StarFunc result for job id P0DJD0

User Input

>input (1748 residues)
MNVMGFNTDRLAWTRNKLRGFYFAKLYYEAKEYDLAKKYVCTYLSVQERDPRAHRFLGLL
YELEENTEKAVECYRRSLELNPPQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSP
AIYKLKEHLLDCEGEDGWNKLFDWIQSELYVRPDDVHMNIRLVELYRSNKRLKDAVARCH
EAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYANLMLLTLST
RDVQESRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMHAGSLLLKMGQHGNNVQ
WQALSELAALCYVIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDF
LKEVVETFANKSGQSVLYNALFSSQSSKDTSFLGSDDIGNIDVQEPELEDLARYDVGAIQ
AHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFL
LGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKRLCTERQKSWWDAVCTLIHRKAVPGNS
AELRLVVQHEINTLRAQEKHGLQPALLVHWAKCLQKMGRGLNSSYDQQEYIGRSVHYWKK
VLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVHGNIEDAVT
AFESIKSVVSYWNLALIFHRKAEDIENDAVFPEEQEECKNYLRKTRDYLIKIIDDSDSNL
SVVKKLPVPLESVKEMLKSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSP
SKSYKYSPKTPPRWAEDQNSLRKMICQEVKAITKLNSSKSASRHRWPTENYGPDSVPDGY
QGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSI
AVSADGFKFGISEPGNQEKKSEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVA
KSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDACKTEDSDDI
HFEPVVQMPEKVELVTGEEGEKVLYSQGVKLFRFDAEISQWKERGLGNLKILKNEVNGKP
RMLMRRDQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLERLAAQFKTPEL
AEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKV
TEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDNVSSSSVHDSPLASS
PVRKNIFRFDESTTGFNFSFKSALSLSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFE
PVVPLPDLVEVSSGEENEQVVFSHRAELYRYDKDVGQWKERGIGDIKILQNYDNKQVRIV
MRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADS
FKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERTDVIQGDDVADA
ASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSNPFAFGNSSATGSLFGFSFNA
PLKSNDSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPMEESSINYTF
KTPEKEPPLWHAEFTKEELVQKLSSTTKSADQLNGLLRETEATSAVLMEQIKLLKSEIRR
LERNQEESAANVEHLKNVLLQFIFLKPGSERESLLPVINTMLQLSPEEKGKLAAVAQGLQ
ETSIPKKK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:7r5j00	0.403	0.901	8.677E-81	756	0.395	0.914	7r5j00.pdb.gz	AI-based structure prediction empowers integrative structural analysis of human nuclear pores
2	AFDB:Q8RWG8	0.079	0.592	5.644E-13	217	0.042	0.341	Q8RWG8.pdb.gz	RBP1B_ARATH Ran-binding protein 1 homolog b OS=Arabidopsis thaliana OX=3702 GN=RANBP1B PE=1 SV=2
3	AFDB:Q9LMK7	0.077	0.565	1.390E-12	228	0.044	0.338	Q9LMK7.pdb.gz	RBP1A_ARATH Ran-binding protein 1 homolog a OS=Arabidopsis thaliana OX=3702 GN=RANBP1A PE=1 SV=1
4	AFDB:Q09717	0.075	0.589	2.224E-12	215	0.046	0.377	Q09717.pdb.gz	RANG_SCHPO Ran-specific GTPase-activating protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=sbp1 PE=1 SV=1
5	AFDB:P92985	0.080	0.589	2.813E-12	219	0.044	0.352	P92985.pdb.gz	RBP1C_ARATH Ran-binding protein 1 homolog c OS=Arabidopsis thaliana OX=3702 GN=RANBP1C PE=2 SV=1
6	AFDB:P41920	0.073	0.614	6.927E-12	201	0.049	0.428	P41920.pdb.gz	YRB1_YEAST Ran-specific GTPase-activating protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YRB1 PE=1 SV=1
7	AFDB:A0A1D8PRQ3	0.075	0.598	1.109E-11	212	0.043	0.354	A0A1D8PRQ3.pdb.gz	A0A1D8PRQ3_CANAL Ran GTPase-binding protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=YRB1 PE=4 SV=1
8	PDB:1k5dB	0.075	0.853	3.016E-11	146	0.040	0.479	1k5dB.pdb.gz	RanGAP mediates GTP hydrolysis without an arginine finger.
9	PDB:3m1iB	0.072	0.927	2.225E-10	131	0.035	0.466	3m1iB.pdb.gz	An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1
10	AFDB:Q9LW88	0.078	0.258	2.471E-9	465	0.048	0.181	Q9LW88.pdb.gz	NU50B_ARATH Nuclear pore complex protein NUP50B OS=Arabidopsis thaliana OX=3702 GN=NUP50B PE=1 SV=1
11	AFDB:Q6PR54	0.072	0.058	3.954E-9	2419	0.130	0.094	Q6PR54.pdb.gz	RIF1_MOUSE Telomere-associated protein RIF1 OS=Mus musculus OX=10090 GN=Rif1 PE=1 SV=2
12	PDB:4bujB	0.095	0.113	1.309E-8	1367	0.057	0.072	4bujB.pdb.gz
13	PDB:7dkhI	0.076	0.130	2.649E-8	914	0.055	0.106	7dkhI.pdb.gz
14	AFDB:F4IAT2	0.080	0.077	2.916E-8	1823	0.116	0.111	F4IAT2.pdb.gz	THOC2_ARATH THO complex subunit 2 OS=Arabidopsis thaliana OX=3702 GN=THO2 PE=1 SV=1
15	AFDB:E1C2U2	0.083	0.068	4.853E-8	2326	0.143	0.107	E1C2U2.pdb.gz	RIF1_CHICK Telomere-associated protein RIF1 OS=Gallus gallus OX=9031 GN=RIF1 PE=3 SV=3
16	PDB:7qdrB	0.097	0.134	1.053E-6	1212	0.066	0.096	7qdrB.pdb.gz
17	PDB:6yj6A	0.105	0.197	3.155E-6	819	0.052	0.111	6yj6A.pdb.gz
18	PDB:6tedQ	0.078	0.134	6.386E-6	890	0.064	0.125	6tedQ.pdb.gz	Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation.
19	PDB:7ntfA	0.107	0.190	8.078E-6	918	0.042	0.080	7ntfA.pdb.gz
20	PDB:6c95A	0.108	0.226	2.151E-5	773	0.044	0.100	6c95A.pdb.gz	Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A8I5YC36	0.0	1280	3114	0.376	0.211	A0A8I5YC36_RAT RAN binding protein 2 OS=Rattus norvegicus OX=10116 GN=Ranbp2 PE=1 SV=1
2	D4A054	0.0	1280	3061	0.376	0.215	D4A054_RAT RAN binding protein 2 OS=Rattus norvegicus OX=10116 GN=Ranbp2 PE=1 SV=3
3	M0R3M4	0.0	1279	3089	0.376	0.213	M0R3M4_RAT RAN binding protein 2 OS=Rattus norvegicus OX=10116 GN=Ranbp2 PE=1 SV=2
4	P49792	0.0	1424	3224	0.406	0.220	RBP2_HUMAN E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2
5	Q9ERU9	0.0	1303	3053	0.376	0.216	RBP2_MOUSE E3 SUMO-protein ligase RanBP2 OS=Mus musculus OX=10090 GN=Ranbp2 PE=1 SV=2
6	Q8IWJ2	1.79e-55	216	1684	0.063	0.065	GCC2_HUMAN GRIP and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GCC2 PE=1 SV=4
7	Q8CHG3	3.15e-49	196	1680	0.056	0.058	GCC2_MOUSE GRIP and coiled-coil domain-containing protein 2 OS=Mus musculus OX=10090 GN=Gcc2 PE=1 SV=3
8	P41920	1.91e-39	148	201	0.046	0.403	YRB1_YEAST Ran-specific GTPase-activating protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YRB1 PE=1 SV=1
9	P34022	5.10e-37	141	203	0.045	0.384	RANG_MOUSE Ran-specific GTPase-activating protein OS=Mus musculus OX=10090 GN=Ranbp1 PE=1 SV=2
10	A0A140VK94	5.67e-37	140	201	0.043	0.373	A0A140VK94_HUMAN RAN binding protein 1, isoform CRA_g OS=Homo sapiens OX=9606 GN=RANBP1 PE=2 SV=1
11	P43487	5.67e-37	140	201	0.043	0.373	RANG_HUMAN Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1
12	A0A8I5ZTU5	8.81e-37	141	219	0.043	0.342	A0A8I5ZTU5_RAT RAN binding protein 1 OS=Rattus norvegicus OX=10116 GN=Ranbp1 PE=1 SV=1
13	D4A2G9	1.84e-36	139	188	0.041	0.383	D4A2G9_RAT RAN binding protein 1 OS=Rattus norvegicus OX=10116 GN=Ranbp1 PE=1 SV=2
14	F6WQW2	3.53e-36	141	278	0.045	0.281	F6WQW2_HUMAN RAN binding protein 1 OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1
15	A0A1D8PRQ3	9.91e-34	132	212	0.035	0.292	A0A1D8PRQ3_CANAL Ran GTPase-binding protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=YRB1 PE=4 SV=1
16	Q21021	1.42e-33	143	860	0.036	0.073	Q21021_CAEEL Nuclear Pore complex Protein OS=Caenorhabditis elegans OX=6239 GN=npp-9 PE=1 SV=2
17	C9JJ34	3.63e-31	122	163	0.038	0.405	C9JJ34_HUMAN RAN binding protein 1 (Fragment) OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1
18	A0A0B4K7J2	8.61e-31	135	2718	0.042	0.027	RBP2_DROME E3 SUMO-protein ligase RanBP2 OS=Drosophila melanogaster OX=7227 GN=Nup358 PE=1 SV=1
19	Q9LMK7	1.52e-30	123	228	0.035	0.272	RBP1A_ARATH Ran-binding protein 1 homolog a OS=Arabidopsis thaliana OX=3702 GN=RANBP1A PE=1 SV=1
20	Q09717	3.16e-30	122	215	0.041	0.335	RANG_SCHPO Ran-specific GTPase-activating protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=sbp1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF20518 Apc1_MidN	2.8e+02	12.0	Anaphase-promoting complex subunit 1 middle domain
2	PF10473 CENP-F_leu_zip	13	17.2	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
3	PF01465 GRIP	6.3e-12	56.5	GRIP domain
4	PF16704 Rab_bind	1.9e-31	119.2	Rab binding domain
5	PF00638 Ran_BP1	1.9e-104	356.0	RanBP1 domain
6	PF00515 TPR_1	0.015	26.3	Tetratricopeptide repeat
7	PF13414 TPR_11	2.5e+02	12.8	TPR repeat
8	PF13428 TPR_14	20	17.3	Tetratricopeptide repeat
9	PF13432 TPR_16	0.19	23.6	Tetratricopeptide repeat
10	PF14559 TPR_19	8.7	18.2	Tetratricopeptide repeat
11	PF07719 TPR_2	0.0055	27.8	Tetratricopeptide repeat
12	PF13174 TPR_6	2.7e+02	13.7	Tetratricopeptide repeat
13	PF13176 TPR_7	9.2	17.6	Tetratricopeptide repeat
14	PF13181 TPR_8	0.094	24.0	Tetratricopeptide repeat
15	PF13371 TPR_9	23	16.5	Tetratricopeptide repeat

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000453170

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000381098	0.769	Glutamate receptor-interacting protein 1
2	9606.ENSP00000446215	0.745	GTP-binding nuclear protein Ran
3	9606.ENSP00000384863	0.691	Exportin-1
4	9606.ENSP00000434570	0.603	SOGA family member 3
5	9606.ENSP00000451768	0.603	Protein SOGA3
6	9606.ENSP00000321038	0.602	Lysoplasmalogenase
7	9606.ENSP00000436679	0.589	Nuclear RNA export factor 1
8	9606.ENSP00000401470	0.575	Ran GTPase-activating protein 1
9	9606.ENSP00000356518	0.566	Testicular spindle-associated protein SHCBP1L
10	9606.ENSP00000318821	0.543	GRIP and coiled-coil domain-containing protein 1
11	9606.ENSP00000336712	0.542	Transportin-1
12	9606.ENSP00000316032	0.541	Nuclear pore complex protein Nup98-Nup96
13	9606.ENSP00000290158	0.524	Importin subunit beta-1
14	9606.ENSP00000309186	0.523	SH3 domain containing ring finger 3
15	9606.ENSP00000362937	0.507	Regulator of chromosome condensation
16	9606.ENSP00000310668	0.500	Nuclear pore complex protein Nup93

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0044877	0.998	protein-containing complex binding
GO:0019789	0.996	SUMO transferase activity
GO:0031267	0.995	small GTPase binding
GO:0061665	0.973	SUMO ligase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.965	cellular process
GO:0051179	0.885	localization
GO:0065007	0.880	biological regulation
GO:0050789	0.874	regulation of biological process
GO:0051641	0.863	cellular localization
GO:0050896	0.840	response to stimulus
GO:0050794	0.805	regulation of cellular process
GO:0051649	0.766	establishment of localization in cell
GO:0046907	0.744	intracellular transport
GO:0051169	0.668	nuclear transport
GO:0071704	0.635	organic substance metabolic process
GO:0006913	0.609	nucleocytoplasmic transport
GO:0033036	0.546	macromolecule localization
GO:1901698	0.545	response to nitrogen compound
GO:0043170	0.508	macromolecule metabolic process
GO:0008104	0.457	protein localization
GO:0006886	0.442	intracellular protein transport
GO:0019222	0.441	regulation of metabolic process
GO:0048518	0.390	positive regulation of biological process
GO:0044238	0.370	primary metabolic process
GO:0006807	0.366	nitrogen compound metabolic process
GO:0060255	0.329	regulation of macromolecule metabolic process
GO:0033365	0.312	protein localization to organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0032991	0.998	protein-containing complex
GO:0005635	0.998	nuclear envelope
GO:0031981	0.997	nuclear lumen
GO:0005737	0.996	cytoplasm
GO:0005643	0.994	nuclear pore
GO:0005654	0.990	nucleoplasm
GO:0005829	0.966	cytosol
GO:0016020	0.917	membrane
GO:0044614	0.380	nuclear pore cytoplasmic filaments
GO:0042175	0.379	nuclear outer membrane-endoplasmic reticulum membrane network
GO:1902494	0.377	catalytic complex
GO:0106068	0.372	SUMO ligase complex
GO:0005642	0.367	annulate lamellae
GO:0042405	0.361	nuclear inclusion body
GO:0044615	0.348	nuclear pore nuclear basket
GO:0048471	0.325	perinuclear region of cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.-.-.-	0.997	Transferases.

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