StarFunc result for job id P11586

User Input

>input (935 residues)
MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAA
EEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAP
EKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY
VPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
GKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSAL
ERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV
PSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPV
SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAF
DAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:B7ZM99	0.821	0.787	0.000	979	0.605	0.578	B7ZM99.pdb.gz	B7ZM99_HUMAN formate--tetrahydrofolate ligase OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1
2	AFDB:F5H2F4	0.968	0.939	0.000	964	0.969	0.940	F5H2F4.pdb.gz	F5H2F4_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=2
3	AFDB:O43007	0.937	0.902	0.000	972	0.547	0.526	O43007.pdb.gz	C1TM_SCHPO C-1-tetrahydrofolate synthase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ade9 PE=3 SV=3
4	AFDB:O96553	0.965	0.933	0.000	968	0.612	0.591	O96553.pdb.gz	C1TC_DROME C-1-tetrahydrofolate synthase, cytoplasmic OS=Drosophila melanogaster OX=7227 GN=pug PE=2 SV=4
5	AFDB:P07245	0.929	0.919	0.000	946	0.583	0.576	P07245.pdb.gz	C1TC_YEAST C-1-tetrahydrofolate synthase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ADE3 PE=1 SV=1
6	AFDB:P09440	0.920	0.884	0.000	975	0.563	0.539	P09440.pdb.gz	C1TM_YEAST C-1-tetrahydrofolate synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MIS1 PE=1 SV=1
7	AFDB:Q3V3R1	0.843	0.810	0.000	977	0.604	0.578	Q3V3R1.pdb.gz	C1TM_MOUSE Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Mus musculus OX=10090 GN=Mthfd1l PE=1 SV=2
8	AFDB:Q6FND0	0.970	0.959	0.000	946	0.589	0.582	Q6FND0.pdb.gz	Q6FND0_CANGA Candida glabrata strain CBS138 chromosome K complete sequence OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=CAGL0K00913g PE=3 SV=1
9	AFDB:Q8WZJ7	0.952	0.950	0.000	937	0.586	0.585	Q8WZJ7.pdb.gz	C1TC_SCHPO C-1-tetrahydrofolate synthase, cytoplasmic OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC839.16 PE=3 SV=1
10	AFDB:Q9SPK5	0.669	0.986	9.968E-101	634	0.450	0.664	Q9SPK5.pdb.gz	FTHS_ARATH Formate--tetrahydrofolate ligase OS=Arabidopsis thaliana OX=3702 GN=THFS PE=2 SV=1
11	PDB:4a26A	0.301	0.934	1.094E-31	296	0.142	0.449	4a26A.pdb.gz
12	PDB:4cjxA	0.303	0.918	2.927E-31	297	0.126	0.397	4cjxA.pdb.gz	Characterization of 2,4-Diamino-6-Oxo-1,6-Dihydropyrimidin-5-Yl Ureido Based Inhibitors of Trypanosoma Brucei Fold and Testing for Antiparasitic Activity.
13	PDB:1b0aA	0.288	0.916	1.984E-30	287	0.133	0.432	1b0aA.pdb.gz
14	PDB:6s4fB	0.297	0.913	3.775E-28	298	0.126	0.396	6s4fB.pdb.gz	Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
15	PDB:2c2xA	0.288	0.936	4.419E-27	280	0.110	0.368	2c2xA.pdb.gz
16	PDB:1ee9A	0.263	0.728	3.134E-16	317	0.073	0.215	1ee9A.pdb.gz	The X-ray structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae.
17	PDB:3h9uC	0.142	0.247	3.300E-7	435	0.060	0.129	3h9uC.pdb.gz	Crystal structure of S-adenosyl homocysteine hydrolase (SAHH) from Trypanosoma brucei
18	PDB:4njmA	0.121	0.298	3.486E-7	303	0.047	0.145	4njmA.pdb.gz	Crystal structures and kinetics of Type III 3-phosphoglycerate dehydrogenase reveal catalysis by lysine.
19	PDB:1a7aA	0.135	0.240	1.611E-6	431	0.057	0.123	1a7aA.pdb.gz	Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
20	PDB:1sc6D	0.101	0.220	1.797E-6	384	0.042	0.102	1sc6D.pdb.gz	Multiconformational states in phosphoglycerate dehydrogenase

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A087WVM4	0.0	1116	913	0.617	0.632	A0A087WVM4_HUMAN formate--tetrahydrofolate ligase OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1
2	B7ZM99	0.0	1114	979	0.613	0.585	B7ZM99_HUMAN formate--tetrahydrofolate ligase OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1
3	F5H2F4	0.0	1855	964	0.969	0.940	F5H2F4_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=2
4	O43007	0.0	989	972	0.543	0.523	C1TM_SCHPO C-1-tetrahydrofolate synthase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ade9 PE=3 SV=3
5	O96553	0.0	1146	968	0.613	0.592	C1TC_DROME C-1-tetrahydrofolate synthase, cytoplasmic OS=Drosophila melanogaster OX=7227 GN=pug PE=2 SV=4
6	P07245	0.0	1030	946	0.583	0.576	C1TC_YEAST C-1-tetrahydrofolate synthase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ADE3 PE=1 SV=1
7	P09440	0.0	1016	975	0.566	0.543	C1TM_YEAST C-1-tetrahydrofolate synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MIS1 PE=1 SV=1
8	P11586	0.0	1919	935	1.000	1.000	C1TC_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4
9	P27653	0.0	1795	935	0.935	0.935	C1TC_RAT C-1-tetrahydrofolate synthase, cytoplasmic OS=Rattus norvegicus OX=10116 GN=Mthfd1 PE=1 SV=3
10	Q3V3R1	0.0	1106	977	0.609	0.582	C1TM_MOUSE Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Mus musculus OX=10090 GN=Mthfd1l PE=1 SV=2
11	Q4Q735	0.0	732	622	0.405	0.609	Q4Q735_LEIMA formate--tetrahydrofolate ligase OS=Leishmania major OX=5664 GN=FTHS PE=3 SV=1
12	Q54G53	0.0	850	638	0.461	0.676	Q54G53_DICDI formate--tetrahydrofolate ligase OS=Dictyostelium discoideum OX=44689 GN=fthS PE=3 SV=1
13	Q6FND0	0.0	1077	946	0.593	0.586	Q6FND0_CANGA Candida glabrata strain CBS138 chromosome K complete sequence OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=CAGL0K00913g PE=3 SV=1
14	Q6UB35	0.0	1118	978	0.612	0.585	C1TM_HUMAN Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1
15	Q8WZJ7	0.0	1034	937	0.584	0.583	C1TC_SCHPO C-1-tetrahydrofolate synthase, cytoplasmic OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC839.16 PE=3 SV=1
16	Q922D8	0.0	1779	935	0.932	0.932	C1TC_MOUSE C-1-tetrahydrofolate synthase, cytoplasmic OS=Mus musculus OX=10090 GN=Mthfd1 PE=1 SV=4
17	Q9SPK5	0.0	853	634	0.451	0.666	FTHS_ARATH Formate--tetrahydrofolate ligase OS=Arabidopsis thaliana OX=3702 GN=THFS PE=2 SV=1
18	V9GYY3	0.0	1858	922	0.970	0.984	V9GYY3_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=2
19	V9GZ78	0.0	1758	854	0.913	1.000	V9GZ78_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=2
20	Q9LHH7	1.44e-85	278	299	0.156	0.488	FOLD2_ARATH Bifunctional protein FolD 2 OS=Arabidopsis thaliana OX=3702 GN=FOLD2 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01261 AP_endonuc_2	6e+02	11.5	Xylose isomerase-like TIM barrel
2	PF01268 FTHFS	9.4e-259	870.9	Formate--tetrahydrofolate ligase
3	PF02423 OCD_Mu_crystall	1.8e+02	12.4	Ornithine cyclodeaminase/mu-crystallin family
4	PF00763 THF_DHG_CYH	3.3e-33	125.7	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
5	PF02882 THF_DHG_CYH_C	5.1e-64	225.9	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000216605

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000371253	0.999	Trifunctional purine biosynthetic protein adenosine-3
2	9606.ENSP00000318868	0.996	Serine hydroxymethyltransferase, cytosolic
3	9606.ENSP00000236959	0.993	Bifunctional purine biosynthesis protein PURH
4	9606.ENSP00000333667	0.993	Serine hydroxymethyltransferase, mitochondrial
5	9606.ENSP00000365777	0.991	Methylenetetrahydrofolate reductase
6	9606.ENSP00000315644	0.988	Thymidylate synthase
7	9606.ENSP00000355536	0.984	Methionine synthase
8	9606.ENSP00000396308	0.981	Dihydrofolate reductase
9	9606.ENSP00000273588	0.974	Aminomethyltransferase, mitochondrial
10	9606.ENSP00000258874	0.973	5-formyltetrahydrofolate cyclo-ligase
11	9606.ENSP00000362344	0.972	Folylpolyglutamate synthase, mitochondrial
12	9606.ENSP00000258494	0.962	Mitochondrial 10-formyltetrahydrofolate dehydrogenase
13	9606.ENSP00000377768	0.961	Dihydrofolate reductase 2, mitochondrial
14	9606.ENSP00000291670	0.960	Formimidoyltransferase-cyclodeaminase
15	9606.ENSP00000273450	0.959	Cytosolic 10-formyltetrahydrofolate dehydrogenase
16	9606.ENSP00000220058	0.954	Methionyl-tRNA formyltransferase, mitochondrial
17	9606.ENSP00000455643	0.939	5-formyltetrahydrofolate cyclo-ligase
18	9606.ENSP00000377617	0.937	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
19	9606.ENSP00000379108	0.934	Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
20	9606.ENSP00000478253	0.910	Monofunctional C1-tetrahydrofolate synthase, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004329	1.000	formate-tetrahydrofolate ligase activity
GO:0019238	1.000	cyclohydrolase activity
GO:0004486	1.000	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO:0005488	0.996	binding
GO:0004488	0.989	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0004477	0.989	methenyltetrahydrofolate cyclohydrolase activity
GO:1901363	0.901	heterocyclic compound binding
GO:0097159	0.901	organic cyclic compound binding
GO:0005515	0.777	protein binding
GO:0043167	0.748	ion binding
GO:0003676	0.399	nucleic acid binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044237	0.995	cellular metabolic process
GO:0044238	0.993	primary metabolic process
GO:1901564	0.993	organonitrogen compound metabolic process
GO:0006725	0.993	cellular aromatic compound metabolic process
GO:1901360	0.992	organic cyclic compound metabolic process
GO:0046483	0.991	heterocycle metabolic process
GO:0044281	0.990	small molecule metabolic process
GO:0042558	0.983	pteridine-containing compound metabolic process
GO:0044271	0.981	cellular nitrogen compound biosynthetic process
GO:0055086	0.980	nucleobase-containing small molecule metabolic process
GO:0019637	0.970	organophosphate metabolic process
GO:0046653	0.969	tetrahydrofolate metabolic process
GO:0072521	0.965	purine-containing compound metabolic process
GO:0009117	0.956	nucleotide metabolic process
GO:0043648	0.951	dicarboxylic acid metabolic process
GO:0044283	0.943	small molecule biosynthetic process
GO:1901576	0.925	organic substance biosynthetic process
GO:1901566	0.906	organonitrogen compound biosynthetic process
GO:1901362	0.861	organic cyclic compound biosynthetic process
GO:0018130	0.860	heterocycle biosynthetic process
GO:0019438	0.854	aromatic compound biosynthetic process
GO:0072522	0.725	purine-containing compound biosynthetic process
GO:0006520	0.683	amino acid metabolic process
GO:1901605	0.584	alpha-amino acid metabolic process
GO:0016053	0.574	organic acid biosynthetic process
GO:0046394	0.562	carboxylic acid biosynthetic process
GO:0006163	0.386	purine nucleotide metabolic process
GO:0006730	0.365	one-carbon metabolic process
GO:0043650	0.328	dicarboxylic acid biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.997	cytosol
GO:0043227	0.839	membrane-bounded organelle
GO:0043231	0.790	intracellular membrane-bounded organelle
GO:0070013	0.412	intracellular organelle lumen
GO:0005739	0.312	mitochondrion

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:20221	1.000	(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-formyltetrahydrofolate + ADP + phosphate
EC:6.3.4.3	1.000	formate--tetrahydrofolate ligase.
EC:3.5.4.-	1.000	In cyclic amidines.
EC:1.5.1.5	1.000	methylenetetrahydrofolate dehydrogenase (NADP(+)).
RHEA:23700	0.989	(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)
RHEA:22812	0.989	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH
EC:3.5.4.9	0.989	methenyltetrahydrofolate cyclohydrolase.

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