StarFunc result for job id P14735

User Input

>input (1019 residues)
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:2g49A	0.949	0.997	0.000	970	0.949	0.997	2g49A.pdb.gz	Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
2	PDB:4iofA	0.907	0.992	0.000	932	0.902	0.986	4iofA.pdb.gz	Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
3	PDB:4iofB	0.813	0.959	0.000	861	0.834	0.987	4iofB.pdb.gz	Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
4	AFDB:A0A0R4IL71	0.962	0.983	0.000	998	0.858	0.876	A0A0R4IL71.pdb.gz	A0A0R4IL71_DANRE Insulin-degrading enzyme OS=Danio rerio OX=7955 GN=CH211-129M12.3 PE=1 SV=1
5	AFDB:P14735	1.000	1.000	0.000	1019	1.000	1.000	P14735.pdb.gz	IDE_HUMAN Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4
6	AFDB:P22817	0.922	0.949	0.000	990	0.443	0.456	P22817.pdb.gz	IDE_DROME Insulin-degrading enzyme OS=Drosophila melanogaster OX=7227 GN=Ide PE=1 SV=4
7	AFDB:O14077	0.911	0.958	2.256E-98	969	0.349	0.367	O14077.pdb.gz	MU138_SCHPO Putative zinc protease mug138 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mug138 PE=1 SV=1
8	AFDB:Q06010	0.911	0.905	2.042E-97	1027	0.373	0.370	Q06010.pdb.gz	STE23_YEAST A-factor-processing enzyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=STE23 PE=1 SV=2
9	AFDB:O22941	0.896	0.940	2.722E-97	970	0.358	0.376	O22941.pdb.gz	IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal OS=Arabidopsis thaliana OX=3702 GN=PXM16 PE=2 SV=1
10	AFDB:A0A1D8PQ06	0.919	0.871	1.505E-92	1077	0.361	0.342	A0A1D8PQ06.pdb.gz	A0A1D8PQ06_CANAL Metalloendopeptidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=STE23 PE=4 SV=1
11	AFDB:P47245	0.895	0.787	5.692E-89	1161	0.332	0.291	P47245.pdb.gz	NRDC_RAT Nardilysin OS=Rattus norvegicus OX=10116 GN=Nrdc PE=1 SV=1
12	AFDB:F4HNU6	0.889	0.885	1.409E-87	1024	0.340	0.338	F4HNU6.pdb.gz	NRDC_ARATH Nardilysin-like OS=Arabidopsis thaliana OX=3702 GN=At1g06900 PE=2 SV=1
13	AFDB:Q7MIS6	0.736	0.801	3.784E-82	925	0.290	0.320	Q7MIS6.pdb.gz	Q7MIS6_VIBVY Protease 3 OS=Vibrio vulnificus (strain YJ016) OX=196600 GN=VV2439 PE=1 SV=1
14	PDB:1q2lA	0.528	0.567	2.870E-73	937	0.247	0.269	1q2lA.pdb.gz	Crystal Structure of pitrilysin, the prototype of insulin-degrading enzymes
15	PDB:6ofsA	0.371	0.414	3.169E-34	905	0.138	0.156	6ofsA.pdb.gz	Protease-associated import systems are widespread in Gram-negative bacteria.
16	PDB:6xovA	0.642	0.673	8.993E-31	966	0.135	0.143	6xovA.pdb.gz	Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
17	PDB:2fgeA	0.634	0.657	5.291E-30	979	0.150	0.156	2fgeA.pdb.gz	The closed structure of presequence protease PreP forms a unique 10 000 A(3) chamber for proteolysis
18	PDB:4rpuA	0.630	0.648	1.253E-29	988	0.135	0.140	4rpuA.pdb.gz	Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60
19	PDB:3s5mA	0.607	0.571	3.401E-27	1094	0.143	0.133	3s5mA.pdb.gz	Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum
20	PDB:7diaA	0.614	0.587	8.420E-26	1072	0.128	0.121	7diaA.pdb.gz	Protease in complex with inhibitor

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0R4IL71	0.0	1869	998	0.857	0.875	A0A0R4IL71_DANRE Insulin-degrading enzyme OS=Danio rerio OX=7955 GN=CH211-129M12.3 PE=1 SV=1
2	A0A1D8PQ06	0.0	629	1077	0.359	0.340	A0A1D8PQ06_CANAL Metalloendopeptidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=STE23 PE=4 SV=1
3	A4QP10	0.0	1866	978	0.857	0.893	A4QP10_DANRE Insulin-degrading enzyme OS=Danio rerio OX=7955 GN=ide PE=1 SV=1
4	F4HNU6	0.0	584	1024	0.324	0.322	NRDC_ARATH Nardilysin-like OS=Arabidopsis thaliana OX=3702 GN=At1g06900 PE=2 SV=1
5	O14077	0.0	654	969	0.355	0.374	MU138_SCHPO Putative zinc protease mug138 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mug138 PE=1 SV=1
6	O22941	0.0	694	970	0.363	0.381	IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal OS=Arabidopsis thaliana OX=3702 GN=PXM16 PE=2 SV=1
7	P14735	0.0	2120	1019	1.000	1.000	IDE_HUMAN Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4
8	P22817	0.0	936	990	0.443	0.456	IDE_DROME Insulin-degrading enzyme OS=Drosophila melanogaster OX=7227 GN=Ide PE=1 SV=4
9	P35559	0.0	2031	1019	0.955	0.955	IDE_RAT Insulin-degrading enzyme OS=Rattus norvegicus OX=10116 GN=Ide PE=1 SV=1
10	Q06010	0.0	714	1027	0.366	0.363	STE23_YEAST A-factor-processing enzyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=STE23 PE=1 SV=2
11	Q9JHR7	0.0	2024	1019	0.950	0.950	IDE_MOUSE Insulin-degrading enzyme OS=Mus musculus OX=10090 GN=Ide PE=1 SV=1
12	O43847	1.11e-174	543	1151	0.304	0.269	NRDC_HUMAN Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3
13	Q8BHG1	1.37e-173	540	1161	0.316	0.277	NRDC_MOUSE Nardilysin OS=Mus musculus OX=10090 GN=Nrdc PE=1 SV=1
14	P47245	1.67e-173	540	1161	0.316	0.277	NRDC_RAT Nardilysin OS=Rattus norvegicus OX=10116 GN=Nrdc PE=1 SV=1
15	Q7MIS6	6.36e-157	489	925	0.287	0.316	Q7MIS6_VIBVY Protease 3 OS=Vibrio vulnificus (strain YJ016) OX=196600 GN=VV2439 PE=1 SV=1
16	Q9VYT3	8.79e-115	383	1147	0.278	0.247	Q9VYT3_DROME FI23714p1 OS=Drosophila melanogaster OX=7227 GN=Nrd1 PE=1 SV=2
17	P05458	8.43e-107	357	962	0.243	0.258	PTRA_ECOLI Protease 3 OS=Escherichia coli (strain K12) OX=83333 GN=ptrA PE=1 SV=1
18	Q57YQ9	8.84e-58	219	1064	0.109	0.104	Q57YQ9_TRYB2 Peptidase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.10K10.800 PE=3 SV=1
19	P40851	1.39e-49	194	1208	0.229	0.193	AXL1_YEAST Putative protease AXL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=AXL1 PE=1 SV=2
20	Q4W6B5	2.96e-10	66.2	469	0.042	0.092	MPPB_DICDI Mitochondrial-processing peptidase subunit beta OS=Dictyostelium discoideum OX=44689 GN=mppB PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00675 Peptidase_M16	4.6e-44	161.5	Insulinase (Peptidase family M16)
2	PF05193 Peptidase_M16_C	4.1e-37	139.5	Peptidase M16 inactive domain
3	PF16187 Peptidase_M16_M	6.9e-103	355.4	Middle or third domain of peptidase_M16
4	PF09035 Tn916-Xis	1.9e+02	13.7	Excisionase from transposon Tn916

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000265986

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000380432	0.999	Insulin
2	9606.ENSP00000284981	0.989	Amyloid-beta A4 protein
3	9606.ENSP00000240652	0.987	Islet amyloid polypeptide
4	9606.ENSP00000202967	0.985	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
5	9606.ENSP00000387662	0.975	Glucagon
6	9606.ENSP00000441543	0.954	Polyubiquitin-C
7	9606.ENSP00000477908	0.935	C-C motif chemokine 3
8	9606.ENSP00000285737	0.931	Lon protease homolog 2, peroxisomal
9	9606.ENSP00000241052	0.926	Catalase
10	9606.ENSP00000369461	0.924	Enoyl-CoA delta isomerase 2, mitochondrial
11	9606.ENSP00000360569	0.922	Non-specific lipid-transfer protein
12	9606.ENSP00000287078	0.916	Peroxisomal leader peptide-processing protease
13	9606.ENSP00000430269	0.913	Bifunctional epoxide hydrolase 2
14	9606.ENSP00000323811	0.912	2-hydroxyacyl-CoA lyase 1
15	9606.ENSP00000265333	0.909	Voltage-dependent anion-selective channel protein 1
16	9606.ENSP00000228476	0.907	D-amino-acid oxidase
17	9606.ENSP00000264198	0.907	Mitochondrial ubiquitin ligase activator of NFKB 1
18	9606.ENSP00000327251	0.907	Nitric oxide synthase, inducible
19	9606.ENSP00000476767	0.907	Peptidyl-prolyl cis-trans isomerase FKBP8
20	9606.ENSP00000262430	0.906	Malonyl-CoA decarboxylase, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.998	protein binding
GO:0004222	0.997	metalloendopeptidase activity
GO:0008270	0.979	zinc ion binding
GO:0042802	0.976	identical protein binding
GO:0042562	0.955	hormone binding
GO:0097159	0.952	organic cyclic compound binding
GO:1901363	0.944	heterocyclic compound binding
GO:0033218	0.927	amide binding
GO:0017046	0.922	peptide hormone binding
GO:0005524	0.919	ATP binding
GO:0043559	0.722	insulin binding
GO:0042803	0.640	protein homodimerization activity
GO:0140035	0.629	ubiquitination-like modification-dependent protein binding
GO:0140036	0.316	ubiquitin-dependent protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.993	cellular process
GO:0071704	0.991	organic substance metabolic process
GO:0044238	0.990	primary metabolic process
GO:0044237	0.980	cellular metabolic process
GO:0019538	0.959	protein metabolic process
GO:0050789	0.956	regulation of biological process
GO:0032501	0.944	multicellular organismal process
GO:0009056	0.630	catabolic process
GO:0050794	0.581	regulation of cellular process
GO:1901575	0.570	organic substance catabolic process
GO:0019222	0.499	regulation of metabolic process
GO:0080090	0.459	regulation of primary metabolic process
GO:0060255	0.451	regulation of macromolecule metabolic process
GO:0048518	0.387	positive regulation of biological process
GO:0051171	0.386	regulation of nitrogen compound metabolic process
GO:0048519	0.368	negative regulation of biological process
GO:0051246	0.345	regulation of protein metabolic process
GO:0044248	0.344	cellular catabolic process
GO:0050896	0.327	response to stimulus
GO:0048522	0.300	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0070013	0.999	intracellular organelle lumen
GO:0005739	0.997	mitochondrion
GO:0005615	0.996	extracellular space
GO:0012505	0.994	endomembrane system
GO:0032991	0.977	protein-containing complex
GO:0005829	0.976	cytosol
GO:0016020	0.966	membrane
GO:0005634	0.954	nucleus
GO:0005777	0.899	peroxisome
GO:0031410	0.869	cytoplasmic vesicle
GO:0005782	0.844	peroxisomal matrix
GO:0005886	0.835	plasma membrane
GO:0070062	0.806	extracellular exosome
GO:0009986	0.766	cell surface
GO:0005768	0.732	endosome
GO:0031981	0.427	nuclear lumen
GO:0031090	0.371	organelle membrane
GO:0098588	0.359	bounding membrane of organelle
GO:0005654	0.317	nucleoplasm
GO:0031904	0.306	endosome lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.4.24.-	0.997	Metalloendopeptidases.

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