StarFunc result for job id P14902

User Input

>input (403 residues)
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P14902	1.000	1.000	1.172E-61	403	1.000	1.000	P14902.pdb.gz	I23O1_HUMAN Indoleamine 2,3-dioxygenase 1 OS=Homo sapiens OX=9606 GN=IDO1 PE=1 SV=1
2	PDB:7a62C	0.940	0.963	6.658E-51	393	0.963	0.987	7a62C.pdb.gz	Influence of the presence of the heme cofactor on the JK-loop structure in indoleamine 2,3-dioxygenase 1.
3	AFDB:Q9ERD9	0.959	0.950	6.675E-44	407	0.625	0.619	Q9ERD9.pdb.gz	I23O1_RAT Indoleamine 2,3-dioxygenase 1 OS=Rattus norvegicus OX=10116 GN=Ido1 PE=2 SV=1
4	AFDB:P28776	0.964	0.954	1.930E-43	407	0.613	0.607	P28776.pdb.gz	I23O1_MOUSE Indoleamine 2,3-dioxygenase 1 OS=Mus musculus OX=10090 GN=Ido1 PE=1 SV=1
5	AFDB:Q8R0V5	0.941	0.936	3.377E-34	405	0.437	0.435	Q8R0V5.pdb.gz	I23O2_MOUSE Indoleamine 2,3-dioxygenase 2 OS=Mus musculus OX=10090 GN=Ido2 PE=1 SV=3
6	AFDB:Q6ZQW0	0.915	0.879	6.546E-33	420	0.424	0.407	Q6ZQW0.pdb.gz	I23O2_HUMAN Indoleamine 2,3-dioxygenase 2 OS=Homo sapiens OX=9606 GN=IDO2 PE=1 SV=5
7	AFDB:A0A1D8PN08	0.884	0.811	1.101E-26	440	0.313	0.286	A0A1D8PN08.pdb.gz	A0A1D8PN08_CANAL indoleamine 2,3-dioxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CAALFM_C500800CA PE=3 SV=1
8	AFDB:Q2UJE7	0.874	0.821	1.873E-26	430	0.318	0.298	Q2UJE7.pdb.gz	Q2UJE7_ASPOR indoleamine 2,3-dioxygenase OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=AO090003001248 PE=3 SV=1
9	AFDB:Q2U3U2	0.875	0.728	8.067E-26	487	0.295	0.244	Q2U3U2.pdb.gz	Q2U3U2_ASPOR indoleamine 2,3-dioxygenase OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=AO090020000618 PE=3 SV=1
10	AFDB:P47125	0.879	0.785	2.905E-24	453	0.300	0.267	P47125.pdb.gz	I23O_YEAST Indoleamine 2,3-dioxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=BNA2 PE=1 SV=1
11	AFDB:O04203	0.289	0.271	2.794E-2	435	0.102	0.094	O04203.pdb.gz	HSPR2_ARATH Nematode resistance protein-like HSPRO2 OS=Arabidopsis thaliana OX=3702 GN=HSPRO2 PE=1 SV=1
12	PDB:7p46A	0.282	0.390	3.752E-2	281	0.109	0.157	7p46A.pdb.gz	Binding of l-kynurenine to X. campestris tryptophan 2,3-dioxygenase.
13	PDB:2zocA	0.098	0.115	1.929E-1	319	0.099	0.125	2zocA.pdb.gz	The comparison of the loop structure of membrane binding sites between human and bovine annexin IV
14	PDB:6pyzC	0.401	0.478	2.016E-1	333	0.107	0.129	6pyzC.pdb.gz	Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase.
15	PDB:6rx4A	0.159	0.141	2.748E-1	474	0.109	0.093	6rx4A.pdb.gz	Homologous bd oxidases share the same architecture but differ in mechanism.
16	PDB:2noxB	0.291	0.420	3.138E-1	266	0.087	0.132	2noxB.pdb.gz	Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.
17	PDB:1axnA	0.102	0.116	3.583E-1	323	0.092	0.115	1axnA.pdb.gz	The high-resolution crystal structure of human annexin III shows subtle differences with annexin V.
18	PDB:7r5jK0	0.195	0.102	4.092E-1	1086	0.124	0.046	7r5jK0.pdb.gz	AI-based structure prediction empowers integrative structural analysis of human nuclear pores
19	PDB:6kseA	0.130	0.093	4.884E-1	607	0.117	0.077	6kseA.pdb.gz	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.
20	PDB:1ycnA	0.093	0.107	5.577E-1	312	0.089	0.115	1ycnA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P14902	0.0	841	403	1.000	1.000	I23O1_HUMAN Indoleamine 2,3-dioxygenase 1 OS=Homo sapiens OX=9606 GN=IDO1 PE=1 SV=1
2	P28776	0.0	514	407	0.613	0.607	I23O1_MOUSE Indoleamine 2,3-dioxygenase 1 OS=Mus musculus OX=10090 GN=Ido1 PE=1 SV=1
3	Q9ERD9	0.0	532	407	0.625	0.619	I23O1_RAT Indoleamine 2,3-dioxygenase 1 OS=Rattus norvegicus OX=10116 GN=Ido1 PE=2 SV=1
4	Q8R0V5	4.77e-123	363	405	0.434	0.432	I23O2_MOUSE Indoleamine 2,3-dioxygenase 2 OS=Mus musculus OX=10090 GN=Ido2 PE=1 SV=3
5	Q6ZQW0	5.51e-113	338	420	0.427	0.410	I23O2_HUMAN Indoleamine 2,3-dioxygenase 2 OS=Homo sapiens OX=9606 GN=IDO2 PE=1 SV=5
6	A0A1D8PN08	3.14e-59	201	440	0.325	0.298	A0A1D8PN08_CANAL indoleamine 2,3-dioxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CAALFM_C500800CA PE=3 SV=1
7	Q2UJE7	4.17e-54	187	430	0.340	0.319	Q2UJE7_ASPOR indoleamine 2,3-dioxygenase OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=AO090003001248 PE=3 SV=1
8	Q2U3U2	1.91e-52	184	487	0.308	0.255	Q2U3U2_ASPOR indoleamine 2,3-dioxygenase OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=AO090020000618 PE=3 SV=1
9	P47125	7.12e-50	176	453	0.313	0.278	I23O_YEAST Indoleamine 2,3-dioxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=BNA2 PE=1 SV=1
10	Q9WUU9	2.1	33.1	1971	0.042	0.009	GANP_MOUSE Germinal-center associated nuclear protein OS=Mus musculus OX=10090 GN=Mcm3ap PE=1 SV=2
11	Q6PST4	2.6	32.7	558	0.065	0.047	ATLA1_RAT Atlastin-1 OS=Rattus norvegicus OX=10116 GN=Atl1 PE=1 SV=1
12	Q8WXF7	2.8	32.7	558	0.065	0.047	ATLA1_HUMAN Atlastin-1 OS=Homo sapiens OX=9606 GN=ATL1 PE=1 SV=1
13	F1QKU2	8.4	31.2	823	0.032	0.016	F1QKU2_DANRE Furin (paired basic amino acid cleaving enzyme) b OS=Danio rerio OX=7955 GN=furinb PE=3 SV=1
14	O60318	8.8	31.2	1980	0.040	0.008	GANP_HUMAN Germinal-center associated nuclear protein OS=Homo sapiens OX=9606 GN=MCM3AP PE=1 SV=2
15	Q8BH66	9.9	30.8	558	0.062	0.045	ATLA1_MOUSE Atlastin-1 OS=Mus musculus OX=10090 GN=Atl1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF08933 DUF1864	1.6	19.1	Domain of unknown function (DUF1864)
2	PF01231 IDO	1.2e-117	405.0	Indoleamine 2,3-dioxygenase
3	PF09773 Meckelin	34	13.9	Meckelin (Transmembrane protein 67)

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000430950

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000444788	0.971	Tryptophan 2,3-dioxygenase
2	9606.ENSP00000264170	0.969	Kynureninase
3	9606.ENSP00000250018	0.942	Belongs to the biopterin-dependent aromatic amino acid hydroxylase family
4	9606.ENSP00000328938	0.936	Kynurenine formamidase
5	9606.ENSP00000369050	0.931	Cytochrome P450 1A1
6	9606.ENSP00000478561	0.927	Cytochrome P450 1B1
7	9606.ENSP00000329093	0.917	Tryptophan hydroxylase 2
8	9606.ENSP00000340684	0.914	Amine oxidase [flavin-containing] A
9	9606.ENSP00000472474	0.913	L-amino-acid oxidase
10	9606.ENSP00000370639	0.912	Acetylserotonin O-methyltransferase
11	9606.ENSP00000403644	0.911	Aromatic-L-amino-acid decarboxylase
12	9606.ENSP00000250615	0.910	Serotonin N-acetyltransferase
13	9606.ENSP00000013222	0.909	Indolethylamine N-methyltransferase
14	9606.ENSP00000367309	0.905	Amine oxidase [flavin-containing] B
15	9606.ENSP00000342007	0.903	Cytochrome P450 1A2
16	9606.ENSP00000330341	0.877	Suppressor of cytokine signaling 3
17	9606.ENSP00000242057	0.857	Aryl hydrocarbon receptor
18	9606.ENSP00000370989	0.835	Programmed cell death 1 ligand 1
19	9606.ENSP00000443432	0.824	Indoleamine 2,3-dioxygenase 2
20	9606.ENSP00000340944	0.804	Tyrosine-protein phosphatase non-receptor type 11

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0033754	1.000	indoleamine 2,3-dioxygenase activity
GO:0009055	0.996	electron transfer activity
GO:0005488	0.987	binding
GO:0005515	0.939	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.999	cellular process
GO:1901564	0.990	organonitrogen compound metabolic process
GO:0042981	0.985	regulation of apoptotic process
GO:1901565	0.979	organonitrogen compound catabolic process
GO:0006520	0.977	amino acid metabolic process
GO:0046395	0.977	carboxylic acid catabolic process
GO:1901360	0.975	organic cyclic compound metabolic process
GO:0048518	0.975	positive regulation of biological process
GO:0048522	0.974	positive regulation of cellular process
GO:1901605	0.970	alpha-amino acid metabolic process
GO:1901361	0.969	organic cyclic compound catabolic process
GO:0019439	0.968	aromatic compound catabolic process
GO:0006586	0.968	indolalkylamine metabolic process
GO:0046700	0.964	heterocycle catabolic process
GO:0044270	0.964	cellular nitrogen compound catabolic process
GO:0009063	0.964	amino acid catabolic process
GO:1901606	0.964	alpha-amino acid catabolic process
GO:0006568	0.961	tryptophan metabolic process
GO:0009074	0.960	aromatic amino acid family catabolic process
GO:2000106	0.934	regulation of leukocyte apoptotic process
GO:0032501	0.875	multicellular organismal process
GO:0050896	0.654	response to stimulus
GO:0070228	0.529	regulation of lymphocyte apoptotic process
GO:0070232	0.512	regulation of T cell apoptotic process
GO:0010942	0.435	positive regulation of cell death
GO:0019222	0.399	regulation of metabolic process
GO:0043065	0.349	positive regulation of apoptotic process
GO:0060255	0.329	regulation of macromolecule metabolic process
GO:0051716	0.321	cellular response to stimulus
GO:0051239	0.317	regulation of multicellular organismal process
GO:0048519	0.317	negative regulation of biological process
GO:0009893	0.313	positive regulation of metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0043226	0.758	organelle
GO:0043229	0.708	intracellular organelle
GO:0071944	0.522	cell periphery
GO:0005886	0.490	plasma membrane
GO:0043227	0.382	membrane-bounded organelle
GO:0043231	0.373	intracellular membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:14189	1.000	D-tryptophan + O2 = N-formyl-D-kynurenine
EC:1.13.11.52	1.000	indoleamine 2,3-dioxygenase.

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