StarFunc result for job id P0DI81

User Input

>input (140 residues)
MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMY
LKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSP
IRSSAFDRKVQFLGKKHLLS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P0DI81	1.000	1.000	1.144E-28	140	1.000	1.000	P0DI81.pdb.gz	TPC2A_HUMAN Trafficking protein particle complex subunit 2 OS=Homo sapiens OX=9606 GN=TRAPPC2 PE=1 SV=1
2	PDB:2j3wA	0.953	0.940	4.631E-25	142	0.979	0.965	2j3wA.pdb.gz
3	AFDB:Q9VUZ1	0.959	0.966	2.099E-19	139	0.571	0.576	Q9VUZ1.pdb.gz	TPPC2_DROME Probable trafficking protein particle complex subunit 2 OS=Drosophila melanogaster OX=7227 GN=Trs20 PE=1 SV=2
4	AFDB:O02173	0.921	0.914	5.880E-19	141	0.543	0.539	O02173.pdb.gz	TPPC2_CAEEL Probable trafficking protein particle complex subunit 2 OS=Caenorhabditis elegans OX=6239 GN=sedl-1 PE=1 SV=1
5	AFDB:Q9USZ5	0.918	0.944	2.843E-17	136	0.457	0.471	Q9USZ5.pdb.gz	TRS20_SCHPO Transport protein particle 20 kDa subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=trs20 PE=3 SV=1
6	AFDB:F4HTY0	0.916	0.950	6.640E-17	135	0.493	0.511	F4HTY0.pdb.gz	F4HTY0_ARATH SNARE-like superfamily protein OS=Arabidopsis thaliana OX=3702 GN=TRAPPC2 PE=1 SV=1
7	PDB:7b6dE	0.907	0.914	1.466E-16	139	0.571	0.576	7b6dE.pdb.gz
8	AFDB:P38334	0.902	0.728	2.844E-14	175	0.407	0.326	P38334.pdb.gz	TRS20_YEAST Trafficking protein particle complex subunit 20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TRS20 PE=1 SV=1
9	AFDB:C8V2D4	0.892	0.613	4.347E-12	207	0.379	0.256	C8V2D4.pdb.gz	C8V2D4_EMENI Trafficking protein particle complex subunit 2/Sedlin, putative (Eurofung) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_11500 PE=4 SV=1
10	PDB:7kmtK	0.818	0.872	1.223E-11	131	0.386	0.412	7kmtK.pdb.gz
11	PDB:7e2dH	0.867	0.827	1.084E-10	147	0.400	0.381	7e2dH.pdb.gz
12	AFDB:A1Z8I0	0.770	0.780	3.626E-9	138	0.264	0.268	A1Z8I0.pdb.gz	A1Z8I0_DROME Trafficking protein particle complex subunit 2-like protein OS=Drosophila melanogaster OX=7227 GN=Dmel\CG9067 PE=1 SV=1
13	AFDB:H3BP13	0.749	0.455	1.753E-8	241	0.221	0.129	H3BP13.pdb.gz	H3BP13_HUMAN Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1
14	AFDB:A0A0B4J294	0.769	0.741	2.233E-8	146	0.193	0.185	A0A0B4J294.pdb.gz	A0A0B4J294_HUMAN Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1
15	PDB:7b6dH	0.730	0.739	1.152E-7	138	0.264	0.268	7b6dH.pdb.gz
16	PDB:7b6dC	0.613	0.596	1.871E-5	145	0.150	0.145	7b6dC.pdb.gz
17	PDB:2j3tD	0.540	0.378	2.859E-5	210	0.186	0.124	2j3tD.pdb.gz
18	PDB:7u05H	0.630	0.511	1.085E-4	179	0.171	0.134	7u05H.pdb.gz
19	PDB:7e94E	0.625	0.552	1.301E-4	162	0.164	0.142	7e94E.pdb.gz
20	PDB:2j3tC	0.654	0.650	2.244E-4	141	0.114	0.113	2j3tC.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P0DI81	1.13e-102	291	140	1.000	1.000	TPC2A_HUMAN Trafficking protein particle complex subunit 2 OS=Homo sapiens OX=9606 GN=TRAPPC2 PE=1 SV=1
2	P0DI82	1.13e-102	291	140	1.000	1.000	TPC2B_HUMAN Trafficking protein particle complex subunit 2B OS=Homo sapiens OX=9606 GN=TRAPPC2B PE=1 SV=1
3	Q6IBE5	1.13e-102	291	140	1.000	1.000	Q6IBE5_HUMAN Trafficking protein particle complex 2, isoform CRA_a OS=Homo sapiens OX=9606 GN=ZNF547 PE=2 SV=1
4	Q9CQP2	4.52e-101	287	140	0.979	0.979	TPPC2_MOUSE Trafficking protein particle complex subunit 2 OS=Mus musculus OX=10090 GN=Trappc2 PE=1 SV=1
5	F5H785	4.65e-77	225	113	0.771	0.956	F5H785_HUMAN Trafficking protein particle complex subunit 2 OS=Homo sapiens OX=9606 GN=TRAPPC2 PE=1 SV=1
6	Q9VUZ1	4.95e-59	181	139	0.571	0.576	TPPC2_DROME Probable trafficking protein particle complex subunit 2 OS=Drosophila melanogaster OX=7227 GN=Trs20 PE=1 SV=2
7	O02173	1.11e-51	162	141	0.543	0.539	TPPC2_CAEEL Probable trafficking protein particle complex subunit 2 OS=Caenorhabditis elegans OX=6239 GN=sedl-1 PE=1 SV=1
8	E5RFG0	5.18e-50	155	74	0.529	1.000	E5RFG0_HUMAN Trafficking protein particle complex subunit 2 (Fragment) OS=Homo sapiens OX=9606 GN=TRAPPC2 PE=3 SV=1
9	F4HTY0	8.70e-46	147	135	0.493	0.511	F4HTY0_ARATH SNARE-like superfamily protein OS=Arabidopsis thaliana OX=3702 GN=TRAPPC2 PE=1 SV=1
10	Q9USZ5	2.77e-45	146	136	0.457	0.471	TRS20_SCHPO Transport protein particle 20 kDa subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=trs20 PE=3 SV=1
11	P38334	2.48e-27	101	175	0.407	0.326	TRS20_YEAST Trafficking protein particle complex subunit 20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TRS20 PE=1 SV=1
12	C8V2D4	8.00e-14	67.4	207	0.250	0.169	C8V2D4_EMENI Trafficking protein particle complex subunit 2/Sedlin, putative (Eurofung) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_11500 PE=4 SV=1
13	Q57YJ1	6.46e-12	60.8	129	0.214	0.233	Q57YJ1_TRYB2 Trafficking protein particle complex subunit OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.11J15.1040 PE=4 SV=1
14	A1Z8I0	3.67e-08	51.2	138	0.264	0.268	A1Z8I0_DROME Trafficking protein particle complex subunit 2-like protein OS=Drosophila melanogaster OX=7227 GN=Dmel\CG9067 PE=1 SV=1
15	Q9UL33	1.75e-05	43.9	140	0.207	0.207	TPC2L_HUMAN Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1
16	Q9ES56	7.02e-05	43.1	219	0.150	0.096	TPPC4_MOUSE Trafficking protein particle complex subunit 4 OS=Mus musculus OX=10090 GN=Trappc4 PE=1 SV=1
17	A0A0B4J294	9.37e-05	42.0	146	0.179	0.171	A0A0B4J294_HUMAN Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1
18	Q9Y296	1.66e-04	42.0	219	0.143	0.091	TPPC4_HUMAN Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1
19	H3BP13	8.29e-04	40.0	241	0.171	0.100	H3BP13_HUMAN Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1
20	Q9VLI9	0.006	37.4	219	0.157	0.100	Q9VLI9_DROME Trafficking protein particle complex subunit OS=Drosophila melanogaster OX=7227 GN=Trs23 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16372 DUF4984	3.1e+02	12.6	Domain of unknown function (DUF4984)
2	PF04628 Sedlin_N	2.2e-46	168.6	Sedlin, N-terminal conserved region
3	PF04099 Sybindin	1.1e-05	36.8	Sybindin-like family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9601.ENSPPYP00000011724

Rank	PPI partner	STRING score	Description
1	9601.ENSPPYP00000001784	0.951	Trafficking protein particle complex subunit
2	9601.ENSPPYP00000010633	0.948	May play a role in vesicular transport from endoplasmic reticulum to Golgi
3	9601.ENSPPYP00000006551	0.939	Trafficking protein particle complex 6B
4	9601.ENSPPYP00000012814	0.935	annotation not available
5	9601.ENSPPYP00000021208	0.935	Trafficking protein particle complex 9
6	9601.ENSPPYP00000004523	0.934	Trafficking protein particle complex subunit 4
7	9601.ENSPPYP00000008931	0.930	Belongs to the TRAPP small subunits family.
8	9601.ENSPPYP00000011308	0.899	Trafficking protein particle complex 6A
9	9601.ENSPPYP00000018975	0.871	Trafficking protein particle complex subunit
10	9601.ENSPPYP00000014158	0.835	Trafficking protein particle complex 12
11	9601.ENSPPYP00000017014	0.824	Trafficking protein particle complex 11
12	9601.ENSPPYP00000008629	0.809	Trafficking protein particle complex 2-like
13	9601.ENSPPYP00000019721	0.766	Uncharacterized protein
14	9601.ENSPPYP00000017331	0.741	Trafficking protein particle complex subunit 13
15	9601.ENSPPYP00000001115	0.728	Vesicle-trafficking protein SEC22b
16	9601.ENSPPYP00000013783	0.709	Ras-related protein Rab-1B
17	9601.ENSPPYP00000003507	0.707	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between [...]
18	9601.ENSPPYP00000015071	0.673	SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
19	9601.ENSPPYP00000023774	0.673	SEC22 vesicle trafficking protein homolog C (S. cerevisiae)
20	9601.ENSPPYP00000016779	0.660	SEC24 homolog D, COPII coat complex component

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0065007	0.928	biological regulation
GO:0050789	0.871	regulation of biological process
GO:0048518	0.816	positive regulation of biological process
GO:0032501	0.812	multicellular organismal process
GO:0019222	0.719	regulation of metabolic process
GO:0032502	0.666	developmental process
GO:0060255	0.638	regulation of macromolecule metabolic process
GO:0048856	0.593	anatomical structure development
GO:0009987	0.582	cellular process
GO:0007275	0.569	multicellular organism development
GO:0010468	0.561	regulation of gene expression
GO:0010604	0.515	positive regulation of macromolecule metabolic process
GO:0010628	0.502	positive regulation of gene expression
GO:0051179	0.462	localization
GO:0051234	0.448	establishment of localization
GO:0048731	0.426	system development
GO:0006810	0.423	transport
GO:0001501	0.418	skeletal system development
GO:0016192	0.386	vesicle-mediated transport
GO:0051641	0.365	cellular localization
GO:0050794	0.348	regulation of cellular process
GO:0048193	0.319	Golgi vesicle transport

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0012505	0.998	endomembrane system
GO:0005737	0.998	cytoplasm
GO:0043231	0.998	intracellular membrane-bounded organelle
GO:0032991	0.980	protein-containing complex
GO:0005783	0.974	endoplasmic reticulum
GO:0031974	0.937	membrane-enclosed lumen
GO:0070013	0.932	intracellular organelle lumen
GO:0005829	0.919	cytosol
GO:0005634	0.919	nucleus
GO:0016020	0.902	membrane
GO:0031981	0.848	nuclear lumen
GO:0005654	0.828	nucleoplasm
GO:0099023	0.818	vesicle tethering complex
GO:0031090	0.773	organelle membrane
GO:0140535	0.758	intracellular protein-containing complex
GO:0030008	0.717	TRAPP complex
GO:0098588	0.650	bounding membrane of organelle
GO:0042175	0.462	nuclear outer membrane-endoplasmic reticulum membrane network
GO:0005794	0.384	Golgi apparatus
GO:0031410	0.377	cytoplasmic vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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