StarFunc result for job id P13747

User Input

>input (358 residues)
MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND
AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH
GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAY
LEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQ
DGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ
PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P13747	1.000	1.000	6.348E-67	358	1.000	1.000	P13747.pdb.gz	HLAE_HUMAN HLA class I histocompatibility antigen, alpha chain E OS=Homo sapiens OX=9606 GN=HLA-E PE=1 SV=4
2	AFDB:P01889	0.781	0.773	1.669E-54	362	0.765	0.757	P01889.pdb.gz	HLAB_HUMAN HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3
3	AFDB:A0A583ZBW8	0.802	0.785	1.859E-54	366	0.757	0.740	A0A583ZBW8.pdb.gz	A0A583ZBW8_HUMAN HLA-C protein OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1
4	AFDB:P04439	0.795	0.780	2.215E-53	365	0.779	0.764	P04439.pdb.gz	HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2
5	AFDB:P01893	0.786	0.778	1.539E-52	362	0.729	0.721	P01893.pdb.gz	HLAH_HUMAN Putative HLA class I histocompatibility antigen, alpha chain H OS=Homo sapiens OX=9606 GN=HLA-H PE=5 SV=3
6	AFDB:P10321	0.782	0.766	1.539E-52	366	0.737	0.721	P10321.pdb.gz	HLAC_HUMAN HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3
7	AFDB:P17693	0.801	0.847	1.935E-51	338	0.701	0.743	P17693.pdb.gz	HLAG_HUMAN HLA class I histocompatibility antigen, alpha chain G OS=Homo sapiens OX=9606 GN=HLA-G PE=1 SV=1
8	AFDB:Q95476	0.808	0.815	2.069E-50	355	0.682	0.687	Q95476.pdb.gz	Q95476_BOVIN MHC Class I (Fragment) OS=Bos taurus OX=9913 GN=JSP.1 PE=2 SV=1
9	AFDB:P14426	0.822	0.814	2.566E-50	362	0.645	0.638	P14426.pdb.gz	HA13_MOUSE H-2 class I histocompatibility antigen, D-K alpha chain OS=Mus musculus OX=10090 GN=H2-D1 PE=1 SV=1
10	AFDB:P30511	0.799	0.826	4.398E-50	346	0.682	0.705	P30511.pdb.gz	HLAF_HUMAN HLA class I histocompatibility antigen, alpha chain F OS=Homo sapiens OX=9606 GN=HLA-F PE=1 SV=3
11	PDB:5j6hA	0.751	0.973	9.499E-43	275	0.564	0.735	5j6hA.pdb.gz	Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.
12	PDB:6d7gA	0.742	0.690	1.813E-42	386	0.587	0.544	6d7gA.pdb.gz
13	PDB:6e1iA	0.761	0.702	5.928E-42	389	0.561	0.517	6e1iA.pdb.gz
14	PDB:2qriA	0.740	0.667	5.768E-40	398	0.525	0.472	2qriA.pdb.gz
15	PDB:6mp0A	0.749	0.692	6.088E-40	388	0.528	0.487	6mp0A.pdb.gz
16	PDB:3nwmA	0.740	0.691	4.713E-39	384	0.534	0.497	3nwmA.pdb.gz
17	PDB:3es6A	0.602	0.752	7.037E-25	277	0.260	0.336	3es6A.pdb.gz	Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma
18	PDB:6fgbA	0.602	0.785	5.023E-22	265	0.215	0.291	6fgbA.pdb.gz
19	PDB:3ov6A	0.576	0.552	6.225E-18	376	0.182	0.173	3ov6A.pdb.gz	The 2.5 A structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation
20	PDB:1cd1A	0.582	0.734	3.681E-17	273	0.184	0.242	1cd1A.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P01889	0.0	509	362	0.765	0.757	HLAB_HUMAN HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3
2	P01893	0.0	521	362	0.718	0.710	HLAH_HUMAN Putative HLA class I histocompatibility antigen, alpha chain H OS=Homo sapiens OX=9606 GN=HLA-H PE=5 SV=3
3	P04439	0.0	564	365	0.746	0.732	HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2
4	P13747	0.0	741	358	1.000	1.000	HLAE_HUMAN HLA class I histocompatibility antigen, alpha chain E OS=Homo sapiens OX=9606 GN=HLA-E PE=1 SV=4
5	P17693	0.0	524	338	0.718	0.760	HLAG_HUMAN HLA class I histocompatibility antigen, alpha chain G OS=Homo sapiens OX=9606 GN=HLA-G PE=1 SV=1
6	Q53YP1	0.0	514	366	0.679	0.664	Q53YP1_HUMAN HLA class I histocompatibility antigen OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1
7	Q5RIP0	0.0	528	366	0.763	0.746	Q5RIP0_HUMAN HLA class I histocompatibility antigen OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1
8	Q5SUL5	0.0	552	365	0.729	0.715	Q5SUL5_HUMAN HLA class I histocompatibility antigen OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=1
9	A0A583ZBW8	3.34e-180	505	366	0.676	0.661	A0A583ZBW8_HUMAN HLA-C protein OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1
10	P10321	1.75e-177	498	366	0.721	0.705	HLAC_HUMAN HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3
11	Q7YQB1	9.86e-177	496	366	0.654	0.639	Q7YQB1_HUMAN MHC class I antigen OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1
12	Q95476	2.11e-170	480	355	0.651	0.656	Q95476_BOVIN MHC Class I (Fragment) OS=Bos taurus OX=9913 GN=JSP.1 PE=2 SV=1
13	P30511	4.36e-169	476	346	0.670	0.694	HLAF_HUMAN HLA class I histocompatibility antigen, alpha chain F OS=Homo sapiens OX=9606 GN=HLA-F PE=1 SV=3
14	P01897	9.16e-161	456	362	0.617	0.610	HA1L_MOUSE H-2 class I histocompatibility antigen, L-D alpha chain OS=Mus musculus OX=10090 GN=H2-L PE=1 SV=2
15	P06339	9.66e-161	456	357	0.640	0.641	HA15_MOUSE H-2 class I histocompatibility antigen, D-37 alpha chain OS=Mus musculus OX=10090 GN=H2-T23 PE=1 SV=1
16	Q4KN81	1.61e-160	455	360	0.623	0.619	Q4KN81_MOUSE Histocompatibility 2, Q region locus 2 OS=Mus musculus OX=10090 GN=H2-Q2 PE=1 SV=1
17	P01902	5.98e-157	446	368	0.617	0.601	HA1D_MOUSE H-2 class I histocompatibility antigen, K-D alpha chain OS=Mus musculus OX=10090 GN=H2-K1 PE=1 SV=1
18	P01899	2.03e-156	445	362	0.606	0.599	HA11_MOUSE H-2 class I histocompatibility antigen, D-B alpha chain OS=Mus musculus OX=10090 GN=H2-D1 PE=1 SV=2
19	P14426	4.50e-156	444	362	0.615	0.608	HA13_MOUSE H-2 class I histocompatibility antigen, D-K alpha chain OS=Mus musculus OX=10090 GN=H2-D1 PE=1 SV=1
20	P01898	5.28e-156	442	325	0.592	0.652	HA10_MOUSE H-2 class I histocompatibility antigen, Q10 alpha chain OS=Mus musculus OX=10090 GN=H2-Q10 PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF07654 C1-set	6.9e-11	53.7	Immunoglobulin C1-set domain
2	PF08205 C2-set_2	0.16	23.3	CD80-like C2-set immunoglobulin domain
3	PF00047 ig	1.6	20.3	Immunoglobulin domain
4	PF13927 Ig_3	0.13	24.1	Immunoglobulin domain
5	PF00129 MHC_I	2.9e-90	312.1	Class I Histocompatibility antigen, domains alpha 1 and 2
6	PF16497 MHC_I_3	0.018	26.1	MHC-I family domain
7	PF06623 MHC_I_C	0.28	22.3	MHC_I C-terminus

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000365817

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000371327	0.999	NKG2-C type II integral membrane protein
2	9606.ENSP00000371333	0.999	Natural killer cells antigen CD94
3	9606.ENSP00000438038	0.999	NKG2-A/NKG2-B type II integral membrane protein
4	9606.ENSP00000452780	0.999	Beta-2-microglobulin
5	9606.ENSP00000365402	0.977	HLA class I histocompatibility antigen, Cw-7 alpha chain
6	9606.ENSP00000259951	0.976	HLA class I histocompatibility antigen, alpha chain F
7	9606.ENSP00000363976	0.963	HLA class II histocompatibility antigen, DM alpha chain
8	9606.ENSP00000399168	0.962	HLA class I histocompatibility antigen, B-7 alpha chain
9	9606.ENSP00000378786	0.959	HLA class II histocompatibility antigen, DR alpha chain
10	9606.ENSP00000393566	0.953	HLA class II histocompatibility antigen, DP alpha 1 chain
11	9606.ENSP00000229829	0.942	HLA class II histocompatibility antigen, DO alpha chain
12	9606.ENSP00000364016	0.940	Proteasome subunit beta type-8
13	9606.ENSP00000386559	0.940	T-cell surface glycoprotein CD8 alpha chain
14	9606.ENSP00000379873	0.939	HLA class I histocompatibility antigen, A-3 alpha chain
15	9606.ENSP00000437563	0.938	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells
16	9606.ENSP00000354394	0.932	Signal transducer and activator of transcription 1-alpha/beta
17	9606.ENSP00000408146	0.931	HLA class II histocompatibility antigen, DP beta 1 chain
18	9606.ENSP00000245414	0.930	Interferon regulatory factor 1
19	9606.ENSP00000353099	0.927	HLA class II histocompatibility antigen, DRB1-15 beta chain
20	9606.ENSP00000404833	0.925	Tapasin

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0003823	0.999	antigen binding
GO:0042277	0.988	peptide binding
GO:0042605	0.962	peptide antigen binding
GO:0044877	0.622	protein-containing complex binding
GO:0030881	0.528	beta-2-microglobulin binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.995	regulation of cellular process
GO:0048518	0.994	positive regulation of biological process
GO:0002376	0.990	immune system process
GO:0050896	0.989	response to stimulus
GO:0050776	0.986	regulation of immune response
GO:0048522	0.982	positive regulation of cellular process
GO:0002684	0.979	positive regulation of immune system process
GO:0002819	0.978	regulation of adaptive immune response
GO:0009987	0.977	cellular process
GO:0048584	0.977	positive regulation of response to stimulus
GO:0048519	0.973	negative regulation of biological process
GO:0001912	0.970	positive regulation of leukocyte mediated cytotoxicity
GO:0002711	0.970	positive regulation of T cell mediated immunity
GO:0001914	0.968	regulation of T cell mediated cytotoxicity
GO:0006955	0.961	immune response
GO:0019882	0.959	antigen processing and presentation
GO:0048523	0.933	negative regulation of cellular process
GO:0002683	0.927	negative regulation of immune system process
GO:0002831	0.914	regulation of response to biotic stimulus
GO:0048002	0.911	antigen processing and presentation of peptide antigen
GO:0031347	0.908	regulation of defense response
GO:0006950	0.904	response to stress
GO:0045088	0.904	regulation of innate immune response
GO:0002698	0.902	negative regulation of immune effector process
GO:0002704	0.892	negative regulation of leukocyte mediated immunity
GO:0001817	0.873	regulation of cytokine production
GO:0032501	0.865	multicellular organismal process
GO:0002715	0.865	regulation of natural killer cell mediated immunity
GO:0042269	0.864	regulation of natural killer cell mediated cytotoxicity
GO:0050865	0.855	regulation of cell activation
GO:0002694	0.852	regulation of leukocyte activation
GO:0050777	0.828	negative regulation of immune response
GO:0032102	0.826	negative regulation of response to external stimulus
GO:0006952	0.805	defense response
GO:0051249	0.801	regulation of lymphocyte activation
GO:0051240	0.792	positive regulation of multicellular organismal process
GO:0001819	0.780	positive regulation of cytokine production
GO:0032502	0.769	developmental process
GO:0031348	0.766	negative regulation of defense response
GO:0050863	0.766	regulation of T cell activation
GO:0048856	0.764	anatomical structure development
GO:0002707	0.729	negative regulation of lymphocyte mediated immunity
GO:0009605	0.716	response to external stimulus
GO:0050867	0.706	positive regulation of cell activation
GO:0009607	0.700	response to biotic stimulus
GO:0044419	0.699	biological process involved in interspecies interaction between organisms
GO:0045824	0.697	negative regulation of innate immune response
GO:0098542	0.689	defense response to other organism
GO:0002696	0.657	positive regulation of leukocyte activation
GO:0001911	0.656	negative regulation of leukocyte mediated cytotoxicity
GO:0002478	0.653	antigen processing and presentation of exogenous peptide antigen
GO:0051716	0.613	cellular response to stimulus
GO:0002700	0.587	regulation of production of molecular mediator of immune response
GO:0002718	0.552	regulation of cytokine production involved in immune response
GO:0002702	0.522	positive regulation of production of molecular mediator of immune response
GO:0002720	0.505	positive regulation of cytokine production involved in immune response
GO:0007154	0.462	cell communication
GO:0023052	0.461	signaling
GO:0007165	0.430	signal transduction
GO:0051251	0.426	positive regulation of lymphocyte activation
GO:0042127	0.390	regulation of cell population proliferation
GO:1903037	0.388	regulation of leukocyte cell-cell adhesion
GO:0050670	0.368	regulation of lymphocyte proliferation
GO:0001916	0.360	positive regulation of T cell mediated cytotoxicity
GO:0042129	0.334	regulation of T cell proliferation
GO:0007166	0.308	cell surface receptor signaling pathway

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0012505	0.999	endomembrane system
GO:0005886	0.999	plasma membrane
GO:0098588	0.999	bounding membrane of organelle
GO:0030659	0.999	cytoplasmic vesicle membrane
GO:0009986	0.997	cell surface
GO:0031984	0.991	organelle subcompartment
GO:0005783	0.989	endoplasmic reticulum
GO:0005789	0.981	endoplasmic reticulum membrane
GO:0098552	0.975	side of membrane
GO:0030666	0.975	endocytic vesicle membrane
GO:0098553	0.973	lumenal side of endoplasmic reticulum membrane
GO:0030670	0.967	phagocytic vesicle membrane
GO:0098796	0.965	membrane protein complex
GO:0005794	0.951	Golgi apparatus
GO:0030662	0.946	coated vesicle membrane
GO:0012507	0.937	ER to Golgi transport vesicle membrane
GO:0055037	0.930	recycling endosome
GO:0000139	0.930	Golgi membrane
GO:0031901	0.929	early endosome membrane
GO:0055038	0.923	recycling endosome membrane
GO:0005576	0.911	extracellular region
GO:0098797	0.887	plasma membrane protein complex
GO:0042611	0.826	MHC protein complex
GO:0005615	0.698	extracellular space
GO:1903561	0.646	extracellular vesicle
GO:0070062	0.619	extracellular exosome
GO:0009897	0.388	external side of plasma membrane
GO:0005634	0.356	nucleus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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