StarFunc result for job id P07550

User Input

>input (413 residues)
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P07550	1.000	1.000	4.134E-52	413	1.000	1.000	P07550.pdb.gz	ADRB2_HUMAN Beta-2 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB2 PE=1 SV=3
2	AFDB:P10608	0.861	0.851	1.155E-47	418	0.884	0.873	P10608.pdb.gz	ADRB2_RAT Beta-2 adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adrb2 PE=1 SV=1
3	AFDB:A0A2R8QNL3	0.746	0.753	7.653E-33	409	0.530	0.535	A0A2R8QNL3.pdb.gz
4	AFDB:E7EYN4	0.740	0.754	8.344E-33	405	0.540	0.551	E7EYN4.pdb.gz
5	AFDB:Q8UUY8	0.740	0.747	1.739E-32	409	0.542	0.548	Q8UUY8.pdb.gz	ADRB2_ONCMY Beta-2 adrenergic receptor OS=Oncorhynchus mykiss OX=8022 GN=adrb2 PE=2 SV=1
6	PDB:5d5aA	0.682	0.639	3.997E-32	442	0.700	0.654	5d5aA.pdb.gz	In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.
7	AFDB:P08588	0.712	0.618	8.599E-32	477	0.513	0.444	P08588.pdb.gz	ADRB1_HUMAN Beta-1 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB1 PE=1 SV=3
8	AFDB:P07700	0.754	0.648	1.022E-31	483	0.494	0.422	P07700.pdb.gz	ADRB1_MELGA Beta-1 adrenergic receptor OS=Meleagris gallopavo OX=9103 GN=ADRB1 PE=1 SV=1
9	AFDB:B3DHM6	0.733	0.776	2.644E-31	390	0.494	0.523	B3DHM6.pdb.gz	B3DHM6_DANRE Adrenergic, beta-1-, receptor OS=Danio rerio OX=7955 GN=zgc:194728 PE=2 SV=1
10	PDB:4ldeA	0.640	0.584	3.044E-31	454	0.659	0.599	4ldeA.pdb.gz	Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
11	AFDB:P13945	0.721	0.729	2.332E-28	408	0.431	0.436	P13945.pdb.gz	ADRB3_HUMAN Beta-3 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB3 PE=1 SV=3
12	AFDB:P25962	0.723	0.746	2.983E-27	400	0.429	0.443	P25962.pdb.gz	ADRB3_MOUSE Beta-3 adrenergic receptor OS=Mus musculus OX=10090 GN=Adrb3 PE=2 SV=2
13	PDB:6iblA	0.635	0.660	2.852E-26	397	0.443	0.461	6iblA.pdb.gz	Molecular basis of beta-arrestin coupling to formoterol-bound beta1-adrenoceptor.
14	PDB:7jvqR	0.626	0.890	1.741E-18	286	0.274	0.395	7jvqR.pdb.gz	Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
15	PDB:7xt8R	0.583	0.803	7.151E-17	294	0.274	0.384	7xt8R.pdb.gz	GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
16	PDB:7e32R	0.586	0.832	2.729E-16	285	0.254	0.368	7e32R.pdb.gz	Structural insights into the lipid and ligand regulation of serotonin receptors.
17	PDB:7e2xR	0.593	0.860	1.292E-15	278	0.254	0.378	7e2xR.pdb.gz	Structural insights into the lipid and ligand regulation of serotonin receptors.
18	PDB:7cmuR	0.579	0.861	6.120E-15	272	0.242	0.368	7cmuR.pdb.gz	Structures of the human dopamine D3 receptor-G i complexes.
19	PDB:7e33R	0.553	0.869	8.280E-15	257	0.230	0.370	7e33R.pdb.gz	Structural insights into the lipid and ligand regulation of serotonin receptors.
20	PDB:7xtbR	0.579	0.845	8.646E-15	278	0.220	0.327	7xtbR.pdb.gz	GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P07550	0.0	862	413	1.000	1.000	ADRB2_HUMAN Beta-2 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB2 PE=1 SV=3
2	P10608	0.0	756	418	0.884	0.873	ADRB2_RAT Beta-2 adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adrb2 PE=1 SV=1
3	P18762	0.0	752	418	0.881	0.871	ADRB2_MOUSE Beta-2 adrenergic receptor OS=Mus musculus OX=10090 GN=Adrb2 PE=1 SV=2
4	I7GPU6	3.12e-156	448	405	0.545	0.556	I7GPU6_DANRE Beta-2 adrenergic receptor OS=Danio rerio OX=7955 GN=adrb2a PE=2 SV=1
5	A0A060YAV5	1.26e-150	434	393	0.516	0.542	A0A060YAV5_ONCMY G-protein coupled receptors family 1 profile domain-containing protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00036180001 PE=3 SV=1
6	A4QNV7	2.23e-147	426	409	0.521	0.526	A4QNV7_DANRE Beta-2 adrenergic receptor OS=Danio rerio OX=7955 GN=zgc:162188 PE=2 SV=1
7	A0A060XC03	2.91e-145	421	401	0.525	0.541	A0A060XC03_ONCMY Beta-2 adrenergic receptor OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00012903001 PE=3 SV=1
8	A0A060Y644	1.08e-144	419	408	0.545	0.551	A0A060Y644_ONCMY Adrenoceptor beta 2, surface b OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00054169001 PE=3 SV=1
9	Q8UUY8	4.33e-142	412	409	0.516	0.521	ADRB2_ONCMY Beta-2 adrenergic receptor OS=Oncorhynchus mykiss OX=8022 GN=adrb2 PE=2 SV=1
10	P07700	5.17e-141	412	483	0.487	0.416	ADRB1_MELGA Beta-1 adrenergic receptor OS=Meleagris gallopavo OX=9103 GN=ADRB1 PE=1 SV=1
11	G1NEX5	6.03e-140	409	457	0.470	0.425	G1NEX5_MELGA Adrenoceptor beta 1 OS=Meleagris gallopavo OX=9103 GN=ADRB1 PE=3 SV=3
12	B3DHM6	4.56e-138	402	390	0.475	0.503	B3DHM6_DANRE Adrenergic, beta-1-, receptor OS=Danio rerio OX=7955 GN=zgc:194728 PE=2 SV=1
13	P08588	9.79e-135	396	477	0.487	0.421	ADRB1_HUMAN Beta-1 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB1 PE=1 SV=3
14	P34971	7.55e-131	386	466	0.472	0.418	ADRB1_MOUSE Beta-1 adrenergic receptor OS=Mus musculus OX=10090 GN=Adrb1 PE=1 SV=2
15	P18090	5.40e-130	384	466	0.470	0.416	ADRB1_RAT Beta-1 adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adrb1 PE=1 SV=1
16	P25962	1.75e-109	329	400	0.407	0.420	ADRB3_MOUSE Beta-3 adrenergic receptor OS=Mus musculus OX=10090 GN=Adrb3 PE=2 SV=2
17	P26255	7.59e-105	317	400	0.390	0.403	ADRB3_RAT Beta-3 adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adrb3 PE=2 SV=2
18	P13945	4.19e-103	313	408	0.378	0.382	ADRB3_HUMAN Beta-3 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB3 PE=1 SV=3
19	Q4LBB9	1.49e-70	233	536	0.339	0.261	OCTB2_DROME Octopamine receptor beta-2R OS=Drosophila melanogaster OX=7227 GN=Octbeta2R PE=2 SV=2
20	Q9VCZ3	3.40e-69	229	508	0.293	0.238	OCTB1_DROME Octopamine receptor beta-1R OS=Drosophila melanogaster OX=7227 GN=Octbeta1R PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00001 7tm_1	1.3e-70	249.3	7 transmembrane receptor (rhodopsin family)
2	PF13853 7tm_4	0.18	23.1	Olfactory receptor
3	PF10320 7TM_GPCR_Srsx	9.4e-11	53.2	Serpentine type 7TM GPCR chemoreceptor Srsx
4	PF10323 7TM_GPCR_Srv	0.0033	28.4	Serpentine type 7TM GPCR chemoreceptor Srv
5	PF10328 7TM_GPCR_Srx	4.1e-05	34.9	Serpentine type 7TM GPCR chemoreceptor Srx

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000305372

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000262613	0.999	Na(+)/H(+) exchange regulatory cofactor NHE-RF1
2	9606.ENSP00000403701	0.999	Beta-arrestin-2
3	9606.ENSP00000409581	0.998	Beta-arrestin-1
4	9606.ENSP00000312262	0.994	Beta-adrenergic receptor kinase 1
5	9606.ENSP00000360141	0.994	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
6	9606.ENSP00000003084	0.993	Cystic fibrosis transmembrane conductance regulator
7	9606.ENSP00000386444	0.990	S-arrestin
8	9606.ENSP00000266376	0.989	Voltage-dependent L-type calcium channel subunit alpha-1C
9	9606.ENSP00000362680	0.989	Proto-oncogene tyrosine-protein kinase Src
10	9606.ENSP00000378207	0.989	A-kinase anchor protein 5
11	9606.ENSP00000384537	0.989	A-kinase anchor protein 12
12	9606.ENSP00000357836	0.982	Sorting nexin-27
13	9606.ENSP00000345502	0.967	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
14	9606.ENSP00000276198	0.965	5-hydroxytryptamine receptor 2C
15	9606.ENSP00000424827	0.964	E3 ubiquitin-protein ligase NEDD4
16	9606.ENSP00000382428	0.962	Disks large homolog 4
17	9606.ENSP00000300935	0.961	Ras-related protein Rab-8A
18	9606.ENSP00000376345	0.961	Growth factor receptor-bound protein 2
19	9606.ENSP00000356042	0.953	Ezrin
20	9606.ENSP00000265138	0.949	Arrestin domain-containing protein 3

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0008227	1.000	G protein-coupled amine receptor activity
GO:0005488	0.996	binding
GO:0005515	0.988	protein binding
GO:0004935	0.988	adrenergic receptor activity
GO:0008528	0.384	G protein-coupled peptide receptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050789	0.998	regulation of biological process
GO:0007165	0.993	signal transduction
GO:0007186	0.983	G protein-coupled receptor signaling pathway
GO:0010243	0.766	response to organonitrogen compound
GO:0048583	0.641	regulation of response to stimulus
GO:0009719	0.617	response to endogenous stimulus
GO:0010646	0.610	regulation of cell communication
GO:0023051	0.607	regulation of signaling
GO:0048518	0.606	positive regulation of biological process
GO:0032501	0.563	multicellular organismal process
GO:0009966	0.525	regulation of signal transduction
GO:0048522	0.512	positive regulation of cellular process
GO:0048519	0.496	negative regulation of biological process
GO:0019222	0.480	regulation of metabolic process
GO:0065009	0.449	regulation of molecular function
GO:0031323	0.444	regulation of cellular metabolic process
GO:0065008	0.440	regulation of biological quality
GO:0048523	0.440	negative regulation of cellular process
GO:0008152	0.419	metabolic process
GO:0060255	0.403	regulation of macromolecule metabolic process
GO:0080090	0.394	regulation of primary metabolic process
GO:0032879	0.368	regulation of localization
GO:0051179	0.367	localization
GO:0070887	0.330	cellular response to chemical stimulus
GO:0051171	0.319	regulation of nitrogen compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0005737	0.994	cytoplasm
GO:0043226	0.914	organelle
GO:0043227	0.902	membrane-bounded organelle
GO:0043229	0.860	intracellular organelle
GO:0043231	0.818	intracellular membrane-bounded organelle
GO:0012505	0.617	endomembrane system
GO:0031982	0.318	vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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