StarFunc result for job id P13612

User Input

>input (1032 residues)
MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHS
HGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLE
ERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI
APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLD
KQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGK
KLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVG
SDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEG
LQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVN
RTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGT
SDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQ
PILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLN
VSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDH
LSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHG
FVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLF
NILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNF
LCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVA
HVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRD
SWSYINSKSNDD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:B8JK39	0.852	0.849	0.000	1036	0.410	0.408	B8JK39.pdb.gz	ITA9_MOUSE Integrin alpha-9 OS=Mus musculus OX=10090 GN=Itga9 PE=1 SV=1
2	AFDB:F1Q8T4	0.722	0.722	0.000	1032	0.403	0.403	F1Q8T4.pdb.gz	F1Q8T4_DANRE Integrin alpha-9 OS=Danio rerio OX=7955 GN=zgc:63474 PE=3 SV=2
3	AFDB:P13612	1.000	1.000	0.000	1032	1.000	1.000	P13612.pdb.gz	ITA4_HUMAN Integrin alpha-4 OS=Homo sapiens OX=9606 GN=ITGA4 PE=1 SV=3
4	AFDB:Q00651	0.955	0.949	0.000	1039	0.846	0.840	Q00651.pdb.gz	ITA4_MOUSE Integrin alpha-4 OS=Mus musculus OX=10090 GN=Itga4 PE=1 SV=1
5	AFDB:Q5I2A9	0.717	0.705	1.933E-83	1053	0.250	0.245	Q5I2A9.pdb.gz	Q5I2A9_DANRE Integrin alpha-5 precursor OS=Danio rerio OX=7955 GN=sb:cb665 PE=1 SV=1
6	AFDB:A0A023GU64	0.723	0.706	1.196E-82	1059	0.257	0.250	A0A023GU64.pdb.gz
7	AFDB:P53708	0.735	0.715	3.462E-82	1063	0.257	0.249	P53708.pdb.gz	ITA8_HUMAN Integrin alpha-8 OS=Homo sapiens OX=9606 GN=ITGA8 PE=1 SV=3
8	AFDB:Q24247	0.583	0.536	6.355E-82	1146	0.256	0.230	Q24247.pdb.gz	ITA1_DROME Integrin alpha-PS1 OS=Drosophila melanogaster OX=7227 GN=mew PE=1 SV=2
9	AFDB:A2ARA8	0.738	0.719	8.186E-82	1062	0.258	0.250	A2ARA8.pdb.gz	ITA8_MOUSE Integrin alpha-8 OS=Mus musculus OX=10090 GN=Itga8 PE=1 SV=1
10	AFDB:P08648	0.725	0.714	3.211E-81	1049	0.255	0.251	P08648.pdb.gz	ITA5_HUMAN Integrin alpha-5 OS=Homo sapiens OX=9606 GN=ITGA5 PE=1 SV=2
11	PDB:3fcsA	0.689	0.770	4.199E-74	913	0.229	0.258	3fcsA.pdb.gz	Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
12	PDB:4g1eA	0.699	0.743	1.100E-71	964	0.236	0.253	4g1eA.pdb.gz	AlphaV Beta3 Integrin Crystal Structures and their Functional Implications
13	PDB:7nxdA	0.491	0.553	1.530E-70	905	0.225	0.256	7nxdA.pdb.gz	Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
14	PDB:7uslA	0.591	0.692	1.050E-65	856	0.207	0.250	7uslA.pdb.gz	Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
15	PDB:4nehA	0.575	0.553	7.950E-65	1084	0.231	0.220	4nehA.pdb.gz	An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
16	PDB:4nenA	0.503	0.490	7.382E-62	1063	0.223	0.216	4nenA.pdb.gz	An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
17	PDB:3k6sC	0.551	0.623	2.685E-60	885	0.219	0.255	3k6sC.pdb.gz	Structure of an integrin with an alphaI domain, complement receptor type 4.
18	PDB:5a42A	0.115	0.085	1.329E-9	1597	0.092	0.059	5a42A.pdb.gz
19	PDB:4rtdA	0.089	0.083	8.223E-9	1122	0.079	0.073	4rtdA.pdb.gz
20	PDB:7sqcO0	0.110	0.105	2.045E-8	1140	0.062	0.056	7sqcO0.pdb.gz	Ciliary central apparatus structure reveals mechanisms of microtubule patterning.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A8I5Y1L1	0.0	1758	1022	0.828	0.836	A0A8I5Y1L1_RAT Integrin subunit alpha 4 OS=Rattus norvegicus OX=10116 GN=Itga4 PE=1 SV=1
2	A0A8I6GL49	0.0	761	983	0.393	0.413	A0A8I6GL49_RAT Integrin subunit alpha 9 OS=Rattus norvegicus OX=10116 GN=Itga9 PE=1 SV=1
3	B8JK39	0.0	796	1036	0.410	0.408	ITA9_MOUSE Integrin alpha-9 OS=Mus musculus OX=10090 GN=Itga9 PE=1 SV=1
4	D3ZMQ3	0.0	1810	1036	0.846	0.843	D3ZMQ3_RAT Integrin subunit alpha 4 OS=Rattus norvegicus OX=10116 GN=Itga4 PE=1 SV=1
5	D3ZN51	0.0	792	1036	0.408	0.406	D3ZN51_RAT Integrin subunit alpha 9 OS=Rattus norvegicus OX=10116 GN=Itga9 PE=1 SV=4
6	F1Q8T4	0.0	788	1032	0.406	0.406	F1Q8T4_DANRE Integrin alpha-9 OS=Danio rerio OX=7955 GN=zgc:63474 PE=3 SV=2
7	P13612	0.0	2154	1032	1.000	1.000	ITA4_HUMAN Integrin alpha-4 OS=Homo sapiens OX=9606 GN=ITGA4 PE=1 SV=3
8	Q00651	0.0	1808	1039	0.844	0.838	ITA4_MOUSE Integrin alpha-4 OS=Mus musculus OX=10090 GN=Itga4 PE=1 SV=1
9	Q13797	0.0	795	1035	0.415	0.414	ITA9_HUMAN Integrin alpha-9 OS=Homo sapiens OX=9606 GN=ITGA9 PE=1 SV=2
10	Q91YD5	0.0	792	1036	0.410	0.408	Q91YD5_MOUSE Integrin alpha 9 protein OS=Mus musculus OX=10090 GN=Itga9 PE=2 SV=1
11	B5DEG1	2.56e-86	303	1062	0.250	0.243	B5DEG1_RAT RGD1564327 protein OS=Rattus norvegicus OX=10116 GN=Itga8 PE=2 SV=1
12	P11688	4.11e-85	299	1053	0.253	0.248	ITA5_MOUSE Integrin alpha-5 OS=Mus musculus OX=10090 GN=Itga5 PE=1 SV=3
13	A0A8I5YCC9	2.53e-84	297	1050	0.252	0.248	A0A8I5YCC9_RAT Integrin subunit alpha 5 OS=Rattus norvegicus OX=10116 GN=Itga5 PE=1 SV=1
14	A2ARA8	2.98e-84	297	1062	0.255	0.248	ITA8_MOUSE Integrin alpha-8 OS=Mus musculus OX=10090 GN=Itga8 PE=1 SV=1
15	A0A8I5Y696	3.91e-84	296	1009	0.225	0.230	A0A8I5Y696_RAT Integrin subunit alpha 8 OS=Rattus norvegicus OX=10116 GN=Itga8 PE=1 SV=1
16	A0A8I6A7G7	3.92e-84	296	1044	0.252	0.249	A0A8I6A7G7_RAT Integrin subunit alpha 5 OS=Rattus norvegicus OX=10116 GN=Itga5 PE=1 SV=1
17	P53708	8.22e-84	296	1063	0.245	0.238	ITA8_HUMAN Integrin alpha-8 OS=Homo sapiens OX=9606 GN=ITGA8 PE=1 SV=3
18	F7F1E3	1.03e-81	290	1086	0.250	0.238	F7F1E3_RAT Integrin subunit alpha 8 OS=Rattus norvegicus OX=10116 GN=Itga8 PE=1 SV=1
19	P43406	3.52e-81	288	1044	0.277	0.274	ITAV_MOUSE Integrin alpha-V OS=Mus musculus OX=10090 GN=Itgav PE=1 SV=2
20	A8WHQ7	1.03e-80	287	1071	0.274	0.264	A8WHQ7_DANRE Integrin alpha-6 isoform X2 OS=Danio rerio OX=7955 GN=itga6a PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01345 DUF11	87	15.0	Domain of unknown function DUF11
2	PF01839 FG-GAP	1.9e-17	73.9	FG-GAP repeat
3	PF13517 FG-GAP_3	2.3e-06	39.4	FG-GAP-like repeat
4	PF18698 HisK_sensor	5.4e+02	12.3	Histidine kinase sensor domain
5	PF00357 Integrin_alpha	2.4	19.4	Integrin alpha cytoplasmic region
6	PF08441 Integrin_alpha2	7.2e-93	323.8	Integrin alpha

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000380227

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000267082	0.999	Integrin beta-7
2	9606.ENSP00000267257	0.999	Paxillin
3	9606.ENSP00000294728	0.999	Vascular cell adhesion protein 1
4	9606.ENSP00000346839	0.999	Fibronectin type III domain containing
5	9606.ENSP00000379350	0.999	Integrin beta-1
6	9606.ENSP00000215637	0.995	Mucosal addressin cell adhesion molecule 1
7	9606.ENSP00000379287	0.988	14-3-3 protein zeta/delta
8	9606.ENSP00000452786	0.984	Integrin beta-3
9	9606.ENSP00000380948	0.983	Integrin beta-2
10	9606.ENSP00000324890	0.981	T-cell-specific surface glycoprotein CD28
11	9606.ENSP00000303939	0.973	Cytotoxic T-lymphocyte protein 4
12	9606.ENSP00000377003	0.966	Tetraspanin-8
13	9606.ENSP00000283249	0.965	Integrin beta-6
14	9606.ENSP00000296181	0.961	Integrin beta-5
15	9606.ENSP00000398632	0.960	CD44 antigen
16	9606.ENSP00000265769	0.959	Disintegrin and metalloproteinase domain-containing protein 28
17	9606.ENSP00000222573	0.955	Integrin beta-8
18	9606.ENSP00000299106	0.955	Junctional adhesion molecule C
19	9606.ENSP00000263645	0.954	CD81 antigen
20	9606.ENSP00000264246	0.946	T-lymphocyte activation antigen CD80

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0050839	1.000	cell adhesion molecule binding
GO:0001968	0.995	fibronectin binding
GO:0044877	0.986	protein-containing complex binding
GO:0060089	0.929	molecular transducer activity
GO:0005102	0.922	signaling receptor binding
GO:0038023	0.909	signaling receptor activity
GO:0005178	0.813	integrin binding
GO:0003823	0.789	antigen binding
GO:0019955	0.534	cytokine binding
GO:0015026	0.451	coreceptor activity
GO:0019956	0.450	chemokine binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.998	cellular process
GO:0050794	0.990	regulation of cellular process
GO:0050896	0.988	response to stimulus
GO:0032501	0.985	multicellular organismal process
GO:0032502	0.984	developmental process
GO:0048518	0.981	positive regulation of biological process
GO:0007155	0.967	cell adhesion
GO:0050900	0.960	leukocyte migration
GO:0048856	0.951	anatomical structure development
GO:0048522	0.938	positive regulation of cellular process
GO:0048869	0.928	cellular developmental process
GO:0048731	0.926	system development
GO:0040012	0.886	regulation of locomotion
GO:0030334	0.882	regulation of cell migration
GO:0031589	0.877	cell-substrate adhesion
GO:0098609	0.875	cell-cell adhesion
GO:0030154	0.875	cell differentiation
GO:0009653	0.869	anatomical structure morphogenesis
GO:0051716	0.867	cellular response to stimulus
GO:0042221	0.859	response to chemical
GO:0045123	0.841	cellular extravasation
GO:0002682	0.803	regulation of immune system process
GO:0007160	0.796	cell-matrix adhesion
GO:0007159	0.717	leukocyte cell-cell adhesion
GO:0007154	0.691	cell communication
GO:0023052	0.675	signaling
GO:0051179	0.623	localization
GO:0007165	0.605	signal transduction
GO:0002685	0.598	regulation of leukocyte migration
GO:0048468	0.586	cell development
GO:2000147	0.574	positive regulation of cell motility
GO:0000902	0.563	cell morphogenesis
GO:0030335	0.553	positive regulation of cell migration
GO:0071840	0.544	cellular component organization or biogenesis
GO:0016043	0.512	cellular component organization
GO:0030155	0.502	regulation of cell adhesion
GO:0009888	0.474	tissue development
GO:0002684	0.464	positive regulation of immune system process
GO:0048523	0.427	negative regulation of cellular process
GO:0019222	0.397	regulation of metabolic process
GO:0010941	0.346	regulation of cell death
GO:0048646	0.344	anatomical structure formation involved in morphogenesis
GO:0048583	0.342	regulation of response to stimulus
GO:0009893	0.333	positive regulation of metabolic process
GO:0007166	0.331	cell surface receptor signaling pathway
GO:0002687	0.325	positive regulation of leukocyte migration
GO:0060255	0.324	regulation of macromolecule metabolic process
GO:0006950	0.314	response to stress
GO:0051239	0.311	regulation of multicellular organismal process
GO:0042981	0.311	regulation of apoptotic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	0.999	plasma membrane
GO:0005576	0.997	extracellular region
GO:0043227	0.996	membrane-bounded organelle
GO:0005615	0.977	extracellular space
GO:0032991	0.969	protein-containing complex
GO:0031982	0.958	vesicle
GO:0043235	0.955	receptor complex
GO:0098796	0.949	membrane protein complex
GO:0043230	0.936	extracellular organelle
GO:0098636	0.935	protein complex involved in cell adhesion
GO:0070062	0.931	extracellular exosome
GO:0098802	0.927	plasma membrane signaling receptor complex
GO:0009986	0.917	cell surface
GO:0043229	0.906	intracellular organelle
GO:0043231	0.903	intracellular membrane-bounded organelle
GO:0008305	0.857	integrin complex
GO:0070161	0.831	anchoring junction
GO:0005925	0.676	focal adhesion
GO:0005737	0.627	cytoplasm
GO:0012505	0.499	endomembrane system
GO:0070013	0.342	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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