StarFunc result for job id P22894

User Input

>input (467 residues)
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P22894	1.000	1.000	5.665E-100	467	1.000	1.000	P22894.pdb.gz	MMP8_HUMAN Neutrophil collagenase OS=Homo sapiens OX=9606 GN=MMP8 PE=1 SV=1
2	AFDB:O88766	0.922	0.924	3.095E-81	466	0.717	0.719	O88766.pdb.gz	MMP8_RAT Neutrophil collagenase OS=Rattus norvegicus OX=10116 GN=Mmp8 PE=2 SV=1
3	AFDB:P03956	0.839	0.836	2.950E-67	469	0.576	0.574	P03956.pdb.gz	MMP1_HUMAN Interstitial collagenase OS=Homo sapiens OX=9606 GN=MMP1 PE=1 SV=3
4	AFDB:Q9EPL5	0.853	0.858	1.969E-65	464	0.503	0.506	Q9EPL5.pdb.gz	MMP1A_MOUSE Interstitial collagenase A OS=Mus musculus OX=10090 GN=Mmp1a PE=2 SV=1
5	AFDB:B5X4P7	0.898	0.887	5.937E-64	473	0.486	0.480	B5X4P7.pdb.gz	B5X4P7_SALSA Collagenase 3 OS=Salmo salar OX=8030 GN=MMP13 PE=2 SV=1
6	AFDB:P45452	0.876	0.869	1.391E-63	471	0.499	0.495	P45452.pdb.gz	MMP13_HUMAN Collagenase 3 OS=Homo sapiens OX=9606 GN=MMP13 PE=1 SV=1
7	AFDB:O55123	0.496	0.487	4.091E-63	476	0.486	0.477	O55123.pdb.gz	MMP10_MOUSE Stromelysin-2 OS=Mus musculus OX=10090 GN=Mmp10 PE=2 SV=1
8	PDB:1su3B	0.794	0.884	5.212E-63	416	0.537	0.603	1su3B.pdb.gz	X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.
9	AFDB:P33435	0.843	0.835	6.087E-63	472	0.488	0.483	P33435.pdb.gz	MMP13_MOUSE Collagenase 3 OS=Mus musculus OX=10090 GN=Mmp13 PE=1 SV=1
10	AFDB:P03957	0.498	0.489	2.122E-62	475	0.484	0.476	P03957.pdb.gz	MMP3_RAT Stromelysin-1 OS=Rattus norvegicus OX=10116 GN=Mmp3 PE=1 SV=1
11	AFDB:P28862	0.496	0.486	2.984E-62	477	0.495	0.484	P28862.pdb.gz	MMP3_MOUSE Stromelysin-1 OS=Mus musculus OX=10090 GN=Mmp3 PE=2 SV=2
12	PDB:1gxdA	0.731	0.567	2.740E-41	624	0.418	0.312	1gxdA.pdb.gz	Structural Insight Into the Complex Formation of Latent Matrix Metalloproteinase 2 with Tissue Inhibitor of Metalloproteinase 2
13	PDB:2mzeA	0.447	0.801	1.031E-21	250	0.244	0.456	2mzeA.pdb.gz	Charge-Triggered Membrane Insertion of Matrix Metalloproteinase-7, Supporter of Innate Immunity and Tumors.
14	PDB:3lp9A	0.338	0.663	3.451E-9	227	0.099	0.203	3lp9A.pdb.gz	Crystal structure and functional insights of hemopexin fold protein from grass pea
15	PDB:5wyjBE	0.204	0.138	2.231E-6	753	0.041	0.025	5wyjBE.pdb.gz	Molecular architecture of the 90S small subunit pre-ribosome.
16	PDB:7d5sBE	0.202	0.122	4.940E-6	865	0.043	0.023	7d5sBE.pdb.gz	Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2)
17	PDB:1aklA	0.261	0.259	6.562E-6	470	0.084	0.083	1aklA.pdb.gz	Crystal structure of the unliganded alkaline protease from Pseudomonas aeruginosa IFO3080 and its conformational changes on ligand binding.
18	PDB:1af0A	0.259	0.258	8.715E-6	470	0.086	0.085	1af0A.pdb.gz	Kinetic characterization of the serralysins: a divergent catalytic mechanism pertaining to astacin-type metalloproteases.
19	PDB:1nr0A	0.233	0.188	1.297E-5	610	0.051	0.039	1nr0A.pdb.gz
20	PDB:7d4iBE	0.202	0.119	1.627E-5	890	0.041	0.021	7d4iBE.pdb.gz	Cryo-EM structure of 90S small ribosomal precursors complex with Dhr1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O70138	0.0	728	465	0.734	0.738	MMP8_MOUSE Neutrophil collagenase OS=Mus musculus OX=10090 GN=Mmp8 PE=2 SV=2
2	O88766	0.0	719	466	0.722	0.723	MMP8_RAT Neutrophil collagenase OS=Rattus norvegicus OX=10116 GN=Mmp8 PE=2 SV=1
3	P03956	0.0	557	469	0.565	0.563	MMP1_HUMAN Interstitial collagenase OS=Homo sapiens OX=9606 GN=MMP1 PE=1 SV=3
4	P22894	0.0	973	467	1.000	1.000	MMP8_HUMAN Neutrophil collagenase OS=Homo sapiens OX=9606 GN=MMP8 PE=1 SV=1
5	P08254	7.80e-170	488	477	0.514	0.503	MMP3_HUMAN Stromelysin-1 OS=Homo sapiens OX=9606 GN=MMP3 PE=1 SV=2
6	P28862	1.49e-167	482	477	0.497	0.486	MMP3_MOUSE Stromelysin-1 OS=Mus musculus OX=10090 GN=Mmp3 PE=2 SV=2
7	P45452	5.96e-166	478	471	0.499	0.495	MMP13_HUMAN Collagenase 3 OS=Homo sapiens OX=9606 GN=MMP13 PE=1 SV=1
8	P33435	2.02e-162	469	472	0.475	0.470	MMP13_MOUSE Collagenase 3 OS=Mus musculus OX=10090 GN=Mmp13 PE=1 SV=1
9	P23097	2.70e-162	468	466	0.471	0.472	MMP13_RAT Collagenase 3 (Fragment) OS=Rattus norvegicus OX=10116 GN=Mmp13 PE=1 SV=1
10	O55123	2.81e-161	466	476	0.488	0.479	MMP10_MOUSE Stromelysin-2 OS=Mus musculus OX=10090 GN=Mmp10 PE=2 SV=1
11	P03957	3.53e-161	466	475	0.484	0.476	MMP3_RAT Stromelysin-1 OS=Rattus norvegicus OX=10116 GN=Mmp3 PE=1 SV=1
12	P09238	1.24e-158	459	476	0.507	0.498	MMP10_HUMAN Stromelysin-2 OS=Homo sapiens OX=9606 GN=MMP10 PE=1 SV=1
13	Q9EPL5	2.95e-158	458	464	0.495	0.498	MMP1A_MOUSE Interstitial collagenase A OS=Mus musculus OX=10090 GN=Mmp1a PE=2 SV=1
14	Q9H306	2.29e-153	447	513	0.480	0.437	MMP27_HUMAN Matrix metalloproteinase-27 OS=Homo sapiens OX=9606 GN=MMP27 PE=1 SV=2
15	P39900	2.50e-152	443	470	0.480	0.477	MMP12_HUMAN Macrophage metalloelastase OS=Homo sapiens OX=9606 GN=MMP12 PE=1 SV=1
16	B5X4P7	1.16e-151	441	473	0.484	0.478	B5X4P7_SALSA Collagenase 3 OS=Salmo salar OX=8030 GN=MMP13 PE=2 SV=1
17	Q9DEE0	3.96e-150	437	475	0.480	0.472	Q9DEE0_ONCMY Matrix metalloproteinase OS=Oncorhynchus mykiss OX=8022 GN=mmp PE=2 SV=1
18	Q9EPL6	9.71e-147	429	463	0.482	0.486	MMP1B_MOUSE Interstitial collagenase B OS=Mus musculus OX=10090 GN=Mmp1b PE=2 SV=1
19	F1QCX8	1.03e-146	429	476	0.458	0.450	F1QCX8_DANRE Matrix metallopeptidase 13a OS=Danio rerio OX=7955 GN=cb1034 PE=3 SV=2
20	O60882	1.45e-142	419	483	0.456	0.441	MMP20_HUMAN Matrix metalloproteinase-20 OS=Homo sapiens OX=9606 GN=MMP20 PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01400 Astacin	2.5e+02	12.7	Astacin (Peptidase family M12A)
2	PF16313 DUF4953	2.3e+02	12.4	Met-zincin
3	PF00045 Hemopexin	3.8e-44	159.7	Hemopexin
4	PF12044 Metallopep	7.9e+02	10.0	Putative peptidase family
5	PF00413 Peptidase_M10	6.2e-59	209.9	Matrixin
6	PF12388 Peptidase_M57	9.1e+02	10.8	Dual-action HEIGH metallo-peptidase
7	PF01471 PG_binding_1	5e-09	47.5	Putative peptidoglycan binding domain
8	PF13582 Reprolysin_3	0.86	21.5	Metallo-peptidase family M12B Reprolysin-like
9	PF13583 Reprolysin_4	40	15.3	Metallo-peptidase family M12B Reprolysin-like
10	PF13688 Reprolysin_5	37	15.9	Metallo-peptidase family M12

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000236826

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000466090	0.971	Neutrophil elastase
2	9606.ENSP00000308938	0.956	Plasminogen
3	9606.ENSP00000331210	0.932	Brevican core protein
4	9606.ENSP00000308720	0.906	Trypsin-1
5	9606.ENSP00000313581	0.905	Kallikrein-2
6	9606.ENSP00000218388	0.896	Metalloproteinase inhibitor 1
7	9606.ENSP00000262768	0.857	Metalloproteinase inhibitor 2
8	9606.ENSP00000434412	0.813	Serpin H1
9	9606.ENSP00000263341	0.763	Interleukin-1 beta
10	9606.ENSP00000287814	0.733	Metalloproteinase inhibitor 4
11	9606.ENSP00000323929	0.727	Alpha-2-macroglobulin
12	9606.ENSP00000387356	0.709	Aggrecan core protein
13	9606.ENSP00000346839	0.707	Fibronectin type III domain containing
14	9606.ENSP00000266085	0.693	Metalloproteinase inhibitor 3
15	9606.ENSP00000306512	0.683	Interleukin-8
16	9606.ENSP00000385675	0.677	Interleukin-6
17	9606.ENSP00000398698	0.675	Tumor necrosis factor
18	9606.ENSP00000295897	0.671	Serum albumin
19	9606.ENSP00000351807	0.662	Elastin
20	9606.ENSP00000361405	0.651	Matrix metalloproteinase-9

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004222	1.000	metalloendopeptidase activity
GO:0008270	0.999	zinc ion binding
GO:0017171	0.971	serine hydrolase activity
GO:0004252	0.926	serine-type endopeptidase activity
GO:0005515	0.597	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050789	0.997	regulation of biological process
GO:0009987	0.993	cellular process
GO:0050794	0.989	regulation of cellular process
GO:0048583	0.978	regulation of response to stimulus
GO:0032501	0.977	multicellular organismal process
GO:0051239	0.960	regulation of multicellular organismal process
GO:0008152	0.952	metabolic process
GO:0048856	0.948	anatomical structure development
GO:0071704	0.942	organic substance metabolic process
GO:0032101	0.930	regulation of response to external stimulus
GO:0031347	0.927	regulation of defense response
GO:0050896	0.926	response to stimulus
GO:0050727	0.911	regulation of inflammatory response
GO:0006807	0.905	nitrogen compound metabolic process
GO:1901564	0.897	organonitrogen compound metabolic process
GO:0050865	0.894	regulation of cell activation
GO:0044238	0.885	primary metabolic process
GO:0048518	0.880	positive regulation of biological process
GO:0043170	0.870	macromolecule metabolic process
GO:0048522	0.862	positive regulation of cellular process
GO:0002694	0.862	regulation of leukocyte activation
GO:0007275	0.845	multicellular organism development
GO:0019538	0.822	protein metabolic process
GO:0006508	0.793	proteolysis
GO:0019222	0.786	regulation of metabolic process
GO:0030198	0.779	extracellular matrix organization
GO:0009056	0.774	catabolic process
GO:0051716	0.732	cellular response to stimulus
GO:0060255	0.726	regulation of macromolecule metabolic process
GO:0022617	0.717	extracellular matrix disassembly
GO:0048519	0.664	negative regulation of biological process
GO:0043030	0.640	regulation of macrophage activation
GO:0009653	0.633	anatomical structure morphogenesis
GO:0032963	0.612	collagen metabolic process
GO:0051171	0.599	regulation of nitrogen compound metabolic process
GO:0009888	0.591	tissue development
GO:0009893	0.563	positive regulation of metabolic process
GO:0031323	0.482	regulation of cellular metabolic process
GO:0048598	0.479	embryonic morphogenesis
GO:0048584	0.475	positive regulation of response to stimulus
GO:0010468	0.470	regulation of gene expression
GO:0042221	0.464	response to chemical
GO:0006950	0.456	response to stress
GO:0051240	0.456	positive regulation of multicellular organismal process
GO:0010604	0.439	positive regulation of macromolecule metabolic process
GO:0010646	0.432	regulation of cell communication
GO:0023051	0.425	regulation of signaling
GO:0009966	0.412	regulation of signal transduction
GO:0051173	0.405	positive regulation of nitrogen compound metabolic process
GO:0048523	0.388	negative regulation of cellular process
GO:0031325	0.384	positive regulation of cellular metabolic process
GO:0080090	0.355	regulation of primary metabolic process
GO:0030154	0.351	cell differentiation
GO:0070887	0.346	cellular response to chemical stimulus
GO:0009892	0.346	negative regulation of metabolic process
GO:0009605	0.344	response to external stimulus
GO:0009889	0.343	regulation of biosynthetic process
GO:0040012	0.325	regulation of locomotion
GO:0001817	0.316	regulation of cytokine production
GO:0065009	0.310	regulation of molecular function
GO:0010033	0.308	response to organic substance

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005615	0.996	extracellular space
GO:0043227	0.960	membrane-bounded organelle
GO:0012505	0.951	endomembrane system
GO:0070013	0.937	intracellular organelle lumen
GO:0071944	0.890	cell periphery
GO:0031982	0.812	vesicle
GO:0005737	0.774	cytoplasm
GO:0043231	0.764	intracellular membrane-bounded organelle
GO:0030141	0.338	secretory granule

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.4.24.-	1.000	Metalloendopeptidases.
EC:3.4.21.-	0.926	Serine endopeptidases.

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