StarFunc result for job id P24941

User Input

>input (298 residues)
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A024RB77	0.984	0.984	7.581E-55	298	1.000	1.000	A0A024RB77.pdb.gz
2	AFDB:G3V5T9	0.976	0.842	2.287E-52	346	1.000	0.861	G3V5T9.pdb.gz	G3V5T9_HUMAN Cyclin dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=1
3	AFDB:P23437	0.973	0.976	1.986E-51	297	0.889	0.892	P23437.pdb.gz	CDK2_XENLA Cyclin-dependent kinase 2 OS=Xenopus laevis OX=8355 GN=cdk2 PE=1 SV=3
4	AFDB:F1SPH6	0.978	0.767	2.219E-51	381	0.983	0.769	F1SPH6.pdb.gz	F1SPH6_PIG Cyclin dependent kinase 2 OS=Sus scrofa OX=9823 GN=CDK2 PE=3 SV=3
5	PDB:4gcjA	0.942	0.924	2.908E-49	304	1.000	0.980	4gcjA.pdb.gz	Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
6	PDB:4ek6A	0.905	0.966	1.299E-48	279	0.933	0.996	4ek6A.pdb.gz	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
7	AFDB:Q00526	0.934	0.913	1.570E-45	305	0.758	0.741	Q00526.pdb.gz	CDK3_HUMAN Cyclin-dependent kinase 3 OS=Homo sapiens OX=9606 GN=CDK3 PE=1 SV=1
8	AFDB:A0A024RB10	0.860	0.968	1.155E-44	264	0.886	1.000	A0A024RB10.pdb.gz
9	AFDB:Q7T3L7	0.939	0.927	5.738E-42	302	0.654	0.646	Q7T3L7.pdb.gz	Q7T3L7_DANRE Cell division control protein 2 OS=Danio rerio OX=7955 GN=cdc2 PE=1 SV=1
10	AFDB:F1NBD7	0.949	0.933	6.411E-42	303	0.658	0.647	F1NBD7.pdb.gz	F1NBD7_CHICK Cyclin dependent kinase 1 OS=Gallus gallus OX=9031 GN=CDK1 PE=1 SV=1
11	AFDB:P24033	0.935	0.923	1.180E-41	302	0.658	0.649	P24033.pdb.gz	CDK1B_XENLA Cyclin-dependent kinase 1-B OS=Xenopus laevis OX=8355 GN=cdk1-b PE=1 SV=2
12	AFDB:P29618	0.930	0.942	2.425E-41	294	0.671	0.680	P29618.pdb.gz	CDKA1_ORYSJ Cyclin-dependent kinase A-1 OS=Oryza sativa subsp. japonica OX=39947 GN=CDKA-1 PE=1 SV=1
13	PDB:4eomC	0.832	0.896	3.550E-39	276	0.903	0.975	4eomC.pdb.gz	An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
14	PDB:4yc3A	0.893	0.902	6.152E-37	295	0.641	0.647	4yc3A.pdb.gz
15	PDB:1unlA	0.869	0.886	4.137E-33	292	0.584	0.596	1unlA.pdb.gz	Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
16	PDB:4krcA	0.862	0.865	5.769E-33	297	0.554	0.556	4krcA.pdb.gz	New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition.
17	PDB:1blxA	0.843	0.825	2.478E-27	305	0.480	0.469	1blxA.pdb.gz	Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.
18	PDB:3mi9A	0.835	0.760	2.028E-24	329	0.409	0.371	3mi9A.pdb.gz	Crystal structure of HIV-1 Tat complexed with human P-TEFb.
19	PDB:2w96B	0.760	0.843	1.577E-23	267	0.419	0.468	2w96B.pdb.gz
20	PDB:7kpvA	0.845	0.712	1.577E-23	357	0.359	0.300	7kpvA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	F1SPH6	0.0	570	381	0.987	0.772	F1SPH6_PIG Cyclin dependent kinase 2 OS=Sus scrofa OX=9823 GN=CDK2 PE=3 SV=3
2	G3V5T9	0.0	592	346	1.000	0.861	G3V5T9_HUMAN Cyclin dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=1
3	O55076	0.0	610	298	0.987	0.987	CDK2_CRIGR Cyclin-dependent kinase 2 OS=Cricetulus griseus OX=10029 GN=CDK2 PE=1 SV=1
4	P23437	0.0	563	297	0.889	0.892	CDK2_XENLA Cyclin-dependent kinase 2 OS=Xenopus laevis OX=8355 GN=cdk2 PE=1 SV=3
5	P24941	0.0	616	298	1.000	1.000	CDK2_HUMAN Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2
6	P97377	0.0	588	346	0.990	0.853	CDK2_MOUSE Cyclin-dependent kinase 2 OS=Mus musculus OX=10090 GN=Cdk2 PE=1 SV=2
7	Q63699	0.0	610	298	0.987	0.987	CDK2_RAT Cyclin-dependent kinase 2 OS=Rattus norvegicus OX=10116 GN=Cdk2 PE=1 SV=1
8	A8UKE6	2.93e-175	485	237	0.785	0.987	A8UKE6_RABIT Cyclin-dependent kinase 2 (Fragment) OS=Oryctolagus cuniculus OX=9986 GN=CDK2 PE=1 SV=1
9	Q00526	3.96e-171	478	305	0.762	0.744	CDK3_HUMAN Cyclin-dependent kinase 3 OS=Homo sapiens OX=9606 GN=CDK3 PE=1 SV=1
10	E7ESI2	6.68e-165	459	238	0.799	1.000	E7ESI2_HUMAN Cyclin dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=1
11	P29618	3.82e-151	426	294	0.671	0.680	CDKA1_ORYSJ Cyclin-dependent kinase A-1 OS=Oryza sativa subsp. japonica OX=39947 GN=CDKA-1 PE=1 SV=1
12	P24100	2.85e-148	419	294	0.668	0.677	CDKA1_ARATH Cyclin-dependent kinase A-1 OS=Arabidopsis thaliana OX=3702 GN=CDKA-1 PE=1 SV=1
13	Q7T3L7	6.96e-147	416	302	0.668	0.659	Q7T3L7_DANRE Cell division control protein 2 OS=Danio rerio OX=7955 GN=cdc2 PE=1 SV=1
14	Q00646	7.21e-146	414	323	0.681	0.628	CDK1_EMENI Cyclin-dependent kinase 1 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=nimX PE=2 SV=1
15	P34117	7.03e-145	410	292	0.651	0.664	CDK5_DICDI Cyclin-dependent kinase 5 homolog OS=Dictyostelium discoideum OX=44689 GN=cdk5 PE=2 SV=2
16	P04551	7.20e-145	410	297	0.651	0.653	CDK1_SCHPO Cyclin-dependent kinase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cdc2 PE=1 SV=1
17	P35567	1.66e-144	410	302	0.668	0.659	CDK1A_XENLA Cyclin-dependent kinase 1-A OS=Xenopus laevis OX=8355 GN=cdk1-a PE=1 SV=1
18	P24033	3.34e-144	409	302	0.664	0.656	CDK1B_XENLA Cyclin-dependent kinase 1-B OS=Xenopus laevis OX=8355 GN=cdk1-b PE=1 SV=2
19	C0SW08	2.07e-143	407	297	0.661	0.663	C0SW08_PIG Cell division cycle 2 OS=Sus scrofa OX=9823 GN=CDK1 PE=1 SV=1
20	P06493	4.00e-143	406	297	0.658	0.660	CDK1_HUMAN Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	0.023	25.4	ABC1 atypical kinase-like domain
2	PF01636 APH	58	15.0	Phosphotransferase enzyme family
3	PF12330 Haspin_kinase	0.29	21.6	Haspin like kinase domain
4	PF14531 Kinase-like	3.5e+02	11.9	Kinase-like
5	PF00069 Pkinase	1.9e-75	265.3	Protein kinase domain
6	PF07714 PK_Tyr_Ser-Thr	2.2e-32	124.0	Protein tyrosine and serine/threonine kinase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61622.XP_010376127.1

Rank	PPI partner	STRING score	Description
1	61622.XP_010352788.1	0.999	Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated
2	61622.XP_010354087.1	0.999	Belongs to the cyclin family.
3	61622.XP_010357447.1	0.999	Belongs to the cyclin family.
4	61622.XP_010358945.1	0.999	Belongs to the cyclin family.
5	61622.XP_010360864.1	0.999	Belongs to the cyclin family.
6	61622.XP_010369310.1	0.999	Cyclin dependent kinase inhibitor 1B
7	61622.XP_010377235.1	0.999	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand
8	61622.XP_010380433.1	0.999	Belongs to the cyclin family.
9	61622.XP_010381400.1	0.999	Belongs to the cyclin family.
10	61622.XP_010387996.1	0.999	Cyclin-dependent kinase inhibitor 1
11	61622.XP_010352983.1	0.998	Belongs to the cyclin family.
12	61622.XP_010378516.1	0.998	Belongs to the cyclin family.
13	61622.XP_010362160.1	0.997	RB transcriptional corepressor 1
14	61622.XP_010367952.1	0.997	Cyclin D3
15	61622.XP_010378521.1	0.996	Belongs to the protein kinase superfamily.
16	61622.XP_010353624.1	0.995	RB transcriptional corepressor like 1
17	61622.XP_010359632.1	0.995	Cyclin-dependent kinases regulatory subunit 1
18	61622.XP_010362971.1	0.995	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 8 mRNAs, 233 ESTs, 7 Proteins, and 93% coverage of the annotated genomic feature by RNAseq alignments, including 1 sample with support for all annotated introns
19	61622.XP_010363228.1	0.995	Histone H1.1
20	61622.XP_010369473.1	0.995	speedy/RINGO cell cycle regulator family member A

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0004674	1.000	protein serine/threonine kinase activity
GO:0004693	0.991	cyclin-dependent protein serine/threonine kinase activity
GO:1901363	0.392	heterocyclic compound binding
GO:0097159	0.390	organic cyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.995	cellular process
GO:0050794	0.990	regulation of cellular process
GO:0050896	0.972	response to stimulus
GO:0019222	0.871	regulation of metabolic process
GO:0008152	0.866	metabolic process
GO:0071704	0.862	organic substance metabolic process
GO:0060255	0.862	regulation of macromolecule metabolic process
GO:0044238	0.855	primary metabolic process
GO:0006807	0.846	nitrogen compound metabolic process
GO:0043170	0.829	macromolecule metabolic process
GO:0051716	0.828	cellular response to stimulus
GO:0044237	0.798	cellular metabolic process
GO:0051171	0.770	regulation of nitrogen compound metabolic process
GO:0080090	0.765	regulation of primary metabolic process
GO:0048518	0.761	positive regulation of biological process
GO:0031323	0.761	regulation of cellular metabolic process
GO:0048522	0.737	positive regulation of cellular process
GO:0048519	0.627	negative regulation of biological process
GO:0048523	0.524	negative regulation of cellular process
GO:0071840	0.498	cellular component organization or biogenesis
GO:0051726	0.483	regulation of cell cycle
GO:1901564	0.477	organonitrogen compound metabolic process
GO:0016043	0.448	cellular component organization
GO:0034641	0.448	cellular nitrogen compound metabolic process
GO:0006950	0.444	response to stress
GO:0007049	0.441	cell cycle
GO:0019219	0.441	regulation of nucleobase-containing compound metabolic process
GO:0010468	0.429	regulation of gene expression
GO:0019538	0.425	protein metabolic process
GO:0007154	0.420	cell communication
GO:0009893	0.419	positive regulation of metabolic process
GO:0006725	0.395	cellular aromatic compound metabolic process
GO:0009889	0.387	regulation of biosynthetic process
GO:0031326	0.376	regulation of cellular biosynthetic process
GO:1901360	0.371	organic cyclic compound metabolic process
GO:0036211	0.367	protein modification process
GO:0048583	0.365	regulation of response to stimulus
GO:0046483	0.354	heterocycle metabolic process
GO:0051173	0.349	positive regulation of nitrogen compound metabolic process
GO:0010604	0.347	positive regulation of macromolecule metabolic process
GO:0006139	0.342	nucleobase-containing compound metabolic process
GO:0023052	0.337	signaling
GO:0031325	0.337	positive regulation of cellular metabolic process
GO:0010556	0.334	regulation of macromolecule biosynthetic process
GO:0007165	0.328	signal transduction
GO:0000278	0.326	mitotic cell cycle
GO:0033554	0.319	cellular response to stress
GO:0051246	0.300	regulation of protein metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	0.999	nucleoplasm
GO:0005829	0.996	cytosol
GO:0043232	0.996	intracellular non-membrane-bounded organelle
GO:0032991	0.992	protein-containing complex
GO:0005856	0.936	cytoskeleton
GO:0015630	0.884	microtubule cytoskeleton
GO:1902494	0.826	catalytic complex
GO:0061695	0.380	transferase complex, transferring phosphorus-containing groups
GO:0000307	0.327	cyclin-dependent protein kinase holoenzyme complex
GO:0005813	0.318	centrosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.1.-	1.000	Phosphotransferases with an alcohol group as acceptor.
EC:2.7.11.22	0.991	cyclin-dependent kinase.

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