StarFunc result for job id P19021

User Input

>input (973 residues)
MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALD
IRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWF
CDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKD
CSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHH
LGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATH
IGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE
HHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESES
DLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQ
PPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSF
DSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALH
QVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFS
PSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVR
EIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFD
MPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMEN
KPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEH
KLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEE
YSAPLPALAPSSS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A0R4IIV2	0.589	0.567	0.000	1017	0.557	0.533	A0A0R4IIV2.pdb.gz
2	AFDB:P10731	0.612	0.613	0.000	972	0.920	0.921	P10731.pdb.gz	AMD_BOVIN Peptidyl-glycine alpha-amidating monooxygenase OS=Bos taurus OX=9913 GN=PAM PE=1 SV=2
3	AFDB:A0A2R8QJB3	0.337	0.646	3.077E-59	500	0.292	0.568	A0A2R8QJB3.pdb.gz
4	AFDB:Q9V5E1	0.317	0.564	5.672E-35	541	0.160	0.288	Q9V5E1.pdb.gz	PAL1_DROME Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1 OS=Drosophila melanogaster OX=7227 GN=Pal1 PE=1 SV=1
5	AFDB:Q9W1L5	0.294	0.686	1.644E-30	406	0.135	0.323	Q9W1L5.pdb.gz	PAL2_DROME Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 OS=Drosophila melanogaster OX=7227 GN=Pal2 PE=1 SV=2
6	PDB:4zelA	0.243	0.413	5.427E-17	550	0.082	0.145	4zelA.pdb.gz	The crystal structure of human dopamine beta-hydroxylase at 2.9 angstrom resolution.
7	PDB:7jvrB	0.226	0.565	9.585E-11	342	0.034	0.096	7jvrB.pdb.gz	Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
8	AFDB:Q8LPL5	0.206	0.386	1.881E-10	481	0.062	0.125	Q8LPL5.pdb.gz	FZR3_ARATH Protein FIZZY-RELATED 3 OS=Arabidopsis thaliana OX=3702 GN=FZR3 PE=1 SV=1
9	PDB:7pzyh	0.216	0.603	5.859E-10	311	0.042	0.132	7pzyh.pdb.gz	E-site drug specificity of the human pathogen Candida albicans ribosome.
10	PDB:3rfhA	0.223	0.651	6.152E-10	291	0.043	0.144	3rfhA.pdb.gz
11	PDB:7mq8LJ	0.206	0.404	6.461E-10	469	0.045	0.094	7mq8LJ.pdb.gz	Nucleolar maturation of the human small subunit processome.
12	PDB:7qdrC	0.217	0.607	6.785E-10	305	0.047	0.151	7qdrC.pdb.gz
13	PDB:2h9lA	0.221	0.589	7.482E-10	321	0.039	0.118	2h9lA.pdb.gz
14	PDB:5nnzA	0.199	0.500	1.107E-9	335	0.042	0.122	5nnzA.pdb.gz
15	PDB:7mq8LS	0.215	0.413	1.162E-9	453	0.050	0.108	7mq8LS.pdb.gz	Nucleolar maturation of the human small subunit processome.
16	PDB:3dm0A	0.221	0.308	1.413E-9	675	0.038	0.055	3dm0A.pdb.gz	Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana.
17	AFDB:Q5ACY4	0.216	0.333	1.875E-9	597	0.059	0.095	Q5ACY4.pdb.gz	Q5ACY4_CANAL Cdh1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CDH1 PE=3 SV=1
18	AFDB:Q8N157	0.229	0.191	3.212E-9	1196	0.109	0.089	Q8N157.pdb.gz	AHI1_HUMAN Jouberin OS=Homo sapiens OX=9606 GN=AHI1 PE=1 SV=1
19	AFDB:A4D1P6	0.222	0.281	8.112E-8	747	0.067	0.087	A4D1P6.pdb.gz	WDR91_HUMAN WD repeat-containing protein 91 OS=Homo sapiens OX=9606 GN=WDR91 PE=1 SV=2
20	AFDB:Q9LTT9	0.194	0.149	4.077E-7	1340	0.082	0.060	Q9LTT9.pdb.gz	VCR_ARATH Varicose-related protein OS=Arabidopsis thaliana OX=3702 GN=VCR PE=2 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P10731	0.0	1779	972	0.903	0.904	AMD_BOVIN Peptidyl-glycine alpha-amidating monooxygenase OS=Bos taurus OX=9913 GN=PAM PE=1 SV=2
2	P14925	0.0	1781	976	0.891	0.888	AMD_RAT Peptidylglycine alpha-amidating monooxygenase OS=Rattus norvegicus OX=10116 GN=Pam PE=1 SV=1
3	P19021	0.0	2024	973	1.000	1.000	AMD_HUMAN Peptidyl-glycine alpha-amidating monooxygenase OS=Homo sapiens OX=9606 GN=PAM PE=1 SV=2
4	P97467	0.0	1763	979	0.895	0.890	AMD_MOUSE Peptidyl-glycine alpha-amidating monooxygenase OS=Mus musculus OX=10090 GN=Pam PE=1 SV=2
5	Q9V5E1	1.76e-70	246	541	0.163	0.294	PAL1_DROME Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1 OS=Drosophila melanogaster OX=7227 GN=Pal1 PE=1 SV=1
6	Q9W1L5	1.11e-62	220	406	0.128	0.308	PAL2_DROME Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 OS=Drosophila melanogaster OX=7227 GN=Pal2 PE=1 SV=2
7	O01404	1.48e-61	216	365	0.124	0.332	PHM_DROME Peptidylglycine alpha-hydroxylating monooxygenase OS=Drosophila melanogaster OX=7227 GN=Phm PE=1 SV=2
8	O43832	5.27e-47	164	97	0.081	0.814	O43832_HUMAN Peptidylglycine alpha-amidating monooxygenase (Fragment) OS=Homo sapiens OX=9606 PE=2 SV=1
9	P09172	1.06e-18	93.6	617	0.087	0.138	DOPO_HUMAN Dopamine beta-hydroxylase OS=Homo sapiens OX=9606 GN=DBH PE=1 SV=3
10	Q05754	2.32e-17	89.4	620	0.089	0.140	DOPO_RAT Dopamine beta-hydroxylase OS=Rattus norvegicus OX=10116 GN=Dbh PE=1 SV=1
11	Q64237	4.42e-17	88.6	622	0.100	0.156	DOPO_MOUSE Dopamine beta-hydroxylase OS=Mus musculus OX=10090 GN=Dbh PE=1 SV=2
12	P15101	6.92e-17	87.8	610	0.096	0.152	DOPO_BOVIN Dopamine beta-hydroxylase OS=Bos taurus OX=9913 GN=DBH PE=1 SV=2
13	H0Z5G7	1.27e-15	84.0	643	0.086	0.131	H0Z5G7_TAEGU Dopamine beta-hydroxylase OS=Taeniopygia guttata OX=59729 GN=DBH PE=3 SV=2
14	B3DGL8	3.77e-14	79.0	614	0.084	0.134	B3DGL8_DANRE Dopamine beta-hydroxylase OS=Danio rerio OX=7955 GN=DBH PE=2 SV=1
15	Q9XTQ6	7.47e-14	78.2	657	0.082	0.122	TBH1_CAEEL Tyramine beta-hydroxylase OS=Caenorhabditis elegans OX=6239 GN=tbh-1 PE=1 SV=3
16	Q6UVY6	7.51e-13	74.7	613	0.075	0.119	MOXD1_HUMAN DBH-like monooxygenase protein 1 OS=Homo sapiens OX=9606 GN=MOXD1 PE=1 SV=1
17	Q6NP60	1.39e-08	61.2	760	0.058	0.074	MOX12_DROME MOXD1 homolog 2 OS=Drosophila melanogaster OX=7227 GN=olf413 PE=2 SV=1
18	Q5JS37	6.37e-08	58.2	347	0.053	0.150	NHLC3_HUMAN NHL repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=NHLRC3 PE=2 SV=1
19	O75382	8.15e-08	58.9	744	0.046	0.060	TRIM3_HUMAN Tripartite motif-containing protein 3 OS=Homo sapiens OX=9606 GN=TRIM3 PE=1 SV=2
20	Q9R1R2	8.37e-08	58.5	744	0.046	0.060	TRIM3_MOUSE Tripartite motif-containing protein 3 OS=Mus musculus OX=10090 GN=Trim3 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01082 Cu2_monooxygen	1.4e-20	85.3	Copper type II ascorbate-dependent monooxygenase, N-terminal domain
2	PF03712 Cu2_monoox_C	1.6e-39	146.4	Copper type II ascorbate-dependent monooxygenase, C-terminal domain
3	PF01436 NHL	7.7e-24	93.6	NHL repeat
4	PF08450 SGL	8.5	17.5	SMP-30/Gluconolactonase/LRE-like region

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000306100

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000435370	0.941	Ubiquitin-like protein FUBI
2	9606.ENSP00000362381	0.817	Torsin-2A
3	9606.ENSP00000376702	0.812	Cytochrome b561
4	9606.ENSP00000354884	0.763	Ras association domain-containing protein 9
5	9606.ENSP00000386104	0.753	Carboxypeptidase E
6	9606.ENSP00000240874	0.731	Kalirin
7	9606.ENSP00000345728	0.699	Copper-transporting ATPase 1
8	9606.ENSP00000349678	0.684	Myosin-binding protein H-like
9	9606.ENSP00000313691	0.681	Ferritin, mitochondrial
10	9606.ENSP00000482552	0.679	Protein FAM170A
11	9606.ENSP00000261070	0.667	Cytochrome c oxidase copper chaperone
12	9606.ENSP00000420270	0.651	Serine/threonine-protein kinase Kist
13	9606.ENSP00000430598	0.630	Copper transport protein ATOX1
14	9606.ENSP00000481244	0.623	Phospholemman
15	9606.ENSP00000360240	0.620	Glycine N-acyltransferase-like protein 3
16	9606.ENSP00000386135	0.614	Death-associated protein kinase 1
17	9606.ENSP00000231004	0.573	Protein-lysine 6-oxidase
18	9606.ENSP00000303507	0.573	Breakpoint cluster region protein
19	9606.ENSP00000357005	0.563	Junctional adhesion molecule A
20	9606.ENSP00000377710	0.561	Four and a half LIM domains protein 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004504	1.000	peptidylglycine monooxygenase activity
GO:0140096	0.992	catalytic activity, acting on a protein
GO:0016842	0.992	amidine-lyase activity
GO:0005488	0.938	binding
GO:0005515	0.813	protein binding
GO:0043167	0.796	ion binding
GO:0046872	0.737	metal ion binding
GO:0004598	0.735	peptidylamidoglycolate lyase activity
GO:0046914	0.555	transition metal ion binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0043603	0.990	amide metabolic process
GO:0071704	0.947	organic substance metabolic process
GO:0006518	0.891	peptide metabolic process
GO:0050896	0.642	response to stimulus
GO:0009987	0.620	cellular process
GO:0065007	0.345	biological regulation

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	0.998	membrane
GO:0005737	0.998	cytoplasm
GO:0031982	0.997	vesicle
GO:0005576	0.996	extracellular region
GO:0012505	0.994	endomembrane system
GO:0005886	0.992	plasma membrane
GO:0043231	0.989	intracellular membrane-bounded organelle
GO:0005829	0.959	cytosol
GO:0005615	0.901	extracellular space
GO:0031090	0.883	organelle membrane
GO:0031410	0.854	cytoplasmic vesicle
GO:0070062	0.829	extracellular exosome
GO:0098588	0.814	bounding membrane of organelle
GO:0099503	0.738	secretory vesicle
GO:0030141	0.730	secretory granule
GO:0030659	0.683	cytoplasmic vesicle membrane
GO:0030667	0.457	secretory granule membrane
GO:0070013	0.310	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:21452	1.000	a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical
EC:1.14.17.3	1.000	peptidylglycine monooxygenase.
EC:4.3.2.-	0.992	Lyases acting on amides, amidines, etc.
RHEA:20924	0.735	a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C-terminal amide + glyoxylate
EC:4.3.2.5	0.735	peptidylamidoglycolate lyase.

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