StarFunc result for job id P04637

User Input

>input (393 residues)
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:K7PPA8	0.648	0.648	4.042E-69	393	1.000	1.000	K7PPA8.pdb.gz	K7PPA8_HUMAN Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=2 SV=1
2	AFDB:Q29537	0.548	0.565	2.275E-60	381	0.804	0.829	Q29537.pdb.gz	P53_CANLF Cellular tumor antigen p53 OS=Canis lupus familiaris OX=9615 GN=TP53 PE=2 SV=2
3	AFDB:Q9TUB2	0.557	0.567	1.332E-59	386	0.827	0.842	Q9TUB2.pdb.gz	P53_PIG Cellular tumor antigen p53 OS=Sus scrofa OX=9823 GN=TP53 PE=2 SV=1
4	AFDB:F1SY23	0.603	0.613	1.111E-58	386	0.804	0.819	F1SY23.pdb.gz	F1SY23_BOVIN Cellular tumor antigen p53 OS=Bos taurus OX=9913 GN=TP53 PE=2 SV=1
5	AFDB:P02340	0.738	0.743	4.306E-58	390	0.774	0.779	P02340.pdb.gz	P53_MOUSE Cellular tumor antigen p53 OS=Mus musculus OX=10090 GN=Tp53 PE=1 SV=4
6	AFDB:P10361	0.695	0.699	1.992E-57	391	0.776	0.780	P10361.pdb.gz	P53_RAT Cellular tumor antigen p53 OS=Rattus norvegicus OX=10116 GN=Tp53 PE=1 SV=1
7	AFDB:P10360	0.617	0.659	1.242E-45	367	0.519	0.556	P10360.pdb.gz	P53_CHICK Cellular tumor antigen p53 OS=Gallus gallus OX=9031 GN=TP53 PE=1 SV=1
8	AFDB:P25035	0.573	0.569	4.218E-42	396	0.506	0.503	P25035.pdb.gz	P53_ONCMY Cellular tumor antigen p53 OS=Oncorhynchus mykiss OX=8022 GN=tp53 PE=2 SV=1
9	AFDB:G1K2L5	0.558	0.586	2.751E-39	374	0.455	0.479	G1K2L5.pdb.gz	G1K2L5_DANRE Cellular tumor antigen p53 OS=Danio rerio OX=7955 GN=brp53 PE=1 SV=1
10	AFDB:D4AA88	0.492	0.284	3.918E-39	684	0.410	0.235	D4AA88.pdb.gz	D4AA88_RAT Tumor protein p73 OS=Rattus norvegicus OX=10116 GN=Tp73 PE=3 SV=1
11	PDB:6xreM	0.371	0.449	1.673E-37	314	0.796	0.997	6xreM.pdb.gz	Structure of the p53/RNA polymerase II assembly.
12	PDB:6drvA	0.192	0.083	6.194E-4	1024	0.038	0.015	6drvA.pdb.gz
13	PDB:7d56C	0.197	0.130	1.332E-3	640	0.053	0.033	7d56C.pdb.gz	Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.
14	PDB:1cd0A	0.146	0.399	2.702E-3	111	0.036	0.126	1cd0A.pdb.gz
15	PDB:4nenA	0.232	0.097	2.866E-3	1063	0.038	0.014	4nenA.pdb.gz	An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
16	PDB:5ir3A	0.145	0.397	2.866E-3	111	0.051	0.180	5ir3A.pdb.gz
17	PDB:8dypA	0.168	0.196	6.163E-3	326	0.043	0.052	8dypA.pdb.gz
18	PDB:3oaiA	0.157	0.129	6.537E-3	488	0.023	0.018	3oaiA.pdb.gz	Crystal structure of the extracellular domain of human myelin protein zero.
19	PDB:4n2iA	0.160	0.102	6.934E-3	662	0.051	0.030	4n2iA.pdb.gz	Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
20	PDB:7u05B	0.144	0.080	8.275E-3	815	0.033	0.016	7u05B.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	E7EQX7	0.0	543	285	0.662	0.912	E7EQX7_HUMAN Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=1
2	F1SY23	0.0	593	386	0.804	0.819	F1SY23_BOVIN Cellular tumor antigen p53 OS=Bos taurus OX=9913 GN=TP53 PE=2 SV=1
3	H2EHT1	0.0	737	354	0.901	1.000	H2EHT1_HUMAN Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=2 SV=1
4	J3KP33	0.0	687	343	0.842	0.965	J3KP33_HUMAN Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=1
5	K7PPA8	0.0	813	393	1.000	1.000	K7PPA8_HUMAN Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=2 SV=1
6	P02340	0.0	598	390	0.774	0.779	P53_MOUSE Cellular tumor antigen p53 OS=Mus musculus OX=10090 GN=Tp53 PE=1 SV=4
7	P04637	0.0	813	393	1.000	1.000	P53_HUMAN Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4
8	P10361	0.0	585	391	0.774	0.777	P53_RAT Cellular tumor antigen p53 OS=Rattus norvegicus OX=10116 GN=Tp53 PE=1 SV=1
9	P13481	0.0	746	393	0.957	0.957	P53_CHLAE Cellular tumor antigen p53 OS=Chlorocebus aethiops OX=9534 GN=TP53 PE=1 SV=1
10	P67939	0.0	593	386	0.804	0.819	P53_BOVIN Cellular tumor antigen p53 OS=Bos taurus OX=9913 GN=TP53 PE=2 SV=1
11	Q29537	0.0	603	381	0.807	0.832	P53_CANLF Cellular tumor antigen p53 OS=Canis lupus familiaris OX=9615 GN=TP53 PE=2 SV=2
12	Q9TUB2	0.0	612	386	0.819	0.834	P53_PIG Cellular tumor antigen p53 OS=Sus scrofa OX=9823 GN=TP53 PE=2 SV=1
13	A0A087X1Q1	4.97e-176	491	234	0.595	1.000	A0A087X1Q1_HUMAN Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=1
14	P25035	2.13e-124	366	396	0.511	0.508	P53_ONCMY Cellular tumor antigen p53 OS=Oncorhynchus mykiss OX=8022 GN=tp53 PE=2 SV=1
15	P10360	2.18e-118	350	367	0.496	0.531	P53_CHICK Cellular tumor antigen p53 OS=Gallus gallus OX=9031 GN=TP53 PE=1 SV=1
16	E7EMR6	9.30e-117	338	165	0.420	1.000	E7EMR6_HUMAN Cellular tumor antigen p53 (Fragment) OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=1
17	G1K2L5	2.83e-116	345	374	0.466	0.489	G1K2L5_DANRE Cellular tumor antigen p53 OS=Danio rerio OX=7955 GN=brp53 PE=1 SV=1
18	P79734	3.56e-116	345	373	0.466	0.491	P53_DANRE Cellular tumor antigen p53 OS=Danio rerio OX=7955 GN=tp53 PE=1 SV=1
19	S4R334	2.64e-96	285	143	0.364	1.000	S4R334_HUMAN Cellular tumor antigen p53 (Fragment) OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=1
20	Q8JHZ5	1.71e-87	274	457	0.356	0.306	Q8JHZ5_DANRE Cellular tumor antigen p53 OS=Danio rerio OX=7955 GN=tp73l PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00870 P53	4.2e-57	204.7	P53 DNA-binding domain
2	PF08563 P53_TAD	2.6e-08	44.3	P53 transactivation motif
3	PF07710 P53_tetramer	9.9e-14	61.8	P53 tetramerisation motif
4	PF18521 TAD2	3.3e-14	63.1	Transactivation domain 2

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000269305

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000212015	0.999	NAD-dependent protein deacetylase sirtuin-1
2	9606.ENSP00000216911	0.999	Aurora kinase A
3	9606.ENSP00000225792	0.999	Probable ATP-dependent RNA helicase DDX5
4	9606.ENSP00000232165	0.999	Ubiquitin-protein ligase E3A
5	9606.ENSP00000254719	0.999	Replication protein A 70 kDa DNA-binding subunit
6	9606.ENSP00000258149	0.999	E3 ubiquitin-protein ligase Mdm2
7	9606.ENSP00000260947	0.999	BRCA1-associated RING domain protein 1
8	9606.ENSP00000262367	0.999	CREB-binding protein
9	9606.ENSP00000263253	0.999	Histone acetyltransferase p300
10	9606.ENSP00000266970	0.999	Cyclin-dependent kinase 2
11	9606.ENSP00000278616	0.999	Serine-protein kinase ATM
12	9606.ENSP00000296930	0.999	Nucleophosmin
13	9606.ENSP00000298139	0.999	Werner syndrome ATP-dependent helicase
14	9606.ENSP00000302564	0.999	Bcl-2-like protein 1
15	9606.ENSP00000321239	0.999	RING finger and CHY zinc finger domain-containing protein 1
16	9606.ENSP00000324806	0.999	Glycogen synthase kinase-3 beta
17	9606.ENSP00000329357	0.999	Transcription factor Sp1
18	9606.ENSP00000332643	0.999	Necdin
19	9606.ENSP00000335153	0.999	Heat shock protein HSP 90-alpha
20	9606.ENSP00000340330	0.999	Histone acetyltransferase KAT5

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0003677	0.999	DNA binding
GO:0043565	0.985	sequence-specific DNA binding
GO:0019899	0.925	enzyme binding
GO:0140110	0.852	transcription regulator activity
GO:0003700	0.793	DNA-binding transcription factor activity
GO:0003690	0.770	double-stranded DNA binding
GO:0044389	0.760	ubiquitin-like protein ligase binding
GO:0031625	0.749	ubiquitin protein ligase binding
GO:0008134	0.436	transcription factor binding
GO:0140297	0.382	DNA-binding transcription factor binding
GO:0061629	0.368	RNA polymerase II-specific DNA-binding transcription factor binding
GO:1990837	0.315	sequence-specific double-stranded DNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.997	regulation of cellular process
GO:0009987	0.990	cellular process
GO:0031323	0.989	regulation of cellular metabolic process
GO:0050896	0.988	response to stimulus
GO:0048518	0.988	positive regulation of biological process
GO:0080090	0.988	regulation of primary metabolic process
GO:0051171	0.988	regulation of nitrogen compound metabolic process
GO:0048523	0.988	negative regulation of cellular process
GO:0060255	0.987	regulation of macromolecule metabolic process
GO:0051716	0.984	cellular response to stimulus
GO:0048522	0.983	positive regulation of cellular process
GO:0010468	0.962	regulation of gene expression
GO:0009893	0.958	positive regulation of metabolic process
GO:0033554	0.957	cellular response to stress
GO:0019219	0.941	regulation of nucleobase-containing compound metabolic process
GO:0031326	0.935	regulation of cellular biosynthetic process
GO:0031325	0.926	positive regulation of cellular metabolic process
GO:0010604	0.923	positive regulation of macromolecule metabolic process
GO:0010556	0.921	regulation of macromolecule biosynthetic process
GO:0051173	0.915	positive regulation of nitrogen compound metabolic process
GO:0006355	0.907	regulation of DNA-templated transcription
GO:0006357	0.902	regulation of transcription by RNA polymerase II
GO:0045935	0.879	positive regulation of nucleobase-containing compound metabolic process
GO:0010557	0.865	positive regulation of macromolecule biosynthetic process
GO:0031328	0.864	positive regulation of cellular biosynthetic process
GO:0051254	0.858	positive regulation of RNA metabolic process
GO:0043068	0.851	positive regulation of programmed cell death
GO:0045893	0.848	positive regulation of DNA-templated transcription
GO:0008152	0.845	metabolic process
GO:0042981	0.813	regulation of apoptotic process
GO:0010646	0.808	regulation of cell communication
GO:0045944	0.795	positive regulation of transcription by RNA polymerase II
GO:0043065	0.776	positive regulation of apoptotic process
GO:0071704	0.755	organic substance metabolic process
GO:0044238	0.749	primary metabolic process
GO:0006807	0.708	nitrogen compound metabolic process
GO:0023051	0.695	regulation of signaling
GO:0010605	0.648	negative regulation of macromolecule metabolic process
GO:0007165	0.634	signal transduction
GO:0032502	0.627	developmental process
GO:0048583	0.627	regulation of response to stimulus
GO:0044237	0.601	cellular metabolic process
GO:0043170	0.577	macromolecule metabolic process
GO:0031324	0.577	negative regulation of cellular metabolic process
GO:0051172	0.576	negative regulation of nitrogen compound metabolic process
GO:0071840	0.574	cellular component organization or biogenesis
GO:0048856	0.536	anatomical structure development
GO:0016043	0.507	cellular component organization
GO:0032501	0.497	multicellular organismal process
GO:0006915	0.472	apoptotic process
GO:0042221	0.454	response to chemical
GO:0045934	0.449	negative regulation of nucleobase-containing compound metabolic process
GO:0009890	0.442	negative regulation of biosynthetic process
GO:0031327	0.432	negative regulation of cellular biosynthetic process
GO:0010558	0.430	negative regulation of macromolecule biosynthetic process
GO:0051253	0.402	negative regulation of RNA metabolic process
GO:0035556	0.398	intracellular signal transduction
GO:0045892	0.367	negative regulation of DNA-templated transcription
GO:0009966	0.342	regulation of signal transduction
GO:1901564	0.336	organonitrogen compound metabolic process
GO:0019538	0.314	protein metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0005654	1.000	nucleoplasm
GO:0005829	0.965	cytosol
GO:0032991	0.312	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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