StarFunc result for job id P13945

User Input

>input (408 residues)
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P13945	1.000	1.000	4.225E-52	408	1.000	1.000	P13945.pdb.gz	ADRB3_HUMAN Beta-3 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB3 PE=1 SV=3
2	AFDB:P25962	0.812	0.828	4.448E-40	400	0.792	0.807	P25962.pdb.gz	ADRB3_MOUSE Beta-3 adrenergic receptor OS=Mus musculus OX=10090 GN=Adrb3 PE=2 SV=2
3	AFDB:P08588	0.740	0.636	5.904E-31	477	0.542	0.463	P08588.pdb.gz	ADRB1_HUMAN Beta-1 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB1 PE=1 SV=3
4	AFDB:P07700	0.735	0.624	2.491E-29	483	0.471	0.398	P07700.pdb.gz	ADRB1_MELGA Beta-1 adrenergic receptor OS=Meleagris gallopavo OX=9103 GN=ADRB1 PE=1 SV=1
5	AFDB:P10608	0.734	0.717	1.013E-28	418	0.444	0.433	P10608.pdb.gz	ADRB2_RAT Beta-2 adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adrb2 PE=1 SV=1
6	AFDB:P07550	0.734	0.726	2.812E-28	413	0.439	0.433	P07550.pdb.gz	ADRB2_HUMAN Beta-2 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB2 PE=1 SV=3
7	AFDB:Q8UUY8	0.729	0.728	9.249E-28	409	0.444	0.443	Q8UUY8.pdb.gz	ADRB2_ONCMY Beta-2 adrenergic receptor OS=Oncorhynchus mykiss OX=8022 GN=adrb2 PE=2 SV=1
8	AFDB:A0A2R8QNL3	0.716	0.714	4.097E-27	409	0.424	0.423	A0A2R8QNL3.pdb.gz
9	AFDB:B3DHM6	0.696	0.727	6.268E-27	390	0.439	0.459	B3DHM6.pdb.gz	B3DHM6_DANRE Adrenergic, beta-1-, receptor OS=Danio rerio OX=7955 GN=zgc:194728 PE=2 SV=1
10	AFDB:E7EYN4	0.723	0.728	2.776E-26	405	0.400	0.402	E7EYN4.pdb.gz
11	PDB:6iblA	0.645	0.662	4.020E-24	397	0.414	0.426	6iblA.pdb.gz	Molecular basis of beta-arrestin coupling to formoterol-bound beta1-adrenoceptor.
12	PDB:5d5aA	0.685	0.633	3.348E-22	442	0.407	0.376	5d5aA.pdb.gz	In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.
13	PDB:4ldeA	0.623	0.562	6.336E-22	454	0.377	0.339	4ldeA.pdb.gz	Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
14	PDB:7jvqR	0.620	0.869	2.979E-17	286	0.250	0.357	7jvqR.pdb.gz	Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
15	PDB:7xt8R	0.618	0.844	3.821E-16	294	0.257	0.357	7xt8R.pdb.gz	GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
16	PDB:7xtbR	0.596	0.854	5.335E-15	278	0.255	0.374	7xtbR.pdb.gz	GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
17	PDB:7e2xR	0.599	0.861	6.886E-15	278	0.255	0.374	7e2xR.pdb.gz	Structural insights into the lipid and ligand regulation of serotonin receptors.
18	PDB:7cmuR	0.591	0.866	8.163E-15	272	0.267	0.401	7cmuR.pdb.gz	Structures of the human dopamine D3 receptor-G i complexes.
19	PDB:7e32R	0.589	0.829	1.197E-14	285	0.243	0.347	7e32R.pdb.gz	Structural insights into the lipid and ligand regulation of serotonin receptors.
20	PDB:7jvrR	0.588	0.870	2.080E-14	269	0.238	0.361	7jvrR.pdb.gz	Structural insights into the human D1 and D2 dopamine receptor signaling complexes.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P13945	0.0	796	408	1.000	1.000	ADRB3_HUMAN Beta-3 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB3 PE=1 SV=3
2	P25962	0.0	566	400	0.792	0.807	ADRB3_MOUSE Beta-3 adrenergic receptor OS=Mus musculus OX=10090 GN=Adrb3 PE=2 SV=2
3	P26255	0.0	539	400	0.787	0.802	ADRB3_RAT Beta-3 adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adrb3 PE=2 SV=2
4	P07700	1.43e-114	345	483	0.458	0.387	ADRB1_MELGA Beta-1 adrenergic receptor OS=Meleagris gallopavo OX=9103 GN=ADRB1 PE=1 SV=1
5	G1NEX5	2.09e-114	343	457	0.458	0.409	G1NEX5_MELGA Adrenoceptor beta 1 OS=Meleagris gallopavo OX=9103 GN=ADRB1 PE=3 SV=3
6	P10608	1.49e-111	335	418	0.434	0.423	ADRB2_RAT Beta-2 adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adrb2 PE=1 SV=1
7	P34971	2.89e-111	336	466	0.441	0.386	ADRB1_MOUSE Beta-1 adrenergic receptor OS=Mus musculus OX=10090 GN=Adrb1 PE=1 SV=2
8	P08588	3.29e-111	336	477	0.461	0.394	ADRB1_HUMAN Beta-1 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB1 PE=1 SV=3
9	P18090	7.75e-111	335	466	0.431	0.378	ADRB1_RAT Beta-1 adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adrb1 PE=1 SV=1
10	P07550	2.43e-110	332	413	0.400	0.395	ADRB2_HUMAN Beta-2 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB2 PE=1 SV=3
11	P18762	4.45e-110	331	418	0.444	0.433	ADRB2_MOUSE Beta-2 adrenergic receptor OS=Mus musculus OX=10090 GN=Adrb2 PE=1 SV=2
12	B3DHM6	1.40e-109	329	390	0.422	0.441	B3DHM6_DANRE Adrenergic, beta-1-, receptor OS=Danio rerio OX=7955 GN=zgc:194728 PE=2 SV=1
13	A0A060YAV5	9.96e-108	324	393	0.422	0.438	A0A060YAV5_ONCMY G-protein coupled receptors family 1 profile domain-containing protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00036180001 PE=3 SV=1
14	I7GPU6	3.81e-102	310	405	0.395	0.398	I7GPU6_DANRE Beta-2 adrenergic receptor OS=Danio rerio OX=7955 GN=adrb2a PE=2 SV=1
15	A0A060XC03	1.76e-101	308	401	0.429	0.436	A0A060XC03_ONCMY Beta-2 adrenergic receptor OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00012903001 PE=3 SV=1
16	A0A060Y644	1.10e-100	307	408	0.426	0.426	A0A060Y644_ONCMY Adrenoceptor beta 2, surface b OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00054169001 PE=3 SV=1
17	Q8UUY8	1.06e-99	304	409	0.426	0.425	ADRB2_ONCMY Beta-2 adrenergic receptor OS=Oncorhynchus mykiss OX=8022 GN=adrb2 PE=2 SV=1
18	A4QNV7	2.92e-98	301	409	0.395	0.394	A4QNV7_DANRE Beta-2 adrenergic receptor OS=Danio rerio OX=7955 GN=zgc:162188 PE=2 SV=1
19	P18841	2.64e-62	211	515	0.331	0.262	ADA1B_MESAU Alpha-1B adrenergic receptor OS=Mesocricetus auratus OX=10036 GN=ADRA1B PE=1 SV=1
20	P15823	3.69e-62	210	515	0.331	0.262	ADA1B_RAT Alpha-1B adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adra1b PE=2 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00001 7tm_1	7.5e-68	240.2	7 transmembrane receptor (rhodopsin family)
2	PF13853 7tm_4	0.17	23.2	Olfactory receptor
3	PF10320 7TM_GPCR_Srsx	2.9e-05	35.2	Serpentine type 7TM GPCR chemoreceptor Srsx
4	PF10323 7TM_GPCR_Srv	2.3e+02	12.5	Serpentine type 7TM GPCR chemoreceptor Srv
5	PF10328 7TM_GPCR_Srx	1.5	20.0	Serpentine type 7TM GPCR chemoreceptor Srx

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000343782

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000360141	0.923	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
2	9606.ENSP00000262999	0.877	Mitochondrial brown fat uncoupling protein 1
3	9606.ENSP00000362680	0.871	Proto-oncogene tyrosine-protein kinase Src
4	9606.ENSP00000305372	0.848	Beta-2 adrenergic receptor
5	9606.ENSP00000312999	0.831	Guanine nucleotide-binding protein G(i) subunit alpha-2
6	9606.ENSP00000343027	0.830	Guanine nucleotide-binding protein G(i) subunit alpha-1
7	9606.ENSP00000358867	0.827	Guanine nucleotide-binding protein G(k) subunit alpha
8	9606.ENSP00000358301	0.811	Beta-1 adrenergic receptor
9	9606.ENSP00000244289	0.776	Hormone-sensitive lipase
10	9606.ENSP00000334051	0.724	Guanine nucleotide-binding protein G(olf) subunit alpha
11	9606.ENSP00000270722	0.719	PR domain zinc finger protein 16
12	9606.ENSP00000471477	0.716	Fibroblast growth factor 21
13	9606.ENSP00000264867	0.708	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
14	9606.ENSP00000320209	0.706	Cell death activator CIDE-A
15	9606.ENSP00000312652	0.689	Leptin
16	9606.ENSP00000450980	0.688	Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine)
17	9606.ENSP00000287820	0.686	Peroxisome proliferator-activated receptor gamma
18	9606.ENSP00000380432	0.681	Insulin
19	9606.ENSP00000337701	0.647	Patatin-like phospholipase domain-containing protein 2
20	9606.ENSP00000389814	0.645	Adiponectin

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004930	1.000	G protein-coupled receptor activity
GO:0043169	0.999	cation binding
GO:0005515	0.998	protein binding
GO:1901338	0.996	catecholamine binding
GO:0008227	0.988	G protein-coupled amine receptor activity
GO:0042802	0.830	identical protein binding
GO:0004935	0.799	adrenergic receptor activity
GO:0046983	0.693	protein dimerization activity
GO:1901363	0.364	heterocyclic compound binding
GO:0005102	0.319	signaling receptor binding
GO:0001664	0.312	G protein-coupled receptor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.999	regulation of cellular process
GO:0051716	0.995	cellular response to stimulus
GO:0007186	0.986	G protein-coupled receptor signaling pathway
GO:0008152	0.758	metabolic process
GO:0048518	0.713	positive regulation of biological process
GO:0048522	0.695	positive regulation of cellular process
GO:0007188	0.673	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0044237	0.659	cellular metabolic process
GO:0071704	0.574	organic substance metabolic process
GO:0032501	0.504	multicellular organismal process
GO:0048583	0.504	regulation of response to stimulus
GO:0044238	0.498	primary metabolic process
GO:0065009	0.479	regulation of molecular function
GO:0010646	0.467	regulation of cell communication
GO:0023051	0.456	regulation of signaling
GO:0019222	0.450	regulation of metabolic process
GO:0050790	0.416	regulation of catalytic activity
GO:0048519	0.378	negative regulation of biological process
GO:0032502	0.372	developmental process
GO:0044093	0.325	positive regulation of molecular function
GO:0009893	0.320	positive regulation of metabolic process
GO:0051239	0.315	regulation of multicellular organismal process
GO:0009966	0.315	regulation of signal transduction
GO:0042221	0.301	response to chemical

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	0.998	plasma membrane
GO:0043226	0.993	organelle
GO:0005622	0.993	intracellular anatomical structure
GO:0043227	0.967	membrane-bounded organelle
GO:0043231	0.963	intracellular membrane-bounded organelle
GO:0032991	0.962	protein-containing complex
GO:0005737	0.949	cytoplasm
GO:0005634	0.661	nucleus
GO:0012505	0.450	endomembrane system

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]