StarFunc result for job id P15529

User Input

>input (392 residues)
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS
VSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAV
ICVVPYRYLQRRKKKGTYLTDETHREVKFTSL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P15529	1.000	1.000	7.658E-70	392	1.000	1.000	P15529.pdb.gz	MCP_HUMAN Membrane cofactor protein OS=Homo sapiens OX=9606 GN=CD46 PE=1 SV=3
2	AFDB:Q9Z0M4	0.626	0.685	1.346E-41	355	0.441	0.487	Q9Z0M4.pdb.gz	MCP_RAT Membrane cofactor protein OS=Rattus norvegicus OX=10116 GN=Cd46 PE=1 SV=1
3	AFDB:A0A024CBD6	0.602	0.646	2.156E-36	363	0.416	0.449	A0A024CBD6.pdb.gz	A0A024CBD6_PIG Membrane cofactor protein OS=Sus scrofa OX=9823 PE=2 SV=1
4	AFDB:Q9DEG0	0.386	0.344	1.602E-26	451	0.245	0.213	Q9DEG0.pdb.gz	Q9DEG0_CHICK Complement regulatory membrane protein OS=Gallus gallus OX=9031 GN=Cremp PE=2 SV=1
5	AFDB:P04003	0.437	0.309	2.978E-26	597	0.260	0.171	P04003.pdb.gz	C4BPA_HUMAN C4b-binding protein alpha chain OS=Homo sapiens OX=9606 GN=C4BPA PE=1 SV=2
6	AFDB:Q2VPA4	0.460	0.335	2.978E-26	569	0.286	0.197	Q2VPA4.pdb.gz	CR1L_HUMAN Complement component receptor 1-like protein OS=Homo sapiens OX=9606 GN=CR1L PE=1 SV=3
7	AFDB:O08569	0.418	0.326	4.060E-26	533	0.230	0.169	O08569.pdb.gz	ZP3R_CAVPO Zona pellucida sperm-binding protein 3 receptor OS=Cavia porcellus OX=10141 GN=ZP3R PE=1 SV=1
8	AFDB:Q63514	0.451	0.337	2.746E-25	558	0.230	0.161	Q63514.pdb.gz	C4BPA_RAT C4b-binding protein alpha chain OS=Rattus norvegicus OX=10116 GN=C4bpa PE=2 SV=1
9	AFDB:Q7TSY4	0.426	0.302	1.674E-24	577	0.217	0.147	Q7TSY4.pdb.gz	ZP3R_RAT Zona pellucida sperm-binding protein 3 receptor OS=Rattus norvegicus OX=10116 GN=Zp3r PE=2 SV=1
10	AFDB:Q60736	0.468	0.334	2.665E-24	579	0.196	0.133	Q60736.pdb.gz	ZP3R_MOUSE Zona pellucida sperm-binding protein 3 receptor OS=Mus musculus OX=10090 GN=Zp3r PE=1 SV=1
11	PDB:2gsxA	0.201	0.098	6.508E-21	951	0.240	0.099	2gsxA.pdb.gz
12	PDB:1c1zA	0.389	0.458	6.652E-20	326	0.184	0.221	1c1zA.pdb.gz
13	PDB:2q7zA	0.224	0.069	9.762E-19	1931	0.214	0.044	2q7zA.pdb.gz
14	PDB:1haqA	0.214	0.090	2.010E-11	1213	0.158	0.051	1haqA.pdb.gz
15	PDB:2xwbF	0.223	0.134	2.278E-10	714	0.097	0.053	2xwbF.pdb.gz	Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
16	PDB:8a7eC	0.241	0.085	1.622E-9	1524	0.138	0.035	8a7eC.pdb.gz	Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
17	PDB:8a7dQ	0.208	0.273	3.707E-9	273	0.115	0.165	8a7dQ.pdb.gz	Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
18	PDB:4e0sB	0.149	0.076	1.879E-7	898	0.120	0.052	4e0sB.pdb.gz	Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
19	PDB:7nycC	0.215	0.120	5.015E-7	809	0.112	0.054	7nycC.pdb.gz	Structural basis of soluble membrane attack complex packaging for clearance.
20	PDB:3t5oA	0.170	0.090	8.406E-7	871	0.105	0.047	3t5oA.pdb.gz	Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P15529	0.0	800	392	1.000	1.000	MCP_HUMAN Membrane cofactor protein OS=Homo sapiens OX=9606 GN=CD46 PE=1 SV=3
2	Q9Z0M4	9.39e-108	322	355	0.439	0.485	MCP_RAT Membrane cofactor protein OS=Rattus norvegicus OX=10116 GN=Cd46 PE=1 SV=1
3	A0A024CBD6	3.39e-93	285	363	0.418	0.452	A0A024CBD6_PIG Membrane cofactor protein OS=Sus scrofa OX=9823 PE=2 SV=1
4	O02839	3.78e-93	285	363	0.418	0.452	MCP_PIG Membrane cofactor protein OS=Sus scrofa OX=9823 GN=CD46 PE=1 SV=1
5	Q9DEG0	7.45e-49	173	451	0.263	0.228	Q9DEG0_CHICK Complement regulatory membrane protein OS=Gallus gallus OX=9031 GN=Cremp PE=2 SV=1
6	Q2VPA4	6.54e-45	165	569	0.296	0.204	CR1L_HUMAN Complement component receptor 1-like protein OS=Homo sapiens OX=9606 GN=CR1L PE=1 SV=3
7	P04003	1.34e-42	159	597	0.286	0.188	C4BPA_HUMAN C4b-binding protein alpha chain OS=Homo sapiens OX=9606 GN=C4BPA PE=1 SV=2
8	O08569	1.39e-39	150	533	0.242	0.178	ZP3R_CAVPO Zona pellucida sperm-binding protein 3 receptor OS=Cavia porcellus OX=10141 GN=ZP3R PE=1 SV=1
9	P17927	2.26e-38	149	2039	0.230	0.044	CR1_HUMAN Complement receptor type 1 OS=Homo sapiens OX=9606 GN=CR1 PE=1 SV=3
10	Q63135	1.03e-36	142	559	0.240	0.168	CR1L_RAT Complement component receptor 1-like protein OS=Rattus norvegicus OX=10116 GN=Cr1l PE=1 SV=1
11	D3Z9F7	3.08e-36	142	1406	0.250	0.070	D3Z9F7_RAT Complement C3d receptor 2 OS=Rattus norvegicus OX=10116 GN=Cr2 PE=4 SV=3
12	Q63514	4.47e-35	137	558	0.224	0.158	C4BPA_RAT C4b-binding protein alpha chain OS=Rattus norvegicus OX=10116 GN=C4bpa PE=2 SV=1
13	P19070	1.08e-34	138	1025	0.245	0.094	CR2_MOUSE Complement receptor type 2 OS=Mus musculus OX=10090 GN=Cr2 PE=1 SV=1
14	Q7TSY4	4.28e-33	132	577	0.199	0.135	ZP3R_RAT Zona pellucida sperm-binding protein 3 receptor OS=Rattus norvegicus OX=10116 GN=Zp3r PE=2 SV=1
15	Q64735	1.01e-32	130	483	0.240	0.195	CR1L_MOUSE Complement component receptor 1-like protein OS=Mus musculus OX=10090 GN=Cr1l PE=1 SV=1
16	Q60736	2.21e-31	127	579	0.199	0.135	ZP3R_MOUSE Zona pellucida sperm-binding protein 3 receptor OS=Mus musculus OX=10090 GN=Zp3r PE=1 SV=1
17	P20023	4.82e-31	127	1033	0.222	0.084	CR2_HUMAN Complement receptor type 2 OS=Homo sapiens OX=9606 GN=CR2 PE=1 SV=2
18	Q4LDE5	1.65e-27	117	3571	0.209	0.023	SVEP1_HUMAN Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SVEP1 PE=1 SV=3
19	A2AVA0	5.17e-26	112	3567	0.207	0.023	SVEP1_MOUSE Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus OX=10090 GN=Svep1 PE=1 SV=1
20	Q61475	2.19e-24	105	390	0.151	0.151	DAF1_MOUSE Complement decay-accelerating factor, GPI-anchored OS=Mus musculus OX=10090 GN=Cd55 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF15820 ECSCR	2.3e+02	13.0	Endothelial cell-specific chemotaxis regulator
2	PF00084 Sushi	2.3e-33	125.8	Sushi repeat (SCR repeat)
3	PF01034 Syndecan	1e+02	14.2	Syndecan domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000313875

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000245907	0.999	Complement C3
2	9606.ENSP00000254958	0.990	Protein jagged-1
3	9606.ENSP00000255416	0.988	Myosin-binding protein H
4	9606.ENSP00000262113	0.970	Myomesin-2
5	9606.ENSP00000415941	0.970	Complement C4-B
6	9606.ENSP00000353408	0.969	Moesin
7	9606.ENSP00000371958	0.969	CD9 antigen
8	9606.ENSP00000348278	0.953	STE20/SPS1-related proline-alanine-rich protein kinase
9	9606.ENSP00000378130	0.947	Complement factor I
10	9606.ENSP00000356991	0.944	Nectin-4
11	9606.ENSP00000396688	0.943	Complement C4-A
12	9606.ENSP00000306190	0.878	Signaling lymphocytic activation molecule
13	9606.ENSP00000379191	0.874	CD59 glycoprotein
14	9606.ENSP00000419945	0.853	Syncytin-1
15	9606.ENSP00000355231	0.849	Beclin-1
16	9606.ENSP00000299367	0.805	Complement C2
17	9606.ENSP00000416561	0.759	Complement factor B
18	9606.ENSP00000357484	0.755	Golgi-associated PDZ and coiled-coil motif-containing protein
19	9606.ENSP00000294904	0.744	RNA-binding motif, single-stranded-interacting protein 1
20	9606.ENSP00000284061	0.739	Diacylglycerol kinase epsilon

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0050839	0.999	cell adhesion molecule binding
GO:0038023	0.995	signaling receptor activity
GO:0045296	0.975	cadherin binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050789	0.994	regulation of biological process
GO:0050896	0.985	response to stimulus
GO:0050794	0.973	regulation of cellular process
GO:0048583	0.971	regulation of response to stimulus
GO:0048518	0.932	positive regulation of biological process
GO:0002682	0.925	regulation of immune system process
GO:0002376	0.908	immune system process
GO:0051249	0.901	regulation of lymphocyte activation
GO:0048522	0.895	positive regulation of cellular process
GO:0048519	0.894	negative regulation of biological process
GO:0022407	0.887	regulation of cell-cell adhesion
GO:0019222	0.883	regulation of metabolic process
GO:0050776	0.873	regulation of immune response
GO:0050863	0.867	regulation of T cell activation
GO:0050867	0.866	positive regulation of cell activation
GO:0002696	0.864	positive regulation of leukocyte activation
GO:0001817	0.847	regulation of cytokine production
GO:0002697	0.827	regulation of immune effector process
GO:0045785	0.815	positive regulation of cell adhesion
GO:0006955	0.813	immune response
GO:0002252	0.810	immune effector process
GO:1903037	0.808	regulation of leukocyte cell-cell adhesion
GO:0051251	0.799	positive regulation of lymphocyte activation
GO:1903039	0.798	positive regulation of leukocyte cell-cell adhesion
GO:0008284	0.794	positive regulation of cell population proliferation
GO:0050870	0.779	positive regulation of T cell activation
GO:0070663	0.764	regulation of leukocyte proliferation
GO:0032944	0.734	regulation of mononuclear cell proliferation
GO:0048585	0.706	negative regulation of response to stimulus
GO:0070665	0.696	positive regulation of leukocyte proliferation
GO:0032946	0.693	positive regulation of mononuclear cell proliferation
GO:0050670	0.688	regulation of lymphocyte proliferation
GO:0010628	0.679	positive regulation of gene expression
GO:0023051	0.668	regulation of signaling
GO:0010646	0.668	regulation of cell communication
GO:0009987	0.661	cellular process
GO:1902105	0.645	regulation of leukocyte differentiation
GO:0009966	0.626	regulation of signal transduction
GO:1902107	0.622	positive regulation of leukocyte differentiation
GO:0045619	0.610	regulation of lymphocyte differentiation
GO:0045621	0.596	positive regulation of lymphocyte differentiation
GO:0002250	0.594	adaptive immune response
GO:0045580	0.585	regulation of T cell differentiation
GO:0032653	0.579	regulation of interleukin-10 production
GO:0048584	0.558	positive regulation of response to stimulus
GO:0001819	0.521	positive regulation of cytokine production
GO:0045582	0.517	positive regulation of T cell differentiation
GO:0048523	0.513	negative regulation of cellular process
GO:0050778	0.488	positive regulation of immune response
GO:0002443	0.466	leukocyte mediated immunity
GO:0050671	0.457	positive regulation of lymphocyte proliferation
GO:0071634	0.455	regulation of transforming growth factor beta production
GO:0042129	0.394	regulation of T cell proliferation
GO:0002449	0.376	lymphocyte mediated immunity
GO:0002460	0.346	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0032501	0.339	multicellular organismal process
GO:0008152	0.302	metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043227	0.998	membrane-bounded organelle
GO:0005886	0.998	plasma membrane
GO:0031982	0.990	vesicle
GO:0005576	0.975	extracellular region
GO:0070062	0.924	extracellular exosome
GO:0009986	0.905	cell surface
GO:0043231	0.615	intracellular membrane-bounded organelle
GO:0030054	0.582	cell junction
GO:0005737	0.511	cytoplasm
GO:0030055	0.504	cell-substrate junction
GO:0005925	0.483	focal adhesion
GO:0012505	0.390	endomembrane system
GO:0031090	0.372	organelle membrane
GO:0031410	0.344	cytoplasmic vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]