StarFunc result for job id P14406

User Input

>input (83 residues)
MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMI
LTVGGTAYAIYELAVASFPKKQE

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P14406	1.000	1.000	3.358E-13	83	1.000	1.000	P14406.pdb.gz	CX7A2_HUMAN Cytochrome c oxidase subunit 7A2, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A2 PE=1 SV=1
2	AFDB:P48771	0.914	0.914	3.412E-11	83	0.807	0.807	P48771.pdb.gz	CX7A2_MOUSE Cytochrome c oxidase subunit 7A2, mitochondrial OS=Mus musculus OX=10090 GN=Cox7a2 PE=1 SV=2
3	AFDB:P24310	0.804	0.842	1.520E-7	79	0.494	0.519	P24310.pdb.gz	CX7A1_HUMAN Cytochrome c oxidase subunit 7A1, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A1 PE=1 SV=2
4	AFDB:P07470	0.695	0.719	2.482E-7	80	0.470	0.487	P07470.pdb.gz	CX7A1_BOVIN Cytochrome c oxidase subunit 7A1, mitochondrial OS=Bos taurus OX=9913 GN=COX7A1 PE=1 SV=2
5	AFDB:P56392	0.692	0.716	2.855E-7	80	0.482	0.500	P56392.pdb.gz	CX7A1_MOUSE Cytochrome c oxidase subunit 7A1, mitochondrial OS=Mus musculus OX=10090 GN=Cox7a1 PE=1 SV=1
6	PDB:2y69J	0.664	0.953	5.665E-6	57	0.410	0.596	2y69J.pdb.gz	A Combined Quantum Chemical and Crystallographic Study on the Oxidized Binuclear Center of Cytochrome C Oxidase.
7	AFDB:O14548	0.707	0.528	6.215E-6	114	0.434	0.316	O14548.pdb.gz	COX7R_HUMAN Cytochrome c oxidase subunit 7A-related protein, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A2L PE=1 SV=2
8	AFDB:Q9VHS2	0.480	0.453	4.181E-3	89	0.349	0.326	Q9VHS2.pdb.gz	COX7A_DROME Cytochrome c oxidase subunit 7A, mitochondrial OS=Drosophila melanogaster OX=7227 GN=COX7A PE=3 SV=1
9	PDB:6hu9g	0.431	0.550	2.728E-1	59	0.217	0.305	6hu9g.pdb.gz	Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1.
10	AFDB:P10174	0.437	0.550	8.556E-1	60	0.217	0.300	P10174.pdb.gz	COX7_YEAST Cytochrome c oxidase subunit 7, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=COX7 PE=1 SV=3
11	AFDB:Q9V392	0.341	0.082	3.992	377	0.157	0.034	Q9V392.pdb.gz	Q9V392_DROME FI01909p OS=Drosophila melanogaster OX=7227 GN=NimC4 PE=2 SV=1
12	AFDB:Q8IHM2	0.356	0.097	6.077	338	0.145	0.036	Q8IHM2.pdb.gz	Q8IHM2_PLAF7 Rifin OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1150200 PE=4 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P14406	1.00e-56	171	83	1.000	1.000	CX7A2_HUMAN Cytochrome c oxidase subunit 7A2, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A2 PE=1 SV=1
2	P48771	1.09e-45	142	83	0.807	0.807	CX7A2_MOUSE Cytochrome c oxidase subunit 7A2, mitochondrial OS=Mus musculus OX=10090 GN=Cox7a2 PE=1 SV=2
3	P24310	1.46e-27	97.1	79	0.482	0.506	CX7A1_HUMAN Cytochrome c oxidase subunit 7A1, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A1 PE=1 SV=2
4	P56392	1.18e-25	92.4	80	0.470	0.487	CX7A1_MOUSE Cytochrome c oxidase subunit 7A1, mitochondrial OS=Mus musculus OX=10090 GN=Cox7a1 PE=1 SV=1
5	P07470	1.13e-24	89.7	80	0.458	0.475	CX7A1_BOVIN Cytochrome c oxidase subunit 7A1, mitochondrial OS=Bos taurus OX=9913 GN=COX7A1 PE=1 SV=2
6	O14548	6.16e-17	71.2	114	0.410	0.298	COX7R_HUMAN Cytochrome c oxidase subunit 7A-related protein, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A2L PE=1 SV=2
7	Q6FGA0	6.16e-17	71.2	114	0.410	0.298	Q6FGA0_HUMAN COX7A2L protein OS=Homo sapiens OX=9606 GN=COX7A2L PE=2 SV=1
8	Q61387	6.64e-12	58.2	111	0.361	0.270	COX7R_MOUSE Cytochrome c oxidase subunit 7A-related protein, mitochondrial OS=Mus musculus OX=10090 GN=Cox7a2l PE=1 SV=1
9	Q9VHS2	1.70e-06	43.9	89	0.289	0.270	COX7A_DROME Cytochrome c oxidase subunit 7A, mitochondrial OS=Drosophila melanogaster OX=7227 GN=COX7A PE=3 SV=1
10	Q04430	1.3	29.3	367	0.133	0.030	PANK_YEAST Pantothenate kinase CAB1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CAB1 PE=1 SV=1
11	O07750	2.6	28.1	140	0.181	0.107	LPPE_MYCTU Probable lipoprotein LppE OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=lppE PE=1 SV=2
12	Q57W59	2.6	28.5	628	0.157	0.021	Q57W59_TRYB2 Choline/ethanolamine kinase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb05.28F8.30 PE=4 SV=1
13	Q7K6A5	2.6	28.5	1419	0.193	0.011	Q7K6A5_PLAF7 Multidrug resistance protein 1 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0523000 PE=4 SV=1
14	Q38BG3	3.5	28.1	450	0.217	0.040	Q38BG3_TRYB2 Expression site-associated gene (ESAG) protein, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.70.2860 PE=4 SV=1
15	H0YBD2	5.4	26.9	95	0.133	0.116	H0YBD2_HUMAN Cytochrome c oxidase subunit 7A2 like (Fragment) OS=Homo sapiens OX=9606 GN=COX7A2L PE=1 SV=1
16	G5ED03	6.6	27.3	844	0.169	0.017	G5ED03_CAEEL Putative Rho guanine nucleotide exchange factor FGD-1 OS=Caenorhabditis elegans OX=6239 GN=fgd-1 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02238 COX7a	1.1e-07	43.5	Cytochrome c oxidase subunit VII

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000359098

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000354876	0.999	Cytochrome c oxidase subunit 2
2	9606.ENSP00000425759	0.998	Cytochrome c oxidase subunit 7C, mitochondrial
3	9606.ENSP00000428895	0.994	Cytochrome c oxidase subunit 6C
4	9606.ENSP00000339720	0.991	Cytochrome c oxidase subunit NDUFA4
5	9606.ENSP00000243997	0.987	ATP synthase subunit epsilon, mitochondrial
6	9606.ENSP00000229379	0.986	Cytochrome c oxidase subunit 6A1, mitochondrial
7	9606.ENSP00000321260	0.986	Cytochrome c oxidase subunit 8A, mitochondrial
8	9606.ENSP00000367939	0.986	Cytochrome b-c1 complex subunit 8
9	9606.ENSP00000246554	0.982	Cytochrome c oxidase subunit 6B1
10	9606.ENSP00000258424	0.981	Cytochrome c oxidase subunit 5B, mitochondrial
11	9606.ENSP00000317780	0.972	Cytochrome c oxidase subunit 5A, mitochondrial
12	9606.ENSP00000252102	0.970	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
13	9606.ENSP00000457513	0.968	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
14	9606.ENSP00000309565	0.953	Cytochrome b-c1 complex subunit 6, mitochondrial
15	9606.ENSP00000418842	0.953	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
16	9606.ENSP00000301587	0.950	ATP synthase subunit d, mitochondrial
17	9606.ENSP00000417142	0.950	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
18	9606.ENSP00000417656	0.950	Cytochrome c oxidase subunit 7B, mitochondrial
19	9606.ENSP00000292475	0.946	ATP synthase subunit f, mitochondrial
20	9606.ENSP00000300688	0.943	ATP synthase subunit g, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0003824	0.798	catalytic activity
GO:0016491	0.668	oxidoreductase activity
GO:0022857	0.655	transmembrane transporter activity
GO:0015453	0.406	oxidoreduction-driven active transmembrane transporter activity
GO:0008324	0.401	monoatomic cation transmembrane transporter activity
GO:0022890	0.387	inorganic cation transmembrane transporter activity
GO:0009055	0.373	electron transfer activity
GO:0004129	0.342	cytochrome-c oxidase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.994	cellular process
GO:0044237	0.979	cellular metabolic process
GO:0006091	0.938	generation of precursor metabolites and energy

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0032991	0.998	protein-containing complex
GO:0019866	0.995	organelle inner membrane
GO:0031966	0.995	mitochondrial membrane
GO:0005743	0.994	mitochondrial inner membrane
GO:0098803	0.967	respiratory chain complex
GO:1902494	0.959	catalytic complex
GO:0098800	0.958	inner mitochondrial membrane protein complex
GO:0005746	0.955	mitochondrial respirasome
GO:0070069	0.924	cytochrome complex
GO:0045277	0.846	respiratory chain complex IV
GO:0005751	0.719	mitochondrial respiratory chain complex IV

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.-.-.-	0.668	Oxidoreductases.
EC:7.-.-.-	0.406	Translocases.
RHEA:11436	0.342	4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O
EC:7.1.1.9	0.342	cytochrome-c oxidase.

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