StarFunc result for job id P04920

User Input

>input (1241 residues)
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE
EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT
IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ
EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR
IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG
REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW
GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL
RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV
ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA
VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT
AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL
LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL
SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS
FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF
YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT
ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ
KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS
KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK
PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH
LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR
MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A9NIM6	0.626	0.631	0.000	1232	0.674	0.679	A9NIM6.pdb.gz	A9NIM6_DANRE Anion exchange protein OS=Danio rerio OX=7955 GN=slc4a2.1 PE=1 SV=1
2	AFDB:B0S7B8	0.647	0.653	0.000	1228	0.639	0.646	B0S7B8.pdb.gz	B0S7B8_DANRE Anion exchange protein OS=Danio rerio OX=7955 GN=slc4a2 PE=3 SV=1
3	AFDB:P04920	1.000	1.000	0.000	1241	1.000	1.000	P04920.pdb.gz	B3A2_HUMAN Anion exchange protein 2 OS=Homo sapiens OX=9606 GN=SLC4A2 PE=1 SV=4
4	AFDB:P48751	0.597	0.600	0.000	1232	0.595	0.600	P48751.pdb.gz	B3A3_HUMAN Anion exchange protein 3 OS=Homo sapiens OX=9606 GN=SLC4A3 PE=1 SV=2
5	PDB:8cs9g	0.413	0.609	1.308E-80	832	0.407	0.607	8cs9g.pdb.gz	Architecture of the human erythrocyte ankyrin-1 complex.
6	PDB:7tvzA	0.486	0.676	1.545E-77	850	0.410	0.599	7tvzA.pdb.gz	Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane.
7	AFDB:O88343	0.533	0.604	4.066E-71	1079	0.304	0.349	O88343.pdb.gz	S4A4_MOUSE Electrogenic sodium bicarbonate cotransporter 1 OS=Mus musculus OX=10090 GN=Slc4a4 PE=1 SV=2
8	AFDB:Q5DTL9	0.549	0.605	4.427E-70	1118	0.309	0.343	Q5DTL9.pdb.gz	S4A10_MOUSE Sodium-driven chloride bicarbonate exchanger OS=Mus musculus OX=10090 GN=Slc4a10 PE=1 SV=2
9	AFDB:G5EDF4	0.562	0.599	6.545E-68	1161	0.293	0.314	G5EDF4.pdb.gz	G5EDF4_CAEEL Anion exchange protein OS=Caenorhabditis elegans OX=6239 GN=abts-1 PE=1 SV=1
10	PDB:4yzfA	0.372	0.958	4.992E-45	475	0.286	0.747	4yzfA.pdb.gz	Crystal structure of the anion exchanger domain of human erythrocyte band 3.
11	PDB:6caaA	0.357	0.894	1.246E-27	477	0.172	0.449	6caaA.pdb.gz
12	PDB:5l25A	0.274	0.788	1.132E-12	399	0.087	0.271	5l25A.pdb.gz
13	PDB:7lguA	0.267	0.462	8.954E-9	680	0.056	0.103	7lguA.pdb.gz	Molecular mechanism of prestin electromotive signal amplification.
14	PDB:7ch1A	0.243	0.434	1.208E-5	640	0.062	0.120	7ch1A.pdb.gz	Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence.
15	PDB:5i6cA	0.215	0.467	4.971E-5	480	0.062	0.160	5i6cA.pdb.gz	Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.
16	PDB:3qe7A	0.205	0.514	6.459E-4	407	0.055	0.167	3qe7A.pdb.gz	Structure and mechanism of the uracil transporter UraA
17	PDB:1a6jB	0.062	0.420	8.772E-3	157	0.017	0.134	1a6jB.pdb.gz
18	AFDB:Q91YE5	0.041	0.031	7.414E-1	1889	0.109	0.071	Q91YE5.pdb.gz	BAZ2A_MOUSE Bromodomain adjacent to zinc finger domain protein 2A OS=Mus musculus OX=10090 GN=Baz2a PE=1 SV=2
19	AFDB:Q9FFY9	0.042	0.068	1.317	640	0.080	0.155	Q9FFY9.pdb.gz	TRP4_ARATH Telomere repeat-binding protein 4 OS=Arabidopsis thaliana OX=3702 GN=TRP4 PE=1 SV=1
20	AFDB:A0A1D8PFD3	0.031	0.036	2.050	1001	0.078	0.097	A0A1D8PFD3.pdb.gz	A0A1D8PFD3_CANAL Snt1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=SNT1 PE=4 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A096X8J7	1353	1170	0.579	0.614	B3A3_DANRE Anion exchange protein 3 OS=Danio rerio OX=7955 GN=Slc4a3 PE=2 SV=1
2	A0A2R8QD45	662	1073	0.309	0.358	A0A2R8QD45_DANRE Anion exchange protein OS=Danio rerio OX=7955 GN=id:ibd2520 PE=1 SV=1
3	A9NIM6	1599	1232	0.669	0.674	A9NIM6_DANRE Anion exchange protein OS=Danio rerio OX=7955 GN=slc4a2.1 PE=1 SV=1
4	B0S7B8	1481	1228	0.639	0.646	B0S7B8_DANRE Anion exchange protein OS=Danio rerio OX=7955 GN=slc4a2 PE=3 SV=1
5	D1FTM8	921	851	0.376	0.548	D1FTM8_DANRE Anion exchange protein OS=Danio rerio OX=7955 GN=slc4a1b PE=2 SV=1
6	E9Q3M5	617	1116	0.299	0.332	S4A5_MOUSE Electrogenic sodium bicarbonate cotransporter 4 OS=Mus musculus OX=10090 GN=Slc4a5 PE=1 SV=1
7	G5EC65	612	1119	0.293	0.324	G5EC65_CAEEL Anion exchange protein OS=Caenorhabditis elegans OX=6239 GN=abts-1 PE=1 SV=1
8	G5EDF4	613	1161	0.293	0.313	G5EDF4_CAEEL Anion exchange protein OS=Caenorhabditis elegans OX=6239 GN=abts-1 PE=1 SV=1
9	M9PB59	649	1134	0.297	0.325	M9PB59_DROME Anion exchange protein OS=Drosophila melanogaster OX=7227 GN=Ndae1 PE=1 SV=1
10	M9PB60	653	1126	0.304	0.335	M9PB60_DROME Anion exchange protein OS=Drosophila melanogaster OX=7227 GN=Ndae1 PE=1 SV=1
11	M9PC92	647	1086	0.297	0.339	M9PC92_DROME Anion exchange protein OS=Drosophila melanogaster OX=7227 GN=Ndae1 PE=1 SV=1
12	M9PC95	643	1046	0.307	0.364	M9PC95_DROME Anion exchange protein OS=Drosophila melanogaster OX=7227 GN=Ndae1 PE=1 SV=1
13	M9PCF0	647	1067	0.302	0.351	M9PCF0_DROME Anion exchange protein OS=Drosophila melanogaster OX=7227 GN=Ndae1 PE=1 SV=1
14	M9PCT2	647	1027	0.294	0.355	M9PCT2_DROME Anion exchange protein OS=Drosophila melanogaster OX=7227 GN=Ndae1 PE=1 SV=1
15	M9PF01	654	1053	0.298	0.351	M9PF01_DROME Anion exchange protein OS=Drosophila melanogaster OX=7227 GN=Ndae1 PE=1 SV=1
16	O13134	672	1035	0.306	0.367	S4A4_AMBTI Electrogenic sodium bicarbonate cotransporter 1 OS=Ambystoma tigrinum OX=8305 GN=SLC4A4 PE=2 SV=1
17	O88343	666	1079	0.299	0.344	S4A4_MOUSE Electrogenic sodium bicarbonate cotransporter 1 OS=Mus musculus OX=10090 GN=Slc4a4 PE=1 SV=2
18	P02730	1007	911	0.434	0.592	B3AT_HUMAN Band 3 anion transport protein OS=Homo sapiens OX=9606 GN=SLC4A1 PE=1 SV=3
19	P04919	963	929	0.414	0.553	B3AT_MOUSE Band 3 anion transport protein OS=Mus musculus OX=10090 GN=Slc4a1 PE=1 SV=1
20	P04920	2513	1241	1.000	1.000	B3A2_HUMAN Anion exchange protein 2 OS=Homo sapiens OX=9606 GN=SLC4A2 PE=1 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF07565 Band_3_cyto	4.6e-103	356.2	Band 3 cytoplasmic domain
2	PF00955 HCO3_cotransp	7e-202	683.3	HCO3- transporter family
3	PF00359 PTS_EIIA_2	2.8	19.3	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000419412

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000309504	0.918	Anion exchange transporter
2	9606.ENSP00000262461	0.811	Solute carrier family 12 member 2
3	9606.ENSP00000379822	0.808	Solute carrier family 12 member 1
4	9606.ENSP00000378920	0.689	Solute carrier family 26 member 6
5	9606.ENSP00000003084	0.666	Cystic fibrosis transmembrane conductance regulator
6	9606.ENSP00000285379	0.655	Carbonic anhydrase 2
7	9606.ENSP00000387694	0.644	Solute carrier family 12 member 5
8	9606.ENSP00000263980	0.629	Sodium/hydrogen exchanger 1
9	9606.ENSP00000355384	0.628	Sodium-independent sulfate anion transporter
10	9606.ENSP00000265715	0.567	Pendrin
11	9606.ENSP00000301873	0.559	Latent-transforming growth factor beta-binding protein 3
12	9606.ENSP00000264938	0.550	Sodium/hydrogen exchanger 3
13	9606.ENSP00000345873	0.543	Chloride anion exchanger
14	9606.ENSP00000354721	0.542	Sulfate anion transporter 1
15	9606.ENSP00000311165	0.526	Aquaporin-1
16	9606.ENSP00000358814	0.524	S-adenosylhomocysteine hydrolase-like protein 1
17	9606.ENSP00000299798	0.523	Sodium/hydrogen exchanger 5
18	9606.ENSP00000318912	0.523	Carbonic anhydrase 13
19	9606.ENSP00000356102	0.510	Solute carrier family 26 member 9
20	9606.ENSP00000395983	0.510	Solute carrier family 12 member 4

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0022853	1.000	active monoatomic ion transmembrane transporter activity
GO:0015106	1.000	bicarbonate transmembrane transporter activity
GO:0015108	1.000	chloride transmembrane transporter activity
GO:0005452	1.000	solute:inorganic anion antiporter activity
GO:0005515	0.995	protein binding
GO:0140900	0.954	chloride:bicarbonate antiporter activity
GO:0008324	0.838	monoatomic cation transmembrane transporter activity
GO:0022890	0.832	inorganic cation transmembrane transporter activity
GO:0046873	0.818	metal ion transmembrane transporter activity
GO:0015081	0.753	sodium ion transmembrane transporter activity
GO:0015293	0.368	symporter activity
GO:0015294	0.321	solute:monoatomic cation symporter activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0006810	0.976	transport
GO:0006811	0.939	monoatomic ion transport
GO:0009987	0.924	cellular process
GO:0065007	0.839	biological regulation
GO:0006820	0.540	monoatomic anion transport
GO:0071702	0.519	organic substance transport
GO:0032502	0.417	developmental process
GO:0050789	0.408	regulation of biological process
GO:0048878	0.407	chemical homeostasis
GO:0048856	0.379	anatomical structure development
GO:0019725	0.341	cellular homeostasis
GO:0050801	0.339	monoatomic ion homeostasis
GO:0006873	0.334	intracellular monoatomic ion homeostasis
GO:0019755	0.327	one-carbon compound transport
GO:0032501	0.306	multicellular organismal process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0098590	0.815	plasma membrane region
GO:0045178	0.546	basal part of cell
GO:0016323	0.540	basolateral plasma membrane
GO:0045177	0.500	apical part of cell
GO:0016324	0.472	apical plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:28695	1.000	hydrogencarbonate(in) = hydrogencarbonate(out)
RHEA:29823	1.000	chloride(in) = chloride(out)
RHEA:34963	0.753	Na(+)(in) = Na(+)(out)

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