StarFunc result for job id P12107

User Input

>input (1806 residues)
MEPWSSRWKTKRWLWDFTVTTLALTFLFQAREVRGAAPVDVLKALDFHNSPEGISKTTGF
CTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPKKGIQSFLLSIYN
EHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIV
DCKKKTTKPLDRSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITGDPKAAYDYCEHYS
PDCDSSAPKAAQAQEPQIDEYAPEDIIEYDYEYGEAEYKEAESVTEGPTVTEETIAQTEA
NIVDDFQEYNYGTMESYQTEAPRHVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLY
ENKEIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHG
AYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLP
GADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRP
GPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDR
GFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTP
GAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKP
GLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEK
GEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVP
GLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKP
GPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKT
GPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKD
GPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQ
GPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSK
GDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQ
GLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEA
GNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPP
GEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAK
GEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLP
GLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPP
GPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEG
MQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDG
EYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKL
LSYLDVEGNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDE
EMSYDNNPFIKTLYDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVG
PVCFLG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:F6T0B3	0.221	0.237	0.000	1650	0.628	0.688	F6T0B3.pdb.gz	F6T0B3_RAT Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=2
2	AFDB:I3ISS1	0.322	0.323	0.000	1803	0.668	0.669	I3ISS1.pdb.gz
3	AFDB:P12107	1.000	1.000	0.000	1806	1.000	1.000	P12107.pdb.gz	COBA1_HUMAN Collagen alpha-1(XI) chain OS=Homo sapiens OX=9606 GN=COL11A1 PE=1 SV=4
4	AFDB:P25940	0.228	0.234	0.000	1745	0.570	0.590	P25940.pdb.gz	CO5A3_HUMAN Collagen alpha-3(V) chain OS=Homo sapiens OX=9606 GN=COL5A3 PE=1 SV=3
5	AFDB:Q9JI03	0.194	0.191	0.000	1840	0.744	0.730	Q9JI03.pdb.gz	CO5A1_RAT Collagen alpha-1(V) chain OS=Rattus norvegicus OX=10116 GN=Col5a1 PE=1 SV=1
6	AFDB:Q9JLI2	0.214	0.221	3.589E-101	1739	0.556	0.577	Q9JLI2.pdb.gz	Q9JLI2_MOUSE Collagen type V alpha 3 chain OS=Mus musculus OX=10090 GN=Col5a3 PE=1 SV=1
7	AFDB:A0MSJ1	0.120	0.129	9.180E-46	1658	0.346	0.377	A0MSJ1.pdb.gz	CRA1B_DANRE Collagen alpha-1(XXVII) chain B OS=Danio rerio OX=7955 GN=col27a1b PE=2 SV=1
8	AFDB:Q8IZC6	0.111	0.109	2.921E-44	1860	0.357	0.346	Q8IZC6.pdb.gz	CORA1_HUMAN Collagen alpha-1(XXVII) chain OS=Homo sapiens OX=9606 GN=COL27A1 PE=1 SV=1
9	AFDB:Q5QNQ9	0.120	0.118	2.776E-43	1845	0.365	0.357	Q5QNQ9.pdb.gz	CORA1_MOUSE Collagen alpha-1(XXVII) chain OS=Mus musculus OX=10090 GN=Col27a1 PE=2 SV=1
10	AFDB:Q17RW2	0.113	0.119	5.669E-43	1714	0.344	0.362	Q17RW2.pdb.gz	COOA1_HUMAN Collagen alpha-1(XXIV) chain OS=Homo sapiens OX=9606 GN=COL24A1 PE=1 SV=2
11	PDB:3v0aB	0.075	0.113	5.227E-7	1150	0.018	0.029	3v0aB.pdb.gz	Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
12	PDB:7zl1A	0.074	0.532	4.702E-6	215	0.017	0.144	7zl1A.pdb.gz
13	PDB:4pbpB	0.065	0.472	1.014E-5	210	0.013	0.110	4pbpB.pdb.gz	Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces.
14	PDB:7qfqA	0.067	0.091	4.469E-5	1291	0.017	0.023	7qfqA.pdb.gz
15	PDB:7ufgA	0.079	0.120	4.469E-5	1151	0.017	0.026	7ufgA.pdb.gz	Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
16	PDB:3o12A	0.055	0.327	9.127E-5	185	0.012	0.114	3o12A.pdb.gz
17	PDB:6l6aA	0.060	0.570	9.127E-5	142	0.008	0.106	6l6aA.pdb.gz	Structures of human galectin-10/monosaccharide complexes demonstrate potential of monosaccharides as effectors in forming Charcot-Leyden crystals.
18	PDB:8a7eC	0.068	0.080	1.137E-4	1524	0.014	0.016	8a7eC.pdb.gz	Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
19	PDB:2a3wA	0.070	0.532	1.201E-4	204	0.013	0.118	2a3wA.pdb.gz	Ligand-assisted Aggregation of Proteins: DIMERIZATION OF SERUM AMYLOID P COMPONENT BY BIVALENT LIGANDS.
20	PDB:1b09A	0.074	0.516	1.341E-4	206	0.017	0.150	1b09A.pdb.gz	The physiological structure of human C-reactive protein and its complex with phosphocholine.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A0G2K069	1389	1736	0.640	0.666	A0A0G2K069_RAT Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=2
2	A0A8I5ZM36	1383	1715	0.639	0.673	A0A8I5ZM36_RAT Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=1
3	A0A8I5ZR92	1153	1676	0.565	0.609	A0A8I5ZR92_RAT Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=1
4	A0A8I5ZY93	1381	1710	0.638	0.674	A0A8I5ZY93_RAT Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=1
5	A0A8I6A1U6	1151	1655	0.566	0.618	A0A8I6A1U6_RAT Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=1
6	A0A8I6AUU9	1375	1689	0.637	0.681	A0A8I6AUU9_RAT Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=1
7	F1R5X4	1436	1721	0.661	0.694	F1R5X4_DANRE Collagen alpha-2(XI) chain isoform X6 OS=Danio rerio OX=7955 GN=col11a1 PE=1 SV=2
8	F6T0B3	1147	1629	0.564	0.625	F6T0B3_RAT Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=2
9	F7EVZ0	1025	1736	0.497	0.517	F7EVZ0_RAT Collagen type V alpha 3 chain OS=Rattus norvegicus OX=10116 GN=Col5a3 PE=4 SV=1
10	O88207	1229	1838	0.640	0.628	CO5A1_MOUSE Collagen alpha-1(V) chain OS=Mus musculus OX=10090 GN=Col5a1 PE=1 SV=2
11	P12107	3391	1806	1.000	1.000	COBA1_HUMAN Collagen alpha-1(XI) chain OS=Homo sapiens OX=9606 GN=COL11A1 PE=1 SV=4
12	P13942	1399	1736	0.647	0.673	COBA2_HUMAN Collagen alpha-2(XI) chain OS=Homo sapiens OX=9606 GN=COL11A2 PE=1 SV=5
13	P20908	1577	1838	0.754	0.741	CO5A1_HUMAN Collagen alpha-1(V) chain OS=Homo sapiens OX=9606 GN=COL5A1 PE=1 SV=3
14	P20909	2423	1804	0.940	0.941	COBA1_RAT Collagen alpha-1(XI) chain OS=Rattus norvegicus OX=10116 GN=Col11a1 PE=1 SV=2
15	P25940	1169	1745	0.562	0.582	CO5A3_HUMAN Collagen alpha-3(V) chain OS=Homo sapiens OX=9606 GN=COL5A3 PE=1 SV=3
16	Q28083	1590	911	0.488	0.968	COBA1_BOVIN Collagen alpha-1(XI) chain (Fragment) OS=Bos taurus OX=9913 GN=COL11A1 PE=1 SV=1
17	Q32S24	1400	1736	0.648	0.675	COBA2_BOVIN Collagen alpha-2(XI) chain OS=Bos taurus OX=9913 GN=COL11A2 PE=3 SV=1
18	Q61245	2466	1804	0.939	0.940	COBA1_MOUSE Collagen alpha-1(XI) chain OS=Mus musculus OX=10090 GN=Col11a1 PE=1 SV=2
19	Q64739	1418	1736	0.637	0.663	COBA2_MOUSE Collagen alpha-2(XI) chain OS=Mus musculus OX=10090 GN=Col11a2 PE=2 SV=3
20	Q6MGB2	1094	1617	0.551	0.616	Q6MGB2_RAT Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01410 COLFI	1.8e-94	327.0	Fibrillar collagen C-terminal domain
2	PF01391 Collagen	6.2e-159	527.2	Collagen triple helix repeat (20 copies)
3	PF00054 Laminin_G_1	32	16.2	Laminin G domain
4	PF02210 Laminin_G_2	0.32	23.0	Laminin G domain
5	PF13385 Laminin_G_3	0.29	22.7	Concanavalin A-like lectin/glucanases superfamily

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000359114

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000369889	0.959	Collagen alpha-1(II) chain
2	9606.ENSP00000297268	0.954	Collagen alpha-2(I) chain
3	9606.ENSP00000251582	0.946	A disintegrin and metalloproteinase with thrombospondin motifs 2
4	9606.ENSP00000266718	0.946	Lumican
5	9606.ENSP00000296585	0.945	Integrin alpha-2
6	9606.ENSP00000223061	0.943	Procollagen C-endopeptidase enhancer 1
7	9606.ENSP00000286657	0.940	A disintegrin and metalloproteinase with thrombospondin motifs 3
8	9606.ENSP00000379350	0.937	Integrin beta-1
9	9606.ENSP00000452786	0.933	Integrin beta-3
10	9606.ENSP00000362304	0.930	A disintegrin and metalloproteinase with thrombospondin motifs 14
11	9606.ENSP00000305714	0.929	Bone morphogenetic protein 1
12	9606.ENSP00000295992	0.927	Procollagen C-endopeptidase enhancer 2
13	9606.ENSP00000261023	0.920	Integrin alpha-V
14	9606.ENSP00000384999	0.920	Prolyl 4-hydroxylase subunit alpha-2
15	9606.ENSP00000061240	0.914	Tolloid-like protein 1
16	9606.ENSP00000401749	0.912	Prolyl 4-hydroxylase subunit alpha-3
17	9606.ENSP00000264828	0.911	Collagen alpha-3(V) chain
18	9606.ENSP00000263556	0.909	Prolyl 4-hydroxylase subunit alpha-1
19	9606.ENSP00000351273	0.909	Caspase-8
20	9606.ENSP00000363840	0.907	Collagen alpha-2(XI) chain

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005198	0.999	structural molecule activity
GO:0008201	0.999	heparin binding
GO:0005201	0.992	extracellular matrix structural constituent
GO:0030020	0.946	extracellular matrix structural constituent conferring tensile strength

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.989	cellular process
GO:0048856	0.987	anatomical structure development
GO:0032501	0.986	multicellular organismal process
GO:0007275	0.930	multicellular organism development
GO:0043062	0.923	extracellular structure organization
GO:0009653	0.913	anatomical structure morphogenesis
GO:0045229	0.910	external encapsulating structure organization
GO:0048513	0.906	animal organ development
GO:0030198	0.896	extracellular matrix organization
GO:0009888	0.803	tissue development
GO:0030199	0.794	collagen fibril organization
GO:0048731	0.583	system development
GO:0065007	0.544	biological regulation
GO:0050789	0.512	regulation of biological process
GO:0050794	0.449	regulation of cellular process
GO:0050896	0.421	response to stimulus
GO:0008152	0.325	metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0062023	0.999	collagen-containing extracellular matrix
GO:0032991	0.995	protein-containing complex
GO:0005576	0.987	extracellular region
GO:0005581	0.984	collagen trimer
GO:0005622	0.981	intracellular anatomical structure
GO:0012505	0.974	endomembrane system
GO:0070013	0.974	intracellular organelle lumen
GO:0043227	0.967	membrane-bounded organelle
GO:0005737	0.965	cytoplasm
GO:0043231	0.944	intracellular membrane-bounded organelle
GO:0005788	0.908	endoplasmic reticulum lumen
GO:0099080	0.748	supramolecular complex
GO:0005615	0.735	extracellular space
GO:0098644	0.734	complex of collagen trimers
GO:0099081	0.662	supramolecular polymer
GO:0099512	0.636	supramolecular fiber
GO:0005583	0.572	fibrillar collagen trimer
GO:0005592	0.378	collagen type XI trimer

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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