StarFunc result for job id P16520

User Input

>input (340 residues)
MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA
MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM
CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF
VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA
ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM
KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P16520	1.000	1.000	2.435E-71	340	1.000	1.000	P16520.pdb.gz	GBB3_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 OS=Homo sapiens OX=9606 GN=GNB3 PE=1 SV=1
2	AFDB:B2R6K4	0.999	0.999	4.238E-65	340	0.824	0.824	B2R6K4.pdb.gz	B2R6K4_HUMAN cDNA, FLJ92996, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1), mRNA OS=Homo sapiens OX=9606 PE=2 SV=1
3	AFDB:A8K3F6	0.998	0.998	7.259E-65	340	0.797	0.797	A8K3F6.pdb.gz	A8K3F6_HUMAN cDNA FLJ77654, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 4 (GNB4), mRNA OS=Homo sapiens OX=9606 PE=2 SV=1
4	AFDB:P11017	0.999	0.999	2.130E-64	340	0.809	0.809	P11017.pdb.gz	GBB2_BOVIN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Bos taurus OX=9913 GN=GNB2 PE=2 SV=3
5	AFDB:P17343	0.999	0.999	3.648E-64	340	0.815	0.815	P17343.pdb.gz	GBB1_CAEEL Guanine nucleotide-binding protein subunit beta-1 OS=Caenorhabditis elegans OX=6239 GN=gpb-1 PE=1 SV=2
6	AFDB:P26308	0.998	0.998	1.258E-63	340	0.774	0.774	P26308.pdb.gz	GBB1_DROME Guanine nucleotide-binding protein subunit beta-1 OS=Drosophila melanogaster OX=7227 GN=Gbeta13F PE=1 SV=1
7	AFDB:P36408	0.984	0.964	3.958E-57	347	0.665	0.651	P36408.pdb.gz	GBB_DICDI Guanine nucleotide-binding protein subunit beta OS=Dictyostelium discoideum OX=44689 GN=gpbA PE=1 SV=1
8	AFDB:Q4WVI4	0.980	0.862	8.506E-56	387	0.647	0.568	Q4WVI4.pdb.gz	Q4WVI4_ASPFU G protein complex beta subunit SfaD OS=Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) OX=330879 GN=AFUA_5G12210 PE=3 SV=1
9	PDB:7jvrB	0.991	0.985	1.365E-54	342	0.829	0.825	7jvrB.pdb.gz	Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
10	AFDB:A0A3S5ZPL0	0.959	0.725	6.141E-47	452	0.521	0.392	A0A3S5ZPL0.pdb.gz	A0A3S5ZPL0_BOVIN G protein subunit beta 5 OS=Bos taurus OX=9913 GN=GNB5 PE=3 SV=1
11	AFDB:P62881	0.974	0.840	1.251E-45	395	0.515	0.443	P62881.pdb.gz	GNB5_MOUSE Guanine nucleotide-binding protein subunit beta-5 OS=Mus musculus OX=10090 GN=Gnb5 PE=1 SV=1
12	PDB:7ewpD	0.906	0.908	8.821E-37	339	0.518	0.519	7ewpD.pdb.gz
13	PDB:7ad3F	0.865	0.923	8.049E-31	318	0.379	0.406	7ad3F.pdb.gz	Structure of the class D GPCR Ste2 dimer coupled to two G proteins.
14	PDB:5mzhB	0.733	0.613	8.335E-28	415	0.238	0.195	5mzhB.pdb.gz
15	PDB:3jcmB	0.803	0.643	4.720E-26	429	0.241	0.191	3jcmB.pdb.gz	The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
16	PDB:2h9lA	0.809	0.855	1.192E-24	321	0.200	0.212	2h9lA.pdb.gz
17	PDB:3dm0A	0.796	0.410	6.323E-24	675	0.212	0.107	3dm0A.pdb.gz	Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana.
18	PDB:1vyhC	0.802	0.876	7.841E-24	310	0.194	0.213	1vyhC.pdb.gz
19	PDB:5nnzA	0.716	0.726	4.389E-23	335	0.218	0.221	5nnzA.pdb.gz
20	PDB:5jcsq	0.685	0.496	5.744E-23	488	0.229	0.160	5jcsq.pdb.gz	Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A8K3F6	591	340	0.797	0.797	A8K3F6_HUMAN cDNA FLJ77654, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 4 (GNB4), mRNA OS=Homo sapiens OX=9606 PE=2 SV=1
2	B2R6K4	587	340	0.824	0.824	B2R6K4_HUMAN cDNA, FLJ92996, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1), mRNA OS=Homo sapiens OX=9606 PE=2 SV=1
3	O35353	568	340	0.791	0.791	GBB4_RAT Guanine nucleotide-binding protein subunit beta-4 OS=Rattus norvegicus OX=10116 GN=Gnb4 PE=2 SV=4
4	P11017	595	340	0.809	0.809	GBB2_BOVIN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Bos taurus OX=9913 GN=GNB2 PE=2 SV=3
5	P16520	702	340	1.000	1.000	GBB3_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 OS=Homo sapiens OX=9606 GN=GNB3 PE=1 SV=1
6	P17343	593	340	0.815	0.815	GBB1_CAEEL Guanine nucleotide-binding protein subunit beta-1 OS=Caenorhabditis elegans OX=6239 GN=gpb-1 PE=1 SV=2
7	P26308	568	340	0.774	0.774	GBB1_DROME Guanine nucleotide-binding protein subunit beta-1 OS=Drosophila melanogaster OX=7227 GN=Gbeta13F PE=1 SV=1
8	P29387	567	340	0.791	0.791	GBB4_MOUSE Guanine nucleotide-binding protein subunit beta-4 OS=Mus musculus OX=10090 GN=Gnb4 PE=1 SV=4
9	P52287	685	340	0.965	0.965	GBB3_RAT Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 OS=Rattus norvegicus OX=10116 GN=Gnb3 PE=1 SV=1
10	P54311	595	340	0.832	0.832	GBB1_RAT Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Rattus norvegicus OX=10116 GN=Gnb1 PE=1 SV=4
11	P54313	595	340	0.809	0.809	GBB2_RAT Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Rattus norvegicus OX=10116 GN=Gnb2 PE=1 SV=4
12	P62871	595	340	0.832	0.832	GBB1_BOVIN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Bos taurus OX=9913 GN=GNB1 PE=1 SV=3
13	P62873	595	340	0.832	0.832	GBB1_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens OX=9606 GN=GNB1 PE=1 SV=3
14	P62874	595	340	0.832	0.832	GBB1_MOUSE Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Mus musculus OX=10090 GN=Gnb1 PE=1 SV=3
15	P62879	595	340	0.809	0.809	GBB2_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Homo sapiens OX=9606 GN=GNB2 PE=1 SV=3
16	P62880	595	340	0.809	0.809	GBB2_MOUSE Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Mus musculus OX=10090 GN=Gnb2 PE=1 SV=3
17	Q61011	686	340	0.971	0.971	GBB3_MOUSE Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 OS=Mus musculus OX=10090 GN=Gnb3 PE=1 SV=2
18	Q6FHM2	595	340	0.809	0.809	Q6FHM2_HUMAN Epididymis secretory sperm binding protein OS=Homo sapiens OX=9606 GN=GNB2 PE=2 SV=1
19	Q6PH57	615	340	0.835	0.835	GBB1_DANRE Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Danio rerio OX=7955 GN=gnb1 PE=2 SV=1
20	Q803H5	613	340	0.829	0.829	Q803H5_DANRE Gnb1l protein OS=Danio rerio OX=7955 GN=gnb1l PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF12894 ANAPC4_WD40	3e-12	58.0	Anaphase-promoting complex subunit 4 WD40 domain
2	PF16025 CaM_bind	4.7e+02	12.6	Calcium-dependent calmodulin binding
3	PF02239 Cytochrom_D1	3e+02	11.3	Cytochrome D1 heme domain
4	PF08662 eIF2A	0.0088	27.5	Eukaryotic translation initiation factor eIF2A
5	PF16529 Ge1_WD40	23	15.5	WD40 region of Ge1, enhancer of mRNA-decapping protein
6	PF20426 NBCH_WD40	4e-09	47.4	Neurobeachin beta propeller domain
7	PF00400 WD40	4.6e-38	139.7	WD domain, G-beta repeat
8	PF17005 WD40_like	0.41	21.5	WD40-like domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 60711.ENSCSAP00000006464

Rank	PPI partner	STRING score	Description
1	60711.ENSCSAP00000008190	0.994	G protein subunit gamma 13
2	60711.ENSCSAP00000007704	0.992	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
3	60711.ENSCSAP00000011177	0.991	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
4	60711.ENSCSAP00000015567	0.988	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
5	60711.ENSCSAP00000017690	0.988	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
6	60711.ENSCSAP00000016650	0.987	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
7	60711.ENSCSAP00000002984	0.986	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
8	60711.ENSCSAP00000006292	0.986	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
9	60711.ENSCSAP00000008916	0.978	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
10	60711.ENSCSAP00000008925	0.971	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
11	60711.ENSCSAP00000008070	0.963	Guanine nucleotide binding protein, alpha transducing 3
12	60711.ENSCSAP00000008394	0.960	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
13	60711.ENSCSAP00000018787	0.960	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
14	60711.ENSCSAP00000003642	0.928	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
15	60711.ENSCSAP00000001466	0.924	G protein subunit alpha o1
16	60711.ENSCSAP00000011662	0.912	Uncharacterized protein
17	60711.ENSCSAP00000010462	0.906	G protein subunit alpha i2
18	60711.ENSCSAP00000016476	0.906	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
19	60711.ENSCSAP00000003285	0.905	Phospholipase C, beta 3 (phosphatidylinositol-specific)
20	60711.ENSCSAP00000018657	0.900	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0016817	0.998	hydrolase activity, acting on acid anhydrides
GO:0017111	0.910	ribonucleoside triphosphate phosphatase activity
GO:0003924	0.880	GTPase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0007154	0.997	cell communication
GO:0050896	0.995	response to stimulus
GO:0050794	0.995	regulation of cellular process
GO:0007165	0.993	signal transduction
GO:0007186	0.969	G protein-coupled receptor signaling pathway

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005622	1.000	intracellular anatomical structure
GO:0043227	0.999	membrane-bounded organelle
GO:0005886	0.999	plasma membrane
GO:0005737	0.993	cytoplasm
GO:0005576	0.974	extracellular region
GO:0032991	0.965	protein-containing complex
GO:0005829	0.958	cytosol
GO:0043229	0.950	intracellular organelle
GO:0043231	0.942	intracellular membrane-bounded organelle
GO:0031982	0.886	vesicle
GO:0042995	0.842	cell projection
GO:0120025	0.764	plasma membrane bounded cell projection
GO:0005615	0.763	extracellular space
GO:1903561	0.763	extracellular vesicle
GO:0098552	0.756	side of membrane
GO:0070062	0.751	extracellular exosome
GO:0098562	0.748	cytoplasmic side of membrane
GO:1902494	0.746	catalytic complex
GO:0098796	0.746	membrane protein complex
GO:1905360	0.734	GTPase complex
GO:0009898	0.728	cytoplasmic side of plasma membrane
GO:0019897	0.726	extrinsic component of plasma membrane
GO:0031234	0.723	extrinsic component of cytoplasmic side of plasma membrane
GO:0044297	0.715	cell body
GO:0005834	0.701	heterotrimeric G-protein complex
GO:0043005	0.592	neuron projection
GO:0031090	0.511	organelle membrane
GO:0098588	0.360	bounding membrane of organelle
GO:0012505	0.330	endomembrane system

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.6.-.-	0.998	Acting on acid anhydrides.
RHEA:23680	0.910	a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate
EC:3.6.1.15	0.910	nucleoside-triphosphate phosphatase.
RHEA:19669	0.880	GTP + H2O = GDP + H(+) + phosphate

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