StarFunc result for job id P16403

User Input

>input (213 residues)
MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLA
ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKV
KKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVA
KPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P02253	0.797	0.797	2.029E-25	213	0.915	0.915	P02253.pdb.gz	H12_BOVIN Histone H1.2 OS=Bos taurus OX=9913 GN=H1-2 PE=1 SV=2
2	AFDB:P43277	0.761	0.735	1.267E-22	221	0.859	0.828	P43277.pdb.gz	H13_MOUSE Histone H1.3 OS=Mus musculus OX=10090 GN=H1-3 PE=1 SV=2
3	AFDB:P15865	0.645	0.630	9.917E-22	219	0.854	0.831	P15865.pdb.gz	H14_RAT Histone H1.4 OS=Rattus norvegicus OX=10116 GN=H1-4 PE=1 SV=3
4	AFDB:P16402	0.679	0.657	2.350E-21	221	0.840	0.810	P16402.pdb.gz	H13_HUMAN Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2
5	AFDB:A5PK20	0.453	0.459	3.815E-20	210	0.775	0.786	A5PK20.pdb.gz	A5PK20_BOVIN H1.12 linker histone, cluster member OS=Bos taurus OX=9913 GN=H1-12 PE=2 SV=1
6	AFDB:P16401	0.669	0.634	9.040E-20	226	0.808	0.761	P16401.pdb.gz	H15_HUMAN Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3
7	AFDB:P43275	0.394	0.394	3.321E-17	213	0.681	0.681	P43275.pdb.gz	H11_MOUSE Histone H1.1 OS=Mus musculus OX=10090 GN=H1-1 PE=1 SV=2
8	AFDB:Q02539	0.414	0.411	4.945E-17	215	0.681	0.674	Q02539.pdb.gz	H11_HUMAN Histone H1.1 OS=Homo sapiens OX=9606 GN=H1-1 PE=1 SV=3
9	AFDB:P06350	0.479	0.489	1.992E-16	207	0.676	0.696	P06350.pdb.gz	H1_ONCMY Histone H1 OS=Oncorhynchus mykiss OX=8022 PE=1 SV=2
10	AFDB:P22492	0.405	0.414	5.997E-14	207	0.540	0.556	P22492.pdb.gz	H1T_HUMAN Histone H1t OS=Homo sapiens OX=9606 GN=H1-6 PE=2 SV=4
11	PDB:7k5yU	0.339	0.933	3.371E-10	75	0.347	0.987	7k5yU.pdb.gz	Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms.
12	PDB:6labV	0.293	0.524	8.432E-4	109	0.207	0.404	6labV.pdb.gz	Engineering nucleosomes for generating diverse chromatin assemblies.
13	PDB:6l9zS	0.281	0.654	1.532E-3	84	0.146	0.369	6l9zS.pdb.gz	Engineering nucleosomes for generating diverse chromatin assemblies.
14	PDB:7kbfK	0.299	0.760	1.750E-3	78	0.103	0.282	7kbfK.pdb.gz	Structural features of nucleosomes in interphase and metaphase chromosomes.
15	PDB:3euhB	0.223	0.157	1.307E-1	321	0.047	0.031	3euhB.pdb.gz
16	PDB:6h1cB	0.290	0.441	1.946E-1	134	0.080	0.127	6h1cB.pdb.gz	Ferric uptake regulator with Mn and Zn form Pseudomonas aeruginosa
17	PDB:2fe3B	0.254	0.366	2.223E-1	143	0.061	0.091	2fe3B.pdb.gz	Crystal structure of the apo-PerR-Zn protein from Bacillus subtilis.
18	PDB:6qpqD	0.249	0.549	3.780E-1	82	0.047	0.122	6qpqD.pdb.gz
19	PDB:2g9wA	0.251	0.431	4.039E-1	119	0.047	0.084	2g9wA.pdb.gz
20	PDB:4a6dA	0.237	0.153	4.039E-1	345	0.052	0.032	4a6dA.pdb.gz	Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P16403	1.09e-127	360	213	1.000	1.000	H12_HUMAN Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2
2	P16402	5.49e-53	171	221	0.592	0.570	H13_HUMAN Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2
3	A5PK20	1.35e-51	167	210	0.765	0.776	A5PK20_BOVIN H1.12 linker histone, cluster member OS=Bos taurus OX=9913 GN=H1-12 PE=2 SV=1
4	P15865	5.60e-49	161	219	0.502	0.489	H14_RAT Histone H1.4 OS=Rattus norvegicus OX=10116 GN=H1-4 PE=1 SV=3
5	P10412	6.05e-49	160	219	0.502	0.489	H14_HUMAN Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2
6	P43274	1.07e-48	160	219	0.502	0.489	H14_MOUSE Histone H1.4 OS=Mus musculus OX=10090 GN=H1-4 PE=1 SV=2
7	P02253	1.01e-43	147	213	0.512	0.512	H12_BOVIN Histone H1.2 OS=Bos taurus OX=9913 GN=H1-2 PE=1 SV=2
8	P43276	2.40e-43	147	223	0.352	0.336	H15_MOUSE Histone H1.5 OS=Mus musculus OX=10090 GN=H1-5 PE=1 SV=2
9	P43277	1.80e-42	144	221	0.488	0.471	H13_MOUSE Histone H1.3 OS=Mus musculus OX=10090 GN=H1-3 PE=1 SV=2
10	P16401	2.78e-40	139	226	0.451	0.425	H15_HUMAN Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3
11	P15864	3.45e-39	135	212	0.507	0.509	H12_MOUSE Histone H1.2 OS=Mus musculus OX=10090 GN=H1-2 PE=1 SV=2
12	P06350	9.14e-36	127	207	0.286	0.295	H1_ONCMY Histone H1 OS=Oncorhynchus mykiss OX=8022 PE=1 SV=2
13	P22492	4.90e-35	125	207	0.540	0.556	H1T_HUMAN Histone H1t OS=Homo sapiens OX=9606 GN=H1-6 PE=2 SV=4
14	Q02539	1.27e-34	124	215	0.385	0.381	H11_HUMAN Histone H1.1 OS=Homo sapiens OX=9606 GN=H1-1 PE=1 SV=3
15	P43275	7.82e-34	122	213	0.390	0.390	H11_MOUSE Histone H1.1 OS=Mus musculus OX=10090 GN=H1-1 PE=1 SV=2
16	P06349	6.64e-32	117	208	0.380	0.389	H1T_RAT Histone H1t OS=Rattus norvegicus OX=10116 GN=H1-6 PE=1 SV=2
17	Q07133	1.30e-31	116	208	0.376	0.385	H1T_MOUSE Histone H1t OS=Mus musculus OX=10090 GN=H1-6 PE=1 SV=4
18	P02255	2.06e-15	74.7	256	0.258	0.215	H1_DROME Histone H1 OS=Drosophila melanogaster OX=7227 GN=His1 PE=1 SV=1
19	Q08GK9	2.57e-14	70.1	178	0.174	0.208	HSPL_MULSU Protamine-like protein OS=Mullus surmuletus OX=87757 GN=pl PE=1 SV=2
20	P10922	6.74e-14	69.3	194	0.197	0.216	H10_MOUSE Histone H1.0 OS=Mus musculus OX=10090 GN=H1-0 PE=2 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF19110 DUF5797	1.8e+02	13.2	Family of unknown function (DUF5797)
2	PF00538 Linker_histone	9.1e-19	78.9	linker histone H1 and H5 family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000339566

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000269305	0.987	Cellular tumor antigen p53
2	9606.ENSP00000345347	0.924	High mobility group protein B1
3	9606.ENSP00000296503	0.923	High mobility group protein B2
4	9606.ENSP00000261366	0.919	Lamin-B1
5	9606.ENSP00000361626	0.910	Nuclease-sensitive element-binding protein 1
6	9606.ENSP00000374213	0.902	E1A-binding protein p400
7	9606.ENSP00000267163	0.901	Retinoblastoma-associated protein
8	9606.ENSP00000475814	0.895	Histone H2A type 2-A
9	9606.ENSP00000349430	0.892	Histone H2B type 1-K
10	9606.ENSP00000289316	0.858	Histone H2B type 1-D
11	9606.ENSP00000364589	0.852	Cullin-4A
12	9606.ENSP00000244537	0.851	Histone cluster 1 H4 family member f
13	9606.ENSP00000448165	0.828	Apoptotic protease-activating factor 1
14	9606.ENSP00000366962	0.825	Histone cluster 1 H2B family member i
15	9606.ENSP00000244573	0.805	Histone H1.1
16	9606.ENSP00000266970	0.782	Cyclin-dependent kinase 2
17	9606.ENSP00000332194	0.767	Histone H2A type 2-C
18	9606.ENSP00000358151	0.755	Histone H2B type 2-E
19	9606.ENSP00000303373	0.749	Histone cluster 1 H2A family member e
20	9606.ENSP00000367022	0.748	Histone H2A type 1-C

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0003677	1.000	DNA binding
GO:0003682	0.993	chromatin binding
GO:0031490	0.983	chromatin DNA binding
GO:0003723	0.757	RNA binding
GO:0005198	0.496	structural molecule activity
GO:0030527	0.378	structural constituent of chromatin

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.987	cellular process
GO:0016043	0.983	cellular component organization
GO:0050789	0.982	regulation of biological process
GO:0071704	0.967	organic substance metabolic process
GO:0044238	0.961	primary metabolic process
GO:0019222	0.952	regulation of metabolic process
GO:0006807	0.947	nitrogen compound metabolic process
GO:0050794	0.943	regulation of cellular process
GO:0060255	0.940	regulation of macromolecule metabolic process
GO:0043170	0.926	macromolecule metabolic process
GO:0048523	0.913	negative regulation of cellular process
GO:0006325	0.861	chromatin organization
GO:0044237	0.832	cellular metabolic process
GO:0019219	0.831	regulation of nucleobase-containing compound metabolic process
GO:0010556	0.806	regulation of macromolecule biosynthetic process
GO:0031326	0.805	regulation of cellular biosynthetic process
GO:0051252	0.798	regulation of RNA metabolic process
GO:0031324	0.769	negative regulation of cellular metabolic process
GO:1901564	0.758	organonitrogen compound metabolic process
GO:0051172	0.755	negative regulation of nitrogen compound metabolic process
GO:0045934	0.753	negative regulation of nucleobase-containing compound metabolic process
GO:0043412	0.747	macromolecule modification
GO:0019538	0.741	protein metabolic process
GO:0010468	0.727	regulation of gene expression
GO:0010605	0.715	negative regulation of macromolecule metabolic process
GO:0036211	0.712	protein modification process
GO:0009890	0.695	negative regulation of biosynthetic process
GO:0031327	0.694	negative regulation of cellular biosynthetic process
GO:0051253	0.650	negative regulation of RNA metabolic process
GO:2001141	0.634	regulation of RNA biosynthetic process
GO:0044260	0.616	cellular macromolecule metabolic process
GO:0006355	0.601	regulation of DNA-templated transcription
GO:0010558	0.551	negative regulation of macromolecule biosynthetic process
GO:0045892	0.514	negative regulation of DNA-templated transcription
GO:0006357	0.507	regulation of transcription by RNA polymerase II
GO:0016570	0.493	histone modification
GO:0032259	0.471	methylation
GO:0008213	0.424	protein alkylation
GO:0018193	0.415	peptidyl-amino acid modification
GO:0048518	0.376	positive regulation of biological process
GO:0048522	0.361	positive regulation of cellular process
GO:0043414	0.361	macromolecule methylation
GO:0018205	0.359	peptidyl-lysine modification
GO:0000122	0.351	negative regulation of transcription by RNA polymerase II
GO:0018022	0.329	peptidyl-lysine methylation

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0000785	1.000	chromatin
GO:0005634	0.997	nucleus
GO:0005654	0.959	nucleoplasm
GO:0032991	0.952	protein-containing complex
GO:0000791	0.608	euchromatin

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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