StarFunc result for job id P26367

User Input

>input (422 residues)
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRY
YETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV
SSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQ
EGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFAR
ERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIP
QPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPT
SPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPR
LQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q6DHA8	0.396	0.432	2.354E-47	384	0.815	0.896	Q6DHA8.pdb.gz
2	AFDB:Q9V490	0.373	0.294	3.660E-37	543	0.640	0.497	Q9V490.pdb.gz	Q9V490_DROME GH14454p OS=Drosophila melanogaster OX=7227 GN=toy PE=2 SV=4
3	AFDB:G5EDS1	0.561	0.523	2.472E-34	455	0.502	0.466	G5EDS1.pdb.gz	VAB3_CAEEL Paired box protein 6 homolog OS=Caenorhabditis elegans OX=6239 GN=vab-3 PE=1 SV=1
4	AFDB:O18381	0.392	0.206	1.874E-31	857	0.592	0.292	O18381.pdb.gz	PAX6_DROME Paired box protein Pax-6 OS=Drosophila melanogaster OX=7227 GN=ey PE=1 SV=3
5	AFDB:O43316	0.387	0.460	2.405E-26	350	0.358	0.431	O43316.pdb.gz	PAX4_HUMAN Paired box protein Pax-4 OS=Homo sapiens OX=9606 GN=PAX4 PE=1 SV=1
6	AFDB:O88436	0.371	0.436	7.192E-26	349	0.377	0.456	O88436.pdb.gz	PAX4_RAT Paired box protein Pax-4 OS=Rattus norvegicus OX=10116 GN=Pax4 PE=2 SV=1
7	AFDB:P06601	0.297	0.208	8.583E-25	613	0.386	0.266	P06601.pdb.gz	PRD_DROME Segmentation protein paired OS=Drosophila melanogaster OX=7227 GN=prd PE=1 SV=1
8	AFDB:O57416	0.305	0.255	1.816E-24	509	0.393	0.326	O57416.pdb.gz	O57416_DANRE Paired box 3a OS=Danio rerio OX=7955 GN=pax3 PE=2 SV=1
9	AFDB:F1Q9S0	0.309	0.280	5.754E-24	469	0.346	0.311	F1Q9S0.pdb.gz	F1Q9S0_DANRE Paired box 3b OS=Danio rerio OX=7955 GN=pax3b PE=3 SV=2
10	AFDB:F1LMV3	0.313	0.276	1.721E-23	484	0.374	0.326	F1LMV3.pdb.gz	F1LMV3_RAT Paired box 3 OS=Rattus norvegicus OX=10116 GN=Pax3 PE=3 SV=2
11	PDB:2hi3A	0.127	0.636	1.711E-1	73	0.055	0.315	2hi3A.pdb.gz
12	PDB:6qdvO	0.098	0.095	2.034E-1	441	0.097	0.093	6qdvO.pdb.gz	A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
13	PDB:5yzgL	0.087	0.088	2.282E-1	419	0.097	0.098	5yzgL.pdb.gz	Structure of a human catalytic step I spliceosome
14	PDB:4egcA	0.130	0.104	3.417E-1	539	0.043	0.033	4egcA.pdb.gz	Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
15	PDB:7cpuSN	0.092	0.211	3.417E-1	150	0.062	0.173	7cpuSN.pdb.gz	A male germ-cell-specific ribosome controls male fertility.
16	PDB:4v6wAN	0.092	0.210	5.420E-1	150	0.069	0.193	4v6wAN.pdb.gz	Structures of the human and Drosophila 80S ribosome.
17	PDB:2cg4A	0.101	0.266	8.115E-1	149	0.043	0.121	2cg4A.pdb.gz	Structural Insight Into Gene Transcriptional Regulation and Effector Binding by the Lrp/Asnc Family.
18	PDB:5khrN	0.106	0.072	8.115E-1	645	0.036	0.023	5khrN.pdb.gz
19	PDB:2gqqC	0.098	0.239	9.107E-1	157	0.043	0.115	2gqqC.pdb.gz
20	PDB:5mqfL	0.082	0.100	1.022	336	0.104	0.131	5mqfL.pdb.gz	Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A0R4IQL7	782	450	0.936	0.878	A0A0R4IQL7_DANRE Paired box 6b OS=Danio rerio OX=7955 GN=Pax6.2 PE=3 SV=1
2	A0A1W2PNS7	579	281	0.666	1.000	A0A1W2PNS7_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
3	A0A1W2PP27	538	260	0.616	1.000	A0A1W2PP27_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
4	A0A1W2PPH0	584	283	0.671	1.000	A0A1W2PPH0_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
5	A0A1W2PPJ2	582	282	0.668	1.000	A0A1W2PPJ2_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
6	A0A1W2PQ31	570	277	0.656	1.000	A0A1W2PQ31_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
7	A0A1W2PQA8	864	419	0.993	1.000	A0A1W2PQA8_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
8	A0A1W2PQM7	775	386	0.915	1.000	A0A1W2PQM7_HUMAN Paired box 6 OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
9	A0A1W2PRA8	590	286	0.678	1.000	A0A1W2PRA8_HUMAN Paired box 6 OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
10	A0A1W2PRG3	687	368	0.832	0.954	A0A1W2PRG3_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
11	A0A1W2PRU4	543	263	0.623	1.000	A0A1W2PRU4_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
12	A0A1W2PS91	767	400	0.915	0.965	A0A1W2PS91_HUMAN Paired box 6 OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
13	A0A1W2PSA8	851	413	0.979	1.000	A0A1W2PSA8_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=1
14	B1B1I9	685	367	0.829	0.954	B1B1I9_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=10
15	E9PKM0	859	417	0.988	1.000	E9PKM0_HUMAN Paired box 6 (Fragment) OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=9
16	F1T0F8	863	436	1.000	0.968	F1T0F8_HUMAN Paired box protein Pax-6 OS=Homo sapiens OX=9606 GN=PAX6 PE=2 SV=1
17	O42348	857	436	0.993	0.961	O42348_CHICK PAX6 protein OS=Gallus gallus OX=9031 GN=Pax-6 PE=2 SV=1
18	P26367	870	422	1.000	1.000	PAX6_HUMAN Paired box protein Pax-6 OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=2
19	P26630	829	437	0.957	0.924	PAX6_DANRE Paired box protein Pax-6 OS=Danio rerio OX=7955 GN=pax6a PE=2 SV=1
20	P63015	870	422	1.000	1.000	PAX6_MOUSE Paired box protein Pax-6 OS=Mus musculus OX=10090 GN=Pax6 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF05920 Homeobox_KN	3.6e+02	12.5	Homeobox KN domain
2	PF00046 Homeodomain	4.3e-19	79.4	Homeodomain
3	PF13384 HTH_23	0.9	20.8	Homeodomain-like domain
4	PF13518 HTH_28	2.5e+02	13.2	Helix-turn-helix domain
5	PF13565 HTH_32	0.027	26.4	Homeodomain-like domain
6	PF12759 HTH_Tnp_IS1	12	16.9	InsA C-terminal domain
7	PF00292 PAX	1.1e-69	243.6	'Paired box' domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 59463.ENSMLUP00000005952

Rank	PPI partner	STRING score	Description
1	59463.ENSMLUP00000015845	0.938	Uncharacterized protein
2	59463.ENSMLUP00000011128	0.895	Meis homeobox 2
3	59463.ENSMLUP00000005024	0.841	Myotrophin
4	59463.ENSMLUP00000004470	0.838	Meis homeobox 1
5	59463.ENSMLUP00000005819	0.835	Importin 13
6	59463.ENSMLUP00000021288	0.815	SRY-box 2
7	59463.ENSMLUP00000000980	0.800	Bone morphogenetic protein 4
8	59463.ENSMLUP00000013493	0.789	E1A binding protein p300
9	59463.ENSMLUP00000003521	0.788	Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
10	59463.ENSMLUP00000014180	0.785	Protein tyrosine phosphatase, non-receptor type 23
11	59463.ENSMLUP00000009694	0.767	Pancreatic and duodenal homeobox 1
12	59463.ENSMLUP00000020920	0.758	Neurogenic differentiation factor
13	59463.ENSMLUP00000012371	0.745	Eyes absent homolog
14	59463.ENSMLUP00000015784	0.745	Eyes absent homolog
15	59463.ENSMLUP00000008537	0.740	NK2 homeobox 2
16	59463.ENSMLUP00000012038	0.740	SIX homeobox 6
17	59463.ENSMLUP00000006137	0.734	Bone morphogenetic protein 2
18	59463.ENSMLUP00000017757	0.728	ISL LIM homeobox 2
19	59463.ENSMLUP00000005487	0.715	T-box, brain, 1
20	59463.ENSMLUP00000001342	0.711	Eomesodermin

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0000981	1.000	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005515	0.995	protein binding
GO:1990837	0.995	sequence-specific double-stranded DNA binding
GO:0000976	0.991	transcription cis-regulatory region binding
GO:0000977	0.814	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000987	0.576	cis-regulatory region sequence-specific DNA binding
GO:0000978	0.358	RNA polymerase II cis-regulatory region sequence-specific DNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0080090	0.995	regulation of primary metabolic process
GO:0051171	0.995	regulation of nitrogen compound metabolic process
GO:0048522	0.995	positive regulation of cellular process
GO:0010468	0.995	regulation of gene expression
GO:0031326	0.995	regulation of cellular biosynthetic process
GO:0031328	0.993	positive regulation of cellular biosynthetic process
GO:0006355	0.992	regulation of DNA-templated transcription
GO:0045935	0.989	positive regulation of nucleobase-containing compound metabolic process
GO:0035883	0.985	enteroendocrine cell differentiation
GO:0010557	0.985	positive regulation of macromolecule biosynthetic process
GO:0045893	0.982	positive regulation of DNA-templated transcription
GO:0031018	0.979	endocrine pancreas development
GO:0001654	0.965	eye development
GO:0006357	0.947	regulation of transcription by RNA polymerase II
GO:0045944	0.890	positive regulation of transcription by RNA polymerase II
GO:0043010	0.859	camera-type eye development
GO:0003309	0.758	type B pancreatic cell differentiation
GO:0002066	0.750	columnar/cuboidal epithelial cell development
GO:0007399	0.702	nervous system development
GO:0009653	0.568	anatomical structure morphogenesis
GO:0007417	0.550	central nervous system development
GO:0090596	0.536	sensory organ morphogenesis
GO:0048592	0.453	eye morphogenesis
GO:0048593	0.370	camera-type eye morphogenesis

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	1.000	nucleus
GO:0005737	0.989	cytoplasm
GO:0005654	0.934	nucleoplasm
GO:0005829	0.850	cytosol

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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