StarFunc result for job id P10635

User Input

>input (497 residues)
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A087X1C5	0.996	0.961	4.617E-73	515	0.940	0.907	A0A087X1C5.pdb.gz	CP2D7_HUMAN Putative cytochrome P450 2D7 OS=Homo sapiens OX=9606 GN=CYP2D7 PE=5 SV=1
2	PDB:3tbgA	0.936	0.996	7.531E-70	467	0.934	0.994	3tbgA.pdb.gz	Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
3	AFDB:Q64680	0.989	0.983	1.340E-63	500	0.767	0.762	Q64680.pdb.gz	CP2D4_RAT Cytochrome P450 2D4 OS=Rattus norvegicus OX=10116 GN=Cyp2d4 PE=2 SV=1
4	AFDB:Q91W87	0.984	0.978	4.737E-63	500	0.751	0.746	Q91W87.pdb.gz	Q91W87_MOUSE Cytochrome P450 OS=Mus musculus OX=10090 GN=Cyp2d22 PE=2 SV=1
5	AFDB:P10633	0.989	0.975	3.773E-62	504	0.712	0.702	P10633.pdb.gz	CP2D1_RAT Cytochrome P450 2D1 OS=Rattus norvegicus OX=10116 GN=Cyp2d1 PE=2 SV=1
6	AFDB:P12938	0.985	0.979	2.192E-61	500	0.720	0.716	P12938.pdb.gz	CP2D3_RAT Cytochrome P450 2D3 OS=Rattus norvegicus OX=10116 GN=Cyp2d3 PE=2 SV=2
7	AFDB:P10634	0.979	0.973	6.434E-58	500	0.718	0.714	P10634.pdb.gz	CP2DQ_RAT Cytochrome P450 2D26 OS=Rattus norvegicus OX=10116 GN=Cyp2d26 PE=1 SV=2
8	AFDB:O54750	0.921	0.914	1.074E-42	501	0.427	0.423	O54750.pdb.gz	CP2J6_MOUSE Cytochrome P450 2J6 OS=Mus musculus OX=10090 GN=Cyp2j6 PE=2 SV=2
9	AFDB:F1Q8C3	0.903	0.889	2.210E-42	505	0.406	0.400	F1Q8C3.pdb.gz	CP2K6_DANRE Cytochrome P450 2K6 OS=Danio rerio OX=7955 GN=cyp2k6 PE=1 SV=1
10	AFDB:O54749	0.919	0.912	1.927E-41	501	0.402	0.399	O54749.pdb.gz	CP2J5_MOUSE Cytochrome P450 2J5 OS=Mus musculus OX=10090 GN=Cyp2j5 PE=1 SV=1
11	AFDB:Q9CRQ9	0.929	0.875	3.966E-41	529	0.406	0.382	Q9CRQ9.pdb.gz	Q9CRQ9_MOUSE Uncharacterized protein (Fragment) OS=Mus musculus OX=10090 GN=Cyp2j9 PE=2 SV=1
12	PDB:4i91A	0.851	0.907	8.887E-39	465	0.376	0.402	4i91A.pdb.gz	Structural and Thermodynamic Basis of (+)-alpha-Pinene Binding to Human Cytochrome P450 2B6.
13	PDB:3c6gB	0.874	0.929	5.650E-38	467	0.378	0.403	3c6gB.pdb.gz	Structural analysis of CYP2R1 in complex with vitamin D3.
14	PDB:4nz2A	0.858	0.916	1.594E-37	464	0.388	0.416	4nz2A.pdb.gz	Structure-based ligand design to overcome CYP inhibition in drug discovery projects.
15	PDB:1z11A	0.858	0.910	1.998E-37	467	0.350	0.373	1z11A.pdb.gz	Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen
16	PDB:2vn0A	0.870	0.930	2.187E-37	464	0.392	0.420	2vn0A.pdb.gz	Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
17	PDB:4gqsA	0.865	0.924	6.754E-37	464	0.382	0.409	4gqsA.pdb.gz	Structural Characterization of Human Cytochrome P450 2C19: ACTIVE SITE DIFFERENCES BETWEEN P450s 2C8, 2C9, AND 2C19.
18	PDB:3t3zA	0.858	0.917	9.261E-37	464	0.370	0.397	3t3zA.pdb.gz	Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine.
19	PDB:4i8vA	0.845	0.878	1.313E-30	477	0.290	0.302	4i8vA.pdb.gz	Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism.
20	PDB:6b82B	0.865	0.913	1.646E-30	470	0.284	0.300	6b82B.pdb.gz	Inherent steroid 17 alpha ,20-lyase activity in defunct cytochrome P450 17A enzymes.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A087X1C5	0.0	904	515	0.940	0.907	CP2D7_HUMAN Putative cytochrome P450 2D7 OS=Homo sapiens OX=9606 GN=CYP2D7 PE=5 SV=1
2	P10633	0.0	707	504	0.712	0.702	CP2D1_RAT Cytochrome P450 2D1 OS=Rattus norvegicus OX=10116 GN=Cyp2d1 PE=2 SV=1
3	P10634	0.0	707	500	0.718	0.714	CP2DQ_RAT Cytochrome P450 2D26 OS=Rattus norvegicus OX=10116 GN=Cyp2d26 PE=1 SV=2
4	P10635	0.0	1012	497	1.000	1.000	CP2D6_HUMAN Cytochrome P450 2D6 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=2
5	P12938	0.0	739	500	0.720	0.716	CP2D3_RAT Cytochrome P450 2D3 OS=Rattus norvegicus OX=10116 GN=Cyp2d3 PE=2 SV=2
6	P12939	0.0	706	504	0.712	0.702	CP2DA_RAT Cytochrome P450 2D10 OS=Rattus norvegicus OX=10116 GN=Cyp2d10 PE=1 SV=1
7	Q64680	0.0	777	500	0.767	0.762	CP2D4_RAT Cytochrome P450 2D4 OS=Rattus norvegicus OX=10116 GN=Cyp2d4 PE=2 SV=1
8	Q91W87	0.0	768	500	0.751	0.746	Q91W87_MOUSE Cytochrome P450 OS=Mus musculus OX=10090 GN=Cyp2d22 PE=2 SV=1
9	Q9JKY7	0.0	770	500	0.753	0.748	Q9JKY7_MOUSE Cytochrome P450 OS=Mus musculus OX=10090 GN=Cyp2d22 PE=1 SV=1
10	P51589	5.33e-130	389	502	0.416	0.412	CP2J2_HUMAN Cytochrome P450 2J2 OS=Homo sapiens OX=9606 GN=CYP2J2 PE=1 SV=2
11	O54750	7.96e-130	388	501	0.437	0.433	CP2J6_MOUSE Cytochrome P450 2J6 OS=Mus musculus OX=10090 GN=Cyp2j6 PE=2 SV=2
12	Q9QXF7	3.49e-128	384	501	0.431	0.427	CP2J4_RAT Cytochrome P450 2J4 OS=Rattus norvegicus OX=10116 GN=CYP2J4 PE=1 SV=1
13	Q5BKA2	4.44e-127	381	501	0.429	0.425	Q5BKA2_RAT Cytochrome P450, family 2, subfamily j, polypeptide 4 OS=Rattus norvegicus OX=10116 GN=Cyp2j4 PE=3 SV=1
14	Q924D1	2.40e-126	379	502	0.408	0.404	Q924D1_MOUSE Cytochrome P450 CYP2J9 OS=Mus musculus OX=10090 GN=Cyp2j9 PE=1 SV=1
15	Q9CRQ9	1.75e-124	375	529	0.406	0.382	Q9CRQ9_MOUSE Uncharacterized protein (Fragment) OS=Mus musculus OX=10090 GN=Cyp2j9 PE=2 SV=1
16	O54749	2.84e-123	371	501	0.400	0.397	CP2J5_MOUSE Cytochrome P450 2J5 OS=Mus musculus OX=10090 GN=Cyp2j5 PE=1 SV=1
17	P10632	1.78e-121	366	490	0.414	0.420	CP2C8_HUMAN Cytochrome P450 2C8 OS=Homo sapiens OX=9606 GN=CYP2C8 PE=1 SV=2
18	P56656	1.30e-119	361	490	0.396	0.402	CP239_MOUSE Cytochrome P450 2C39 OS=Mus musculus OX=10090 GN=Cyp2c39 PE=1 SV=2
19	Q9DEW9	1.30e-118	359	490	0.388	0.394	Q9DEW9_ICTPU Cytochrome P450 OS=Ictalurus punctatus OX=7998 GN=LOC100335049 PE=2 SV=1
20	A0A0G2K921	2.03e-118	356	432	0.390	0.449	A0A0G2K921_RAT Cytochrome P450, family 2, subfamily j, polypeptide 4 OS=Rattus norvegicus OX=10116 GN=Cyp2j3 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00067 p450	2.8e-129	443.5	Cytochrome P450

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000353820

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000340684	0.955	Amine oxidase [flavin-containing] A
2	9606.ENSP00000337915	0.951	Cytochrome P450 3A4
3	9606.ENSP00000356729	0.948	Dimethylaniline monooxygenase [N-oxide-forming] 3
4	9606.ENSP00000367309	0.945	Amine oxidase [flavin-containing] B
5	9606.ENSP00000481732	0.943	Dimethylaniline monooxygenase [N-oxide-forming] 1
6	9606.ENSP00000254090	0.936	Dimethylaniline monooxygenase [N-oxide-forming] 5
7	9606.ENSP00000356723	0.932	Dimethylaniline monooxygenase [N-oxide-forming] 4
8	9606.ENSP00000209929	0.931	Dimethylaniline monooxygenase [N-oxide-forming] 2
9	9606.ENSP00000355995	0.931	Corticosteroid 11-beta-dehydrogenase isozyme 1
10	9606.ENSP00000369050	0.924	Cytochrome P450 1A1
11	9606.ENSP00000301141	0.922	Cytochrome P450 2A6
12	9606.ENSP00000290354	0.921	Carbonyl reductase [NADPH] 3
13	9606.ENSP00000260970	0.915	Peptidyl-prolyl cis-trans isomerase G
14	9606.ENSP00000290349	0.915	Carbonyl reductase [NADPH] 1
15	9606.ENSP00000332679	0.915	Cytochrome P450 2A13
16	9606.ENSP00000303174	0.914	UDP-glucuronosyltransferase 1-6
17	9606.ENSP00000304845	0.914	UDP-glucuronosyltransferase 1-1
18	9606.ENSP00000360372	0.914	Cytochrome P450 2C19
19	9606.ENSP00000362549	0.914	UDP-glucuronosyltransferase 1-8
20	9606.ENSP00000304811	0.913	UDP-glucuronosyltransferase 2B7

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0016705	1.000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0004497	1.000	monooxygenase activity
GO:0016712	0.994	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0005488	0.950	binding
GO:0097159	0.821	organic cyclic compound binding
GO:1901363	0.792	heterocyclic compound binding
GO:0046906	0.710	tetrapyrrole binding
GO:0005515	0.502	protein binding
GO:0016709	0.391	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0020037	0.304	heme binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0042221	0.998	response to chemical
GO:0044237	0.996	cellular metabolic process
GO:0009410	0.991	response to xenobiotic stimulus
GO:0071704	0.990	organic substance metabolic process
GO:0051716	0.981	cellular response to stimulus
GO:0006805	0.965	xenobiotic metabolic process
GO:0044238	0.895	primary metabolic process
GO:0006629	0.705	lipid metabolic process
GO:0065007	0.586	biological regulation
GO:0044281	0.583	small molecule metabolic process
GO:0006082	0.442	organic acid metabolic process
GO:0043436	0.433	oxoacid metabolic process
GO:0019752	0.421	carboxylic acid metabolic process
GO:0032787	0.367	monocarboxylic acid metabolic process
GO:1901360	0.329	organic cyclic compound metabolic process
GO:0065008	0.323	regulation of biological quality

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0012505	0.997	endomembrane system
GO:0016020	0.986	membrane
GO:0031090	0.931	organelle membrane
GO:0005783	0.826	endoplasmic reticulum
GO:0005789	0.784	endoplasmic reticulum membrane
GO:0005739	0.496	mitochondrion

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.14.-.-	1.000	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2.
EC:1.14.14.-	0.994	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen.
EC:1.14.13.-	0.391	With NADH or NADPH as one donor, and incorporation of one atom of oxygen.

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