StarFunc result for job id P09467

User Input

>input (338 residues)
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P00637	0.989	0.989	3.411E-71	338	0.905	0.905	P00637.pdb.gz	F16P1_RABIT Fructose-1,6-bisphosphatase 1 OS=Oryctolagus cuniculus OX=9986 GN=FBP1 PE=1 SV=4
2	AFDB:P19112	0.992	0.924	3.857E-69	363	0.852	0.793	P19112.pdb.gz	F16P1_RAT Fructose-1,6-bisphosphatase 1 OS=Rattus norvegicus OX=10116 GN=Fbp1 PE=1 SV=2
3	AFDB:Q7T337	0.990	0.993	3.884E-66	337	0.793	0.795	Q7T337.pdb.gz	Q7T337_DANRE fructose-bisphosphatase OS=Danio rerio OX=7955 GN=cb598 PE=1 SV=1
4	AFDB:A0A060XAF0	0.974	0.977	2.426E-65	337	0.766	0.769	A0A060XAF0.pdb.gz	A0A060XAF0_ONCMY fructose-bisphosphatase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00063051001 PE=3 SV=1
5	AFDB:O00757	0.992	0.989	1.608E-64	339	0.766	0.764	O00757.pdb.gz	F16P2_HUMAN Fructose-1,6-bisphosphatase isozyme 2 OS=Homo sapiens OX=9606 GN=FBP2 PE=1 SV=2
6	PDB:7ezfD	0.912	0.936	2.864E-64	329	0.970	0.997	7ezfD.pdb.gz	Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.
7	PDB:1bk4A	0.918	0.987	1.609E-58	314	0.837	0.901	1bk4A.pdb.gz	Structure of rabbit liver fructose 1,6-bisphosphatase at 2.3 A resolution.
8	PDB:5q0cA	0.915	0.942	2.439E-57	328	0.754	0.777	5q0cA.pdb.gz	Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(4-methoxyphenyl)thiophen-2-yl]sulfonylurea and with f2,6p
9	AFDB:Q9MA79	0.965	0.956	1.091E-53	341	0.568	0.563	Q9MA79.pdb.gz	F16P2_ARATH Fructose-1,6-bisphosphatase, cytosolic OS=Arabidopsis thaliana OX=3702 GN=CYFBP PE=1 SV=1
10	AFDB:Q6RYT0	0.954	0.932	4.051E-48	346	0.476	0.465	Q6RYT0.pdb.gz	F16P_DICDI Fructose-1,6-bisphosphatase OS=Dictyostelium discoideum OX=44689 GN=fbp PE=3 SV=1
11	PDB:5k55A	0.814	0.948	9.141E-48	290	0.642	0.748	5k55A.pdb.gz	Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase.
12	AFDB:P25851	0.924	0.752	4.581E-46	417	0.459	0.372	P25851.pdb.gz	F16P1_ARATH Fructose-1,6-bisphosphatase 1, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=CFBP1 PE=1 SV=2
13	AFDB:G5EAZ6	0.960	0.915	5.470E-46	355	0.459	0.437	G5EAZ6.pdb.gz	G5EAZ6_EMENI fructose-bisphosphatase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_05604 PE=3 SV=1
14	AFDB:Q38EA4	0.949	0.917	6.929E-46	350	0.441	0.426	Q38EA4.pdb.gz	Q38EA4_TRYB2 fructose-bisphosphatase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.211.0540 PE=3 SV=1
15	PDB:5oeyC	0.907	0.940	4.279E-44	326	0.441	0.457	5oeyC.pdb.gz	Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
16	PDB:2qvrA	0.925	0.942	1.402E-41	332	0.423	0.431	2qvrA.pdb.gz	Structures of Mammalian and Bacterial Fructose-1,6-bisphosphatase Reveal the Basis for Synergism in AMP/Fructose 2,6-Bisphosphate Inhibition.
17	PDB:7ns5A	0.885	0.937	2.130E-39	319	0.423	0.448	7ns5A.pdb.gz	GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
18	PDB:5oeyD	0.858	0.962	3.222E-39	301	0.411	0.462	5oeyD.pdb.gz	Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
19	PDB:2gq1A	0.858	0.934	1.589E-38	310	0.399	0.435	2gq1A.pdb.gz	Novel Allosteric Activation Site in Escherichia coli Fructose-1,6-bisphosphatase.
20	PDB:6ib8B	0.603	0.739	4.634E-10	270	0.127	0.159	6ib8B.pdb.gz	Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A060XAF0	0.0	556	337	0.766	0.769	A0A060XAF0_ONCMY fructose-bisphosphatase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00063051001 PE=3 SV=1
2	A0A060Y8H0	0.0	560	337	0.775	0.777	A0A060Y8H0_ONCMY fructose-bisphosphatase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00015701001 PE=3 SV=1
3	O00757	0.0	526	339	0.766	0.764	F16P2_HUMAN Fructose-1,6-bisphosphatase isozyme 2 OS=Homo sapiens OX=9606 GN=FBP2 PE=1 SV=2
4	P00637	0.0	644	338	0.905	0.905	F16P1_RABIT Fructose-1,6-bisphosphatase 1 OS=Oryctolagus cuniculus OX=9986 GN=FBP1 PE=1 SV=4
5	P09467	0.0	695	338	1.000	1.000	F16P1_HUMAN Fructose-1,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=FBP1 PE=1 SV=5
6	P19112	0.0	619	363	0.852	0.793	F16P1_RAT Fructose-1,6-bisphosphatase 1 OS=Rattus norvegicus OX=10116 GN=Fbp1 PE=1 SV=2
7	Q7T337	0.0	572	337	0.793	0.795	Q7T337_DANRE fructose-bisphosphatase OS=Danio rerio OX=7955 GN=cb598 PE=1 SV=1
8	Q9QXD6	0.0	622	338	0.849	0.849	F16P1_MOUSE Fructose-1,6-bisphosphatase 1 OS=Mus musculus OX=10090 GN=Fbp1 PE=1 SV=3
9	Q9Z1N1	0.0	548	339	0.749	0.746	F16P2_RAT Fructose-1,6-bisphosphatase isozyme 2 OS=Rattus norvegicus OX=10116 GN=Fbp2 PE=1 SV=1
10	Q9MA79	1.79e-134	388	341	0.568	0.563	F16P2_ARATH Fructose-1,6-bisphosphatase, cytosolic OS=Arabidopsis thaliana OX=3702 GN=CYFBP PE=1 SV=1
11	Q6RYT0	1.05e-106	317	346	0.479	0.468	F16P_DICDI Fructose-1,6-bisphosphatase OS=Dictyostelium discoideum OX=44689 GN=fbp PE=3 SV=1
12	P09201	1.71e-101	304	348	0.462	0.448	F16P_YEAST Fructose-1,6-bisphosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=FBP1 PE=1 SV=2
13	P25851	3.55e-99	301	417	0.453	0.367	F16P1_ARATH Fructose-1,6-bisphosphatase 1, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=CFBP1 PE=1 SV=2
14	G5EAZ6	4.36e-97	293	355	0.467	0.445	G5EAZ6_EMENI fructose-bisphosphatase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_05604 PE=3 SV=1
15	A0A1D8PKW2	8.15e-96	289	331	0.467	0.477	A0A1D8PKW2_CANAL fructose-bisphosphatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=FBP1 PE=3 SV=1
16	Q9I8D4	1.03e-95	283	168	0.402	0.810	Q9I8D4_CHICK fructose-bisphosphatase (Fragment) OS=Gallus gallus OX=9031 GN=FBP1 PE=2 SV=1
17	P09202	6.02e-95	287	347	0.441	0.429	F16P_SCHPO Fructose-1,6-bisphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=fbp1 PE=3 SV=1
18	Q9I8D3	4.47e-92	273	166	0.373	0.759	Q9I8D3_CHICK fructose-bisphosphatase (Fragment) OS=Gallus gallus OX=9031 GN=FBP2 PE=2 SV=1
19	Q38EA4	5.92e-92	280	350	0.438	0.423	Q38EA4_TRYB2 fructose-bisphosphatase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.211.0540 PE=3 SV=1
20	P0A993	1.62e-91	278	332	0.432	0.440	F16PA_ECOLI Fructose-1,6-bisphosphatase class 1 OS=Escherichia coli (strain K12) OX=83333 GN=fbp PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00316 FBPase	8.8e-83	288.1	Fructose-1-6-bisphosphatase, N-terminal domain
2	PF18913 FBPase_C	4.5e-48	173.8	Fructose-1-6-bisphosphatase, C-terminal domain
3	PF00459 Inositol_P	0.77	20.8	Inositol monophosphatase family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000408025

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000363988	0.975	Belongs to the class I fructose-bisphosphate aldolase family
2	9606.ENSP00000321259	0.974	Transaldolase
3	9606.ENSP00000378669	0.971	Fructose-bisphosphate aldolase A
4	9606.ENSP00000405573	0.968	Glucose-6-phosphate isomerase
5	9606.ENSP00000226253	0.967	Belongs to the class I fructose-bisphosphate aldolase family
6	9606.ENSP00000290573	0.964	Hexokinase-2
7	9606.ENSP00000391481	0.962	Transketolase
8	9606.ENSP00000402103	0.959	Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine . Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern [...]
9	9606.ENSP00000292432	0.958	Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) . Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate .
10	9606.ENSP00000346643	0.956	Putative hexokinase HKDC1
11	9606.ENSP00000345771	0.950	ATP-dependent 6-phosphofructokinase, muscle type
12	9606.ENSP00000364486	0.949	Fructose-1,6-bisphosphatase isozyme 2
13	9606.ENSP00000269848	0.944	ATP-dependent 6-phosphofructokinase, liver type
14	9606.ENSP00000370517	0.944	ATP-dependent 6-phosphofructokinase, platelet type
15	9606.ENSP00000318318	0.941	Mannose-6-phosphate isomerase
16	9606.ENSP00000280605	0.939	Transketolase-like protein 2
17	9606.ENSP00000358931	0.936	Transketolase-like protein 1
18	9606.ENSP00000437955	0.857	Hypoxia-inducible factor 1-alpha
19	9606.ENSP00000443319	0.837	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
20	9606.ENSP00000232375	0.829	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0042132	0.999	fructose 1,6-bisphosphate 1-phosphatase activity
GO:0005488	0.982	binding
GO:0005515	0.970	protein binding
GO:0042802	0.703	identical protein binding
GO:0043167	0.542	ion binding
GO:1901363	0.318	heterocyclic compound binding
GO:0097159	0.318	organic cyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044238	0.994	primary metabolic process
GO:0005975	0.945	carbohydrate metabolic process
GO:0009987	0.944	cellular process
GO:0044237	0.928	cellular metabolic process
GO:0044281	0.917	small molecule metabolic process
GO:0005996	0.701	monosaccharide metabolic process
GO:0019318	0.689	hexose metabolic process
GO:0006793	0.560	phosphorus metabolic process
GO:0006796	0.550	phosphate-containing compound metabolic process
GO:1901576	0.546	organic substance biosynthetic process
GO:0019637	0.508	organophosphate metabolic process
GO:1901135	0.419	carbohydrate derivative metabolic process
GO:0006006	0.346	glucose metabolic process
GO:0044283	0.338	small molecule biosynthetic process
GO:0016051	0.336	carbohydrate biosynthetic process
GO:0050896	0.314	response to stimulus
GO:0046364	0.310	monosaccharide biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol
GO:0005615	0.999	extracellular space
GO:0005634	0.995	nucleus
GO:0031982	0.945	vesicle
GO:0070062	0.935	extracellular exosome
GO:0070013	0.824	intracellular organelle lumen
GO:0016020	0.648	membrane
GO:0012505	0.372	endomembrane system

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:11064	0.999	beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate
EC:3.1.3.11	0.999	fructose-bisphosphatase.

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