StarFunc result for job id P05121

User Input

>input (402 residues)
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P05121	1.000	1.000	3.631E-84	402	1.000	1.000	P05121.pdb.gz	PAI1_HUMAN Plasminogen activator inhibitor 1 OS=Homo sapiens OX=9606 GN=SERPINE1 PE=1 SV=1
2	AFDB:P13909	0.928	0.928	3.797E-72	402	0.853	0.853	P13909.pdb.gz	PAI1_BOVIN Plasminogen activator inhibitor 1 OS=Bos taurus OX=9913 GN=SERPINE1 PE=1 SV=1
3	AFDB:P20961	0.929	0.929	9.207E-72	402	0.808	0.808	P20961.pdb.gz	PAI1_RAT Plasminogen activator inhibitor 1 OS=Rattus norvegicus OX=10116 GN=Serpine1 PE=2 SV=1
4	AFDB:P22777	0.927	0.927	4.792E-69	402	0.789	0.789	P22777.pdb.gz	PAI1_MOUSE Plasminogen activator inhibitor 1 OS=Mus musculus OX=10090 GN=Serpine1 PE=1 SV=1
5	PDB:4aqhB	0.845	0.885	2.202E-59	383	0.943	0.990	4aqhB.pdb.gz	Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 that Accelerates the Transition Into the Latent Conformation
6	PDB:3lw2A	0.830	0.912	2.178E-52	365	0.711	0.784	3lw2A.pdb.gz
7	PDB:4dteA	0.892	0.957	1.172E-50	374	0.410	0.441	4dteA.pdb.gz
8	AFDB:F1QRB8	0.899	0.921	2.210E-49	392	0.410	0.421	F1QRB8.pdb.gz	F1QRB8_DANRE Plasminogen activator inhibitor 1 OS=Danio rerio OX=7955 GN=PAI-1 PE=1 SV=1
9	AFDB:P07092	0.894	0.905	2.820E-48	397	0.400	0.406	P07092.pdb.gz	GDN_RAT Glia-derived nexin OS=Rattus norvegicus OX=10116 GN=Serpine2 PE=1 SV=1
10	AFDB:P07093	0.910	0.919	7.225E-48	398	0.398	0.402	P07093.pdb.gz	GDN_HUMAN Glia-derived nexin OS=Homo sapiens OX=9606 GN=SERPINE2 PE=1 SV=1
11	PDB:4dy7F	0.883	0.937	2.354E-46	378	0.388	0.413	4dy7F.pdb.gz	Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
12	AFDB:O35684	0.871	0.855	1.053E-40	410	0.306	0.300	O35684.pdb.gz	NEUS_MOUSE Neuroserpin OS=Mus musculus OX=10090 GN=Serpini1 PE=1 SV=1
13	AFDB:Q90935	0.866	0.850	1.113E-40	410	0.333	0.327	Q90935.pdb.gz	NEUS_CHICK Neuroserpin OS=Gallus gallus OX=9031 GN=SERPINI1 PE=1 SV=1
14	AFDB:Q99574	0.845	0.829	5.988E-39	410	0.306	0.300	Q99574.pdb.gz	NEUS_HUMAN Neuroserpin OS=Homo sapiens OX=9606 GN=SERPINI1 PE=1 SV=1
15	PDB:4ga7A	0.842	0.915	4.731E-37	369	0.271	0.295	4ga7A.pdb.gz
16	PDB:1hp7A	0.852	0.908	2.355E-36	376	0.276	0.295	1hp7A.pdb.gz	A 2.1 A resolution structure of an uncleaved alpha(1)-antitrypsin shows variability of the reactive center and other loops.
17	PDB:2zv6B	0.834	0.900	2.355E-36	371	0.286	0.310	2zv6B.pdb.gz
18	PDB:3f5nB	0.819	0.872	5.403E-36	376	0.301	0.322	3f5nB.pdb.gz
19	PDB:2ol2A	0.815	0.905	5.524E-35	360	0.256	0.286	2ol2A.pdb.gz
20	PDB:2h4rA	0.834	0.901	6.522E-35	371	0.271	0.294	2h4rA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P05121	0.0	834	402	1.000	1.000	PAI1_HUMAN Plasminogen activator inhibitor 1 OS=Homo sapiens OX=9606 GN=SERPINE1 PE=1 SV=1
2	P13909	0.0	722	402	0.853	0.853	PAI1_BOVIN Plasminogen activator inhibitor 1 OS=Bos taurus OX=9913 GN=SERPINE1 PE=1 SV=1
3	P20961	0.0	684	402	0.808	0.808	PAI1_RAT Plasminogen activator inhibitor 1 OS=Rattus norvegicus OX=10116 GN=Serpine1 PE=2 SV=1
4	P22777	0.0	660	402	0.786	0.786	PAI1_MOUSE Plasminogen activator inhibitor 1 OS=Mus musculus OX=10090 GN=Serpine1 PE=1 SV=1
5	F1QRB8	2.51e-121	358	392	0.410	0.421	F1QRB8_DANRE Plasminogen activator inhibitor 1 OS=Danio rerio OX=7955 GN=PAI-1 PE=1 SV=1
6	A8WGQ0	2.81e-119	353	384	0.405	0.424	A8WGQ0_DANRE Plasminogen activator inhibitor 1 precursor OS=Danio rerio OX=7955 GN=si:ch211-138a11.1 PE=2 SV=1
7	Q07235	6.52e-105	317	397	0.396	0.401	GDN_MOUSE Glia-derived nexin OS=Mus musculus OX=10090 GN=Serpine2 PE=1 SV=2
8	P07092	1.71e-104	316	397	0.393	0.398	GDN_RAT Glia-derived nexin OS=Rattus norvegicus OX=10116 GN=Serpine2 PE=1 SV=1
9	P07093	6.62e-100	304	398	0.391	0.394	GDN_HUMAN Glia-derived nexin OS=Homo sapiens OX=9606 GN=SERPINE2 PE=1 SV=1
10	Q90935	7.18e-76	243	410	0.326	0.320	NEUS_CHICK Neuroserpin OS=Gallus gallus OX=9031 GN=SERPINI1 PE=1 SV=1
11	Q9JLD2	2.00e-73	236	410	0.316	0.310	NEUS_RAT Neuroserpin OS=Rattus norvegicus OX=10116 GN=Serpini1 PE=1 SV=1
12	O35684	3.49e-73	236	410	0.313	0.307	NEUS_MOUSE Neuroserpin OS=Mus musculus OX=10090 GN=Serpini1 PE=1 SV=1
13	Q99574	6.70e-73	235	410	0.308	0.302	NEUS_HUMAN Neuroserpin OS=Homo sapiens OX=9606 GN=SERPINI1 PE=1 SV=1
14	O75830	2.36e-64	213	405	0.303	0.301	SPI2_HUMAN Serpin I2 OS=Homo sapiens OX=9606 GN=SERPINI2 PE=1 SV=1
15	G3V7A3	8.06e-61	204	405	0.289	0.286	G3V7A3_RAT Serpin family I member 2 OS=Rattus norvegicus OX=10116 GN=Serpini2 PE=3 SV=1
16	Q9D1Q5	8.10e-61	203	387	0.318	0.331	Q9D1Q5_MOUSE Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B OS=Mus musculus OX=10090 GN=Serpinb3b PE=1 SV=1
17	Q8BHL1	2.40e-60	202	387	0.313	0.326	Q8BHL1_MOUSE Squamous cell carcinoma antigen 2 related protein 1 OS=Mus musculus OX=10090 GN=Serpinb3b PE=2 SV=1
18	Q6UKZ2	5.32e-60	201	387	0.313	0.326	Q6UKZ2_MOUSE Serine (Or cysteine) peptidase inhibitor, clade B (Ovalbumin), member 3B OS=Mus musculus OX=10090 GN=Serpinb3b PE=2 SV=1
19	Q9JK88	1.13e-58	198	405	0.286	0.284	SPI2_MOUSE Serpin I2 OS=Mus musculus OX=10090 GN=Serpini2 PE=1 SV=1
20	Q6P217	3.92e-57	193	377	0.303	0.324	Q6P217_MOUSE Serine (Or cysteine) peptidase inhibitor, clade B, member 9b OS=Mus musculus OX=10090 GN=Serpinb9b PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00079 Serpin	2.1e-104	361.4	Serpin (serine protease inhibitor)

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000223095

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000220809	0.999	Tissue-type plasminogen activator
2	9606.ENSP00000226218	0.999	Vitronectin
3	9606.ENSP00000243077	0.999	Prolow-density lipoprotein receptor-related protein 1
4	9606.ENSP00000339328	0.999	Urokinase plasminogen activator surface receptor
5	9606.ENSP00000361850	0.999	Urokinase-type plasminogen activator
6	9606.ENSP00000308938	0.995	Plasminogen
7	9606.ENSP00000371532	0.991	Very low-density lipoprotein receptor
8	9606.ENSP00000262160	0.975	Mothers against decapentaplegic homolog 2
9	9606.ENSP00000332973	0.971	Mothers against decapentaplegic homolog 3
10	9606.ENSP00000262158	0.964	Mothers against decapentaplegic homolog 7
11	9606.ENSP00000341551	0.961	Mothers against decapentaplegic homolog 4
12	9606.ENSP00000452786	0.959	Integrin beta-3
13	9606.ENSP00000454071	0.943	Low-density lipoprotein receptor
14	9606.ENSP00000261023	0.936	Integrin alpha-V
15	9606.ENSP00000384517	0.930	Aryl hydrocarbon receptor nuclear translocator-like protein 1
16	9606.ENSP00000266503	0.927	Aryl hydrocarbon receptor nuclear translocator-like protein 2
17	9606.ENSP00000419465	0.927	WW domain-containing transcription regulator protein 1
18	9606.ENSP00000308741	0.926	Circadian locomoter output cycles protein kaput
19	9606.ENSP00000296181	0.923	Integrin beta-5
20	9606.ENSP00000415786	0.915	Glia-derived nexin

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004867	1.000	serine-type endopeptidase inhibitor activity
GO:0019899	0.998	enzyme binding
GO:0002020	0.851	protease binding
GO:0005102	0.644	signaling receptor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050896	0.996	response to stimulus
GO:0050794	0.995	regulation of cellular process
GO:0048519	0.995	negative regulation of biological process
GO:0019222	0.995	regulation of metabolic process
GO:0048518	0.994	positive regulation of biological process
GO:0048583	0.991	regulation of response to stimulus
GO:0051246	0.986	regulation of protein metabolic process
GO:0009892	0.985	negative regulation of metabolic process
GO:0009987	0.978	cellular process
GO:0010629	0.978	negative regulation of gene expression
GO:0051239	0.972	regulation of multicellular organismal process
GO:0032501	0.970	multicellular organismal process
GO:0061041	0.966	regulation of wound healing
GO:0070613	0.965	regulation of protein processing
GO:0051248	0.965	negative regulation of protein metabolic process
GO:0048523	0.963	negative regulation of cellular process
GO:0010955	0.963	negative regulation of protein processing
GO:0051241	0.955	negative regulation of multicellular organismal process
GO:0009893	0.951	positive regulation of metabolic process
GO:0048856	0.935	anatomical structure development
GO:0051240	0.934	positive regulation of multicellular organismal process
GO:0050818	0.921	regulation of coagulation
GO:0042221	0.911	response to chemical
GO:0006950	0.904	response to stress
GO:0022603	0.901	regulation of anatomical structure morphogenesis
GO:0007275	0.898	multicellular organism development
GO:1901342	0.893	regulation of vasculature development
GO:0010604	0.889	positive regulation of macromolecule metabolic process
GO:0009605	0.885	response to external stimulus
GO:0048584	0.880	positive regulation of response to stimulus
GO:0065008	0.870	regulation of biological quality
GO:0032102	0.869	negative regulation of response to external stimulus
GO:0051094	0.866	positive regulation of developmental process
GO:0048731	0.853	system development
GO:0044419	0.847	biological process involved in interspecies interaction between organisms
GO:0009607	0.844	response to biotic stimulus
GO:0010646	0.840	regulation of cell communication
GO:0048522	0.839	positive regulation of cellular process
GO:0050878	0.837	regulation of body fluid levels
GO:0042127	0.835	regulation of cell population proliferation
GO:0009966	0.832	regulation of signal transduction
GO:0051716	0.826	cellular response to stimulus
GO:0002682	0.823	regulation of immune system process
GO:0051336	0.808	regulation of hydrolase activity
GO:0045765	0.806	regulation of angiogenesis
GO:0042981	0.802	regulation of apoptotic process
GO:0009617	0.797	response to bacterium
GO:0044092	0.787	negative regulation of molecular function
GO:0072359	0.772	circulatory system development
GO:0032879	0.762	regulation of localization
GO:0030334	0.761	regulation of cell migration
GO:0090303	0.759	positive regulation of wound healing
GO:0051093	0.740	negative regulation of developmental process
GO:0009719	0.726	response to endogenous stimulus
GO:0010033	0.721	response to organic substance
GO:0030193	0.719	regulation of blood coagulation
GO:0043086	0.714	negative regulation of catalytic activity
GO:0031323	0.707	regulation of cellular metabolic process
GO:0009891	0.706	positive regulation of biosynthetic process
GO:0051130	0.702	positive regulation of cellular component organization
GO:0040013	0.699	negative regulation of locomotion
GO:0052547	0.694	regulation of peptidase activity
GO:0070887	0.691	cellular response to chemical stimulus
GO:0071495	0.674	cellular response to endogenous stimulus
GO:0010628	0.658	positive regulation of gene expression
GO:0052548	0.647	regulation of endopeptidase activity
GO:1901701	0.642	cellular response to oxygen-containing compound
GO:0051346	0.638	negative regulation of hydrolase activity
GO:0061045	0.636	negative regulation of wound healing
GO:0010466	0.623	negative regulation of peptidase activity
GO:0006952	0.610	defense response
GO:0051049	0.608	regulation of transport
GO:0048513	0.605	animal organ development
GO:0009725	0.599	response to hormone
GO:0071310	0.582	cellular response to organic substance
GO:0009653	0.581	anatomical structure morphogenesis
GO:0010951	0.579	negative regulation of endopeptidase activity
GO:0045766	0.566	positive regulation of angiogenesis
GO:0008152	0.547	metabolic process
GO:0001944	0.527	vasculature development
GO:0051173	0.524	positive regulation of nitrogen compound metabolic process
GO:0016525	0.490	negative regulation of angiogenesis
GO:0001568	0.472	blood vessel development
GO:0071704	0.465	organic substance metabolic process
GO:0033993	0.426	response to lipid
GO:0007154	0.425	cell communication
GO:0019219	0.424	regulation of nucleobase-containing compound metabolic process
GO:0044238	0.416	primary metabolic process
GO:0035239	0.416	tube morphogenesis
GO:0023052	0.409	signaling
GO:0051252	0.403	regulation of RNA metabolic process
GO:0048514	0.400	blood vessel morphogenesis
GO:0010556	0.358	regulation of macromolecule biosynthetic process
GO:0007165	0.358	signal transduction
GO:0031326	0.347	regulation of cellular biosynthetic process
GO:0023056	0.342	positive regulation of signaling
GO:0010647	0.338	positive regulation of cell communication
GO:0001817	0.323	regulation of cytokine production
GO:0006807	0.322	nitrogen compound metabolic process
GO:0043170	0.316	macromolecule metabolic process
GO:0031325	0.316	positive regulation of cellular metabolic process
GO:2001141	0.312	regulation of RNA biosynthetic process
GO:0006355	0.303	regulation of DNA-templated transcription

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005615	0.998	extracellular space
GO:0012505	0.992	endomembrane system
GO:0043231	0.975	intracellular membrane-bounded organelle
GO:0043233	0.956	organelle lumen
GO:0070013	0.954	intracellular organelle lumen
GO:0005737	0.949	cytoplasm
GO:0071944	0.902	cell periphery
GO:0031982	0.869	vesicle
GO:0031410	0.842	cytoplasmic vesicle
GO:0070062	0.738	extracellular exosome
GO:0016020	0.678	membrane
GO:0030141	0.614	secretory granule
GO:0032991	0.552	protein-containing complex
GO:0062023	0.409	collagen-containing extracellular matrix
GO:0005886	0.393	plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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