StarFunc result for job id P10398

User Input

>input (606 residues)
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q96II5	0.634	0.631	3.010E-101	609	0.998	0.993	Q96II5.pdb.gz	Q96II5_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=1
2	AFDB:A0A0S2Z559	0.761	0.694	1.195E-75	668	0.617	0.560	A0A0S2Z559.pdb.gz	A0A0S2Z559_HUMAN non-specific serine/threonine protein kinase (Fragment) OS=Homo sapiens OX=9606 GN=RAF1 PE=2 SV=1
3	AFDB:L7RRS6	0.713	0.669	1.449E-74	648	0.611	0.571	L7RRS6.pdb.gz	L7RRS6_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=2 SV=1
4	AFDB:P09560	0.760	0.724	1.367E-72	638	0.589	0.560	P09560.pdb.gz	RAF1_XENLA RAF proto-oncogene serine/threonine-protein kinase OS=Xenopus laevis OX=8355 GN=raf1 PE=2 SV=1
5	AFDB:H7C560	0.707	0.566	1.445E-72	767	0.584	0.462	H7C560.pdb.gz	H7C560_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=2
6	AFDB:P28028	0.735	0.598	1.064E-71	751	0.597	0.482	P28028.pdb.gz	BRAF_MOUSE Serine/threonine-protein kinase B-raf OS=Mus musculus OX=10090 GN=Braf PE=1 SV=4
7	AFDB:A0A2R8Y8E0	0.738	0.560	1.154E-70	807	0.596	0.447	A0A2R8Y8E0.pdb.gz	A0A2R8Y8E0_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=1
8	AFDB:P11346	0.584	0.483	2.208E-58	739	0.441	0.361	P11346.pdb.gz	KRAF1_DROME Raf homolog serine/threonine-protein kinase Raf OS=Drosophila melanogaster OX=7227 GN=Raf PE=1 SV=6
9	PDB:7mfdA	0.539	0.785	1.085E-47	410	0.502	0.741	7mfdA.pdb.gz	Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
10	AFDB:Q61097	0.417	0.294	2.243E-30	873	0.267	0.186	Q61097.pdb.gz	KSR1_MOUSE Kinase suppressor of Ras 1 OS=Mus musculus OX=10090 GN=Ksr1 PE=1 SV=1
11	AFDB:Q24170	0.414	0.265	5.592E-29	966	0.269	0.169	Q24170.pdb.gz	Q24170_DROME KSR OS=Drosophila melanogaster OX=7227 GN=ksr PE=2 SV=1
12	PDB:6uanB	0.378	0.849	1.086E-28	261	0.314	0.728	6uanB.pdb.gz
13	PDB:7z37CP1	0.274	0.817	3.439E-20	193	0.259	0.813	7z37CP1.pdb.gz	Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.
14	PDB:2h8hA	0.387	0.519	3.945E-19	445	0.137	0.187	2h8hA.pdb.gz	N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
15	PDB:4btfA	0.361	0.514	9.553E-17	413	0.104	0.153	4btfA.pdb.gz
16	PDB:4fl2A	0.379	0.412	1.128E-16	555	0.117	0.128	4fl2A.pdb.gz	Structural and biophysical characterization of the syk activation switch.
17	PDB:4k2rA	0.371	0.406	2.320E-16	551	0.116	0.127	4k2rA.pdb.gz	Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker.
18	PDB:8dksA	0.332	0.675	4.039E-16	283	0.134	0.286	8dksA.pdb.gz	Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.
19	PDB:1k9aB	0.369	0.500	5.633E-16	441	0.129	0.177	1k9aB.pdb.gz
20	PDB:6s73A	0.367	0.788	9.808E-16	269	0.094	0.212	6s73A.pdb.gz	Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A0R4IN14	722	643	0.602	0.568	A0A0R4IN14_DANRE non-specific serine/threonine protein kinase OS=Danio rerio OX=7955 GN=c-raf PE=1 SV=2
2	A0A0S2Z559	729	668	0.619	0.561	A0A0S2Z559_HUMAN non-specific serine/threonine protein kinase (Fragment) OS=Homo sapiens OX=9606 GN=RAF1 PE=2 SV=1
3	A0A2R8Y8E0	680	807	0.597	0.449	A0A2R8Y8E0_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=1
4	A0A2U3TZI2	679	806	0.597	0.449	A0A2U3TZI2_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=1
5	A0A8I6ADL5	697	785	0.601	0.464	A0A8I6ADL5_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Braf PE=3 SV=1
6	A0A8I6AFV6	693	797	0.599	0.455	A0A8I6AFV6_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Braf PE=1 SV=1
7	A0A8I6ATH0	681	804	0.609	0.459	A0A8I6ATH0_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Braf PE=1 SV=1
8	D3KYU7	721	626	0.596	0.577	D3KYU7_DANRE non-specific serine/threonine protein kinase OS=Danio rerio OX=7955 GN=raf1 PE=1 SV=1
9	F1M9C3	660	718	0.579	0.489	F1M9C3_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Braf PE=1 SV=4
10	H7C560	693	767	0.596	0.471	H7C560_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=2
11	L7RRS6	731	648	0.619	0.579	L7RRS6_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=2 SV=1
12	P04049	731	648	0.619	0.579	RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1
13	P04627	1197	604	0.952	0.955	ARAF_MOUSE Serine/threonine-protein kinase A-Raf OS=Mus musculus OX=10090 GN=Araf PE=1 SV=2
14	P09560	713	638	0.597	0.567	RAF1_XENLA RAF proto-oncogene serine/threonine-protein kinase OS=Xenopus laevis OX=8355 GN=raf1 PE=2 SV=1
15	P10398	1264	606	1.000	1.000	ARAF_HUMAN Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2
16	P11345	728	648	0.620	0.580	RAF1_RAT RAF proto-oncogene serine/threonine-protein kinase OS=Rattus norvegicus OX=10116 GN=Raf1 PE=1 SV=1
17	P14056	1200	604	0.955	0.959	ARAF_RAT Serine/threonine-protein kinase A-Raf OS=Rattus norvegicus OX=10116 GN=Araf PE=1 SV=1
18	P15056	692	766	0.596	0.471	BRAF_HUMAN Serine/threonine-protein kinase B-raf OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=4
19	P28028	678	751	0.583	0.470	BRAF_MOUSE Serine/threonine-protein kinase B-raf OS=Mus musculus OX=10090 GN=Braf PE=1 SV=4
20	Q5FBD1	803	608	0.675	0.673	Q5FBD1_DANRE non-specific serine/threonine protein kinase OS=Danio rerio OX=7955 GN=ARAF PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	0.75	20.4	ABC1 atypical kinase-like domain
2	PF01636 APH	63	14.9	Phosphotransferase enzyme family
3	PF00130 C1_1	4.3e-07	41.0	Phorbol esters/diacylglycerol binding domain (C1 domain)
4	PF06293 Kdo	3.2e+02	12.1	Lipopolysaccharide kinase (Kdo/WaaP) family
5	PF14531 Kinase-like	0.004	28.1	Kinase-like
6	PF00069 Pkinase	2e-50	183.2	Protein kinase domain
7	PF17667 Pkinase_fungal	15	15.8	Fungal protein kinase
8	PF07714 PK_Tyr_Ser-Thr	8.6e-57	203.9	Protein tyrosine and serine/threonine kinase
9	PF02196 RBD	1.5e-18	77.8	Raf-like Ras-binding domain
10	PF11470 TUG-UBL1	1.7e+02	13.8	TUG ubiquitin-like domain
11	PF08746 zf-RING-like	5.4	18.6	RING-like domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000290277

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000407586	0.998	GTPase HRas
2	9606.ENSP00000262948	0.995	Dual specificity mitogen-activated protein kinase kinase 2
3	9606.ENSP00000302486	0.995	Dual specificity mitogen-activated protein kinase kinase 1
4	9606.ENSP00000256078	0.989	GTPase KRas
5	9606.ENSP00000358548	0.981	GTPase NRas
6	9606.ENSP00000288602	0.974	Serine/threonine-protein kinase B-raf
7	9606.ENSP00000320171	0.961	Pyruvate kinase PKM
8	9606.ENSP00000358464	0.953	Leucine-rich repeat protein SHOC-2
9	9606.ENSP00000256196	0.942	Ras-related protein R-Ras2
10	9606.ENSP00000379287	0.935	14-3-3 protein zeta/delta
11	9606.ENSP00000289104	0.934	Ras-related protein M-Ras
12	9606.ENSP00000376943	0.930	Bcl-2-like protein 11
13	9606.ENSP00000246792	0.927	Ras-related protein R-Ras
14	9606.ENSP00000416040	0.927	Belongs to the UPF0606 family
15	9606.ENSP00000221138	0.925	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
16	9606.ENSP00000418447	0.925	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
17	9606.ENSP00000251849	0.923	RAF proto-oncogene serine/threonine-protein kinase
18	9606.ENSP00000012443	0.922	Serine/threonine-protein phosphatase 5
19	9606.ENSP00000380692	0.921	Lysine-specific demethylase 7A
20	9606.ENSP00000324804	0.918	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0004672	0.997	protein kinase activity
GO:0004674	0.925	protein serine/threonine kinase activity
GO:0019899	0.702	enzyme binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.998	regulation of cellular process
GO:0009987	0.994	cellular process
GO:0050896	0.991	response to stimulus
GO:0019538	0.988	protein metabolic process
GO:0043412	0.980	macromolecule modification
GO:0023052	0.972	signaling
GO:0007154	0.971	cell communication
GO:0016310	0.959	phosphorylation
GO:0006468	0.936	protein phosphorylation
GO:0051716	0.922	cellular response to stimulus
GO:0007165	0.888	signal transduction
GO:0048583	0.869	regulation of response to stimulus
GO:0048519	0.814	negative regulation of biological process
GO:0023051	0.790	regulation of signaling
GO:0010646	0.787	regulation of cell communication
GO:0048518	0.774	positive regulation of biological process
GO:0009966	0.735	regulation of signal transduction
GO:0048523	0.688	negative regulation of cellular process
GO:0048522	0.676	positive regulation of cellular process
GO:0019222	0.664	regulation of metabolic process
GO:0060255	0.623	regulation of macromolecule metabolic process
GO:0051171	0.576	regulation of nitrogen compound metabolic process
GO:0080090	0.572	regulation of primary metabolic process
GO:0031323	0.568	regulation of cellular metabolic process
GO:0035556	0.532	intracellular signal transduction
GO:0051246	0.402	regulation of protein metabolic process
GO:1902531	0.401	regulation of intracellular signal transduction
GO:0048584	0.367	positive regulation of response to stimulus
GO:0009893	0.357	positive regulation of metabolic process
GO:0010604	0.349	positive regulation of macromolecule metabolic process
GO:0051173	0.334	positive regulation of nitrogen compound metabolic process
GO:0042981	0.325	regulation of apoptotic process
GO:0007166	0.325	cell surface receptor signaling pathway
GO:0031399	0.314	regulation of protein modification process
GO:0031325	0.314	positive regulation of cellular metabolic process
GO:0009967	0.306	positive regulation of signal transduction
GO:1902533	0.303	positive regulation of intracellular signal transduction

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol
GO:0043231	0.955	intracellular membrane-bounded organelle
GO:0016020	0.917	membrane
GO:0071944	0.537	cell periphery
GO:0005886	0.462	plasma membrane
GO:0005634	0.301	nucleus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.1.-	0.997	Phosphotransferases with an alcohol group as acceptor.

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