StarFunc result for job id P0C091

User Input

>input (2139 residues)
MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP
SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG
PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK
LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV
DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA
ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ
GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA
FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ
LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD
DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA
PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL
GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL
THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV
NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL
EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV
SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL
ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA
HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGESFIV
YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS
LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE
FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI
QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG
HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI
NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA
RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH
TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL
TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF
SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG
FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL
NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY
LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII
LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV
ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF
SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL
SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK
FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:F1R4B2	0.269	0.266	0.000	2167	0.265	0.262	F1R4B2.pdb.gz
2	AFDB:P0C091	1.000	1.000	0.000	2139	1.000	1.000	P0C091.pdb.gz	FREM3_HUMAN FRAS1-related extracellular matrix protein 3 OS=Homo sapiens OX=9606 GN=FREM3 PE=3 SV=2
3	AFDB:Q5H8B9	0.334	0.336	0.000	2123	0.675	0.680	Q5H8B9.pdb.gz	FREM3_MOUSE FRAS1-related extracellular matrix protein 3 OS=Mus musculus OX=10090 GN=Frem3 PE=2 SV=2
4	AFDB:Q5H8C1	0.254	0.250	0.000	2179	0.278	0.273	Q5H8C1.pdb.gz	FREM1_HUMAN FRAS1-related extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=FREM1 PE=1 SV=3
5	AFDB:Q684R7	0.282	0.277	0.000	2191	0.282	0.275	Q684R7.pdb.gz	FREM1_MOUSE FRAS1-related extracellular matrix protein 1 OS=Mus musculus OX=10090 GN=Frem1 PE=1 SV=1
6	AFDB:Q6UVK1	0.138	0.128	1.663E-97	2322	0.169	0.155	Q6UVK1.pdb.gz	CSPG4_HUMAN Chondroitin sulfate proteoglycan 4 OS=Homo sapiens OX=9606 GN=CSPG4 PE=1 SV=2
7	AFDB:Q8VHY0	0.110	0.103	1.097E-95	2327	0.168	0.155	Q8VHY0.pdb.gz	CSPG4_MOUSE Chondroitin sulfate proteoglycan 4 OS=Mus musculus OX=10090 GN=Cspg4 PE=1 SV=3
8	AFDB:Q9VJ82	0.090	0.082	2.222E-89	2381	0.163	0.146	Q9VJ82.pdb.gz	Q9VJ82_DROME Kon-tiki, isoform B OS=Drosophila melanogaster OX=7227 GN=kon PE=4 SV=3
9	AFDB:Q54KF7	0.080	0.088	1.478E-45	1927	0.116	0.129	Q54KF7.pdb.gz	SIBA_DICDI Integrin beta-like protein A OS=Dictyostelium discoideum OX=44689 GN=sibA PE=1 SV=2
10	AFDB:P56741	0.062	0.083	3.283E-22	1274	0.086	0.144	P56741.pdb.gz	MYPC_RAT Myosin-binding protein C, cardiac-type OS=Rattus norvegicus OX=10116 GN=Mybpc3 PE=1 SV=2
11	PDB:7sqcO0	0.072	0.111	4.547E-21	1140	0.055	0.103	7sqcO0.pdb.gz	Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
12	PDB:1e07A	0.092	0.224	8.815E-13	642	0.035	0.117	1e07A.pdb.gz
13	PDB:4aq1A	0.060	0.130	1.062E-12	721	0.042	0.125	4aq1A.pdb.gz	Sbsb Structure and Lattice Reconstruction Unveil Ca21 Triggered S-Layer Assembly
14	PDB:5a42A	0.070	0.084	2.134E-12	1597	0.061	0.082	5a42A.pdb.gz
15	PDB:5oj2B	0.074	0.142	2.134E-12	692	0.042	0.129	5oj2B.pdb.gz
16	PDB:7q5zA	0.064	0.085	9.035E-12	1344	0.047	0.074	7q5zA.pdb.gz
17	PDB:7q1yA	0.067	0.097	1.195E-11	1374	0.044	0.068	7q1yA.pdb.gz
18	PDB:4lnvA	0.073	0.102	2.292E-11	1276	0.048	0.081	4lnvA.pdb.gz
19	PDB:6h03A	0.090	0.135	6.091E-11	1223	0.046	0.080	6h03A.pdb.gz
20	PDB:7nycA	0.059	0.069	6.685E-11	1542	0.046	0.064	7nycA.pdb.gz	Structural basis of soluble membrane attack complex packaging for clearance.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	B6IDE6	0.0	2334	3113	0.545	0.374	B6IDE6_DANRE FRAS1-related extracellular matrix protein 2 precursor OS=Danio rerio OX=7955 GN=bla PE=1 SV=1
2	D7PS89	0.0	794	2167	0.272	0.269	D7PS89_DANRE FRAS1-related extracellular matrix protein 1 precursor OS=Danio rerio OX=7955 GN=rfl PE=2 SV=1
3	D7PS91	0.0	2335	3119	0.545	0.374	D7PS91_DANRE FRAS1-related extracellular matrix 2a OS=Danio rerio OX=7955 GN=bla PE=1 SV=1
4	P0C091	0.0	4402	2139	1.000	1.000	FREM3_HUMAN FRAS1-related extracellular matrix protein 3 OS=Homo sapiens OX=9606 GN=FREM3 PE=3 SV=2
5	Q5H8B9	0.0	2905	2123	0.671	0.676	FREM3_MOUSE FRAS1-related extracellular matrix protein 3 OS=Mus musculus OX=10090 GN=Frem3 PE=2 SV=2
6	Q5H8C1	0.0	842	2179	0.287	0.281	FREM1_HUMAN FRAS1-related extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=FREM1 PE=1 SV=3
7	Q5SZK8	0.0	2416	3169	0.578	0.390	FREM2_HUMAN FRAS1-related extracellular matrix protein 2 OS=Homo sapiens OX=9606 GN=FREM2 PE=1 SV=3
8	Q684R7	0.0	838	2191	0.287	0.280	FREM1_MOUSE FRAS1-related extracellular matrix protein 1 OS=Mus musculus OX=10090 GN=Frem1 PE=1 SV=1
9	Q6NVD0	0.0	2405	3160	0.568	0.384	FREM2_MOUSE FRAS1-related extracellular matrix protein 2 OS=Mus musculus OX=10090 GN=Frem2 PE=1 SV=2
10	A0A0R4IQJ3	1.07e-175	602	4003	0.247	0.132	A0A0R4IQJ3_DANRE Extracellular matrix protein FRAS1 isoform X1 OS=Danio rerio OX=7955 GN=id:ibd5080 PE=1 SV=2
11	F1Q633	1.62e-175	602	3970	0.247	0.133	F1Q633_DANRE Extracellular matrix protein FRAS1 OS=Danio rerio OX=7955 GN=id:ibd5080 PE=1 SV=1
12	Q80T14	1.06e-174	599	4010	0.254	0.135	FRAS1_MOUSE Extracellular matrix organizing protein FRAS1 OS=Mus musculus OX=10090 GN=Fras1 PE=1 SV=2
13	Q6UVK1	5.20e-52	206	2322	0.115	0.106	CSPG4_HUMAN Chondroitin sulfate proteoglycan 4 OS=Homo sapiens OX=9606 GN=CSPG4 PE=1 SV=2
14	Q8VHY0	1.10e-43	178	2327	0.110	0.101	CSPG4_MOUSE Chondroitin sulfate proteoglycan 4 OS=Mus musculus OX=10090 GN=Cspg4 PE=1 SV=3
15	Q00657	1.10e-41	172	2326	0.111	0.102	CSPG4_RAT Chondroitin sulfate proteoglycan 4 OS=Rattus norvegicus OX=10116 GN=Cspg4 PE=1 SV=2
16	Q9VJ82	4.15e-28	127	2381	0.110	0.099	Q9VJ82_DROME Kon-tiki, isoform B OS=Drosophila melanogaster OX=7227 GN=kon PE=4 SV=3
17	A3RLX3	5.08e-28	127	2381	0.110	0.099	A3RLX3_DROME Kon-tiki OS=Drosophila melanogaster OX=7227 GN=Kon PE=1 SV=1
18	A0A0B4LHD9	2.47e-12	74.7	657	0.029	0.094	A0A0B4LHD9_DROME Na/Ca-exchange protein, isoform I OS=Drosophila melanogaster OX=7227 GN=Calx PE=1 SV=1
19	O18367	2.70e-12	75.1	950	0.030	0.068	O18367_DROME CALX OS=Drosophila melanogaster OX=7227 GN=Calx PE=2 SV=1
20	A0A0B4K6R7	2.77e-12	74.7	950	0.029	0.065	A0A0B4K6R7_DROME Na/Ca-exchange protein, isoform D OS=Drosophila melanogaster OX=7227 GN=Calx PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF17963 Big_9	5.5e-10	51.1	Bacterial Ig domain
2	PF16184 Cadherin_3	3.6e-231	762.7	Cadherin-like
3	PF17803 Cadherin_4	0.0001	34.1	Bacterial cadherin-like domain
4	PF03160 Calx-beta	5.1e-43	156.6	Calx-beta domain
5	PF13028 DUF3889	2.6e+02	12.9	Protein of unknown function (DUF3889)
6	PF05660 DUF807	3.2e+02	12.7	Coxiella burnetii protein of unknown function (DUF807)
7	PF19309 Frem_N	8.5e-93	321.3	Frem protein N-terminal domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000332886

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000264668	0.732	Methionine synthase reductase
2	9606.ENSP00000217270	0.726	Prokineticin receptor 2
3	9606.ENSP00000351430	0.656	Glycophorin-E
4	9606.ENSP00000428540	0.643	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
5	9606.ENSP00000295666	0.633	Insulin-like growth factor-binding protein 7
6	9606.ENSP00000258774	0.623	Checkpoint protein HUS1
7	9606.ENSP00000427690	0.595	Glycophorin-B
8	9606.ENSP00000271588	0.590	Hemicentin-1
9	9606.ENSP00000381098	0.560	Glutamate receptor-interacting protein 1
10	9606.ENSP00000350310	0.543	Plasma membrane calcium-transporting ATPase 4
11	9606.ENSP00000326330	0.538	Fraser extracellular matrix complex subunit 1
12	9606.ENSP00000217320	0.531	TLD domain-containing protein 2
13	9606.ENSP00000382513	0.526	Zinc finger protein 594
14	9606.ENSP00000286808	0.525	Claudin-17
15	9606.ENSP00000312299	0.508	Protein FRG2-like-2
16	9606.ENSP00000323847	0.504	ADP-ribosylation factor-like protein 14

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0007275	0.959	multicellular organism development
GO:0009987	0.882	cellular process
GO:0065007	0.438	biological regulation
GO:0050789	0.423	regulation of biological process
GO:0050794	0.376	regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0062023	0.997	collagen-containing extracellular matrix
GO:0005576	0.990	extracellular region
GO:0005615	0.916	extracellular space
GO:0005886	0.909	plasma membrane
GO:0043226	0.879	organelle
GO:0043227	0.869	membrane-bounded organelle
GO:0031982	0.538	vesicle
GO:0005622	0.436	intracellular anatomical structure
GO:0043229	0.391	intracellular organelle
GO:0070062	0.376	extracellular exosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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