StarFunc result for job id P15056

User Input

>input (766 residues)
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A2R8Y8E0	0.390	0.371	0.000	807	0.995	0.944	A0A2R8Y8E0.pdb.gz	A0A2R8Y8E0_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=1
2	AFDB:H7C560	0.389	0.388	0.000	767	0.993	0.992	H7C560.pdb.gz	H7C560_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=2
3	AFDB:A0A0S2Z559	0.388	0.444	1.188E-72	668	0.475	0.545	A0A0S2Z559.pdb.gz	A0A0S2Z559_HUMAN non-specific serine/threonine protein kinase (Fragment) OS=Homo sapiens OX=9606 GN=RAF1 PE=2 SV=1
4	AFDB:L7RRS6	0.386	0.455	1.255E-72	648	0.462	0.546	L7RRS6.pdb.gz	L7RRS6_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=2 SV=1
5	AFDB:A0A0R4IN14	0.400	0.475	2.092E-71	643	0.477	0.568	A0A0R4IN14.pdb.gz	A0A0R4IN14_DANRE non-specific serine/threonine protein kinase OS=Danio rerio OX=7955 GN=c-raf PE=1 SV=2
6	AFDB:A0A0R4IC22	0.387	0.452	9.282E-71	654	0.479	0.561	A0A0R4IC22.pdb.gz
7	AFDB:P09560	0.380	0.455	6.765E-70	638	0.473	0.567	P09560.pdb.gz	RAF1_XENLA RAF proto-oncogene serine/threonine-protein kinase OS=Xenopus laevis OX=8355 GN=raf1 PE=2 SV=1
8	AFDB:Q96II5	0.394	0.493	1.312E-69	609	0.463	0.583	Q96II5.pdb.gz	Q96II5_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=1
9	AFDB:Q5FBD1	0.385	0.483	5.505E-69	608	0.482	0.607	Q5FBD1.pdb.gz	Q5FBD1_DANRE non-specific serine/threonine protein kinase OS=Danio rerio OX=7955 GN=ARAF PE=1 SV=1
10	PDB:7mfdA	0.349	0.639	8.386E-55	410	0.535	1.000	7mfdA.pdb.gz	Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
11	PDB:6uanB	0.307	0.870	3.788E-34	261	0.339	0.996	6uanB.pdb.gz
12	AFDB:A0A2R8Y5H9	0.334	0.278	2.170E-31	928	0.262	0.217	A0A2R8Y5H9.pdb.gz	A0A2R8Y5H9_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=KSR1 PE=1 SV=1
13	PDB:7z37CP1	0.218	0.819	3.532E-20	193	0.206	0.819	7z37CP1.pdb.gz	Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.
14	PDB:2h8hA	0.314	0.526	1.483E-19	445	0.116	0.200	2h8hA.pdb.gz	N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
15	PDB:4fl2A	0.313	0.427	5.140E-17	555	0.093	0.128	4fl2A.pdb.gz	Structural and biophysical characterization of the syk activation switch.
16	PDB:1k9aB	0.299	0.509	1.313E-16	441	0.106	0.184	1k9aB.pdb.gz
17	PDB:8dksA	0.270	0.679	1.638E-16	283	0.106	0.286	8dksA.pdb.gz	Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.
18	PDB:4btfA	0.291	0.514	3.746E-16	413	0.087	0.162	4btfA.pdb.gz
19	PDB:4k2rA	0.303	0.416	5.512E-16	551	0.084	0.116	4k2rA.pdb.gz	Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker.
20	PDB:6s73A	0.297	0.800	1.333E-15	269	0.078	0.223	6s73A.pdb.gz	Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A0R4IN14	681	643	0.484	0.577	A0A0R4IN14_DANRE non-specific serine/threonine protein kinase OS=Danio rerio OX=7955 GN=c-raf PE=1 SV=2
2	A0A0S2Z559	696	668	0.480	0.551	A0A0S2Z559_HUMAN non-specific serine/threonine protein kinase (Fragment) OS=Homo sapiens OX=9606 GN=RAF1 PE=2 SV=1
3	A0A2R8Y8E0	1565	807	0.995	0.944	A0A2R8Y8E0_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=1
4	A0A2U3TZI2	1573	806	1.000	0.950	A0A2U3TZI2_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=1
5	A0A8I6ADL5	1527	785	0.967	0.944	A0A8I6ADL5_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Braf PE=3 SV=1
6	A0A8I6AFV6	1518	797	0.967	0.930	A0A8I6AFV6_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Braf PE=1 SV=1
7	A0A8I6ATH0	1378	804	0.916	0.873	A0A8I6ATH0_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Braf PE=1 SV=1
8	D3KYU7	688	626	0.490	0.599	D3KYU7_DANRE non-specific serine/threonine protein kinase OS=Danio rerio OX=7955 GN=raf1 PE=1 SV=1
9	F1M9C3	1335	718	0.860	0.918	F1M9C3_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Braf PE=1 SV=4
10	H7C560	1584	767	0.995	0.993	H7C560_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=2
11	L7RRS6	702	648	0.483	0.571	L7RRS6_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=2 SV=1
12	P04049	702	648	0.483	0.571	RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1
13	P04627	694	604	0.465	0.589	ARAF_MOUSE Serine/threonine-protein kinase A-Raf OS=Mus musculus OX=10090 GN=Araf PE=1 SV=2
14	P09560	704	638	0.478	0.574	RAF1_XENLA RAF proto-oncogene serine/threonine-protein kinase OS=Xenopus laevis OX=8355 GN=raf1 PE=2 SV=1
15	P10398	700	606	0.477	0.602	ARAF_HUMAN Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2
16	P11345	704	648	0.480	0.568	RAF1_RAT RAF proto-oncogene serine/threonine-protein kinase OS=Rattus norvegicus OX=10116 GN=Raf1 PE=1 SV=1
17	P11346	593	739	0.453	0.470	KRAF1_DROME Raf homolog serine/threonine-protein kinase Raf OS=Drosophila melanogaster OX=7227 GN=Raf PE=1 SV=6
18	P14056	693	604	0.462	0.586	ARAF_RAT Serine/threonine-protein kinase A-Raf OS=Rattus norvegicus OX=10116 GN=Araf PE=1 SV=1
19	P15056	1592	766	1.000	1.000	BRAF_HUMAN Serine/threonine-protein kinase B-raf OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=4
20	P28028	1457	751	0.928	0.947	BRAF_MOUSE Serine/threonine-protein kinase B-raf OS=Mus musculus OX=10090 GN=Braf PE=1 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	1.2	19.8	ABC1 atypical kinase-like domain
2	PF01636 APH	2.4e+02	13.0	Phosphotransferase enzyme family
3	PF00130 C1_1	1.2e-08	46.0	Phorbol esters/diacylglycerol binding domain (C1 domain)
4	PF03107 C1_2	11	17.7	C1 domain
5	PF06293 Kdo	5.2e+02	11.4	Lipopolysaccharide kinase (Kdo/WaaP) family
6	PF14531 Kinase-like	0.00012	33.1	Kinase-like
7	PF00069 Pkinase	4.4e-54	195.2	Protein kinase domain
8	PF17667 Pkinase_fungal	33	14.7	Fungal protein kinase
9	PF07714 PK_Tyr_Ser-Thr	2.1e-60	215.8	Protein tyrosine and serine/threonine kinase
10	PF02196 RBD	2.6e-23	93.0	Raf-like Ras-binding domain
11	PF08746 zf-RING-like	0.46	22.0	RING-like domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000288602

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000256078	0.999	GTPase KRas
2	9606.ENSP00000302486	0.999	Dual specificity mitogen-activated protein kinase kinase 1
3	9606.ENSP00000407586	0.999	GTPase HRas
4	9606.ENSP00000358548	0.998	GTPase NRas
5	9606.ENSP00000379287	0.997	14-3-3 protein zeta/delta
6	9606.ENSP00000262948	0.996	Dual specificity mitogen-activated protein kinase kinase 2
7	9606.ENSP00000251849	0.993	RAF proto-oncogene serine/threonine-protein kinase
8	9606.ENSP00000268182	0.989	Ras GTPase-activating-like protein IQGAP1
9	9606.ENSP00000371267	0.988	14-3-3 protein theta
10	9606.ENSP00000215832	0.987	Mitogen-activated protein kinase 1
11	9606.ENSP00000263025	0.982	Mitogen-activated protein kinase 3
12	9606.ENSP00000358723	0.982	Ras-related protein Rap-1A
13	9606.ENSP00000361930	0.979	14-3-3 protein beta/alpha
14	9606.ENSP00000306330	0.977	14-3-3 protein gamma
15	9606.ENSP00000290277	0.974	Serine/threonine-protein kinase A-Raf
16	9606.ENSP00000381958	0.974	Kinase suppressor of Ras 1
17	9606.ENSP00000248975	0.973	14-3-3 protein eta
18	9606.ENSP00000264335	0.971	14-3-3 protein epsilon
19	9606.ENSP00000340989	0.965	14-3-3 protein sigma
20	9606.ENSP00000358464	0.952	Leucine-rich repeat protein SHOC-2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004674	0.999	protein serine/threonine kinase activity
GO:0019901	0.998	protein kinase binding
GO:0044877	0.997	protein-containing complex binding
GO:0031434	0.983	mitogen-activated protein kinase kinase binding
GO:0004709	0.980	MAP kinase kinase kinase activity
GO:0031267	0.976	small GTPase binding
GO:0042802	0.549	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:1902531	0.989	regulation of intracellular signal transduction
GO:0009987	0.987	cellular process
GO:0010941	0.987	regulation of cell death
GO:0050896	0.986	response to stimulus
GO:0071704	0.986	organic substance metabolic process
GO:0044238	0.986	primary metabolic process
GO:0043170	0.980	macromolecule metabolic process
GO:0070374	0.977	positive regulation of ERK1 and ERK2 cascade
GO:0043412	0.971	macromolecule modification
GO:0006807	0.967	nitrogen compound metabolic process
GO:0044237	0.967	cellular metabolic process
GO:0043067	0.957	regulation of programmed cell death
GO:0042981	0.953	regulation of apoptotic process
GO:0016310	0.951	phosphorylation
GO:0036211	0.937	protein modification process
GO:0048523	0.932	negative regulation of cellular process
GO:0042221	0.925	response to chemical
GO:0014074	0.920	response to purine-containing compound
GO:0043066	0.912	negative regulation of apoptotic process
GO:0006468	0.904	protein phosphorylation
GO:1990089	0.894	response to nerve growth factor
GO:0071363	0.867	cellular response to growth factor stimulus
GO:0051591	0.862	response to cAMP
GO:1901214	0.783	regulation of neuron death
GO:1901652	0.759	response to peptide
GO:0051716	0.742	cellular response to stimulus
GO:1901215	0.728	negative regulation of neuron death
GO:0043524	0.715	negative regulation of neuron apoptotic process
GO:0019222	0.631	regulation of metabolic process
GO:0007154	0.624	cell communication
GO:0060255	0.603	regulation of macromolecule metabolic process
GO:0007165	0.562	signal transduction
GO:0080090	0.471	regulation of primary metabolic process
GO:0051171	0.469	regulation of nitrogen compound metabolic process
GO:0031323	0.429	regulation of cellular metabolic process
GO:1990090	0.322	cellular response to nerve growth factor stimulus
GO:0010604	0.308	positive regulation of macromolecule metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	1.000	membrane
GO:0005829	1.000	cytosol
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0071944	0.995	cell periphery
GO:0005634	0.986	nucleus
GO:0005886	0.979	plasma membrane
GO:0070013	0.950	intracellular organelle lumen
GO:0120025	0.563	plasma membrane bounded cell projection
GO:0043005	0.360	neuron projection
GO:0031981	0.350	nuclear lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.1.-	0.999	Phosphotransferases with an alcohol group as acceptor.
EC:2.7.11.25	0.980	mitogen-activated protein kinase kinase kinase.

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