StarFunc result for job id P22897

User Input

>input (1456 residues)
MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRW
VSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYG
NRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYA
DCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTW
HQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY
LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPT
HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND
ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEW
PLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLT
TIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC
VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCF
KLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYG
SPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQ
KGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQS
ESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV
TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIF
GFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTF
LWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQ
TRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNA
FAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK
TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQAS
LECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNW
NTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMD
PSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSD
MKDLVGNIEQNEHSVI

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P22897	1.000	1.000	0.000	1456	1.000	1.000	P22897.pdb.gz	MRC1_HUMAN Macrophage mannose receptor 1 OS=Homo sapiens OX=9606 GN=MRC1 PE=1 SV=1
2	AFDB:Q13018	0.463	0.461	0.000	1463	0.288	0.286	Q13018.pdb.gz	PLA2R_HUMAN Secretory phospholipase A2 receptor OS=Homo sapiens OX=9606 GN=PLA2R1 PE=1 SV=2
3	AFDB:Q4TU93	0.459	0.452	0.000	1480	0.343	0.337	Q4TU93.pdb.gz	MRC2_RAT C-type mannose receptor 2 OS=Rattus norvegicus OX=10116 GN=Mrc2 PE=1 SV=1
4	AFDB:Q61830	0.910	0.910	0.000	1456	0.819	0.819	Q61830.pdb.gz	MRC1_MOUSE Macrophage mannose receptor 1 OS=Mus musculus OX=10090 GN=Mrc1 PE=1 SV=2
5	AFDB:Q62028	0.469	0.459	0.000	1487	0.291	0.284	Q62028.pdb.gz	PLA2R_MOUSE Secretory phospholipase A2 receptor OS=Mus musculus OX=10090 GN=Pla2r1 PE=1 SV=1
6	AFDB:O60449	0.480	0.417	2.824E-100	1722	0.273	0.231	O60449.pdb.gz	LY75_HUMAN Lymphocyte antigen 75 OS=Homo sapiens OX=9606 GN=LY75 PE=1 SV=3
7	AFDB:Q60767	0.457	0.392	2.761E-96	1723	0.269	0.228	Q60767.pdb.gz	LY75_MOUSE Lymphocyte antigen 75 OS=Mus musculus OX=10090 GN=Ly75 PE=1 SV=2
8	PDB:7qsrA	0.463	0.502	3.004E-91	1335	0.271	0.295	7qsrA.pdb.gz
9	PDB:7jptA	0.443	0.482	2.357E-85	1327	0.256	0.281	7jptA.pdb.gz
10	AFDB:P90732	0.095	0.224	1.783E-18	545	0.067	0.178	P90732.pdb.gz	P90732_CAEEL Cubilin OS=Caenorhabditis elegans OX=6239 GN=clec-41 PE=1 SV=1
11	AFDB:Q9XUA7	0.110	0.455	5.623E-18	295	0.046	0.227	Q9XUA7.pdb.gz	Q9XUA7_CAEEL C-type lectin domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=clec-187 PE=1 SV=1
12	AFDB:Q0KKW8	0.086	0.378	2.173E-16	318	0.039	0.179	Q0KKW8.pdb.gz	Q0KKW8_BOMMO Multi-binding protein OS=Bombyx mori OX=7091 GN=BmMBP PE=2 SV=1
13	PDB:1qddA	0.085	0.796	1.387E-9	144	0.030	0.299	1qddA.pdb.gz	Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine.
14	PDB:7wz8A	0.081	0.627	2.219E-9	180	0.030	0.239	7wz8A.pdb.gz
15	PDB:5f2qB	0.083	0.838	2.734E-9	135	0.027	0.296	5f2qB.pdb.gz	C-type lectin from Bothrops jararacussu
16	PDB:4mthA	0.084	0.814	1.790E-8	139	0.026	0.273	4mthA.pdb.gz	Antibacterial membrane attack by a pore-forming intestinal C-type lectin.
17	PDB:1htnA	0.078	0.657	1.003E-7	156	0.027	0.250	1htnA.pdb.gz	Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil.
18	PDB:1gz2A	0.080	0.777	2.435E-7	139	0.023	0.237	1gz2A.pdb.gz
19	PDB:1bj3A	0.068	0.679	1.228E-6	129	0.029	0.326	1bj3A.pdb.gz	Crystal structure of coagulation factor IX-binding protein from habu snake venom at 2.6 A: implication of central loop swapping based on deletion in the linker region.
20	PDB:3bx4C	0.072	0.698	1.437E-6	134	0.027	0.291	3bx4C.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P22897	0.0	3042	1456	1.000	1.000	MRC1_HUMAN Macrophage mannose receptor 1 OS=Homo sapiens OX=9606 GN=MRC1 PE=1 SV=1
2	Q13018	0.0	598	1463	0.295	0.293	PLA2R_HUMAN Secretory phospholipase A2 receptor OS=Homo sapiens OX=9606 GN=PLA2R1 PE=1 SV=2
3	Q4TU93	0.0	815	1480	0.345	0.340	MRC2_RAT C-type mannose receptor 2 OS=Rattus norvegicus OX=10116 GN=Mrc2 PE=1 SV=1
4	Q61830	0.0	2518	1456	0.820	0.820	MRC1_MOUSE Macrophage mannose receptor 1 OS=Mus musculus OX=10090 GN=Mrc1 PE=1 SV=2
5	Q62028	0.0	601	1487	0.297	0.291	PLA2R_MOUSE Secretory phospholipase A2 receptor OS=Mus musculus OX=10090 GN=Pla2r1 PE=1 SV=1
6	Q64449	0.0	824	1479	0.343	0.338	MRC2_MOUSE C-type mannose receptor 2 OS=Mus musculus OX=10090 GN=Mrc2 PE=1 SV=3
7	Q9UBG0	0.0	800	1479	0.339	0.333	MRC2_HUMAN C-type mannose receptor 2 OS=Homo sapiens OX=9606 GN=MRC2 PE=1 SV=2
8	Q60767	5.98e-150	501	1723	0.274	0.232	LY75_MOUSE Lymphocyte antigen 75 OS=Mus musculus OX=10090 GN=Ly75 PE=1 SV=2
9	Q4LDF5	3.41e-149	499	1732	0.266	0.223	Q4LDF5_CHICK DEC-205 protein OS=Gallus gallus OX=9031 GN=DEC205 PE=2 SV=1
10	O60449	2.92e-148	496	1722	0.273	0.231	LY75_HUMAN Lymphocyte antigen 75 OS=Homo sapiens OX=9606 GN=LY75 PE=1 SV=3
11	Q17452	3.75e-25	110	308	0.047	0.224	Q17452_CAEEL C-type lectin domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=clec-52 PE=1 SV=1
12	P55068	3.25e-17	90.1	883	0.040	0.066	PGCB_RAT Brevican core protein OS=Rattus norvegicus OX=10116 GN=Bcan PE=1 SV=2
13	L0N7P8	4.12e-17	84.0	216	0.034	0.231	L0N7P8_ONCMY CD209 antigen-like protein A OS=Oncorhynchus mykiss OX=8022 GN=cd209A PE=2 SV=1
14	O14594	6.25e-17	89.7	1321	0.051	0.056	NCAN_HUMAN Neurocan core protein OS=Homo sapiens OX=9606 GN=NCAN PE=1 SV=3
15	P06734	6.31e-17	85.9	321	0.046	0.209	FCER2_HUMAN Low affinity immunoglobulin epsilon Fc receptor OS=Homo sapiens OX=9606 GN=FCER2 PE=1 SV=1
16	P20693	6.44e-17	86.3	331	0.036	0.160	FCER2_MOUSE Low affinity immunoglobulin epsilon Fc receptor OS=Mus musculus OX=10090 GN=Fcer2 PE=1 SV=1
17	P13608	1.29e-16	89.0	2364	0.076	0.047	PGCA_BOVIN Aggrecan core protein OS=Bos taurus OX=9913 GN=ACAN PE=1 SV=3
18	P55067	1.69e-16	88.2	1257	0.052	0.060	NCAN_RAT Neurocan core protein OS=Rattus norvegicus OX=10116 GN=Ncan PE=1 SV=1
19	P55066	2.24e-16	87.8	1268	0.054	0.062	NCAN_MOUSE Neurocan core protein OS=Mus musculus OX=10090 GN=Ncan PE=1 SV=1
20	Q61361	2.39e-16	87.4	883	0.039	0.065	PGCB_MOUSE Brevican core protein OS=Mus musculus OX=10090 GN=Bcan PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02440 Adeno_E3_CR1	24	16.1	Adenovirus E3 region protein CR1
2	PF03498 CDtoxinA	2.4e+02	12.7	Cytolethal distending toxin A/C domain
3	PF05966 Chordopox_A33R	2	19.2	Chordopoxvirus A33R protein
4	PF00040 fn2	1.6e-12	58.6	Fibronectin type II domain
5	PF00059 Lectin_C	1.1e-170	568.4	Lectin C-type domain
6	PF00652 Ricin_B_lectin	8.1e-05	34.3	Ricin-type beta-trefoil lectin domain
7	PF05473 UL45	0.0015	29.8	UL45 protein, carbohydrate-binding C-type lectin-like
8	PF00193 Xlink	0.23	23.1	Extracellular link domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000455897

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000352071	0.913	Scavenger receptor cysteine-rich type 1 protein M130
2	9606.ENSP00000349446	0.875	Arginase-1
3	9606.ENSP00000358165	0.872	High affinity immunoglobulin gamma Fc receptor I
4	9606.ENSP00000332049	0.859	T-lymphocyte activation antigen CD86
5	9606.ENSP00000250092	0.858	Macrosialin
6	9606.ENSP00000441691	0.850	Integrin alpha-M
7	9606.ENSP00000412237	0.847	Interleukin-10
8	9606.ENSP00000454623	0.835	Integrin alpha-X
9	9606.ENSP00000220809	0.824	Tissue-type plasminogen activator
10	9606.ENSP00000231449	0.823	Interleukin-4
11	9606.ENSP00000283243	0.823	Secretory phospholipase A2 receptor
12	9606.ENSP00000307513	0.822	C-type mannose receptor 2
13	9606.ENSP00000411355	0.810	Receptor-type tyrosine-protein phosphatase C
14	9606.ENSP00000286301	0.798	Macrophage colony-stimulating factor 1 receptor
15	9606.ENSP00000398698	0.796	Tumor necrosis factor
16	9606.ENSP00000263341	0.789	Interleukin-1 beta
17	9606.ENSP00000264246	0.776	T-lymphocyte activation antigen CD80
18	9606.ENSP00000262101	0.764	Macrophage scavenger receptor types I and II
19	9606.ENSP00000304915	0.763	Interleukin-13
20	9606.ENSP00000295755	0.761	Resistin-like beta

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005537	1.000	mannose binding
GO:0038024	0.969	cargo receptor activity
GO:0038023	0.808	signaling receptor activity
GO:0004888	0.707	transmembrane signaling receptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050896	0.977	response to stimulus
GO:0051179	0.946	localization
GO:0009987	0.943	cellular process
GO:0051716	0.865	cellular response to stimulus
GO:0006810	0.864	transport
GO:0006897	0.843	endocytosis
GO:0065007	0.798	biological regulation
GO:0050789	0.788	regulation of biological process
GO:0006898	0.781	receptor-mediated endocytosis
GO:0006950	0.779	response to stress
GO:0002376	0.745	immune system process
GO:0006955	0.732	immune response
GO:0009605	0.717	response to external stimulus
GO:0006952	0.705	defense response
GO:0044419	0.685	biological process involved in interspecies interaction between organisms
GO:0009607	0.685	response to biotic stimulus
GO:0009617	0.682	response to bacterium
GO:0048518	0.681	positive regulation of biological process
GO:0042221	0.640	response to chemical
GO:0010033	0.578	response to organic substance
GO:0050794	0.527	regulation of cellular process
GO:0070887	0.476	cellular response to chemical stimulus
GO:0032501	0.318	multicellular organismal process
GO:0071310	0.303	cellular response to organic substance

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0043227	0.961	membrane-bounded organelle
GO:0012505	0.955	endomembrane system
GO:0005622	0.941	intracellular anatomical structure
GO:0043229	0.913	intracellular organelle
GO:0043231	0.894	intracellular membrane-bounded organelle
GO:0005737	0.889	cytoplasm
GO:0031982	0.849	vesicle
GO:0031410	0.772	cytoplasmic vesicle
GO:0031090	0.676	organelle membrane
GO:0005768	0.663	endosome
GO:0030659	0.626	cytoplasmic vesicle membrane
GO:0009986	0.532	cell surface
GO:0098588	0.532	bounding membrane of organelle
GO:0010008	0.386	endosome membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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