StarFunc result for job id P15559

User Input

>input (274 residues)
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P15559	1.000	1.000	5.212E-60	274	1.000	1.000	P15559.pdb.gz	NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 OS=Homo sapiens OX=9606 GN=NQO1 PE=1 SV=1
2	PDB:5ea2C	0.993	0.986	9.211E-58	276	0.996	0.989	5ea2C.pdb.gz	A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.
3	AFDB:P05982	0.995	0.995	1.847E-54	274	0.854	0.854	P05982.pdb.gz	NQO1_RAT NAD(P)H dehydrogenase [quinone] 1 OS=Rattus norvegicus OX=10116 GN=Nqo1 PE=1 SV=4
4	PDB:1dxqA	0.983	0.986	9.577E-51	273	0.854	0.857	1dxqA.pdb.gz	Structures of Recombinant Mouse and Human Nad(P)H:Quinone Oxidoreductases:Species Comparison and Structural Changes with Substrate Binding and Release
5	AFDB:A0A2R8PW65	0.987	0.936	4.570E-41	289	0.489	0.464	A0A2R8PW65.pdb.gz	A0A2R8PW65_DANRE NAD(P)H dehydrogenase [quinone] 1 isoform 1 OS=Danio rerio OX=7955 GN=wu:fb63c10 PE=1 SV=1
6	AFDB:Q6AY80	0.809	0.959	5.052E-34	231	0.398	0.472	Q6AY80.pdb.gz	NQO2_RAT Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Rattus norvegicus OX=10116 GN=Nqo2 PE=1 SV=3
7	AFDB:P16083	0.796	0.943	4.079E-33	231	0.391	0.463	P16083.pdb.gz	NQO2_HUMAN Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=5
8	PDB:4fglD	0.793	0.931	9.779E-33	233	0.394	0.464	4fglD.pdb.gz	Crystal structures of quinone reductase 2 bound to antimalarial drugs reveal conformational change upon reduction
9	AFDB:Q9HUJ0	0.819	0.956	1.446E-27	234	0.343	0.402	Q9HUJ0.pdb.gz	Q9HUJ0_PSEAE NAD(P)H quinone oxidoreductase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA4975 PE=4 SV=1
10	AFDB:Q5TD07	0.643	0.907	1.141E-19	193	0.307	0.435	Q5TD07.pdb.gz	Q5TD07_HUMAN N-ribosyldihydronicotinamide:quinone reductase 2 OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=1
11	AFDB:Q9I4B3	0.619	0.804	7.931E-16	208	0.197	0.260	Q9I4B3.pdb.gz	Q9I4B3_PSEAE Probable NAD(P)H dehydrogenase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA1225 PE=4 SV=1
12	AFDB:P0A756	0.555	0.809	1.998E-13	184	0.172	0.255	P0A756.pdb.gz	KEFG_ECOLI Glutathione-regulated potassium-efflux system ancillary protein KefG OS=Escherichia coli (strain K12) OX=83333 GN=kefG PE=3 SV=1
13	AFDB:P43340	0.580	0.790	2.888E-13	196	0.168	0.235	P43340.pdb.gz	YCAK_ECOLI Uncharacterized NAD(P)H oxidoreductase YcaK OS=Escherichia coli (strain K12) OX=83333 GN=ycaK PE=3 SV=2
14	PDB:3l9wB	0.540	0.422	5.591E-12	357	0.179	0.137	3l9wB.pdb.gz	Mechanism of ligand-gated potassium efflux in bacterial pathogens.
15	PDB:3l9xA	0.539	0.445	8.595E-12	336	0.175	0.143	3l9xA.pdb.gz	Mechanism of ligand-gated potassium efflux in bacterial pathogens.
16	PDB:2b3dA	0.560	0.779	7.165E-10	193	0.157	0.223	2b3dA.pdb.gz	Modulator of drug activity B from Escherichia coli: crystal structure of a prokaryotic homologue of DT-diaphorase.
17	PDB:1tikA	0.543	0.707	7.619E-10	203	0.146	0.197	1tikA.pdb.gz
18	PDB:3r6wA	0.517	0.647	2.448E-9	211	0.131	0.171	3r6wA.pdb.gz	Activation of nitrofurazone by azoreductases: multiple activities in one enzyme.
19	PDB:5mjiA	0.463	0.499	2.603E-9	252	0.146	0.159	5mjiA.pdb.gz	The Crystal Structure of RosB: Insights into the Reaction Mechanism of the First Member of a Family of Flavodoxin-like Enzymes.
20	PDB:2q62D	0.425	0.484	2.609E-7	235	0.117	0.136	2q62D.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	H3BNV2	0.0	524	253	0.923	1.000	H3BNV2_HUMAN NAD(P)H dehydrogenase, quinone 1, isoform CRA_a OS=Homo sapiens OX=9606 GN=NQO1 PE=1 SV=1
2	P15559	0.0	567	274	1.000	1.000	NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 OS=Homo sapiens OX=9606 GN=NQO1 PE=1 SV=1
3	Q64669	0.0	503	274	0.865	0.865	NQO1_MOUSE NAD(P)H dehydrogenase [quinone] 1 OS=Mus musculus OX=10090 GN=Nqo1 PE=1 SV=3
4	P05982	1.03e-179	497	274	0.854	0.854	NQO1_RAT NAD(P)H dehydrogenase [quinone] 1 OS=Rattus norvegicus OX=10116 GN=Nqo1 PE=1 SV=4
5	Q6P0H2	2.19e-102	301	275	0.496	0.495	Q6P0H2_DANRE NAD(P)H dehydrogenase [quinone] 1 isoform 2 OS=Danio rerio OX=7955 GN=wu:fb63c10 PE=1 SV=1
6	A0A2R8PW65	2.06e-98	291	289	0.496	0.471	A0A2R8PW65_DANRE NAD(P)H dehydrogenase [quinone] 1 isoform 1 OS=Danio rerio OX=7955 GN=wu:fb63c10 PE=1 SV=1
7	Q6AY80	1.76e-76	234	231	0.401	0.476	NQO2_RAT Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Rattus norvegicus OX=10116 GN=Nqo2 PE=1 SV=3
8	P16083	4.19e-73	225	231	0.391	0.463	NQO2_HUMAN Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=5
9	Q9HUJ0	1.80e-50	167	234	0.343	0.402	Q9HUJ0_PSEAE NAD(P)H quinone oxidoreductase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA4975 PE=4 SV=1
10	Q5TD07	1.08e-49	164	193	0.318	0.451	Q5TD07_HUMAN N-ribosyldihydronicotinamide:quinone reductase 2 OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=1
11	Q5TD05	2.06e-42	144	139	0.259	0.511	Q5TD05_HUMAN N-ribosyldihydronicotinamide:quinone reductase 2 (Fragment) OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=1
12	Q9I4B3	1.48e-17	80.9	208	0.193	0.255	Q9I4B3_PSEAE Probable NAD(P)H dehydrogenase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA1225 PE=4 SV=1
13	P0A754	2.56e-14	71.2	176	0.135	0.210	KEFF_ECOLI Glutathione-regulated potassium-efflux system ancillary protein KefF OS=Escherichia coli (strain K12) OX=83333 GN=kefF PE=1 SV=1
14	P43340	6.19e-09	56.6	196	0.128	0.179	YCAK_ECOLI Uncharacterized NAD(P)H oxidoreductase YcaK OS=Escherichia coli (strain K12) OX=83333 GN=ycaK PE=3 SV=2
15	P0A756	6.24e-04	42.0	184	0.124	0.185	KEFG_ECOLI Glutathione-regulated potassium-efflux system ancillary protein KefG OS=Escherichia coli (strain K12) OX=83333 GN=kefG PE=3 SV=1
16	Q9HZ17	0.001	41.2	213	0.066	0.085	AZOR3_PSEAE FMN-dependent NADH:quinone oxidoreductase 3 OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=azoR3 PE=1 SV=1
17	P41407	0.084	35.8	201	0.146	0.199	AZOR_ECOLI FMN-dependent NADH:quinone oxidoreductase OS=Escherichia coli (strain K12) OX=83333 GN=azoR PE=1 SV=3
18	Q9I0Q6	0.099	35.8	196	0.066	0.092	Q9I0Q6_PSEAE Flavodoxin-like fold domain-containing protein OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA2580 PE=4 SV=1
19	Q9I2E2	0.14	35.0	202	0.088	0.119	AZOR2_PSEAE FMN-dependent NADH:quinone oxidoreductase 2 OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=azoR2 PE=1 SV=1
20	P0AEY5	0.25	34.3	193	0.062	0.088	MDAB_ECOLI NADPH:quinone oxidoreductase MdaB OS=Escherichia coli (strain K12) OX=83333 GN=mdaB PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02525 Flavodoxin_2	2.7e-45	166.1	Flavodoxin-like fold
2	PF03358 FMN_red	1.4e-05	36.3	NADPH-dependent FMN reductase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000319788

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000269305	0.996	Cellular tumor antigen p53
2	9606.ENSP00000378426	0.942	Vitamin K epoxide reductase complex subunit 1
3	9606.ENSP00000216117	0.916	Heme oxygenase 1
4	9606.ENSP00000233838	0.916	Vitamin K-dependent gamma-carboxylase
5	9606.ENSP00000264731	0.905	Tumor protein 63
6	9606.ENSP00000380252	0.905	Nuclear factor erythroid 2-related factor 2
7	9606.ENSP00000403077	0.901	Vitamin K epoxide reductase complex subunit 1 like 1
8	9606.ENSP00000229416	0.895	Glutamate-cysteine ligase catalytic subunit
9	9606.ENSP00000359258	0.895	Glutamate-cysteine ligase modifier subunit
10	9606.ENSP00000171111	0.892	Kelch-like ECH-associated protein 1
11	9606.ENSP00000234111	0.890	Ornithine decarboxylase
12	9606.ENSP00000399805	0.882	Quinone oxidoreductase
13	9606.ENSP00000286621	0.857	Adenosine kinase
14	9606.ENSP00000369050	0.761	Cytochrome P450 1A1
15	9606.ENSP00000434516	0.761	Thioredoxin reductase 1, cytoplasmic
16	9606.ENSP00000241052	0.760	Catalase
17	9606.ENSP00000295256	0.757	Hematopoietic prostaglandin D synthase
18	9606.ENSP00000233627	0.753	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
19	9606.ENSP00000311469	0.740	Glutathione S-transferase Mu 1
20	9606.ENSP00000221130	0.736	Glutathione reductase, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0050136	0.999	NADH dehydrogenase (quinone) activity
GO:1901363	0.986	heterocyclic compound binding
GO:0097159	0.986	organic cyclic compound binding
GO:0042802	0.961	identical protein binding
GO:0003676	0.783	nucleic acid binding
GO:0043167	0.673	ion binding
GO:0016653	0.434	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
GO:0003723	0.413	RNA binding
GO:0036094	0.380	small molecule binding
GO:0043168	0.356	anion binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044237	0.995	cellular metabolic process
GO:0050896	0.990	response to stimulus
GO:0006950	0.981	response to stress
GO:0042221	0.969	response to chemical
GO:0051716	0.966	cellular response to stimulus
GO:0006979	0.956	response to oxidative stress
GO:0042180	0.927	cellular ketone metabolic process
GO:1901661	0.912	quinone metabolic process
GO:0065007	0.909	biological regulation
GO:0070887	0.849	cellular response to chemical stimulus
GO:0006766	0.663	vitamin metabolic process
GO:0033554	0.567	cellular response to stress
GO:0006807	0.510	nitrogen compound metabolic process
GO:0050789	0.473	regulation of biological process
GO:0050794	0.451	regulation of cellular process
GO:0044238	0.368	primary metabolic process
GO:1901700	0.359	response to oxygen-containing compound
GO:0006775	0.345	fat-soluble vitamin metabolic process
GO:0034599	0.339	cellular response to oxidative stress
GO:0009410	0.325	response to xenobiotic stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol
GO:0043231	0.932	intracellular membrane-bounded organelle
GO:0005634	0.793	nucleus
GO:0070013	0.716	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:46160	0.999	a quinone + H(+) + NADH = a quinol + NAD(+)
EC:1.6.5.11	0.999	Transferred entry: 1.6.5.9.
EC:1.6.2.-	0.434	With a heme protein as acceptor.

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