StarFunc result for job id P23396

User Input

>input (243 residues)
MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLG
EKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACY
GVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQG
VLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPV
PTA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q6TLG8	0.934	0.927	2.355E-47	245	0.967	0.959	Q6TLG8.pdb.gz
2	AFDB:Q06559	0.927	0.916	3.985E-42	246	0.790	0.780	Q06559.pdb.gz	RS3_DROME Small ribosomal subunit protein uS3 OS=Drosophila melanogaster OX=7227 GN=RpS3 PE=1 SV=1
3	AFDB:Q9SIP7	0.889	0.864	3.025E-41	250	0.774	0.752	Q9SIP7.pdb.gz	RS31_ARATH Small ribosomal subunit protein uS3z OS=Arabidopsis thaliana OX=3702 GN=RPS3A PE=1 SV=1
4	AFDB:Q5B5U3	0.907	0.836	1.746E-37	264	0.683	0.629	Q5B5U3.pdb.gz	Q5B5U3_EMENI 40S ribosomal protein S3 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_04087 PE=3 SV=1
5	PDB:6fecg	0.851	0.907	3.480E-37	227	0.930	0.996	6fecg.pdb.gz	Structure of a human cap-dependent 48S translation pre-initiation complex.
6	AFDB:O60128	0.887	0.866	2.449E-36	249	0.663	0.647	O60128.pdb.gz	RS3_SCHPO Small ribosomal subunit protein uS3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rps3 PE=1 SV=1
7	AFDB:Q6FNJ4	0.883	0.870	4.526E-36	247	0.671	0.660	Q6FNJ4.pdb.gz	Q6FNJ4_CANGA 40S ribosomal protein S3 OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=CAGL0J11220g PE=3 SV=1
8	AFDB:Q8IKH8	0.876	0.962	3.654E-35	221	0.626	0.688	Q8IKH8.pdb.gz	Q8IKH8_PLAF7 40S ribosomal protein S3 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1465900 PE=1 SV=1
9	PDB:4v6wAD	0.880	0.940	2.813E-34	227	0.786	0.841	4v6wAD.pdb.gz	Structures of the human and Drosophila 80S ribosome.
10	AFDB:P90526	0.859	0.957	2.531E-33	218	0.551	0.615	P90526.pdb.gz	RS3_DICDI Small ribosomal subunit protein uS3 OS=Dictyostelium discoideum OX=44689 GN=rps3 PE=1 SV=1
11	PDB:5datS3	0.846	0.918	1.524E-32	223	0.634	0.691	5datS3.pdb.gz	Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
12	AFDB:Q38EW1	0.850	0.778	1.807E-32	266	0.519	0.474	Q38EW1.pdb.gz	Q38EW1_TRYB2 40S ribosomal protein S3, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.160.4450 PE=3 SV=1
13	AFDB:A0A1D8PSV5	0.867	0.840	3.340E-32	251	0.547	0.530	A0A1D8PSV5.pdb.gz	RS3_CANAL Small ribosomal subunit protein uS3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=RPS3 PE=1 SV=1
14	PDB:7pzyE	0.851	0.924	3.190E-30	223	0.539	0.587	7pzyE.pdb.gz	E-site drug specificity of the human pathogen Candida albicans ribosome.
15	PDB:4v8mAX	0.797	0.939	7.803E-25	205	0.506	0.600	4v8mAX.pdb.gz	High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome.
16	PDB:3j7aD	0.624	0.957	4.116E-18	157	0.494	0.764	3j7aD.pdb.gz	Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
17	PDB:3j9zSC	0.676	0.705	1.451E-16	232	0.218	0.228	3j9zSC.pdb.gz	Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G.
18	PDB:7kgbc	0.654	0.759	8.614E-16	207	0.177	0.208	7kgbc.pdb.gz	Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
19	PDB:5mrcCC	0.437	0.327	1.178E-7	339	0.107	0.077	5mrcCC.pdb.gz	The structure of the yeast mitochondrial ribosome.
20	PDB:1wf3A	0.193	0.166	1.219E-2	296	0.078	0.064	1wf3A.pdb.gz	Crystal structure of GTP-binding protein TT1341 from Thermus thermophilus HB8

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P23396	1.61e-178	491	243	1.000	1.000	RS3_HUMAN Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2
2	Q0Z8U2	1.61e-178	491	243	1.000	1.000	RS3_PIG Small ribosomal subunit protein uS3 OS=Sus scrofa OX=9823 GN=RPS3 PE=1 SV=1
3	P62908	3.66e-178	490	243	0.996	0.996	RS3_MOUSE Small ribosomal subunit protein uS3 OS=Mus musculus OX=10090 GN=Rps3 PE=1 SV=1
4	P62909	3.66e-178	490	243	0.996	0.996	RS3_RAT Small ribosomal subunit protein uS3 OS=Rattus norvegicus OX=10116 GN=Rps3 PE=1 SV=1
5	Q7ZVD9	6.30e-170	469	245	0.959	0.951	Q7ZVD9_DANRE DNA-(apurinic or apyrimidinic site) lyase OS=Danio rerio OX=7955 GN=wu:fb13d09 PE=1 SV=1
6	E9PL09	2.68e-166	460	231	0.951	1.000	E9PL09_HUMAN Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=1
7	Q06559	5.62e-139	391	246	0.794	0.785	RS3_DROME Small ribosomal subunit protein uS3 OS=Drosophila melanogaster OX=7227 GN=RpS3 PE=1 SV=1
8	Q9SIP7	7.05e-130	369	250	0.749	0.728	RS31_ARATH Small ribosomal subunit protein uS3z OS=Arabidopsis thaliana OX=3702 GN=RPS3A PE=1 SV=1
9	Q9FJA6	7.38e-128	363	248	0.757	0.742	RS33_ARATH Small ribosomal subunit protein uS3x OS=Arabidopsis thaliana OX=3702 GN=RPS3C PE=1 SV=1
10	Q9M339	1.64e-125	357	249	0.728	0.711	RS32_ARATH Small ribosomal subunit protein uS3y OS=Arabidopsis thaliana OX=3702 GN=RPS3B PE=1 SV=1
11	Q5B5U3	2.61e-115	332	264	0.691	0.636	Q5B5U3_EMENI 40S ribosomal protein S3 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_04087 PE=3 SV=1
12	O60128	1.18e-112	325	249	0.663	0.647	RS3_SCHPO Small ribosomal subunit protein uS3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rps3 PE=1 SV=1
13	Q6FNJ4	4.24e-110	318	247	0.667	0.656	Q6FNJ4_CANGA 40S ribosomal protein S3 OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=CAGL0J11220g PE=3 SV=1
14	P05750	1.40e-107	311	240	0.654	0.662	RS3_YEAST Small ribosomal subunit protein uS3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPS3 PE=1 SV=5
15	Q8IKH8	6.94e-105	304	221	0.626	0.688	Q8IKH8_PLAF7 40S ribosomal protein S3 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1465900 PE=1 SV=1
16	P90526	1.83e-90	268	218	0.556	0.619	RS3_DICDI Small ribosomal subunit protein uS3 OS=Dictyostelium discoideum OX=44689 GN=rps3 PE=1 SV=1
17	H0YEU2	3.73e-90	265	171	0.523	0.743	H0YEU2_HUMAN Ribosomal protein S3 (Fragment) OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=1
18	A0A1D8PSV5	4.39e-88	263	251	0.564	0.546	RS3_CANAL Small ribosomal subunit protein uS3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=RPS3 PE=1 SV=1
19	Q389I7	6.17e-88	261	214	0.523	0.593	Q389I7_TRYB2 40S ribosomal protein S3, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.26.0370 PE=1 SV=1
20	Q38EW1	8.75e-87	260	266	0.523	0.477	Q38EW1_TRYB2 40S ribosomal protein S3, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.160.4450 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF07650 KH_2	4.4e-08	44.1	KH domain
2	PF00189 Ribosomal_S3_C	2.9e-20	83.8	Ribosomal protein S3, C-terminal domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 89462.XP_006074139.1

Rank	PPI partner	STRING score	Description
1	89462.XP_006046787.1	0.999	40S ribosomal protein S28
2	89462.XP_006053495.1	0.999	40S ribosomal protein S9
3	89462.XP_006054218.1	0.999	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 17 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 30 samples with support for all annotated introns
4	89462.XP_006056556.1	0.999	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 ESTs, 9 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 30 samples with support for all annotated introns
5	89462.XP_006059412.1	0.999	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 14 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 30 samples with support for all annotated introns
6	89462.XP_006071069.1	0.999	Uncharacterized protein LOC102401365
7	89462.XP_006075960.1	0.999	Guanine nucleotide-binding protein subunit beta-2-like 1
8	89462.XP_006080163.1	0.999	40S ribosomal protein S11
9	89462.XP_006039696.1	0.998	40S ribosomal protein S14-like
10	89462.XP_006040067.1	0.998	40S ribosomal protein S5-like
11	89462.XP_006040183.1	0.998	40S ribosomal protein S3a-like
12	89462.XP_006042089.1	0.998	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 15 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 30 samples with support for all annotated introns
13	89462.XP_006048351.1	0.998	40S ribosomal protein S18-like
14	89462.XP_006050373.1	0.998	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 13 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 30 samples with support for all annotated introns
15	89462.XP_006050406.1	0.998	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 100% coverage of the annotated genomic feature by RNAseq alignments, including 30 samples with support for all annotated introns
16	89462.XP_006050587.1	0.998	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 12 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 30 samples with support for all annotated introns
17	89462.XP_006052653.1	0.998	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 20 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 28 samples with support for all annotated introns
18	89462.XP_006061062.1	0.998	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 ESTs, 25 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 30 samples with support for all annotated introns
19	89462.XP_006064132.1	0.998	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 29 Proteins, and 98% coverage of the annotated genomic feature by RNAseq alignments
20	89462.XP_006067329.1	0.998	40S ribosomal protein S5

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005488	0.998	binding
GO:0003735	0.998	structural constituent of ribosome
GO:0005515	0.994	protein binding
GO:0003676	0.992	nucleic acid binding
GO:0140097	0.970	catalytic activity, acting on DNA
GO:0003906	0.933	DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0003729	0.923	mRNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0071704	0.988	organic substance metabolic process
GO:0044237	0.988	cellular metabolic process
GO:0006807	0.985	nitrogen compound metabolic process
GO:0044260	0.978	cellular macromolecule metabolic process
GO:0034641	0.976	cellular nitrogen compound metabolic process
GO:0044238	0.967	primary metabolic process
GO:1901564	0.945	organonitrogen compound metabolic process
GO:0043603	0.937	amide metabolic process
GO:0010467	0.936	gene expression
GO:0009058	0.935	biosynthetic process
GO:0019538	0.935	protein metabolic process
GO:0006412	0.926	translation
GO:0065007	0.742	biological regulation
GO:0050794	0.543	regulation of cellular process
GO:0050896	0.540	response to stimulus
GO:0032501	0.532	multicellular organismal process
GO:0048856	0.526	anatomical structure development
GO:0019222	0.389	regulation of metabolic process
GO:0030154	0.356	cell differentiation
GO:0031323	0.355	regulation of cellular metabolic process
GO:0048468	0.351	cell development
GO:0051716	0.333	cellular response to stimulus
GO:0051090	0.315	regulation of DNA-binding transcription factor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.999	cytoplasm
GO:0043229	0.999	intracellular organelle
GO:0032991	0.997	protein-containing complex
GO:0015935	0.986	small ribosomal subunit
GO:0005829	0.985	cytosol
GO:0043231	0.982	intracellular membrane-bounded organelle
GO:0016020	0.955	membrane
GO:0022627	0.953	cytosolic small ribosomal subunit
GO:0031090	0.925	organelle membrane
GO:0012505	0.899	endomembrane system
GO:0031967	0.883	organelle envelope
GO:0005739	0.799	mitochondrion
GO:0031966	0.721	mitochondrial membrane
GO:0005743	0.454	mitochondrial inner membrane
GO:0070013	0.393	intracellular organelle lumen
GO:0030054	0.322	cell junction

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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