StarFunc result for job id P0CG39

User Input

>input (1038 residues)
MVAEVDSMPAASSVKKPFVLRSKMGKWCRHCFPCCRGSGKSNVGTSGDQDDSTMKTLRSK
MGKWCCHCFPCCRGSGKSNVGAWGDYDDSAFVEPRYHVRREDLDKLHRAAWWGKVARKDL
IVMLRDTDVNKQDKQKRTALHLASANGNSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQ
EDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLL
LGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLS
GQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQ
PEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPEN
QQFPDNESEEYHRICELVSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPE
KRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRT
PESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLS
CKKERDFLHENSMLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNLLKALQLN
ELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGCPRQQGMMGGMHQKESYVGKE
AQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANRE
KMTQIMFETFNTPAMYVAIQAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLR
LDLAGRELTDYLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMVASSSSLE
KSYELPDGQVITISNEWFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNT
VLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWI
SKQEYDESGPSIVHRKCF

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P07829	0.360	0.991	3.348E-59	376	0.304	0.840	P07829.pdb.gz	ACT3_DICDI Actin-3 OS=Dictyostelium discoideum OX=44689 GN=act3 PE=3 SV=3
2	AFDB:B6VNT8	0.360	0.989	2.575E-58	377	0.311	0.857	B6VNT8.pdb.gz	B6VNT8_PIG Actin alpha cardiac muscle 1 OS=Sus scrofa OX=9823 GN=ACTC1 PE=1 SV=1
3	AFDB:Q562R1	0.359	0.988	1.175E-57	376	0.303	0.838	Q562R1.pdb.gz	ACTBL_HUMAN Beta-actin-like protein 2 OS=Homo sapiens OX=9606 GN=ACTBL2 PE=1 SV=2
4	AFDB:P10989	0.360	0.991	4.229E-57	375	0.301	0.832	P10989.pdb.gz	ACT_SCHPO Actin OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=act1 PE=1 SV=1
5	AFDB:P0CJ46	0.358	0.983	4.650E-57	377	0.294	0.809	P0CJ46.pdb.gz	ACT1_ARATH Actin-1 OS=Arabidopsis thaliana OX=3702 GN=ACT1 PE=1 SV=1
6	AFDB:Q8RYC2	0.359	0.982	1.711E-55	378	0.266	0.730	Q8RYC2.pdb.gz	ACT5_ARATH Putative actin-5 OS=Arabidopsis thaliana OX=3702 GN=ACT5 PE=5 SV=1
7	AFDB:A0A1D8PFR4	0.359	0.986	2.068E-55	376	0.289	0.798	A0A1D8PFR4.pdb.gz	A0A1D8PFR4_CANAL Actin OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=ACT1 PE=3 SV=1
8	PDB:1c0gA	0.349	0.975	5.282E-55	368	0.306	0.864	1c0gA.pdb.gz	Structural basis for the higher Ca(2+)-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/Tetrahymena actin chimeras.
9	AFDB:P86287	0.359	0.987	5.874E-55	376	0.274	0.755	P86287.pdb.gz	ACT1_PLAFX Actin-1 OS=Plasmodium falciparum (isolate HB3) OX=137071 GN=ACT1 PE=1 SV=1
10	AFDB:P07828	0.357	0.970	9.002E-55	380	0.276	0.755	P07828.pdb.gz	ACT18_DICDI Actin-18 OS=Dictyostelium discoideum OX=44689 GN=act18 PE=3 SV=3
11	PDB:1yagA	0.355	0.982	2.192E-54	372	0.295	0.823	1yagA.pdb.gz	The structure of nonvertebrate actin: Implications for the ATP hydrolytic mechanism
12	AFDB:Q4YU79	0.360	0.989	4.108E-54	376	0.253	0.699	Q4YU79.pdb.gz	ACT2_PLABA Actin-2 OS=Plasmodium berghei (strain Anka) OX=5823 GN=ACT2 PE=1 SV=1
13	PDB:6tu4A	0.352	0.964	1.936E-51	372	0.274	0.763	6tu4A.pdb.gz	High-resolution structures of malaria parasite actomyosin and actin filaments.
14	PDB:4cbxA	0.342	0.984	4.213E-48	358	0.245	0.709	4cbxA.pdb.gz	Structural Differences Explain Diverse Functions of Plasmodium Actins.
15	PDB:4pl7A	0.331	0.893	5.459E-47	382	0.265	0.720	4pl7A.pdb.gz	Structural basis of thymosin-beta 4/profilin exchange leading to actin filament polymerization.
16	PDB:4a7fA	0.346	0.922	5.188E-45	375	0.309	0.856	4a7fA.pdb.gz	Structure of the Rigor Actin-Tropomyosin-Myosin Complex.
17	PDB:7nvmK	0.274	0.837	9.935E-37	317	0.278	0.912	7nvmK.pdb.gz	Snapshots of actin and tubulin folding inside the TRiC chaperonin.
18	PDB:6ltjK	0.302	0.972	1.523E-36	317	0.280	0.918	6ltjK.pdb.gz	Structure of nucleosome-bound human BAF complex.
19	PDB:5kg8B	0.295	0.950	1.923E-34	313	0.257	0.853	5kg8B.pdb.gz
20	PDB:6w18B	0.325	0.893	3.890E-30	367	0.162	0.458	6w18B.pdb.gz	Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A1D8PFR4	651	376	0.287	0.793	A0A1D8PFR4_CANAL Actin OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=ACT1 PE=3 SV=1
2	A0JP26	809	581	0.388	0.694	POTB3_HUMAN POTE ankyrin domain family member B3 OS=Homo sapiens OX=9606 GN=POTEB3 PE=1 SV=2
3	A5A3E0	2084	1075	0.968	0.935	POTEF_HUMAN POTE ankyrin domain family member F OS=Homo sapiens OX=9606 GN=POTEF PE=1 SV=2
4	B6VNT8	690	377	0.311	0.857	B6VNT8_PIG Actin alpha cardiac muscle 1 OS=Sus scrofa OX=9823 GN=ACTC1 PE=1 SV=1
5	F1P476	691	377	0.310	0.854	F1P476_CHICK Actin, alpha 2, smooth muscle, aorta OS=Gallus gallus OX=9031 GN=ACTA2 PE=3 SV=2
6	F1RCB6	679	377	0.303	0.836	F1RCB6_DANRE Actin alpha cardiac muscle 1a OS=Danio rerio OX=7955 GN=zgc:86725 PE=1 SV=1
7	G1NS52	718	376	0.324	0.894	G1NS52_MELGA Uncharacterized protein OS=Meleagris gallopavo OX=9103 GN=LOC100542800 PE=3 SV=1
8	G3CKA6	702	376	0.314	0.867	G3CKA6_SPOFR Actin OS=Spodoptera frugiperda OX=7108 PE=1 SV=1
9	O45815	663	375	0.306	0.848	O45815_CAEEL Actin OS=Caenorhabditis elegans OX=6239 GN=act-5 PE=1 SV=1
10	P02572	712	376	0.319	0.880	ACT2_DROME Actin-42A OS=Drosophila melanogaster OX=7227 GN=Act42A PE=1 SV=3
11	P07828	625	380	0.276	0.755	ACT18_DICDI Actin-18 OS=Dictyostelium discoideum OX=44689 GN=act18 PE=3 SV=3
12	P07829	684	376	0.304	0.840	ACT3_DICDI Actin-3 OS=Dictyostelium discoideum OX=44689 GN=act3 PE=3 SV=3
13	P07830	691	376	0.311	0.859	ACT1_DICDI Major actin OS=Dictyostelium discoideum OX=44689 GN=act1 PE=1 SV=2
14	P08023	690	377	0.309	0.851	ACTA_CHICK Actin, aortic smooth muscle OS=Gallus gallus OX=9031 GN=ACTA2 PE=3 SV=2
15	P0CG38	2143	1075	0.994	0.960	POTEI_HUMAN POTE ankyrin domain family member I OS=Homo sapiens OX=9606 GN=POTEI PE=3 SV=1
16	P0CG39	2175	1038	1.000	1.000	POTEJ_HUMAN POTE ankyrin domain family member J OS=Homo sapiens OX=9606 GN=POTEJ PE=3 SV=1
17	P0CJ46	659	377	0.294	0.809	ACT1_ARATH Actin-1 OS=Arabidopsis thaliana OX=3702 GN=ACT1 PE=1 SV=1
18	P0CJ47	659	377	0.294	0.809	ACT3_ARATH Actin-3 OS=Arabidopsis thaliana OX=3702 GN=ACT3 PE=1 SV=1
19	P0DM41	711	376	0.318	0.878	ACT1_CAEEL Actin-1 OS=Caenorhabditis elegans OX=6239 GN=act-1 PE=1 SV=1
20	P0DM42	711	376	0.318	0.878	ACT3_CAEEL Actin-3 OS=Caenorhabditis elegans OX=6239 GN=act-3 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00022 Actin	3.3e-136	465.6	Actin
2	PF00023 Ank	9.4e-21	84.5	Ankyrin repeat
3	PF12796 Ank_2	1.4e-26	104.2	Ankyrin repeats (3 copies)
4	PF13606 Ank_3	2e-14	63.1	Ankyrin repeat
5	PF13637 Ank_4	2e-22	90.5	Ankyrin repeats (many copies)
6	PF13857 Ank_5	8e-24	94.7	Ankyrin repeats (many copies)
7	PF14915 CCDC144C	9.8e-10	49.6	CCDC144C protein coiled-coil region

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000387176

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000348128	0.777	Supervillin
2	9606.ENSP00000338013	0.634	Coiled-coil domain containing 183
3	9606.ENSP00000379451	0.624	Zinc finger protein 418
4	9606.ENSP00000457991	0.612	PH domain leucine-rich repeat-containing protein phosphatase 2
5	9606.ENSP00000414906	0.610	Dynactin subunit 4
6	9606.ENSP00000221462	0.605	Protein phosphatase 1 regulatory subunit 37
7	9606.ENSP00000318297	0.599	RuvB-like 1
8	9606.ENSP00000392513	0.576	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4
9	9606.ENSP00000392206	0.575	ArfGAP with GTPase domain, ankyrin repeat and PH domain 10
10	9606.ENSP00000336842	0.570	Actin-related protein 8
11	9606.ENSP00000417653	0.557	Drebrin-like protein
12	9606.ENSP00000427687	0.545	WD repeat-containing protein 1
13	9606.ENSP00000355205	0.538	DNA helicase INO80
14	9606.ENSP00000352925	0.529	Transformation/transcription domain-associated protein
15	9606.ENSP00000336831	0.521	Plastin-1
16	9606.ENSP00000401010	0.519	F-actin-capping protein subunit beta
17	9606.ENSP00000473172	0.512	RuvB-like 2
18	9606.ENSP00000381581	0.510	Plastin-2
19	9606.ENSP00000229922	0.509	Adenylyl cyclase-associated protein 2
20	9606.ENSP00000361883	0.509	Adenylyl cyclase-associated protein 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0008092	0.607	cytoskeletal protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0001895	0.990	retina homeostasis
GO:0009987	0.491	cellular process
GO:0065007	0.335	biological regulation
GO:0050794	0.328	regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0070062	1.000	extracellular exosome
GO:0005622	0.830	intracellular anatomical structure
GO:0043229	0.809	intracellular organelle
GO:0043231	0.531	intracellular membrane-bounded organelle
GO:0043232	0.415	intracellular non-membrane-bounded organelle
GO:0005737	0.396	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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