StarFunc result for job id P27707

User Input

>input (260 residues)
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P48769	0.939	0.939	8.621E-43	260	0.915	0.915	P48769.pdb.gz	DCK_RAT Deoxycytidine kinase OS=Rattus norvegicus OX=10116 GN=Dck PE=1 SV=1
2	AFDB:D6RFG8	0.911	0.750	3.333E-41	317	0.969	0.795	D6RFG8.pdb.gz	D6RFG8_HUMAN Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1
3	AFDB:A0A1L8HV70	0.913	0.896	2.348E-38	265	0.800	0.785	A0A1L8HV70.pdb.gz	DCK1_XENLA Deoxycytidine kinase 1 OS=Xenopus laevis OX=8355 GN=dck.1.L PE=1 SV=1
4	PDB:2no0A	0.884	0.949	3.368E-37	242	0.919	0.988	2no0A.pdb.gz	Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.
5	AFDB:Q5ZMF3	0.912	0.922	4.054E-37	257	0.788	0.798	Q5ZMF3.pdb.gz	DCK_CHICK Deoxycytidine kinase OS=Gallus gallus OX=9031 GN=DCK PE=1 SV=1
6	PDB:2a2zB	0.840	0.987	2.966E-33	221	0.846	0.995	2a2zB.pdb.gz	Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
7	AFDB:Q6DD33	0.940	0.926	7.182E-33	264	0.665	0.655	Q6DD33.pdb.gz	DCK2_XENLA Deoxycytidine kinase 2 OS=Xenopus laevis OX=8355 GN=dck.2 PE=1 SV=1
8	AFDB:Q5ZJM7	0.910	0.893	3.235E-32	265	0.615	0.604	Q5ZJM7.pdb.gz	DCK2_CHICK Deoxycytidine kinase 2 OS=Gallus gallus OX=9031 GN=DCK2 PE=1 SV=1
9	AFDB:Q16854	0.853	0.802	2.924E-25	277	0.485	0.455	Q16854.pdb.gz	DGUOK_HUMAN Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2
10	AFDB:A0A0G2K478	0.867	0.815	4.037E-25	277	0.446	0.419	A0A0G2K478.pdb.gz	A0A0G2K478_RAT Deoxyguanosine kinase OS=Rattus norvegicus OX=10116 GN=Dguok PE=4 SV=2
11	AFDB:Q9QX60	0.868	0.816	8.119E-25	277	0.465	0.437	Q9QX60.pdb.gz	DGUOK_MOUSE Deoxyguanosine kinase, mitochondrial OS=Mus musculus OX=10090 GN=Dguok PE=1 SV=3
12	AFDB:D3ZDE4	0.836	0.783	1.390E-24	278	0.431	0.403	D3ZDE4.pdb.gz	D3ZDE4_RAT Deoxyguanosine kinase OS=Rattus norvegicus OX=10116 GN=Dguok PE=3 SV=1
13	PDB:2vp4D	0.673	0.869	6.545E-16	199	0.265	0.347	2vp4D.pdb.gz	Structural Studies of Nucleoside Analog and Feedback Inhibitor Binding to Drosophila Melanogaster Multisubstrate Deoxyribonucleoside Kinase.
14	PDB:4tmkA	0.488	0.581	1.211E-6	210	0.181	0.224	4tmkA.pdb.gz	Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
15	PDB:7qsdO	0.655	0.542	2.861E-6	320	0.165	0.134	7qsdO.pdb.gz	Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
16	PDB:7ak5O	0.640	0.531	9.333E-6	320	0.169	0.138	7ak5O.pdb.gz	Structural basis for a complex I mutation that blocks pathological ROS production.
17	PDB:2wwfC	0.488	0.579	2.456E-5	212	0.154	0.189	2wwfC.pdb.gz	Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
18	PDB:3tmkA	0.463	0.542	4.681E-5	216	0.169	0.204	3tmkA.pdb.gz	Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
19	PDB:2c95A	0.463	0.591	1.106E-4	195	0.123	0.164	2c95A.pdb.gz	Structure of Adenylate Kinase 1 in Complex with P1, P4-Di(Adenosine)Tetraphosphate
20	PDB:5nrnB	0.496	0.592	1.300E-4	211	0.127	0.156	5nrnB.pdb.gz	Mtb TMK crystal structure in complex with compound LS3080

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	D6RFG8	0.0	530	317	0.969	0.795	D6RFG8_HUMAN Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1
2	F5CTF3	0.0	545	260	1.000	1.000	F5CTF3_HUMAN Deoxynucleoside kinase OS=Homo sapiens OX=9606 PE=2 SV=1
3	P27707	0.0	545	260	1.000	1.000	DCK_HUMAN Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1
4	P43346	0.0	510	260	0.935	0.935	DCK_MOUSE Deoxycytidine kinase OS=Mus musculus OX=10090 GN=Dck PE=1 SV=1
5	P48769	0.0	499	260	0.915	0.915	DCK_RAT Deoxycytidine kinase OS=Rattus norvegicus OX=10116 GN=Dck PE=1 SV=1
6	A0A1L8HV70	1.26e-159	445	265	0.804	0.789	DCK1_XENLA Deoxycytidine kinase 1 OS=Xenopus laevis OX=8355 GN=dck.1.L PE=1 SV=1
7	Q5ZMF3	2.14e-153	429	257	0.796	0.805	DCK_CHICK Deoxycytidine kinase OS=Gallus gallus OX=9031 GN=DCK PE=1 SV=1
8	Q6DD33	4.00e-128	365	264	0.669	0.659	DCK2_XENLA Deoxycytidine kinase 2 OS=Xenopus laevis OX=8355 GN=dck.2 PE=1 SV=1
9	Q5ZJM7	1.82e-122	351	265	0.615	0.604	DCK2_CHICK Deoxycytidine kinase 2 OS=Gallus gallus OX=9031 GN=DCK2 PE=1 SV=1
10	Q16854	1.51e-85	258	277	0.481	0.451	DGUOK_HUMAN Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2
11	Q9QX60	1.87e-83	253	277	0.465	0.437	DGUOK_MOUSE Deoxyguanosine kinase, mitochondrial OS=Mus musculus OX=10090 GN=Dguok PE=1 SV=3
12	D3ZDE4	8.19e-77	236	278	0.415	0.388	D3ZDE4_RAT Deoxyguanosine kinase OS=Rattus norvegicus OX=10116 GN=Dguok PE=3 SV=1
13	A0A8I5ZV32	1.39e-76	236	309	0.431	0.362	A0A8I5ZV32_RAT Deoxyguanosine kinase OS=Rattus norvegicus OX=10116 GN=Dguok PE=1 SV=1
14	Q6GPW6	6.45e-75	230	265	0.438	0.430	DGUOK_XENLA Deoxyguanosine kinase, mitochondrial OS=Xenopus laevis OX=8355 GN=dguok PE=1 SV=1
15	B5DEP0	5.26e-59	187	180	0.335	0.483	B5DEP0_RAT Dguok protein OS=Rattus norvegicus OX=10116 GN=Dguok PE=2 SV=1
16	A0A0G2K478	1.10e-42	150	333	0.388	0.303	A0A0G2K478_RAT Deoxyguanosine kinase OS=Rattus norvegicus OX=10116 GN=Dguok PE=4 SV=2
17	D3ZGQ2	4.48e-41	144	270	0.327	0.315	D3ZGQ2_RAT Thymidine kinase 2 OS=Rattus norvegicus OX=10116 GN=Tk2 PE=3 SV=1
18	Q501D4	1.17e-39	146	580	0.335	0.150	Q501D4_ARATH At1g72040 OS=Arabidopsis thaliana OX=3702 GN=DNK PE=1 SV=1
19	Q9R088	2.89e-39	139	270	0.327	0.315	KITM_MOUSE Thymidine kinase 2, mitochondrial OS=Mus musculus OX=10090 GN=Tk2 PE=1 SV=2
20	O00142	1.25e-38	137	265	0.308	0.302	KITM_HUMAN Thymidine kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TK2 PE=1 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13207 AAA_17	3e+02	13.2	AAA domain
2	PF13238 AAA_18	1.4	20.9	AAA domain
3	PF13521 AAA_28	11	17.7	AAA domain
4	PF13671 AAA_33	3.2	19.4	AAA domain
5	PF01121 CoaE	6.9e+02	11.3	Dephospho-CoA kinase
6	PF01712 dNK	4.1e-75	263.7	Deoxynucleoside kinase
7	PF02223 Thymidylate_kin	1.1	20.4	Thymidylate kinase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000286648

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000364212	0.985	Cytidine deaminase
2	9606.ENSP00000349576	0.981	Deoxycytidylate deaminase
3	9606.ENSP00000339479	0.974	Cytosolic purine 5'-nucleotidase
4	9606.ENSP00000360939	0.970	UMP-CMP kinase
5	9606.ENSP00000245552	0.954	5'(3')-deoxyribonucleotidase, cytosolic type
6	9606.ENSP00000354532	0.954	Purine nucleoside phosphorylase
7	9606.ENSP00000361965	0.954	Adenosine deaminase
8	9606.ENSP00000360561	0.950	Ectonucleoside triphosphate diphosphohydrolase 8
9	9606.ENSP00000484415	0.950	Cytosolic 5'-nucleotidase 3A
10	9606.ENSP00000373674	0.949	5'(3')-deoxyribonucleotidase, mitochondrial
11	9606.ENSP00000235628	0.943	Cytosolic 5'-nucleotidase 1A
12	9606.ENSP00000367615	0.943	Adenine phosphoribosyltransferase
13	9606.ENSP00000256722	0.940	UMP-CMP kinase 2, mitochondrial
14	9606.ENSP00000352904	0.937	Cytosolic 5'-nucleotidase 1B
15	9606.ENSP00000389948	0.935	7-methylguanosine phosphate-specific 5'-nucleotidase
16	9606.ENSP00000322524	0.933	dCTP pyrophosphatase 1
17	9606.ENSP00000257770	0.927	5'-nucleotidase
18	9606.ENSP00000360250	0.927	Ectonucleoside triphosphate diphosphohydrolase 1
19	9606.ENSP00000355689	0.926	Guanylate kinase
20	9606.ENSP00000378743	0.918	Adenylate kinase 4, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004137	0.999	deoxycytidine kinase activity
GO:0004138	0.992	deoxyguanosine kinase activity
GO:0004136	0.982	deoxyadenosine kinase activity
GO:0005488	0.948	binding
GO:0005515	0.734	protein binding
GO:0042802	0.302	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.997	organic substance metabolic process
GO:0044238	0.996	primary metabolic process
GO:0006793	0.995	phosphorus metabolic process
GO:0006796	0.994	phosphate-containing compound metabolic process
GO:1901360	0.986	organic cyclic compound metabolic process
GO:0034641	0.986	cellular nitrogen compound metabolic process
GO:0006753	0.983	nucleoside phosphate metabolic process
GO:0009117	0.963	nucleotide metabolic process
GO:0009058	0.961	biosynthetic process
GO:0034654	0.946	nucleobase-containing compound biosynthetic process
GO:1901293	0.929	nucleoside phosphate biosynthetic process
GO:1901564	0.921	organonitrogen compound metabolic process
GO:1901135	0.589	carbohydrate derivative metabolic process
GO:0009123	0.553	nucleoside monophosphate metabolic process
GO:0009124	0.449	nucleoside monophosphate biosynthetic process
GO:0072527	0.398	pyrimidine-containing compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0005829	0.998	cytosol
GO:0043233	0.995	organelle lumen
GO:0005654	0.993	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:20061	0.999	2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+)
EC:2.7.1.74	0.999	deoxycytidine kinase.
RHEA:19201	0.992	2'-deoxyguanosine + ATP = ADP + dGMP + H(+)
EC:2.7.1.113	0.992	deoxyguanosine kinase.
RHEA:23452	0.982	2'-deoxyadenosine + ATP = ADP + dAMP + H(+)
EC:2.7.1.76	0.982	deoxyadenosine kinase.

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