StarFunc result for job id P25398

User Input

>input (132 residues)
MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPM
YVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQA
KDVIEEYFKCKK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P25398	1.000	1.000	5.388E-27	132	1.000	1.000	P25398.pdb.gz	RS12_HUMAN Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3
2	AFDB:O74322	0.907	0.810	5.134E-19	148	0.606	0.541	O74322.pdb.gz	RS12B_SCHPO Small ribosomal subunit protein eS12B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rps1202 PE=3 SV=1
3	AFDB:P80455	0.918	0.873	6.188E-19	139	0.629	0.597	P80455.pdb.gz	RS12_DROME Small ribosomal subunit protein eS12 OS=Drosophila melanogaster OX=7227 GN=RpS12 PE=1 SV=2
4	AFDB:Q54PX9	0.910	0.884	1.902E-17	136	0.508	0.493	Q54PX9.pdb.gz	RS12_DICDI Small ribosomal subunit protein eS12 OS=Dictyostelium discoideum OX=44689 GN=rps12 PE=1 SV=1
5	AFDB:Q9S9P1	0.909	0.835	2.597E-17	144	0.492	0.451	Q9S9P1.pdb.gz	RS121_ARATH Small ribosomal subunit protein eS12z OS=Arabidopsis thaliana OX=3702 GN=RPS12A PE=2 SV=1
6	AFDB:Q9SKZ3	0.892	0.819	2.597E-17	144	0.500	0.458	Q9SKZ3.pdb.gz	RS122_ARATH Small ribosomal subunit protein eS12y OS=Arabidopsis thaliana OX=3702 GN=RPS12C PE=1 SV=1
7	PDB:6fecr	0.819	0.867	3.014E-17	124	0.939	1.000	6fecr.pdb.gz	Structure of a human cap-dependent 48S translation pre-initiation complex.
8	AFDB:P48589	0.889	0.822	9.023E-17	143	0.500	0.462	P48589.pdb.gz	RS12_YEAST Small ribosomal subunit protein eS12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPS12 PE=1 SV=1
9	AFDB:Q03253	0.861	0.792	1.685E-15	144	0.356	0.326	Q03253.pdb.gz	RS12_TRYBB Small ribosomal subunit protein eS12 OS=Trypanosoma brucei brucei OX=5702 GN=RPS12 PE=2 SV=2
10	AFDB:Q38AC1	0.834	0.777	6.231E-15	142	0.356	0.331	Q38AC1.pdb.gz	Q38AC1_TRYB2 40S ribosomal protein S12 OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.6k15.2050 PE=3 SV=1
11	PDB:4v6wAM	0.800	0.882	9.926E-12	119	0.591	0.655	4v6wAM.pdb.gz	Structures of the human and Drosophila 80S ribosome.
12	PDB:6faiM	0.762	0.800	3.449E-11	125	0.477	0.504	6faiM.pdb.gz	Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit.
13	PDB:5fciC2	0.817	0.867	1.637E-10	124	0.432	0.460	5fciC2.pdb.gz	?
14	PDB:5ndvC2	0.699	0.892	3.252E-9	102	0.402	0.520	5ndvC2.pdb.gz	Aminoglycoside interactions and impacts on the eukaryotic ribosome.
15	AFDB:P62009	0.623	0.664	4.079E-8	123	0.242	0.260	P62009.pdb.gz	RL7A_PYRHO Large ribosomal subunit protein eL8 OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) OX=70601 GN=rpl7ae PE=1 SV=1
16	PDB:2kg4A	0.649	0.534	1.546E-7	165	0.288	0.230	2kg4A.pdb.gz
17	PDB:5y7mA	0.623	0.655	2.544E-7	125	0.220	0.232	5y7mA.pdb.gz	Crystal structures of the archaeal RNase P protein Rpp38 in complex with RNA fragments containing a K-turn motif.
18	PDB:2aleA	0.665	0.665	1.285E-6	132	0.167	0.167	2aleA.pdb.gz	Analysis of pre-mRNA and pre-rRNA processing factor Snu13p structure and mutants.
19	PDB:2walA	0.690	0.620	1.648E-6	149	0.242	0.215	2walA.pdb.gz
20	PDB:1xbiA	0.707	0.783	2.114E-6	118	0.205	0.229	1xbiA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P25398	1.05e-92	265	132	1.000	1.000	RS12_HUMAN Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3
2	P63323	1.05e-92	265	132	1.000	1.000	RS12_MOUSE Small ribosomal subunit protein eS12 OS=Mus musculus OX=10090 GN=Rps12 PE=1 SV=3
3	P63324	1.33e-91	262	132	0.992	0.992	RS12_RAT Small ribosomal subunit protein eS12 OS=Rattus norvegicus OX=10116 GN=Rps12 PE=1 SV=2
4	P80455	3.98e-54	168	139	0.614	0.583	RS12_DROME Small ribosomal subunit protein eS12 OS=Drosophila melanogaster OX=7227 GN=RpS12 PE=1 SV=2
5	O74322	1.62e-49	157	148	0.576	0.514	RS12B_SCHPO Small ribosomal subunit protein eS12B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rps1202 PE=3 SV=1
6	Q9SKZ3	1.68e-42	139	144	0.470	0.431	RS122_ARATH Small ribosomal subunit protein eS12y OS=Arabidopsis thaliana OX=3702 GN=RPS12C PE=1 SV=1
7	Q54PX9	4.35e-42	137	136	0.508	0.493	RS12_DICDI Small ribosomal subunit protein eS12 OS=Dictyostelium discoideum OX=44689 GN=rps12 PE=1 SV=1
8	Q9S9P1	3.96e-40	132	144	0.470	0.431	RS121_ARATH Small ribosomal subunit protein eS12z OS=Arabidopsis thaliana OX=3702 GN=RPS12A PE=2 SV=1
9	P48589	3.34e-30	107	143	0.485	0.448	RS12_YEAST Small ribosomal subunit protein eS12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPS12 PE=1 SV=1
10	Q6FP23	2.23e-28	103	142	0.470	0.437	Q6FP23_CANGA 40S ribosomal protein S12 OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=RPS12 PE=3 SV=1
11	Q03253	3.80e-26	97.4	144	0.348	0.319	RS12_TRYBB Small ribosomal subunit protein eS12 OS=Trypanosoma brucei brucei OX=5702 GN=RPS12 PE=2 SV=2
12	Q38AC1	9.57e-26	96.3	142	0.333	0.310	Q38AC1_TRYB2 40S ribosomal protein S12 OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.6k15.2050 PE=3 SV=1
13	F1R8Z0	2.81e-08	51.6	157	0.212	0.178	F1R8Z0_DANRE Growth arrest and DNA damage-inducible protein GADD45 alpha OS=Danio rerio OX=7955 GN=gadd45al PE=3 SV=1
14	P24522	4.15e-06	45.8	165	0.295	0.236	GA45A_HUMAN Growth arrest and DNA damage-inducible protein GADD45 alpha OS=Homo sapiens OX=9606 GN=GADD45A PE=1 SV=1
15	P48316	3.23e-05	43.5	165	0.288	0.230	GA45A_MOUSE Growth arrest and DNA damage-inducible protein GADD45 alpha OS=Mus musculus OX=10090 GN=Gadd45a PE=1 SV=1
16	P48317	4.74e-05	42.7	165	0.288	0.230	GA45A_RAT Growth arrest and DNA damage-inducible protein GADD45 alpha OS=Rattus norvegicus OX=10116 GN=Gadd45a PE=2 SV=1
17	O75293	4.87e-04	40.0	160	0.197	0.163	GA45B_HUMAN Growth arrest and DNA damage-inducible protein GADD45 beta OS=Homo sapiens OX=9606 GN=GADD45B PE=1 SV=1
18	A0A087WZQ0	0.003	37.7	147	0.258	0.231	A0A087WZQ0_HUMAN Growth arrest and DNA damage inducible alpha OS=Homo sapiens OX=9606 GN=GADD45A PE=1 SV=1
19	P62009	0.003	37.4	123	0.144	0.154	RL7A_PYRHO Large ribosomal subunit protein eL8 OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) OX=70601 GN=rpl7ae PE=1 SV=1
20	Q57VM1	0.003	38.5	276	0.189	0.091	Q57VM1_TRYB2 60S ribosomal protein L7a OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.29O4.580 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01248 Ribosomal_L7Ae	4.9e-27	104.8	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 1026970.XP_008820326.1

Rank	PPI partner	STRING score	Description
1	1026970.XP_008820997.1	0.999	Ribosomal protein S5
2	1026970.XP_008821230.1	0.999	Ribosomal protein S27a
3	1026970.XP_008822798.1	0.999	60S ribosomal protein L18a isoform X1
4	1026970.XP_008823268.1	0.999	Ribosomal protein L12
5	1026970.XP_008823295.1	0.999	60S ribosomal protein L21
6	1026970.XP_008824172.1	0.999	40S ribosomal protein S25
7	1026970.XP_008825153.1	0.999	40S ribosomal protein S15a
8	1026970.XP_008825977.1	0.999	Ribosomal protein S9
9	1026970.XP_008826880.1	0.999	60S ribosomal protein L17
10	1026970.XP_008826905.1	0.999	60S ribosomal protein L23a
11	1026970.XP_008828092.1	0.999	Ribosomal protein S29
12	1026970.XP_008831299.1	0.999	40S ribosomal protein S20
13	1026970.XP_008831459.1	0.999	60S ribosomal protein L9
14	1026970.XP_008832600.1	0.999	Ribosomal protein L8
15	1026970.XP_008835382.1	0.999	40S ribosomal protein S15
16	1026970.XP_008835642.1	0.999	40S ribosomal protein S17
17	1026970.XP_008836782.1	0.999	60S ribosomal protein L35a
18	1026970.XP_008838322.1	0.999	60S ribosomal protein L10a
19	1026970.XP_008838351.1	0.999	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 15 mRNAs, 14 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 8 samples with support for all annotated introns
20	1026970.XP_008838402.1	0.999	40S ribosomal protein S18

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003735	1.000	structural constituent of ribosome
GO:0005515	0.996	protein binding
GO:0003723	0.996	RNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0071704	0.992	organic substance metabolic process
GO:0044238	0.991	primary metabolic process
GO:0044237	0.991	cellular metabolic process
GO:0006807	0.989	nitrogen compound metabolic process
GO:0043170	0.983	macromolecule metabolic process
GO:0034641	0.980	cellular nitrogen compound metabolic process
GO:0010467	0.972	gene expression
GO:0006412	0.955	translation
GO:0050789	0.941	regulation of biological process
GO:0050794	0.923	regulation of cellular process
GO:0002181	0.875	cytoplasmic translation
GO:0048518	0.782	positive regulation of biological process
GO:0048522	0.643	positive regulation of cellular process
GO:0048583	0.458	regulation of response to stimulus
GO:0030111	0.448	regulation of Wnt signaling pathway
GO:0009967	0.403	positive regulation of signal transduction
GO:0060828	0.399	regulation of canonical Wnt signaling pathway
GO:0090263	0.347	positive regulation of canonical Wnt signaling pathway
GO:0050896	0.344	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol
GO:1990904	0.999	ribonucleoprotein complex
GO:0005840	0.998	ribosome
GO:0044391	0.987	ribosomal subunit
GO:0022626	0.985	cytosolic ribosome
GO:0015935	0.917	small ribosomal subunit
GO:0030054	0.911	cell junction
GO:0043227	0.884	membrane-bounded organelle
GO:0022627	0.881	cytosolic small ribosomal subunit
GO:0005634	0.868	nucleus
GO:0045202	0.814	synapse
GO:0015934	0.585	large ribosomal subunit
GO:0022625	0.489	cytosolic large ribosomal subunit
GO:0070013	0.449	intracellular organelle lumen
GO:0031981	0.396	nuclear lumen
GO:0016020	0.315	membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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