StarFunc result for job id P10746

User Input

>input (265 residues)
MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI
FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG
NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL
NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS
CTAESPTPQALATGIRKALQPHGCC

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P10746	1.000	1.000	1.460E-55	265	1.000	1.000	P10746.pdb.gz	HEM4_HUMAN Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1
2	AFDB:P51163	0.980	0.980	2.136E-46	265	0.777	0.777	P51163.pdb.gz	HEM4_MOUSE Uroporphyrinogen-III synthase OS=Mus musculus OX=10090 GN=Uros PE=1 SV=1
3	PDB:1jr2A	0.924	0.941	3.459E-45	260	0.981	1.000	1jr2A.pdb.gz
4	AFDB:P87214	0.793	0.834	3.125E-22	251	0.275	0.291	P87214.pdb.gz	HEM4_SCHPO Uroporphyrinogen-III synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ups1 PE=3 SV=1
5	AFDB:P06174	0.756	0.732	8.484E-19	275	0.253	0.244	P06174.pdb.gz	HEM4_YEAST Uroporphyrinogen-III synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HEM4 PE=1 SV=2
6	AFDB:Q6MX34	0.672	0.344	1.587E-16	565	0.219	0.103	Q6MX34.pdb.gz	Q6MX34_MYCTU Probable uroporphyrin-III C-methyltransferase HemD (Uroporphyrinogen III methylase) (Urogen III methylase) (SUMT) (Urogen III methylase) (UROM) OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=hemD PE=1 SV=1
7	AFDB:O48721	0.643	0.546	6.252E-12	321	0.185	0.153	O48721.pdb.gz	HEM4_ARATH Uroporphyrinogen-III synthase, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=UROS PE=1 SV=2
8	AFDB:P95217	0.542	0.414	7.931E-12	381	0.170	0.118	P95217.pdb.gz	P95217_MYCTU Possible transcriptional regulatory protein OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=Rv0260c PE=1 SV=1
9	AFDB:P09126	0.618	0.656	8.058E-11	246	0.189	0.203	P09126.pdb.gz	HEM4_ECOLI Uroporphyrinogen-III synthase OS=Escherichia coli (strain K12) OX=83333 GN=hemD PE=3 SV=1
10	PDB:4yp9B	0.268	0.221	1.871E-5	342	0.128	0.099	4yp9B.pdb.gz	Discovery of Glycomimetic Agonists from a Protocell Metabolism, Proto-natural Product Libraries
11	PDB:4njmA	0.181	0.164	2.837E-5	303	0.113	0.099	4njmA.pdb.gz	Crystal structures and kinetics of Type III 3-phosphoglycerate dehydrogenase reveal catalysis by lysine.
12	PDB:1dbpA	0.286	0.281	8.777E-5	271	0.109	0.107	1dbpA.pdb.gz	Identical mutations at corresponding positions in two homologous proteins with nonidentical effects.
13	AFDB:Q76KF5	0.175	0.159	9.404E-5	299	0.109	0.097	Q76KF5.pdb.gz	Q76KF5_ENTHI D 3 phosphoglycerate dehydrogenase putative OS=Entamoeba histolytica OX=5759 GN=EhPGDH PE=1 SV=1
14	AFDB:O76864	0.164	0.136	3.478E-4	352	0.113	0.085	O76864.pdb.gz	O76864_DROME EG:100G10.4 protein OS=Drosophila melanogaster OX=7227 GN=EG:100G10.4 PE=4 SV=1
15	PDB:1zvvA	0.280	0.238	8.917E-4	332	0.109	0.087	1zvvA.pdb.gz	Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation.
16	PDB:1zmrA	0.218	0.163	1.931E-3	386	0.143	0.098	1zmrA.pdb.gz	Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability.
17	PDB:3ma0A	0.251	0.223	2.050E-3	313	0.106	0.089	3ma0A.pdb.gz	Conformational changes and ligand recognition of Escherichia coli D-xylose binding protein revealed
18	PDB:2vk2A	0.254	0.232	3.298E-3	296	0.098	0.088	2vk2A.pdb.gz	Furanose-Specific Sugar Transport: Characterization of a Bacterial Galactofuranose-Binding Protein.
19	PDB:2a0fA	0.160	0.143	7.142E-3	310	0.140	0.119	2a0fA.pdb.gz	Structure of the E.coli Aspartate Transcarbamoylase Trapped in the Middle of the Catalytic Cycle.
20	PDB:2g37B	0.196	0.177	7.142E-3	300	0.121	0.107	2g37B.pdb.gz	Structure and Kinetics of Monofunctional Proline Dehydrogenase from Thermus thermophilus.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P10746	0.0	544	265	1.000	1.000	HEM4_HUMAN Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1
2	Q5XIF2	6.42e-154	431	265	0.777	0.777	Q5XIF2_RAT uroporphyrinogen-III synthase OS=Rattus norvegicus OX=10116 GN=Uros PE=3 SV=1
3	P51163	3.32e-152	427	265	0.777	0.777	HEM4_MOUSE Uroporphyrinogen-III synthase OS=Mus musculus OX=10090 GN=Uros PE=1 SV=1
4	P87214	1.04e-20	90.1	251	0.268	0.283	HEM4_SCHPO Uroporphyrinogen-III synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ups1 PE=3 SV=1
5	P06174	2.55e-13	70.1	275	0.275	0.265	HEM4_YEAST Uroporphyrinogen-III synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HEM4 PE=1 SV=2
6	Q6MX34	0.011	39.3	565	0.181	0.085	Q6MX34_MYCTU Probable uroporphyrin-III C-methyltransferase HemD (Uroporphyrinogen III methylase) (Urogen III methylase) (SUMT) (Urogen III methylase) (UROM) OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=hemD PE=1 SV=1
7	Q7G065	1.7	32.3	518	0.098	0.050	GLGL2_ORYSJ Glucose-1-phosphate adenylyltransferase large subunit 2, cytosolic OS=Oryza sativa subsp. japonica OX=39947 GN=AGPL2 PE=1 SV=1
8	O17586	1.9	32.0	246	0.091	0.098	PSA6_CAEEL Proteasome subunit alpha type-6 OS=Caenorhabditis elegans OX=6239 GN=pas-1 PE=1 SV=1
9	A0A8I6A1B9	3.8	31.2	356	0.057	0.042	A0A8I6A1B9_RAT SIX homeobox 3 OS=Rattus norvegicus OX=10116 GN=Six3 PE=3 SV=1
10	A0A0G2K2C0	3.9	31.2	344	0.057	0.044	A0A0G2K2C0_RAT SIX homeobox 3 OS=Rattus norvegicus OX=10116 GN=Six3 PE=3 SV=2
11	O95343	4.0	31.2	332	0.057	0.045	SIX3_HUMAN Homeobox protein SIX3 OS=Homo sapiens OX=9606 GN=SIX3 PE=1 SV=1
12	Q9ET75	4.0	31.2	337	0.057	0.045	Q9ET75_RAT Homeobox protein Six3 OS=Rattus norvegicus OX=10116 GN=Six3 PE=1 SV=1
13	A0A8I6G4X0	4.2	31.2	358	0.057	0.042	A0A8I6G4X0_RAT SIX homeobox 3 OS=Rattus norvegicus OX=10116 GN=Six3 PE=3 SV=1
14	A0A0G2JWI0	4.3	31.2	350	0.057	0.043	A0A0G2JWI0_RAT SIX homeobox 3 OS=Rattus norvegicus OX=10116 GN=Six3 PE=3 SV=2
15	Q62233	4.4	30.8	333	0.057	0.045	SIX3_MOUSE Homeobox protein SIX3 OS=Mus musculus OX=10090 GN=Six3 PE=1 SV=2
16	Q17436	4.8	31.2	727	0.128	0.047	EDG1_CAEEL Protein edg-1 OS=Caenorhabditis elegans OX=6239 GN=edg-1 PE=1 SV=2
17	P51533	6.4	30.8	1564	0.098	0.017	PDR10_YEAST ATP-dependent permease PDR10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PDR10 PE=1 SV=1
18	W0SKS3	6.7	30.4	400	0.068	0.045	U6DT_PETCR Umbelliferone 6-dimethylallyltransferase, chloroplastic OS=Petroselinum crispum OX=4043 GN=PcPT PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02602 HEM4	6.8e-40	148.4	Uroporphyrinogen-III synthase HemD

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000357787

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000278715	0.997	Porphobilinogen deaminase
2	9606.ENSP00000246337	0.996	Uroporphyrinogen decarboxylase
3	9606.ENSP00000386284	0.978	Delta-aminolevulinic acid dehydratase
4	9606.ENSP00000264193	0.957	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
5	9606.ENSP00000372326	0.948	Ferrochelatase, mitochondrial
6	9606.ENSP00000356978	0.935	Protoporphyrinogen oxidase
7	9606.ENSP00000357748	0.909	BRCA2 and CDKN1A-interacting protein
8	9606.ENSP00000332369	0.846	5-aminolevulinate synthase, erythroid-specific, mitochondrial
9	9606.ENSP00000284690	0.814	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
10	9606.ENSP00000378416	0.805	5-aminolevulinate synthase, nonspecific, mitochondrial
11	9606.ENSP00000273158	0.787	Solute carrier family 25 member 38
12	9606.ENSP00000258955	0.735	Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
13	9606.ENSP00000265316	0.727	ATP-binding cassette sub-family B member 6, mitochondrial
14	9606.ENSP00000264808	0.694	PR domain zinc finger protein 5
15	9606.ENSP00000301457	0.682	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
16	9606.ENSP00000373610	0.647	Otoancorin
17	9606.ENSP00000265023	0.643	Kininogen-1
18	9606.ENSP00000334851	0.629	Regulator of G-protein signaling 7-binding protein
19	9606.ENSP00000445920	0.613	Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial
20	9606.ENSP00000366482	0.603	Frataxin, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004852	1.000	uroporphyrinogen-III synthase activity
GO:0005488	0.915	binding
GO:0005515	0.509	protein binding
GO:1901363	0.495	heterocyclic compound binding
GO:0097159	0.495	organic cyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044237	0.996	cellular metabolic process
GO:0006807	0.986	nitrogen compound metabolic process
GO:1901360	0.974	organic cyclic compound metabolic process
GO:1901362	0.963	organic cyclic compound biosynthetic process
GO:0018130	0.939	heterocycle biosynthetic process
GO:0019438	0.938	aromatic compound biosynthetic process
GO:0044271	0.929	cellular nitrogen compound biosynthetic process
GO:1901566	0.927	organonitrogen compound biosynthetic process
GO:0033014	0.912	tetrapyrrole biosynthetic process
GO:0044281	0.909	small molecule metabolic process
GO:0042168	0.907	heme metabolic process
GO:0006783	0.901	heme biosynthetic process
GO:0016053	0.890	organic acid biosynthetic process
GO:0046394	0.842	carboxylic acid biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0043231	0.966	intracellular membrane-bounded organelle
GO:0005739	0.676	mitochondrion
GO:0043233	0.626	organelle lumen
GO:0070013	0.612	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:18965	1.000	hydroxymethylbilane = H2O + uroporphyrinogen III
EC:4.2.1.75	1.000	uroporphyrinogen-III synthase.

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