StarFunc result for job id P05112

User Input

>input (153 residues)
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL
NSCPVKEANQSTLENFLERLKTIMREKYSKCSS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P05112	1.000	1.000	8.630E-25	153	1.000	1.000	P05112.pdb.gz	IL4_HUMAN Interleukin-4 OS=Homo sapiens OX=9606 GN=IL4 PE=1 SV=1
2	PDB:1itlA	0.783	0.913	3.974E-16	130	0.843	0.992	1itlA.pdb.gz
3	AFDB:F1CFE1	0.764	0.870	3.051E-12	133	0.601	0.692	F1CFE1.pdb.gz	F1CFE1_PIG Interleukin-4 OS=Sus scrofa OX=9823 GN=IL-4 PE=2 SV=1
4	AFDB:P07750	0.701	0.763	3.925E-8	140	0.392	0.429	P07750.pdb.gz	IL4_MOUSE Interleukin-4 OS=Mus musculus OX=10090 GN=Il4 PE=1 SV=1
5	AFDB:P20096	0.694	0.720	1.434E-7	147	0.412	0.429	P20096.pdb.gz	IL4_RAT Interleukin-4 OS=Rattus norvegicus OX=10116 GN=Il4 PE=2 SV=2
6	AFDB:D1YSM1	0.504	0.595	1.050E-3	127	0.203	0.244	D1YSM1.pdb.gz	D1YSM1_DANRE Interleukin 4 precursor OS=Danio rerio OX=7955 GN=il-4 PE=2 SV=1
7	AFDB:E7FKY2	0.456	0.476	5.378E-3	145	0.216	0.228	E7FKY2.pdb.gz	E7FKY2_ONCMY Interleukin 4/13A OS=Oncorhynchus mykiss OX=8022 GN=IL4/13A PE=2 SV=1
8	AFDB:O42288	0.488	0.517	1.183E-2	143	0.170	0.182	O42288.pdb.gz	O42288_CHICK Interleukin OS=Gallus gallus OX=9031 GN=IL2 PE=2 SV=1
9	AFDB:P40225	0.458	0.240	6.060E-2	353	0.163	0.071	P40225.pdb.gz	TPO_HUMAN Thrombopoietin OS=Homo sapiens OX=9606 GN=THPO PE=1 SV=1
10	AFDB:O35256	0.299	0.233	1.064E-1	227	0.163	0.110	O35256.pdb.gz	PR4A1_MOUSE Prolactin-4A1 OS=Mus musculus OX=10090 GN=Prl4a1 PE=2 SV=1
11	AFDB:Q2XNF5	0.429	0.380	1.126E-1	183	0.124	0.104	Q2XNF5.pdb.gz	EPO_DANRE Erythropoietin OS=Danio rerio OX=7955 GN=epo PE=1 SV=1
12	PDB:5l6yC	0.482	0.753	1.272E-1	94	0.150	0.245	5l6yC.pdb.gz
13	PDB:7zxkC	0.360	0.335	1.272E-1	166	0.137	0.127	7zxkC.pdb.gz
14	PDB:1f6fA	0.343	0.294	2.363E-1	183	0.170	0.142	1f6fA.pdb.gz
15	PDB:3qb1G	0.446	0.572	3.924E-1	111	0.105	0.144	3qb1G.pdb.gz
16	PDB:7ra9A	0.439	0.513	5.501E-1	126	0.118	0.143	7ra9A.pdb.gz
17	PDB:7u7nD	0.361	0.296	5.501E-1	191	0.163	0.131	7u7nD.pdb.gz
18	PDB:1cnt1	0.336	0.336	8.160E-1	150	0.144	0.147	1cnt1.pdb.gz
19	PDB:1ga3A	0.475	0.621	8.160E-1	113	0.111	0.150	1ga3A.pdb.gz
20	PDB:3d48P	0.327	0.306	8.160E-1	165	0.131	0.121	3d48P.pdb.gz	Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P05112	4.88e-112	316	153	1.000	1.000	IL4_HUMAN Interleukin-4 OS=Homo sapiens OX=9606 GN=IL4 PE=1 SV=1
2	F1CFE1	7.59e-57	176	133	0.608	0.699	F1CFE1_PIG Interleukin-4 OS=Sus scrofa OX=9823 GN=IL-4 PE=2 SV=1
3	Q04745	7.59e-57	176	133	0.608	0.699	IL4_PIG Interleukin-4 OS=Sus scrofa OX=9823 GN=IL4 PE=2 SV=1
4	P20096	1.71e-31	112	147	0.412	0.429	IL4_RAT Interleukin-4 OS=Rattus norvegicus OX=10116 GN=Il4 PE=2 SV=2
5	P07750	8.56e-28	102	140	0.405	0.443	IL4_MOUSE Interleukin-4 OS=Mus musculus OX=10090 GN=Il4 PE=1 SV=1
6	Q5W4U1	3.45e-05	43.5	136	0.190	0.213	Q5W4U1_CHICK Interleukin-4 OS=Gallus gallus OX=9031 GN=IL-4 PE=2 SV=1
7	O74824	0.076	34.7	308	0.144	0.071	RAGAB_SCHPO GTP-binding protein gtr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gtr1 PE=3 SV=1
8	Q63486	0.32	33.1	313	0.118	0.058	RRAGA_RAT Ras-related GTP-binding protein A OS=Rattus norvegicus OX=10116 GN=Rraga PE=1 SV=1
9	Q7L523	0.32	33.1	313	0.118	0.058	RRAGA_HUMAN Ras-related GTP-binding protein A OS=Homo sapiens OX=9606 GN=RRAGA PE=1 SV=1
10	Q80X95	0.32	33.1	313	0.118	0.058	RRAGA_MOUSE Ras-related GTP-binding protein A OS=Mus musculus OX=10090 GN=Rraga PE=1 SV=1
11	Q7ZUI2	0.34	33.1	315	0.118	0.057	Q7ZUI2_DANRE Ras-related GTP-binding protein OS=Danio rerio OX=7955 GN=zgc:56499 PE=1 SV=1
12	D1YSM1	0.69	31.2	127	0.190	0.228	D1YSM1_DANRE Interleukin 4 precursor OS=Danio rerio OX=7955 GN=il-4 PE=2 SV=1
13	Q00582	0.77	32.0	310	0.111	0.055	RAGAB_YEAST GTP-binding protein GTR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GTR1 PE=1 SV=1
14	P21327	2.3	30.4	400	0.183	0.070	INPP_BOVIN Inositol polyphosphate 1-phosphatase OS=Bos taurus OX=9913 GN=INPP1 PE=1 SV=2
15	Q9VHJ4	2.4	30.4	311	0.111	0.055	Q9VHJ4_DROME GH04846p OS=Drosophila melanogaster OX=7227 GN=RagA-B PE=1 SV=1
16	Q40882	5.8	29.3	228	0.190	0.127	Q40882_PETHY Fbp11 protein OS=Petunia hybrida OX=4102 GN=fbp11 PE=1 SV=1
17	Q9P6I3	5.9	29.3	442	0.131	0.045	YHG7_SCHPO Putative mannan endo-1,6-alpha-mannosidase C1198.07c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC1198.07c PE=3 SV=2
18	A0A0B4KEP9	6.7	29.3	827	0.105	0.019	A0A0B4KEP9_DROME KCNQ potassium channel, isoform J OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
19	Q9U518	8.0	28.9	590	0.078	0.020	ASPG_DIRIM L-asparaginase OS=Dirofilaria immitis OX=6287 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00727 IL4	7.8e-50	179.2	Interleukin 4
2	PF11051 Mannosyl_trans3	1e+02	13.7	Mannosyltransferase putative

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000231449

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000363318	0.999	Cytokine receptor common subunit gamma
2	9606.ENSP00000379111	0.999	Interleukin-4 receptor subunit alpha
3	9606.ENSP00000360730	0.998	Interleukin-13 receptor subunit alpha-1
4	9606.ENSP00000398698	0.993	Tumor necrosis factor
5	9606.ENSP00000300134	0.991	Signal transducer and activator of transcription 6
6	9606.ENSP00000385675	0.991	Interleukin-6
7	9606.ENSP00000263341	0.990	Interleukin-1 beta
8	9606.ENSP00000306512	0.986	Interleukin-8
9	9606.ENSP00000225831	0.985	C-C motif chemokine 2
10	9606.ENSP00000263339	0.983	Interleukin-1 alpha
11	9606.ENSP00000280357	0.980	Interleukin-18
12	9606.ENSP00000343204	0.973	Tyrosine-protein kinase JAK1
13	9606.ENSP00000219235	0.969	C-C motif chemokine 22
14	9606.ENSP00000361359	0.969	Tumor necrosis factor receptor superfamily member 5
15	9606.ENSP00000293328	0.967	Signal transducer and activator of transcription 5B
16	9606.ENSP00000341208	0.967	Signal transducer and activator of transcription 5A
17	9606.ENSP00000391676	0.964	Tyrosine-protein kinase JAK3
18	9606.ENSP00000327048	0.960	Transcription factor Maf
19	9606.ENSP00000329418	0.959	Suppressor of cytokine signaling 1
20	9606.ENSP00000346839	0.958	Fibronectin type III domain containing

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0070851	1.000	growth factor receptor binding
GO:0005126	1.000	cytokine receptor binding
GO:0005136	0.874	interleukin-4 receptor binding
GO:0003824	0.476	catalytic activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.996	regulation of cellular process
GO:0048522	0.992	positive regulation of cellular process
GO:0050896	0.991	response to stimulus
GO:0009987	0.990	cellular process
GO:0060255	0.986	regulation of macromolecule metabolic process
GO:0048583	0.985	regulation of response to stimulus
GO:0010628	0.979	positive regulation of gene expression
GO:0051239	0.978	regulation of multicellular organismal process
GO:0010562	0.978	positive regulation of phosphorus metabolic process
GO:0051173	0.976	positive regulation of nitrogen compound metabolic process
GO:0019220	0.976	regulation of phosphate metabolic process
GO:0001934	0.972	positive regulation of protein phosphorylation
GO:0048584	0.970	positive regulation of response to stimulus
GO:0043066	0.968	negative regulation of apoptotic process
GO:0060284	0.963	regulation of cell development
GO:0009966	0.959	regulation of signal transduction
GO:0051094	0.957	positive regulation of developmental process
GO:0048856	0.948	anatomical structure development
GO:2000026	0.948	regulation of multicellular organismal development
GO:0044237	0.938	cellular metabolic process
GO:0009967	0.927	positive regulation of signal transduction
GO:0032501	0.926	multicellular organismal process
GO:0001817	0.920	regulation of cytokine production
GO:0002376	0.919	immune system process
GO:0045935	0.917	positive regulation of nucleobase-containing compound metabolic process
GO:0071704	0.910	organic substance metabolic process
GO:2000351	0.906	regulation of endothelial cell apoptotic process
GO:0001819	0.901	positive regulation of cytokine production
GO:0031341	0.897	regulation of cell killing
GO:0044238	0.893	primary metabolic process
GO:0046427	0.892	positive regulation of receptor signaling pathway via JAK-STAT
GO:0030154	0.890	cell differentiation
GO:0042127	0.887	regulation of cell population proliferation
GO:0002684	0.886	positive regulation of immune system process
GO:0006950	0.874	response to stress
GO:1904036	0.871	negative regulation of epithelial cell apoptotic process
GO:0031342	0.865	negative regulation of cell killing
GO:0051716	0.855	cellular response to stimulus
GO:0008284	0.855	positive regulation of cell population proliferation
GO:0032101	0.852	regulation of response to external stimulus
GO:0065009	0.850	regulation of molecular function
GO:0080134	0.848	regulation of response to stress
GO:0030155	0.837	regulation of cell adhesion
GO:0050865	0.836	regulation of cell activation
GO:0045597	0.834	positive regulation of cell differentiation
GO:0002696	0.834	positive regulation of leukocyte activation
GO:0006807	0.833	nitrogen compound metabolic process
GO:0001775	0.833	cell activation
GO:0031326	0.828	regulation of cellular biosynthetic process
GO:0010556	0.826	regulation of macromolecule biosynthetic process
GO:0010720	0.820	positive regulation of cell development
GO:0006955	0.819	immune response
GO:0031347	0.819	regulation of defense response
GO:0050776	0.818	regulation of immune response
GO:0006355	0.818	regulation of DNA-templated transcription
GO:0043170	0.815	macromolecule metabolic process
GO:0010605	0.809	negative regulation of macromolecule metabolic process
GO:0044093	0.805	positive regulation of molecular function
GO:0032879	0.797	regulation of localization
GO:0007154	0.796	cell communication
GO:0046649	0.781	lymphocyte activation
GO:0006952	0.759	defense response
GO:0023052	0.753	signaling
GO:0050727	0.751	regulation of inflammatory response
GO:0050730	0.749	regulation of peptidyl-tyrosine phosphorylation
GO:0002697	0.745	regulation of immune effector process
GO:1901564	0.734	organonitrogen compound metabolic process
GO:0042113	0.724	B cell activation
GO:0048468	0.722	cell development
GO:0050731	0.722	positive regulation of peptidyl-tyrosine phosphorylation
GO:0048585	0.711	negative regulation of response to stimulus
GO:0019538	0.689	protein metabolic process
GO:0032102	0.688	negative regulation of response to external stimulus
GO:0002699	0.683	positive regulation of immune effector process
GO:0042531	0.683	positive regulation of tyrosine phosphorylation of STAT protein
GO:0006793	0.680	phosphorus metabolic process
GO:0050728	0.650	negative regulation of inflammatory response
GO:0043412	0.647	macromolecule modification
GO:0036211	0.644	protein modification process
GO:0006796	0.628	phosphate-containing compound metabolic process
GO:0002700	0.626	regulation of production of molecular mediator of immune response
GO:0007165	0.595	signal transduction
GO:0050790	0.591	regulation of catalytic activity
GO:0002637	0.574	regulation of immunoglobulin production
GO:0009891	0.566	positive regulation of biosynthetic process
GO:0042221	0.457	response to chemical
GO:0009605	0.420	response to external stimulus
GO:0070887	0.403	cellular response to chemical stimulus
GO:0010033	0.395	response to organic substance
GO:0031328	0.388	positive regulation of cellular biosynthetic process
GO:0010557	0.368	positive regulation of macromolecule biosynthetic process
GO:0007166	0.350	cell surface receptor signaling pathway
GO:0045893	0.340	positive regulation of DNA-templated transcription
GO:0071310	0.305	cellular response to organic substance

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005615	0.998	extracellular space
GO:0071944	0.881	cell periphery
GO:0005886	0.861	plasma membrane
GO:0005622	0.413	intracellular anatomical structure
GO:0043231	0.389	intracellular membrane-bounded organelle
GO:0005737	0.387	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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