StarFunc result for job id P0DP25

User Input

>input (149 residues)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O16305	0.910	0.910	2.078E-25	149	0.980	0.980	O16305.pdb.gz	CALM_CAEEL Calmodulin OS=Caenorhabditis elegans OX=6239 GN=cmd-1 PE=1 SV=3
2	AFDB:P69097	0.862	0.862	1.404E-24	149	0.893	0.893	P69097.pdb.gz	CALM_TRYBB Calmodulin OS=Trypanosoma brucei brucei OX=5702 PE=3 SV=2
3	AFDB:P24044	0.776	0.776	2.161E-24	149	0.893	0.893	P24044.pdb.gz	CALM_PLAFA Calmodulin OS=Plasmodium falciparum OX=5833 GN=CAM PE=1 SV=4
4	AFDB:P60204	0.912	0.912	2.764E-24	149	0.846	0.846	P60204.pdb.gz	CALM_EMENI Calmodulin OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=camA PE=1 SV=2
5	AFDB:P02599	0.941	0.923	3.537E-24	152	0.886	0.868	P02599.pdb.gz	CALM_DICDI Calmodulin OS=Dictyostelium discoideum OX=44689 GN=calA PE=1 SV=3
6	AFDB:P07463	0.702	0.702	4.256E-24	149	0.886	0.886	P07463.pdb.gz	CALM_PARTE Calmodulin OS=Paramecium tetraurelia OX=5888 GN=CAM PE=1 SV=3
7	AFDB:F4IVN6	0.771	0.652	1.072E-23	181	0.886	0.729	F4IVN6.pdb.gz	F4IVN6_ARATH Calmodulin 5 OS=Arabidopsis thaliana OX=3702 GN=CAM5 PE=1 SV=1
8	AFDB:P27482	0.866	0.866	2.112E-23	149	0.846	0.846	P27482.pdb.gz	CALL3_HUMAN Calmodulin-like protein 3 OS=Homo sapiens OX=9606 GN=CALML3 PE=1 SV=2
9	AFDB:J9VTH9	0.594	0.594	1.717E-22	149	0.826	0.826	J9VTH9.pdb.gz	J9VTH9_CRYNH Calmodulin OS=Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) OX=235443 GN=CNAG_01557 PE=4 SV=2
10	AFDB:P05933	0.974	0.967	5.536E-22	150	0.745	0.740	P05933.pdb.gz	CALM_SCHPO Calmodulin OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cam1 PE=1 SV=1
11	PDB:2f2pA	0.711	0.641	7.202E-22	169	0.960	0.846	2f2pA.pdb.gz	Structure of calmodulin bound to a calcineurin Peptide: a new way of making an old binding mode.
12	PDB:5a2hA	0.714	0.723	1.109E-21	147	0.872	0.884	5a2hA.pdb.gz	Crystal Structure of Arabidopsis Thaliana Calmodulin7 and Insight Into its Mode of DNA Binding.
13	PDB:1osaA	0.616	0.619	1.707E-21	148	0.866	0.872	1osaA.pdb.gz	Structure of the recombinant Paramecium tetraurelia calmodulin at 1.68 A resolution.
14	PDB:6ya9A	0.510	0.199	2.415E-20	400	0.960	0.357	6ya9A.pdb.gz	Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging.
15	PDB:1ggzA	0.626	0.643	3.718E-20	144	0.812	0.840	1ggzA.pdb.gz	Crystal structure of human calmodulin-like protein: insights into its functional role.
16	PDB:6hr1A	0.501	0.192	6.885E-20	406	0.960	0.352	6hr1A.pdb.gz	Chimeric single alpha-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology.
17	PDB:6xyrA	0.504	0.224	1.275E-19	348	0.966	0.414	6xyrA.pdb.gz	Chimeric single alpha-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology.
18	PDB:4e53A	0.651	0.594	2.671E-19	168	0.993	0.881	4e53A.pdb.gz
19	PDB:6xu4A	0.509	0.202	1.296E-17	389	0.805	0.308	6xu4A.pdb.gz	FGCaMP7, an Improved Version of Fungi-Based Ratiometric Calcium Indicator for In Vivo Visualization of Neuronal Activity.
20	PDB:2n6aA	0.470	0.434	1.659E-17	162	0.933	0.858	2n6aA.pdb.gz	An investigation of calcium mediate signaling by the Connexin 36 gap junction protein

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	B4DJ51	2.26e-105	298	149	1.000	1.000	B4DJ51_HUMAN Calmodulin 1 (Phosphorylase kinase, delta), isoform CRA_a OS=Homo sapiens OX=9606 GN=HEL-S-72 PE=1 SV=1
2	P0DP23	2.26e-105	298	149	1.000	1.000	CALM1_HUMAN Calmodulin-1 OS=Homo sapiens OX=9606 GN=CALM1 PE=1 SV=1
3	P0DP24	2.26e-105	298	149	1.000	1.000	CALM2_HUMAN Calmodulin-2 OS=Homo sapiens OX=9606 GN=CALM2 PE=1 SV=1
4	P0DP25	2.26e-105	298	149	1.000	1.000	CALM3_HUMAN Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1
5	P0DP26	2.26e-105	298	149	1.000	1.000	CALM1_MOUSE Calmodulin-1 OS=Mus musculus OX=10090 GN=Calm1 PE=1 SV=1
6	P0DP27	2.26e-105	298	149	1.000	1.000	CALM2_MOUSE Calmodulin-2 OS=Mus musculus OX=10090 GN=Calm2 PE=1 SV=1
7	P0DP28	2.26e-105	298	149	1.000	1.000	CALM3_MOUSE Calmodulin-3 OS=Mus musculus OX=10090 GN=Calm3 PE=1 SV=1
8	P0DP29	2.26e-105	298	149	1.000	1.000	CALM1_RAT Calmodulin-1 OS=Rattus norvegicus OX=10116 GN=Calm1 PE=1 SV=1
9	P0DP30	2.26e-105	298	149	1.000	1.000	CALM2_RAT Calmodulin-2 OS=Rattus norvegicus OX=10116 GN=Calm2 PE=1 SV=1
10	P0DP31	2.26e-105	298	149	1.000	1.000	CALM3_RAT Calmodulin-3 OS=Rattus norvegicus OX=10116 GN=Calm3 PE=1 SV=1
11	P0DP33	2.26e-105	298	149	1.000	1.000	CALM1_XENLA Calmodulin-1 OS=Xenopus laevis OX=8355 GN=calm1 PE=1 SV=1
12	P0DP34	2.26e-105	298	149	1.000	1.000	CAM2A_XENLA Calmodulin-2 A OS=Xenopus laevis OX=8355 GN=calm2-a PE=1 SV=1
13	P0DP35	2.26e-105	298	149	1.000	1.000	CAM2B_XENLA Calmodulin-2 B OS=Xenopus laevis OX=8355 GN=calm2-b PE=1 SV=1
14	P62149	2.26e-105	298	149	1.000	1.000	CALM_CHICK Calmodulin OS=Gallus gallus OX=9031 GN=CALM PE=1 SV=2
15	P62157	2.26e-105	298	149	1.000	1.000	CALM_BOVIN Calmodulin OS=Bos taurus OX=9913 GN=CALM PE=1 SV=2
16	G1NK53	1.07e-104	297	148	0.993	1.000	G1NK53_MELGA Calmodulin 1 OS=Meleagris gallopavo OX=9103 GN=CALM1 PE=4 SV=1
17	P62152	2.04e-103	293	149	0.980	0.980	CALM_DROME Calmodulin OS=Drosophila melanogaster OX=7227 GN=Cam PE=1 SV=2
18	O16305	4.79e-103	293	149	0.980	0.980	CALM_CAEEL Calmodulin OS=Caenorhabditis elegans OX=6239 GN=cmd-1 PE=1 SV=3
19	P69097	4.39e-97	278	149	0.893	0.893	CALM_TRYBB Calmodulin OS=Trypanosoma brucei brucei OX=5702 PE=3 SV=2
20	P04464	8.67e-97	277	149	0.906	0.906	CALM_WHEAT Calmodulin OS=Triticum aestivum OX=4565 PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF05042 Caleosin	2.2	19.7	Caleosin related protein
2	PF02627 CMD	8e+02	11.5	Carboxymuconolactone decarboxylase family
3	PF08269 dCache_2	2.1e+02	12.5	Cache domain
4	PF00404 Dockerin_1	0.9	21.1	Dockerin type I domain
5	PF06513 DUF1103	2.8	19.0	Repeat of unknown function (DUF1103)
6	PF10025 DUF2267	57	15.5	Uncharacterized conserved protein (DUF2267)
7	PF11829 DUF3349	50	16.1	Protein of unknown function (DUF3349)
8	PF17195 DUF5132	8.3e+02	11.5	Protein of unknown function (DUF5132)
9	PF17743 DUF5580	21	15.2	Family of unknown function (DUF5580)
10	PF00036 EF-hand_1	2.6e-40	144.1	EF hand
11	PF08976 EF-hand_11	0.0071	28.6	EF-hand domain
12	PF12763 EF-hand_4	7.3e-07	40.4	Cytoskeletal-regulatory complex EF hand
13	PF13202 EF-hand_5	1.2e-24	95.8	EF hand
14	PF13405 EF-hand_6	5.4e-27	102.3	EF-hand domain
15	PF13499 EF-hand_7	2.9e-34	128.7	EF-hand domain pair
16	PF13833 EF-hand_8	9.7e-30	113.4	EF-hand domain pair
17	PF14658 EF-hand_9	2e-13	61.8	EF-hand domain
18	PF08726 EFhand_Ca_insen	0.16	23.4	Ca2+ insensitive EF hand
19	PF02906 Fe_hyd_lg_C	1.5e+02	13.4	Iron only hydrogenase large subunit, C-terminal domain
20	PF09114 MotA_activ	1.8e+02	13.6	Transcription factor MotA, activation domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 32507.XP_006799422.1

Rank	PPI partner	STRING score	Description
1	32507.XP_006799233.1	0.961	Myosin light chain kinase, smooth muscle-like
2	32507.XP_006803925.1	0.941	Nitric oxide synthase, brain-like isoform X1
3	32507.XP_006806063.1	0.923	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like
4	32507.XP_006808363.1	0.913	Calcium/calmodulin-dependent protein kinase type II subunit alpha-like
5	32507.XP_006782794.1	0.908	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like
6	32507.XP_006780523.1	0.869	Phosphorylase b kinase regulatory subunit beta-like
7	32507.XP_006782237.1	0.864	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1
8	32507.XP_006782380.1	0.862	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity
9	32507.XP_006789608.1	0.851	GTPase KRas-like
10	32507.XP_006780484.1	0.850	Phosphorylase b kinase regulatory subunit alpha, liver isoform-like isoform X1
11	32507.XP_006794070.1	0.850	Belongs to the protein kinase superfamily.
12	32507.XP_006792116.1	0.848	Belongs to the protein kinase superfamily.
13	32507.XP_006795595.1	0.848	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like
14	32507.XP_006801097.1	0.848	Belongs to the protein kinase superfamily.
15	32507.XP_006797597.1	0.843	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1
16	32507.XP_006791210.1	0.824	Myosin light chain kinase, smooth muscle-like
17	32507.XP_006810116.1	0.824	Myosin light chain kinase, smooth muscle-like
18	32507.XP_006802528.1	0.822	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like
19	32507.XP_006797573.1	0.806	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like
20	32507.XP_006798715.1	0.804	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005509	0.976	calcium ion binding
GO:0019899	0.733	enzyme binding
GO:0098772	0.564	molecular function regulator activity
GO:0030234	0.484	enzyme regulator activity
GO:0019904	0.311	protein domain specific binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.987	cellular process
GO:0050789	0.986	regulation of biological process
GO:0050794	0.981	regulation of cellular process
GO:0065009	0.977	regulation of molecular function
GO:0044770	0.977	cell cycle phase transition
GO:0051049	0.968	regulation of transport
GO:0019932	0.968	second-messenger-mediated signaling
GO:0051279	0.963	regulation of release of sequestered calcium ion into cytosol
GO:0019722	0.962	calcium-mediated signaling
GO:0044839	0.961	cell cycle G2/M phase transition
GO:2001257	0.961	regulation of cation channel activity
GO:0034763	0.960	negative regulation of transmembrane transport
GO:1901019	0.960	regulation of calcium ion transmembrane transporter activity
GO:0043271	0.956	negative regulation of monoatomic ion transport
GO:0051926	0.950	negative regulation of calcium ion transport
GO:0032413	0.950	negative regulation of ion transmembrane transporter activity
GO:0032501	0.944	multicellular organismal process
GO:0044093	0.933	positive regulation of molecular function
GO:1904064	0.932	positive regulation of cation transmembrane transport
GO:0051928	0.931	positive regulation of calcium ion transport
GO:1904063	0.925	negative regulation of cation transmembrane transport
GO:1904427	0.921	positive regulation of calcium ion transmembrane transport
GO:1901020	0.916	negative regulation of calcium ion transmembrane transporter activity
GO:2001259	0.915	positive regulation of cation channel activity
GO:2001258	0.915	negative regulation of cation channel activity
GO:0051281	0.911	positive regulation of release of sequestered calcium ion into cytosol
GO:0000086	0.907	G2/M transition of mitotic cell cycle
GO:0010880	0.902	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0048856	0.895	anatomical structure development
GO:0010799	0.893	regulation of peptidyl-threonine phosphorylation
GO:0010646	0.867	regulation of cell communication
GO:0007275	0.835	multicellular organism development
GO:0048731	0.828	system development
GO:0045937	0.818	positive regulation of phosphate metabolic process
GO:1901021	0.817	positive regulation of calcium ion transmembrane transporter activity
GO:0023051	0.807	regulation of signaling
GO:0050790	0.806	regulation of catalytic activity
GO:0042221	0.804	response to chemical
GO:0010800	0.799	positive regulation of peptidyl-threonine phosphorylation
GO:0035306	0.767	positive regulation of dephosphorylation
GO:0010921	0.736	regulation of phosphatase activity
GO:0010033	0.731	response to organic substance
GO:0071840	0.727	cellular component organization or biogenesis
GO:0035304	0.727	regulation of protein dephosphorylation
GO:0016043	0.716	cellular component organization
GO:0065008	0.711	regulation of biological quality
GO:0048513	0.702	animal organ development
GO:0044057	0.702	regulation of system process
GO:0051179	0.688	localization
GO:1901385	0.685	regulation of voltage-gated calcium channel activity
GO:0051234	0.640	establishment of localization
GO:0051345	0.640	positive regulation of hydrolase activity
GO:0009966	0.634	regulation of signal transduction
GO:0006996	0.537	organelle organization
GO:0051641	0.528	cellular localization
GO:0051726	0.462	regulation of cell cycle
GO:0051649	0.429	establishment of localization in cell
GO:0048869	0.392	cellular developmental process
GO:0008152	0.386	metabolic process
GO:0044238	0.355	primary metabolic process
GO:0071704	0.350	organic substance metabolic process
GO:0044237	0.313	cellular metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	0.999	membrane
GO:0005737	0.999	cytoplasm
GO:0043229	0.997	intracellular organelle
GO:0032991	0.993	protein-containing complex
GO:0005886	0.987	plasma membrane
GO:0043232	0.955	intracellular non-membrane-bounded organelle
GO:0005634	0.946	nucleus
GO:0005829	0.938	cytosol
GO:0031982	0.796	vesicle
GO:0042995	0.707	cell projection
GO:0012505	0.638	endomembrane system
GO:0120025	0.598	plasma membrane bounded cell projection
GO:1990351	0.557	transporter complex
GO:0098796	0.545	membrane protein complex
GO:1902495	0.535	transmembrane transporter complex
GO:0030054	0.525	cell junction
GO:0034702	0.524	ion channel complex
GO:0034703	0.499	cation channel complex
GO:0099081	0.434	supramolecular polymer
GO:0043209	0.421	myelin sheath
GO:0099512	0.402	supramolecular fiber
GO:0045202	0.369	synapse
GO:0015630	0.365	microtubule cytoskeleton
GO:0070013	0.337	intracellular organelle lumen
GO:0098797	0.335	plasma membrane protein complex
GO:0031981	0.327	nuclear lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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