO:0070848	0.656	response to growth factor
GO:0018108	0.641	peptidyl-tyrosine phosphorylation
GO:0046777	0.627	protein autophosphorylation
GO:0035556	0.625	intracellular signal transduction
GO:0007173	0.621	epidermal growth factor receptor signaling pathway
GO:0051049	0.610	regulation of transport
GO:0007275	0.570	multicellular organism development
GO:0032880	0.551	regulation of protein localization
GO:0006950	0.528	response to stress
GO:0010562	0.510	positive regulation of phosphorus metabolic process
GO:0048731	0.495	system development
GO:0010468	0.494	regulation of gene expression
GO:0042327	0.478	positive regulation of phosphorylation
GO:0031326	0.476	regulation of cellular biosynthetic process
GO:0010556	0.474	regulation of macromolecule biosynthetic process
GO:0019219	0.472	regulation of nucleobase-containing compound metabolic process
GO:0008284	0.464	positive regulation of cell population proliferation
GO:0001934	0.433	positive regulation of protein phosphorylation
GO:0042221	0.406	response to chemical
GO:0051239	0.400	regulation of multicellular organismal process
GO:0048869	0.382	cellular developmental process
GO:0030154	0.374	cell differentiation
GO:0043410	0.351	positive regulation of MAPK cascade
GO:0009653	0.348	anatomical structure morphogenesis
GO:2001141	0.347	regulation of RNA biosynthetic process
GO:0007399	0.342	nervous system development
GO:0006355	0.342	regulation of DNA-templated transcription
GO:0071840	0.337	cellular component organization or biogenesis
GO:0071363	0.328	cellular response to growth factor stimulus
GO:0048513	0.322	animal organ development
GO:0010557	0.313	positive regulation of macromolecule biosynthetic process
GO:0031328	0.312	positive regulation of cellular biosynthetic process
GO:0045935	0.312	positive regulation of nucleobase-containing compound metabolic process
GO:0016043	0.307	cellular component organization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0005737	0.999	cytoplasm
GO:0005829	0.982	cytosol
GO:0043231	0.877	intracellular membrane-bounded organelle
GO:0098590	0.627	plasma membrane region
GO:0009925	0.575	basal plasma membrane
GO:0005634	0.557	nucleus
GO:0016323	0.526	basolateral plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:10596	0.999	ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
EC:2.7.10.1	0.984	receptor protein-tyrosine kinase.

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