StarFunc result for job id P16234

User Input

>input (1089 residues)
MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
SDLVEDSFL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P05622	0.434	0.430	0.000	1098	0.450	0.446	P05622.pdb.gz	PGFRB_MOUSE Platelet-derived growth factor receptor beta OS=Mus musculus OX=10090 GN=Pdgfrb PE=1 SV=2
2	AFDB:P16234	1.000	1.000	0.000	1089	1.000	1.000	P16234.pdb.gz	PGFRA_HUMAN Platelet-derived growth factor receptor alpha OS=Homo sapiens OX=9606 GN=PDGFRA PE=1 SV=1
3	AFDB:Q9PUF6	0.687	0.688	0.000	1087	0.803	0.804	Q9PUF6.pdb.gz	PGFRA_CHICK Platelet-derived growth factor receptor alpha OS=Gallus gallus OX=9031 GN=PDGFRA PE=2 SV=1
4	AFDB:A0A2R8QHE8	0.363	0.367	1.516E-103	1072	0.421	0.428	A0A2R8QHE8.pdb.gz
5	AFDB:P05532	0.335	0.362	1.655E-83	979	0.320	0.355	P05532.pdb.gz	KIT_MOUSE Mast/stem cell growth factor receptor Kit OS=Mus musculus OX=10090 GN=Kit PE=1 SV=3
6	AFDB:P10721	0.332	0.367	3.107E-81	976	0.312	0.348	P10721.pdb.gz	KIT_HUMAN Mast/stem cell growth factor receptor Kit OS=Homo sapiens OX=9606 GN=KIT PE=1 SV=1
7	AFDB:F1QPE2	0.320	0.362	7.779E-77	943	0.291	0.336	F1QPE2.pdb.gz
8	AFDB:A0A0B4J203	0.315	0.403	1.936E-70	849	0.469	0.602	A0A0B4J203.pdb.gz	A0A0B4J203_HUMAN Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 PE=3 SV=1
9	AFDB:P35968	0.314	0.267	3.829E-69	1356	0.300	0.241	P35968.pdb.gz	VGFR2_HUMAN Vascular endothelial growth factor receptor 2 OS=Homo sapiens OX=9606 GN=KDR PE=1 SV=2
10	AFDB:P36888	0.304	0.332	9.211E-68	993	0.281	0.308	P36888.pdb.gz	FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 OS=Homo sapiens OX=9606 GN=FLT3 PE=1 SV=2
11	PDB:2h8hA	0.218	0.506	2.141E-18	445	0.109	0.267	2h8hA.pdb.gz	N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
12	PDB:1k9aB	0.218	0.524	2.248E-18	441	0.098	0.243	1k9aB.pdb.gz
13	PDB:4fl2A	0.223	0.422	1.187E-17	555	0.096	0.187	4fl2A.pdb.gz	Structural and biophysical characterization of the syk activation switch.
14	PDB:4k2rA	0.217	0.419	7.975E-16	551	0.084	0.167	4k2rA.pdb.gz	Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker.
15	PDB:1e07A	0.146	0.214	5.119E-15	642	0.078	0.132	1e07A.pdb.gz
16	PDB:2rcjC	0.131	0.202	5.119E-15	523	0.066	0.138	2rcjC.pdb.gz
17	PDB:5oj2B	0.166	0.243	2.979E-14	692	0.090	0.142	5oj2B.pdb.gz
18	PDB:6s73A	0.213	0.783	1.729E-12	269	0.062	0.249	6s73A.pdb.gz	Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
19	PDB:6dldD	0.131	0.439	3.110E-12	269	0.047	0.190	6dldD.pdb.gz
20	PDB:7mfdA	0.201	0.490	1.057E-11	410	0.078	0.207	7mfdA.pdb.gz	Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0B4J203	0.0	1067	849	0.469	0.602	A0A0B4J203_HUMAN Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 PE=3 SV=1
2	D9MNA7	0.0	804	1064	0.420	0.430	D9MNA7_DANRE receptor protein-tyrosine kinase OS=Danio rerio OX=7955 GN=pdgfrb2 PE=2 SV=1
3	P05622	0.0	888	1098	0.444	0.440	PGFRB_MOUSE Platelet-derived growth factor receptor beta OS=Mus musculus OX=10090 GN=Pdgfrb PE=1 SV=2
4	P09619	0.0	872	1106	0.438	0.431	PGFRB_HUMAN Platelet-derived growth factor receptor beta OS=Homo sapiens OX=9606 GN=PDGFRB PE=1 SV=1
5	P16234	0.0	2253	1089	1.000	1.000	PGFRA_HUMAN Platelet-derived growth factor receptor alpha OS=Homo sapiens OX=9606 GN=PDGFRA PE=1 SV=1
6	P20786	0.0	2020	1088	0.909	0.910	PGFRA_RAT Platelet-derived growth factor receptor alpha OS=Rattus norvegicus OX=10116 GN=Pdgfra PE=1 SV=2
7	P26618	0.0	2035	1089	0.918	0.918	PGFRA_MOUSE Platelet-derived growth factor receptor alpha OS=Mus musculus OX=10090 GN=Pdgfra PE=1 SV=3
8	Q05030	0.0	881	1097	0.445	0.442	PGFRB_RAT Platelet-derived growth factor receptor beta OS=Rattus norvegicus OX=10116 GN=Pdgfrb PE=2 SV=2
9	Q8JFR5	0.0	566	976	0.355	0.397	KITA_DANRE Mast/stem cell growth factor receptor kita OS=Danio rerio OX=7955 GN=kita PE=2 SV=2
10	Q9DE49	0.0	1274	1059	0.607	0.624	PGFRA_DANRE Platelet-derived growth factor receptor alpha OS=Danio rerio OX=7955 GN=pdgfra PE=2 SV=1
11	Q9PUF6	0.0	1762	1087	0.803	0.805	PGFRA_CHICK Platelet-derived growth factor receptor alpha OS=Gallus gallus OX=9031 GN=PDGFRA PE=2 SV=1
12	B8A5K6	3.41e-174	538	957	0.330	0.375	B8A5K6_DANRE Mast/stem cell growth factor receptor OS=Danio rerio OX=7955 GN=kitb PE=3 SV=1
13	P10721	5.38e-170	527	976	0.323	0.361	KIT_HUMAN Mast/stem cell growth factor receptor Kit OS=Homo sapiens OX=9606 GN=KIT PE=1 SV=1
14	Q63116	1.31e-169	526	978	0.332	0.370	Q63116_RAT Mast/stem cell growth factor receptor OS=Rattus norvegicus OX=10116 GN=Kit PE=1 SV=1
15	A0A0G2JTL4	1.39e-169	526	970	0.330	0.370	A0A0G2JTL4_RAT Mast/stem cell growth factor receptor OS=Rattus norvegicus OX=10116 GN=Kit PE=1 SV=2
16	P05532	9.07e-169	524	979	0.331	0.368	KIT_MOUSE Mast/stem cell growth factor receptor Kit OS=Mus musculus OX=10090 GN=Kit PE=1 SV=3
17	P09581	1.55e-160	503	977	0.306	0.341	CSF1R_MOUSE Macrophage colony-stimulating factor 1 receptor OS=Mus musculus OX=10090 GN=Csf1r PE=1 SV=3
18	Q00495	1.83e-158	497	978	0.304	0.338	CSF1R_RAT Macrophage colony-stimulating factor 1 receptor OS=Rattus norvegicus OX=10116 GN=Csf1r PE=1 SV=1
19	P07333	1.13e-157	495	972	0.301	0.337	CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor OS=Homo sapiens OX=9606 GN=CSF1R PE=1 SV=2
20	Q9I8N6	4.00e-151	478	977	0.295	0.329	CSF1R_DANRE Macrophage colony-stimulating factor 1 receptor OS=Danio rerio OX=7955 GN=csf1r PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF08205 C2-set_2	1.3e+02	14.0	CD80-like C2-set immunoglobulin domain
2	PF02480 Herpes_gE	2.1e+02	12.7	Alphaherpesvirus glycoprotein E
3	PF07679 I-set	2.9e-19	80.2	Immunoglobulin I-set domain
4	PF00047 ig	1.9e-13	61.7	Immunoglobulin domain
5	PF13895 Ig_2	9.8e-12	56.3	Immunoglobulin domain
6	PF13927 Ig_3	5.9e-22	89.3	Immunoglobulin domain
7	PF18452 Ig_6	2.3e+02	13.0	Immunoglobulin domain
8	PF14531 Kinase-like	3.6e+02	11.9	Kinase-like
9	PF00069 Pkinase	2.5e-40	150.1	Protein kinase domain
10	PF07714 PK_Tyr_Ser-Thr	7.1e-105	361.5	Protein tyrosine and serine/threonine kinase
11	PF07686 V-set	0.42	22.2	Immunoglobulin V-set domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000257290

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000346508	0.999	Platelet-derived growth factor subunit A
2	9606.ENSP00000330382	0.997	Platelet-derived growth factor subunit B
3	9606.ENSP00000422464	0.993	Platelet-derived growth factor C
4	9606.ENSP00000300574	0.990	Adapter molecule crk
5	9606.ENSP00000428056	0.990	Phosphatidylinositol 3-kinase regulatory subunit alpha
6	9606.ENSP00000261799	0.983	Platelet-derived growth factor receptor beta
7	9606.ENSP00000263967	0.976	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
8	9606.ENSP00000340944	0.975	Tyrosine-protein phosphatase non-receptor type 11
9	9606.ENSP00000244007	0.973	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
10	9606.ENSP00000346300	0.972	Crk-like protein
11	9606.ENSP00000407586	0.968	GTPase HRas
12	9606.ENSP00000376345	0.965	Growth factor receptor-bound protein 2
13	9606.ENSP00000256078	0.961	GTPase KRas
14	9606.ENSP00000376865	0.960	Platelet-derived growth factor D
15	9606.ENSP00000275493	0.958	Epidermal growth factor receptor
16	9606.ENSP00000261023	0.950	Integrin alpha-V
17	9606.ENSP00000339191	0.948	Caveolin-1
18	9606.ENSP00000358548	0.947	GTPase NRas
19	9606.ENSP00000274376	0.937	Ras GTPase-activating protein 1
20	9606.ENSP00000290894	0.935	SH2 domain-containing adapter protein F

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004714	0.999	transmembrane receptor protein tyrosine kinase activity
GO:0019838	0.995	growth factor binding
GO:0042802	0.971	identical protein binding
GO:0005102	0.971	signaling receptor binding
GO:0070851	0.748	growth factor receptor binding
GO:0046983	0.743	protein dimerization activity
GO:0042803	0.730	protein homodimerization activity
GO:0005017	0.627	platelet-derived growth factor receptor activity
GO:0048407	0.588	platelet-derived growth factor binding
GO:0005021	0.304	vascular endothelial growth factor receptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050896	0.993	response to stimulus
GO:0009987	0.992	cellular process
GO:0048856	0.989	anatomical structure development
GO:0050789	0.985	regulation of biological process
GO:0050794	0.984	regulation of cellular process
GO:0048731	0.975	system development
GO:0048522	0.968	positive regulation of cellular process
GO:0051716	0.966	cellular response to stimulus
GO:0019222	0.957	regulation of metabolic process
GO:0048513	0.925	animal organ development
GO:0007154	0.917	cell communication
GO:0023052	0.916	signaling
GO:0060255	0.863	regulation of macromolecule metabolic process
GO:0007165	0.858	signal transduction
GO:0051171	0.775	regulation of nitrogen compound metabolic process
GO:0031323	0.731	regulation of cellular metabolic process
GO:0080090	0.729	regulation of primary metabolic process
GO:0048519	0.728	negative regulation of biological process
GO:0010604	0.727	positive regulation of macromolecule metabolic process
GO:0042221	0.715	response to chemical
GO:0009653	0.696	anatomical structure morphogenesis
GO:0048583	0.695	regulation of response to stimulus
GO:0008152	0.660	metabolic process
GO:0071704	0.630	organic substance metabolic process
GO:0051239	0.622	regulation of multicellular organismal process
GO:0048523	0.603	negative regulation of cellular process
GO:0070887	0.601	cellular response to chemical stimulus
GO:0007166	0.577	cell surface receptor signaling pathway
GO:0044238	0.570	primary metabolic process
GO:0006950	0.541	response to stress
GO:0007167	0.537	enzyme-linked receptor protein signaling pathway
GO:0007169	0.534	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042127	0.532	regulation of cell population proliferation
GO:0044237	0.526	cellular metabolic process
GO:0008284	0.514	positive regulation of cell population proliferation
GO:0051173	0.510	positive regulation of nitrogen compound metabolic process
GO:0042325	0.505	regulation of phosphorylation
GO:0048869	0.501	cellular developmental process
GO:0030154	0.494	cell differentiation
GO:0050793	0.491	regulation of developmental process
GO:0030335	0.486	positive regulation of cell migration
GO:0006807	0.485	nitrogen compound metabolic process
GO:0009967	0.485	positive regulation of signal transduction
GO:0031325	0.483	positive regulation of cellular metabolic process
GO:0010468	0.480	regulation of gene expression
GO:0042327	0.470	positive regulation of phosphorylation
GO:0043170	0.469	macromolecule metabolic process
GO:0051247	0.463	positive regulation of protein metabolic process
GO:0031399	0.461	regulation of protein modification process
GO:0065009	0.458	regulation of molecular function
GO:1902531	0.455	regulation of intracellular signal transduction
GO:0001932	0.437	regulation of protein phosphorylation
GO:1902533	0.434	positive regulation of intracellular signal transduction
GO:0009719	0.395	response to endogenous stimulus
GO:0044093	0.384	positive regulation of molecular function
GO:0035295	0.375	tube development
GO:0050790	0.359	regulation of catalytic activity
GO:0071495	0.356	cellular response to endogenous stimulus
GO:0045595	0.352	regulation of cell differentiation
GO:0031401	0.348	positive regulation of protein modification process
GO:0001934	0.324	positive regulation of protein phosphorylation
GO:0070848	0.322	response to growth factor
GO:0071840	0.314	cellular component organization or biogenesis
GO:0009889	0.309	regulation of biosynthetic process
GO:0051128	0.304	regulation of cellular component organization
GO:0016477	0.301	cell migration

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0005886	1.000	plasma membrane
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0005634	0.982	nucleus
GO:0012505	0.962	endomembrane system
GO:0031974	0.711	membrane-enclosed lumen
GO:0070013	0.687	intracellular organelle lumen
GO:0031981	0.632	nuclear lumen
GO:0005654	0.468	nucleoplasm
GO:0030054	0.444	cell junction
GO:0031090	0.312	organelle membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.10.1	0.999	receptor protein-tyrosine kinase.

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