StarFunc result for job id P08397

User Input

>input (361 residues)
MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTG
DKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPH
DAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQ
QEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHD
PETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH
VPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLNDA
H

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P08397	1.000	1.000	1.157E-81	361	1.000	1.000	P08397.pdb.gz	HEM3_HUMAN Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2
2	PDB:7aakA	0.888	0.928	1.452E-65	345	0.953	0.997	7aakA.pdb.gz	Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism.
3	PDB:3ecrA	0.859	0.973	4.946E-62	318	0.881	1.000	3ecrA.pdb.gz	Structural insight into acute intermittent porphyria.
4	AFDB:Q09899	0.852	0.914	1.014E-41	336	0.402	0.432	Q09899.pdb.gz	HEM3_SCHPO Porphobilinogen deaminase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=hem3 PE=1 SV=2
5	AFDB:P28789	0.829	0.914	8.623E-41	327	0.360	0.398	P28789.pdb.gz	HEM3_YEAST Porphobilinogen deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HEM3 PE=1 SV=1
6	AFDB:P06983	0.825	0.949	8.285E-40	313	0.391	0.450	P06983.pdb.gz	HEM3_ECOLI Porphobilinogen deaminase OS=Escherichia coli (strain K12) OX=83333 GN=hemC PE=1 SV=2
7	AFDB:O94048	0.824	0.874	3.181E-39	340	0.382	0.406	O94048.pdb.gz	HEM3_CANAL Porphobilinogen deaminase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=HEM3 PE=3 SV=1
8	PDB:1ah5A	0.774	0.931	1.456E-36	299	0.380	0.458	1ah5A.pdb.gz	Determination of the structure of seleno-methionine-labelled hydroxymethylbilane synthase in its active form by multi-wavelength anomalous dispersion.
9	AFDB:P9WMP3	0.774	0.899	3.129E-34	309	0.357	0.417	P9WMP3.pdb.gz	HEM3_MYCTU Porphobilinogen deaminase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=hemC PE=1 SV=1
10	AFDB:Q43316	0.797	0.754	4.248E-34	382	0.332	0.314	Q43316.pdb.gz	HEM3_ARATH Porphobilinogen deaminase, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=HEMC PE=1 SV=1
11	AFDB:Q8I5V3	0.788	0.659	5.904E-30	435	0.269	0.223	Q8I5V3.pdb.gz	Q8I5V3_PLAF7 hydroxymethylbilane synthase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1209600 PE=3 SV=1
12	AFDB:P04846	0.389	0.493	2.450E-8	272	0.125	0.165	P04846.pdb.gz	NLPA_ECOLI Lipoprotein 28 OS=Escherichia coli (strain K12) OX=83333 GN=nlpA PE=1 SV=1
13	AFDB:P42883	0.345	0.362	3.129E-8	340	0.078	0.082	P42883.pdb.gz	THI12_YEAST 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=THI12 PE=3 SV=1
14	PDB:4eswA	0.334	0.349	4.565E-8	342	0.083	0.088	4eswA.pdb.gz
15	PDB:4h67C	0.334	0.351	7.445E-8	338	0.083	0.089	4h67C.pdb.gz	The Last Piece in the Vitamin B1 Biosynthesis Puzzle: STRUCTURAL AND FUNCTIONAL INSIGHT INTO YEAST 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE (HMP-P) SYNTHASE.
16	PDB:2x26A	0.345	0.389	2.530E-7	308	0.089	0.104	2x26A.pdb.gz
17	PDB:7yhjE	0.352	0.567	2.689E-7	193	0.075	0.140	7yhjE.pdb.gz
18	PDB:2x7qA	0.336	0.380	4.662E-7	306	0.089	0.105	2x7qA.pdb.gz	The Conserved Candida Albicans Ca3427 Gene Product Defines a New Family of Proteins Exhibiting the Generic Periplasmic Binding Protein Structural Fold
19	PDB:1hslA	0.336	0.456	2.430E-6	238	0.083	0.126	1hslA.pdb.gz	Refined 1.89-A structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins.
20	PDB:1wdnA	0.287	0.407	2.066E-5	223	0.091	0.148	1wdnA.pdb.gz	The structure of glutamine-binding protein complexed with glutamine at 1.94 A resolution: comparisons with other amino acid binding proteins.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P08397	0.0	741	361	1.000	1.000	HEM3_HUMAN Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2
2	P19356	0.0	678	361	0.909	0.909	HEM3_RAT Porphobilinogen deaminase OS=Rattus norvegicus OX=10116 GN=Hmbs PE=1 SV=2
3	O94048	1.34e-78	246	340	0.393	0.418	HEM3_CANAL Porphobilinogen deaminase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=HEM3 PE=3 SV=1
4	P06983	2.28e-78	244	313	0.402	0.463	HEM3_ECOLI Porphobilinogen deaminase OS=Escherichia coli (strain K12) OX=83333 GN=hemC PE=1 SV=2
5	P28789	3.12e-77	242	327	0.368	0.407	HEM3_YEAST Porphobilinogen deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HEM3 PE=1 SV=1
6	Q09899	9.44e-75	236	336	0.360	0.387	HEM3_SCHPO Porphobilinogen deaminase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=hem3 PE=1 SV=2
7	P9WMP3	3.88e-53	179	309	0.335	0.392	HEM3_MYCTU Porphobilinogen deaminase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=hemC PE=1 SV=1
8	Q43316	1.71e-51	177	382	0.324	0.306	HEM3_ARATH Porphobilinogen deaminase, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=HEMC PE=1 SV=1
9	Q8I5V3	6.51e-34	132	435	0.277	0.230	Q8I5V3_PLAF7 hydroxymethylbilane synthase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1209600 PE=3 SV=1
10	Q9FXD1	1.5	33.5	651	0.089	0.049	Q9FXD1_ARATH Signal recognition particle subunit SRP72 OS=Arabidopsis thaliana OX=3702 GN=At1g67650 PE=1 SV=1
11	Q8C156	1.7	33.1	731	0.075	0.037	CND2_MOUSE Condensin complex subunit 2 OS=Mus musculus OX=10090 GN=Ncaph PE=1 SV=1
12	P15215	1.8	33.1	1639	0.075	0.016	LAMC1_DROME Laminin subunit gamma-1 OS=Drosophila melanogaster OX=7227 GN=LanB2 PE=2 SV=2
13	O94657	2.4	32.3	413	0.061	0.053	XDJ1_SCHPO DnaJ protein homolog xdj1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=xdj1 PE=3 SV=1
14	Q9LNW3	3.0	32.3	442	0.039	0.032	P2C03_ARATH Protein phosphatase 2C 3 OS=Arabidopsis thaliana OX=3702 GN=AIP1 PE=1 SV=1
15	P9WN77	3.6	32.0	334	0.047	0.051	GPDA_MYCTU Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=gpsA PE=1 SV=1
16	Q9M3D6	4.7	32.0	725	0.044	0.022	AB19G_ARATH ABC transporter G family member 19 OS=Arabidopsis thaliana OX=3702 GN=ABCG19 PE=1 SV=1
17	Q9USN5	8.6	31.2	1106	0.053	0.017	GDH2_SCHPO Probable NAD-specific glutamate dehydrogenase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gdh2 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02142 MGS	4.4e+02	12.5	MGS-like domain
2	PF01379 Porphobil_deam	2.7e-80	280.3	Porphobilinogen deaminase, dipyromethane cofactor binding domain
3	PF03900 Porphobil_deamC	2e-18	77.8	Porphobilinogen deaminase, C-terminal domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000278715

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000357787	0.997	Uroporphyrinogen-III synthase
2	9606.ENSP00000386284	0.997	Delta-aminolevulinic acid dehydratase
3	9606.ENSP00000246337	0.993	Uroporphyrinogen decarboxylase
4	9606.ENSP00000264193	0.949	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
5	9606.ENSP00000372326	0.936	Ferrochelatase, mitochondrial
6	9606.ENSP00000356978	0.935	Protoporphyrinogen oxidase
7	9606.ENSP00000378416	0.855	5-aminolevulinate synthase, nonspecific, mitochondrial
8	9606.ENSP00000332369	0.816	5-aminolevulinate synthase, erythroid-specific, mitochondrial
9	9606.ENSP00000011619	0.811	Ran-binding protein 9
10	9606.ENSP00000264932	0.808	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
11	9606.ENSP00000311430	0.759	L ribosomal proteins
12	9606.ENSP00000379287	0.746	14-3-3 protein zeta/delta
13	9606.ENSP00000229239	0.735	Glyceraldehyde-3-phosphate dehydrogenase
14	9606.ENSP00000431445	0.735	T-cell surface glycoprotein CD3 gamma chain
15	9606.ENSP00000452780	0.733	Beta-2-microglobulin
16	9606.ENSP00000375942	0.731	TATA-box-binding protein
17	9606.ENSP00000300692	0.729	T-cell surface glycoprotein CD3 delta chain
18	9606.ENSP00000375730	0.717	60S ribosomal protein L13a
19	9606.ENSP00000298556	0.702	Hypoxanthine-guanine phosphoribosyltransferase
20	9606.ENSP00000266126	0.697	Translation initiation factor eIF-2B subunit beta

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0004418	0.999	hydroxymethylbilane synthase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044237	0.995	cellular metabolic process
GO:0006807	0.992	nitrogen compound metabolic process
GO:1901564	0.970	organonitrogen compound metabolic process
GO:1901360	0.924	organic cyclic compound metabolic process
GO:0044249	0.923	cellular biosynthetic process
GO:0006725	0.921	cellular aromatic compound metabolic process
GO:0046483	0.920	heterocycle metabolic process
GO:0034641	0.897	cellular nitrogen compound metabolic process
GO:1901576	0.879	organic substance biosynthetic process
GO:0044271	0.876	cellular nitrogen compound biosynthetic process
GO:0006779	0.833	porphyrin-containing compound biosynthetic process
GO:0042440	0.786	pigment metabolic process
GO:0042168	0.411	heme metabolic process
GO:0046148	0.387	pigment biosynthetic process
GO:0050896	0.372	response to stimulus
GO:0044238	0.306	primary metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0043231	0.970	intracellular membrane-bounded organelle
GO:0005634	0.920	nucleus
GO:0043232	0.844	intracellular non-membrane-bounded organelle
GO:0070013	0.607	intracellular organelle lumen
GO:0016020	0.319	membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:13185	0.999	H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)
EC:2.5.1.61	0.999	hydroxymethylbilane synthase.

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