StarFunc result for job id P13489

User Input

>input (461 residues)
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A140VJT8	0.999	0.999	7.155E-85	461	1.000	1.000	A0A140VJT8.pdb.gz	A0A140VJT8_HUMAN Ribonuclease inhibitor OS=Homo sapiens OX=9606 PE=2 SV=1
2	PDB:1a4yA	0.989	0.992	2.478E-77	460	0.998	1.000	1a4yA.pdb.gz
3	AFDB:P59046	0.773	0.353	4.431E-38	1061	0.332	0.144	P59046.pdb.gz	NAL12_HUMAN NACHT, LRR and PYD domains-containing protein 12 OS=Homo sapiens OX=9606 GN=NLRP12 PE=1 SV=2
4	AFDB:E9Q5R7	0.822	0.376	3.660E-37	1054	0.315	0.138	E9Q5R7.pdb.gz	NAL12_MOUSE NACHT, LRR and PYD domains-containing protein 12 OS=Mus musculus OX=10090 GN=Nlrp12 PE=1 SV=1
5	AFDB:H0YCR7	0.494	0.798	1.141E-36	285	0.492	0.796	H0YCR7.pdb.gz	H0YCR7_HUMAN Ribonuclease inhibitor (Fragment) OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=1
6	AFDB:Q86W24	0.883	0.386	3.102E-35	1093	0.317	0.134	Q86W24.pdb.gz	NAL14_HUMAN NACHT, LRR and PYD domains-containing protein 14 OS=Homo sapiens OX=9606 GN=NLRP14 PE=1 SV=1
7	AFDB:P59047	0.855	0.346	4.907E-34	1200	0.302	0.116	P59047.pdb.gz	NALP5_HUMAN NACHT, LRR and PYD domains-containing protein 5 OS=Homo sapiens OX=9606 GN=NLRP5 PE=1 SV=2
8	AFDB:F1MT67	0.863	0.376	9.397E-34	1098	0.306	0.128	F1MT67.pdb.gz	F1MT67_BOVIN NLR family pyrin domain containing 5 OS=Bos taurus OX=9913 GN=NLRP5 PE=3 SV=3
9	AFDB:D4A523	0.574	0.284	8.406E-32	1035	0.308	0.137	D4A523.pdb.gz	NLRP3_RAT NACHT, LRR and PYD domains-containing protein 3 OS=Rattus norvegicus OX=10116 GN=Nlrp3 PE=3 SV=2
10	AFDB:Q96P20	0.584	0.285	3.083E-31	1036	0.284	0.126	Q96P20.pdb.gz	NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 OS=Homo sapiens OX=9606 GN=NLRP3 PE=1 SV=3
11	AFDB:Q7RTR0	0.802	0.387	2.547E-30	991	0.273	0.127	Q7RTR0.pdb.gz	NLRP9_HUMAN NACHT, LRR and PYD domains-containing protein 9 OS=Homo sapiens OX=9606 GN=NLRP9 PE=1 SV=1
12	PDB:7pzcA	0.718	0.343	4.133E-23	1010	0.286	0.131	7pzcA.pdb.gz	Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.
13	PDB:7lfhA	0.678	0.406	7.668E-20	806	0.286	0.164	7lfhA.pdb.gz
14	PDB:6npyA	0.635	0.375	9.738E-17	798	0.249	0.144	6npyA.pdb.gz	Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
15	PDB:6o60C	0.474	0.538	5.069E-15	389	0.206	0.244	6o60C.pdb.gz	GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
16	PDB:3oglB	0.592	0.498	2.294E-10	568	0.171	0.139	3oglB.pdb.gz	Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
17	PDB:1k5dC	0.325	0.393	1.297E-9	344	0.148	0.198	1k5dC.pdb.gz	RanGAP mediates GTP hydrolysis without an arginine finger.
18	PDB:7sa1B	0.602	0.468	2.001E-9	624	0.217	0.160	7sa1B.pdb.gz
19	PDB:2p1nB	0.628	0.522	5.597E-9	571	0.145	0.117	2p1nB.pdb.gz	Mechanism of auxin perception by the TIR1 ubiquitin ligase
20	PDB:4kxfP	0.533	0.311	6.950E-9	866	0.171	0.091	4kxfP.pdb.gz	Crystal structure of NLRC4 reveals its autoinhibition mechanism

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A140VJT8	0.0	899	461	1.000	1.000	A0A140VJT8_HUMAN Ribonuclease inhibitor OS=Homo sapiens OX=9606 PE=2 SV=1
2	P13489	0.0	899	461	1.000	1.000	RINI_HUMAN Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2
3	H0YCR7	2.68e-154	441	285	0.492	0.796	H0YCR7_HUMAN Ribonuclease inhibitor (Fragment) OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=1
4	E9PIM9	3.36e-135	389	199	0.432	1.000	E9PIM9_HUMAN Ribonuclease inhibitor (Fragment) OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=1
5	E9PLZ3	4.44e-131	378	194	0.421	1.000	E9PLZ3_HUMAN Ribonuclease inhibitor (Fragment) OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=1
6	E9PMJ3	9.28e-128	370	189	0.410	1.000	E9PMJ3_HUMAN Ribonuclease inhibitor (Fragment) OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=1
7	E9PIK5	1.06e-94	285	181	0.323	0.823	E9PIK5_HUMAN Ribonuclease inhibitor (Fragment) OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=1
8	P59046	8.73e-78	264	1061	0.325	0.141	NAL12_HUMAN NACHT, LRR and PYD domains-containing protein 12 OS=Homo sapiens OX=9606 GN=NLRP12 PE=1 SV=2
9	E9Q5R7	2.16e-67	235	1054	0.310	0.136	NAL12_MOUSE NACHT, LRR and PYD domains-containing protein 12 OS=Mus musculus OX=10090 GN=Nlrp12 PE=1 SV=1
10	Q86W24	4.06e-59	211	1093	0.302	0.127	NAL14_HUMAN NACHT, LRR and PYD domains-containing protein 14 OS=Homo sapiens OX=9606 GN=NLRP14 PE=1 SV=1
11	P59047	4.94e-59	211	1200	0.308	0.118	NALP5_HUMAN NACHT, LRR and PYD domains-containing protein 5 OS=Homo sapiens OX=9606 GN=NLRP5 PE=1 SV=2
12	Q8R4B8	7.46e-59	210	1033	0.258	0.115	NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3 OS=Mus musculus OX=10090 GN=Nlrp3 PE=1 SV=1
13	Q647I9	3.60e-57	206	1098	0.304	0.128	NALP5_BOVIN NACHT, LRR and PYD domains-containing protein 5 OS=Bos taurus OX=9913 GN=NLRP5 PE=2 SV=1
14	D4A523	4.93e-57	205	1035	0.260	0.116	NLRP3_RAT NACHT, LRR and PYD domains-containing protein 3 OS=Rattus norvegicus OX=10116 GN=Nlrp3 PE=3 SV=2
15	Q96P20	1.42e-56	204	1036	0.254	0.113	NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 OS=Homo sapiens OX=9606 GN=NLRP3 PE=1 SV=3
16	F1MT67	6.89e-56	202	1098	0.299	0.126	F1MT67_BOVIN NLR family pyrin domain containing 5 OS=Bos taurus OX=9913 GN=NLRP5 PE=3 SV=3
17	P59045	1.02e-47	178	1033	0.258	0.115	NAL11_HUMAN NACHT, LRR and PYD domains-containing protein 11 OS=Homo sapiens OX=9606 GN=NLRP11 PE=2 SV=2
18	Q9R1M5	1.61e-44	169	1163	0.267	0.106	NALP5_MOUSE NACHT, LRR and PYD domains-containing protein 5 OS=Mus musculus OX=10090 GN=Nlrp5 PE=1 SV=2
19	Q96MN2	7.32e-44	167	994	0.252	0.117	NALP4_HUMAN NACHT, LRR and PYD domains-containing protein 4 OS=Homo sapiens OX=9606 GN=NLRP4 PE=1 SV=3
20	Q7RTR0	8.49e-44	167	991	0.247	0.115	NLRP9_HUMAN NACHT, LRR and PYD domains-containing protein 9 OS=Homo sapiens OX=9606 GN=NLRP9 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00560 LRR_1	0.27	22.7	Leucine Rich Repeat
2	PF12799 LRR_4	8.1e-11	53.2	Leucine Rich repeats (2 copies)
3	PF13516 LRR_6	4.2e-32	118.5	Leucine Rich repeat
4	PF13855 LRR_8	0.0035	28.4	Leucine rich repeat
5	PF18779 LRR_RI_capping	2.6e-14	63.9	Capping Ribonuclease inhibitor Leucine Rich Repeat

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000433999

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000336762	0.999	Angiogenin
2	9606.ENSP00000381057	0.980	Ribonuclease pancreatic
3	9606.ENSP00000425979	0.905	Ribonuclease 3
4	9606.ENSP00000303276	0.848	Non-secretory ribonuclease
5	9606.ENSP00000263209	0.780	Microprocessor complex subunit DGCR8
6	9606.ENSP00000265351	0.761	Exportin-5
7	9606.ENSP00000437256	0.758	Endoribonuclease Dicer
8	9606.ENSP00000356985	0.646	Death effector domain-containing protein
9	9606.ENSP00000308258	0.622	Phosphatidylserine synthase 2
10	9606.ENSP00000220592	0.603	Protein argonaute-2
11	9606.ENSP00000428657	0.537	Baculoviral IAP repeat-containing protein 1
12	9606.ENSP00000362300	0.532	Protein argonaute-1
13	9606.ENSP00000381216	0.505	Far upstream element-binding protein 2
14	9606.ENSP00000266987	0.501	RISC-loading complex subunit TARBP2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0098772	0.995	molecular function regulator activity
GO:0004857	0.990	enzyme inhibitor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050789	0.989	regulation of biological process
GO:0051239	0.973	regulation of multicellular organismal process
GO:0009987	0.795	cellular process
GO:1901342	0.696	regulation of vasculature development
GO:0045765	0.598	regulation of angiogenesis
GO:0048519	0.564	negative regulation of biological process
GO:0050794	0.562	regulation of cellular process
GO:0019222	0.539	regulation of metabolic process
GO:0048518	0.537	positive regulation of biological process
GO:0060255	0.503	regulation of macromolecule metabolic process
GO:0010468	0.416	regulation of gene expression
GO:0050896	0.351	response to stimulus
GO:0048522	0.351	positive regulation of cellular process
GO:0048523	0.303	negative regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0005654	0.999	nucleoplasm
GO:0032991	0.961	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]