StarFunc result for job id P08670

User Input

>input (466 residues)
MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGV
YATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDK
VRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAE
DIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEE
EIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSE
AANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQD
TIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSS
LNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P02543	0.567	0.567	3.074E-55	466	0.981	0.981	P02543.pdb.gz	VIME_PIG Vimentin OS=Sus scrofa OX=9823 GN=VIM PE=1 SV=2
2	AFDB:F1NJ08	0.402	0.406	2.801E-48	460	0.876	0.887	F1NJ08.pdb.gz
3	AFDB:P48674	0.676	0.682	1.194E-41	461	0.727	0.735	P48674.pdb.gz	VIME_ONCMY Vimentin OS=Oncorhynchus mykiss OX=8022 GN=vim PE=2 SV=1
4	AFDB:F1QAM8	0.688	0.703	2.075E-41	455	0.689	0.705	F1QAM8.pdb.gz
5	AFDB:P17661	0.618	0.614	5.209E-36	470	0.627	0.621	P17661.pdb.gz	DESM_HUMAN Desmin OS=Homo sapiens OX=9606 GN=DES PE=1 SV=3
6	AFDB:A0A2R8PYZ9	0.581	0.572	3.138E-35	474	0.586	0.576	A0A2R8PYZ9.pdb.gz
7	AFDB:P02542	0.479	0.481	3.861E-35	464	0.607	0.610	P02542.pdb.gz	DESM_CHICK Desmin OS=Gallus gallus OX=9031 GN=DES PE=1 SV=2
8	AFDB:Q58EE9	0.563	0.587	2.326E-34	444	0.571	0.599	Q58EE9.pdb.gz	GFAP_DANRE Glial fibrillary acidic protein OS=Danio rerio OX=7955 GN=gfap PE=1 SV=2
9	AFDB:P15331	0.509	0.501	2.121E-33	475	0.571	0.560	P15331.pdb.gz	PERI_MOUSE Peripherin OS=Mus musculus OX=10090 GN=Prph PE=1 SV=2
10	AFDB:P03995	0.532	0.571	1.536E-31	430	0.526	0.570	P03995.pdb.gz	GFAP_MOUSE Glial fibrillary acidic protein OS=Mus musculus OX=10090 GN=Gfap PE=1 SV=4
11	PDB:7rroE2	0.042	0.112	1.910	144	0.021	0.069	7rroE2.pdb.gz	De novo identification of mammalian ciliary motility proteins using cryo-EM.
12	PDB:6hndB	0.055	0.054	2.192	470	0.013	0.013	6hndB.pdb.gz	Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties.
13	PDB:6v8oQ	0.051	0.081	2.349	264	0.015	0.027	6v8oQ.pdb.gz	Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement.
14	PDB:3ul5D	0.043	0.178	3.810	84	0.015	0.083	3ul5D.pdb.gz
15	PDB:5lcwA	0.048	0.019	4.082	1441	0.013	0.004	5lcwA.pdb.gz	Molecular basis of APC/C regulation by the spindle assembly checkpoint.
16	PDB:7egbA	0.049	0.043	4.082	558	0.011	0.009	7egbA.pdb.gz	Structural insights into preinitiation complex assembly on core promoters.
17	PDB:1u6zB	0.039	0.036	4.374	500	0.011	0.010	1u6zB.pdb.gz
18	PDB:2k8pA	0.051	0.110	5.023	189	0.019	0.048	2k8pA.pdb.gz
19	PDB:7mscq	0.046	0.157	5.023	95	0.015	0.074	7mscq.pdb.gz	Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis.
20	PDB:6mpbB	0.046	0.048	5.382	446	0.002	0.002	6mpbB.pdb.gz	Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A060XL43	673	449	0.708	0.735	A0A060XL43_ONCMY IF rod domain-containing protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00043362001 PE=3 SV=1
2	F1R8W3	528	488	0.592	0.566	F1R8W3_DANRE Desmin a OS=Danio rerio OX=7955 GN=cb290 PE=1 SV=1
3	F1R8W4	538	473	0.592	0.584	F1R8W4_DANRE Desmin a OS=Danio rerio OX=7955 GN=cb290 PE=1 SV=1
4	O73665	554	448	0.607	0.632	O73665_CHICK Desmin (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=1
5	P02542	548	464	0.573	0.575	DESM_CHICK Desmin OS=Gallus gallus OX=9031 GN=DES PE=1 SV=2
6	P02543	926	466	0.981	0.981	VIME_PIG Vimentin OS=Sus scrofa OX=9823 GN=VIM PE=1 SV=2
7	P02544	912	465	0.970	0.972	VIME_MESAU Vimentin OS=Mesocricetus auratus OX=10036 GN=VIM PE=1 SV=2
8	P08670	941	466	1.000	1.000	VIME_HUMAN Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4
9	P09654	813	460	0.865	0.876	VIME_CHICK Vimentin OS=Gallus gallus OX=9031 GN=VIM PE=3 SV=2
10	P20152	920	466	0.974	0.974	VIME_MOUSE Vimentin OS=Mus musculus OX=10090 GN=Vim PE=1 SV=3
11	P31000	920	466	0.974	0.974	VIME_RAT Vimentin OS=Rattus norvegicus OX=10116 GN=Vim PE=1 SV=2
12	P31001	533	469	0.627	0.623	DESM_MOUSE Desmin OS=Mus musculus OX=10090 GN=Des PE=1 SV=3
13	P48616	927	466	0.976	0.976	VIME_BOVIN Vimentin OS=Bos taurus OX=9913 GN=VIM PE=1 SV=3
14	P48670	860	448	0.921	0.958	VIME_CRIGR Vimentin (Fragment) OS=Cricetulus griseus OX=10029 GN=VIM PE=2 SV=1
15	P48674	681	461	0.719	0.727	VIME_ONCMY Vimentin OS=Oncorhynchus mykiss OX=8022 GN=vim PE=2 SV=1
16	P48675	533	469	0.627	0.623	DESM_RAT Desmin OS=Rattus norvegicus OX=10116 GN=Des PE=1 SV=2
17	Q05AI8	540	474	0.582	0.572	Q05AI8_DANRE Desmin OS=Danio rerio OX=7955 GN=zgc:154009 PE=2 SV=1
18	Q58EE9	532	444	0.567	0.595	GFAP_DANRE Glial fibrillary acidic protein OS=Danio rerio OX=7955 GN=gfap PE=1 SV=2
19	Q5XFN2	527	469	0.618	0.614	DESM_CANLF Desmin OS=Canis lupus familiaris OX=9615 GN=DES PE=1 SV=3
20	Q9YHX5	654	455	0.695	0.712	Q9YHX5_DANRE Vimentin OS=Danio rerio OX=7955 GN=cb28 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00170 bZIP_1	4e+02	12.5	bZIP transcription factor
2	PF07889 DUF1664	8.7	17.8	Protein of unknown function (DUF1664)
3	PF14988 DUF4515	1.9	19.9	Domain of unknown function (DUF4515)
4	PF04504 DUF573	3.6e+02	13.2	Protein of unknown function, DUF573
5	PF00038 Filament	1.4e-107	371.6	Intermediate filament protein
6	PF04732 Filament_head	1e-17	76.0	Intermediate filament head (DNA binding) region
7	PF02183 HALZ	2.9e+02	13.1	Homeobox associated leucine zipper
8	PF06009 Laminin_II	8.9e+02	11.3	Laminin Domain II
9	PF10620 MdcG	97	14.1	Phosphoribosyl-dephospho-CoA transferase MdcG
10	PF16331 TolA_bind_tri	26	16.3	TolA binding protein trimerisation
11	PF07926 TPR_MLP1_2	4.1e+02	12.4	TPR/MLP1/MLP2-like protein

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9593.ENSGGOP00000009353

Rank	PPI partner	STRING score	Description
1	9593.ENSGGOP00000002673	0.829	Desmin
2	9593.ENSGGOP00000016185	0.749	Transforming growth factor, beta 1
3	9593.ENSGGOP00000017521	0.717	V-akt murine thymoma viral oncogene homolog 1
4	9593.ENSGGOP00000021659	0.694	Caspase 3, apoptosis-related cysteine peptidase
5	9593.ENSGGOP00000004757	0.678	Barrier to autointegration factor 2
6	9593.ENSGGOP00000023505	0.678	Barrier to autointegration factor 1
7	9593.ENSGGOP00000013869	0.667	Gigaxonin
8	9593.ENSGGOP00000007184	0.664	Caspase 7, apoptosis-related cysteine peptidase
9	9593.ENSGGOP00000009171	0.664	Emerin
10	9593.ENSGGOP00000003146	0.659	Valosin containing protein
11	9593.ENSGGOP00000019549	0.651	Snail family zinc finger 1
12	9593.ENSGGOP00000016184	0.649	Nebulin
13	9593.ENSGGOP00000018631	0.639	Caspase 6, apoptosis-related cysteine peptidase
14	9593.ENSGGOP00000026616	0.639	Zinc finger E-box binding homeobox 1
15	9593.ENSGGOP00000009633	0.625	Major histocompatibility complex, class II, DR alpha
16	9593.ENSGGOP00000007562	0.616	V-akt murine thymoma viral oncogene homolog 3
17	9593.ENSGGOP00000000205	0.613	Caspase 8, apoptosis-related cysteine peptidase
18	9593.ENSGGOP00000003328	0.599	Thymopoietin
19	9593.ENSGGOP00000011766	0.599	LEM domain containing 1
20	9593.ENSGGOP00000006954	0.597	Titin-cap

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005198	0.955	structural molecule activity
GO:0005200	0.917	structural constituent of cytoskeleton
GO:0042802	0.696	identical protein binding
GO:0003676	0.391	nucleic acid binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.988	cellular process
GO:0050789	0.968	regulation of biological process
GO:0050896	0.957	response to stimulus
GO:0050794	0.903	regulation of cellular process
GO:0019222	0.803	regulation of metabolic process
GO:0048518	0.793	positive regulation of biological process
GO:0032502	0.747	developmental process
GO:0048856	0.716	anatomical structure development
GO:0060255	0.714	regulation of macromolecule metabolic process
GO:0071840	0.703	cellular component organization or biogenesis
GO:0048522	0.702	positive regulation of cellular process
GO:0016043	0.691	cellular component organization
GO:0032501	0.684	multicellular organismal process
GO:0051171	0.614	regulation of nitrogen compound metabolic process
GO:0080090	0.613	regulation of primary metabolic process
GO:0031323	0.598	regulation of cellular metabolic process
GO:0006996	0.581	organelle organization
GO:0045104	0.562	intermediate filament cytoskeleton organization
GO:0051716	0.554	cellular response to stimulus
GO:0007275	0.466	multicellular organism development
GO:0010468	0.449	regulation of gene expression
GO:0009893	0.446	positive regulation of metabolic process
GO:0048519	0.418	negative regulation of biological process
GO:0031325	0.410	positive regulation of cellular metabolic process
GO:0010604	0.388	positive regulation of macromolecule metabolic process
GO:0007154	0.379	cell communication
GO:0009889	0.376	regulation of biosynthetic process
GO:0031326	0.374	regulation of cellular biosynthetic process
GO:0010556	0.372	regulation of macromolecule biosynthetic process
GO:0051239	0.370	regulation of multicellular organismal process
GO:0023052	0.357	signaling
GO:0007165	0.341	signal transduction
GO:0019219	0.328	regulation of nucleobase-containing compound metabolic process
GO:0051246	0.320	regulation of protein metabolic process
GO:0051173	0.313	positive regulation of nitrogen compound metabolic process
GO:0042221	0.312	response to chemical
GO:0048523	0.306	negative regulation of cellular process
GO:0044085	0.300	cellular component biogenesis

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005856	0.999	cytoskeleton
GO:0045111	0.982	intermediate filament cytoskeleton
GO:0043227	0.977	membrane-bounded organelle
GO:0005737	0.975	cytoplasm
GO:0043231	0.973	intracellular membrane-bounded organelle
GO:0070013	0.899	intracellular organelle lumen
GO:0005634	0.894	nucleus
GO:0005829	0.887	cytosol
GO:0099080	0.746	supramolecular complex
GO:0099512	0.700	supramolecular fiber
GO:0099513	0.590	polymeric cytoskeletal fiber
GO:0005882	0.473	intermediate filament
GO:0016020	0.407	membrane
GO:0042995	0.381	cell projection

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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