StarFunc result for job id P28068

User Input

>input (263 residues)
MITFLPLLLGLSLGCTGAGGFVAHVESTCLLDDAGTPKDFTYCISFNKDLLTCWDPEENK
MAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATHTQPFWGSLTNRTRPPSVQVA
KTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQPNGDWTYQTLSHL
ALTPSYGDTYTCVVEHIGAPEPILRDWTPGLSPMQTLKVSVSAVTLGLGLIIFSLGVISW
RRAGHSSYTPLPGSNYSEGWHIS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A1V0E3P2	0.801	0.801	1.895E-46	263	0.996	0.996	A0A1V0E3P2.pdb.gz	A0A1V0E3P2_HUMAN HLA-DMB OS=Homo sapiens OX=9606 GN=HLA-DMB PE=4 SV=1
2	AFDB:B7ZNR3	0.827	0.833	1.513E-39	261	0.726	0.732	B7ZNR3.pdb.gz	B7ZNR3_MOUSE Histocompatibility 2, class II, locus Mb2 OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
3	AFDB:Q5K595	0.634	0.676	1.854E-18	245	0.243	0.261	Q5K595.pdb.gz	Q5K595_SALSA MHC class II antigen beta chain (Fragment) OS=Salmo salar OX=8030 GN=DAB PE=4 SV=1
4	AFDB:Q30154	0.673	0.666	2.720E-18	266	0.224	0.222	Q30154.pdb.gz	DRB5_HUMAN HLA class II histocompatibility antigen, DR beta 5 chain OS=Homo sapiens OX=9606 GN=HLA-DRB5 PE=1 SV=1
5	AFDB:P13762	0.662	0.656	3.036E-18	266	0.228	0.226	P13762.pdb.gz	DRB4_HUMAN HLA class II histocompatibility antigen, DR beta 4 chain OS=Homo sapiens OX=9606 GN=HLA-DRB4 PE=1 SV=2
6	AFDB:P79483	0.636	0.629	8.141E-18	266	0.232	0.229	P79483.pdb.gz	DRB3_HUMAN HLA class II histocompatibility antigen, DR beta 3 chain OS=Homo sapiens OX=9606 GN=HLA-DRB3 PE=1 SV=1
7	AFDB:A0A0G4PYZ0	0.639	0.632	1.071E-17	266	0.221	0.218	A0A0G4PYZ0.pdb.gz	A0A0G4PYZ0_HUMAN MHC class II antigen OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=1
8	AFDB:P13765	0.642	0.622	1.333E-17	273	0.243	0.234	P13765.pdb.gz	DOB_HUMAN HLA class II histocompatibility antigen, DO beta chain OS=Homo sapiens OX=9606 GN=HLA-DOB PE=1 SV=1
9	AFDB:A0A1C3PI11	0.656	0.667	1.488E-17	258	0.232	0.236	A0A1C3PI11.pdb.gz	A0A1C3PI11_HUMAN HLA class II histocompatibility antigen DP beta chain OS=Homo sapiens OX=9606 GN=HLA-DPB1 PE=1 SV=1
10	AFDB:P04230	0.646	0.644	2.183E-17	264	0.232	0.231	P04230.pdb.gz	HB21_MOUSE H-2 class II histocompatibility antigen, E-B beta chain OS=Mus musculus OX=10090 GN=H2-Eb1 PE=1 SV=1
11	PDB:6cplA	0.355	0.505	5.468E-13	180	0.171	0.250	6cplA.pdb.gz	CD4+T cell-mediated HLA class II cross-restriction in HIV controllers.
12	PDB:3es6A	0.499	0.479	9.984E-12	277	0.156	0.148	3es6A.pdb.gz	Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma
13	PDB:5j6hA	0.442	0.427	1.177E-11	275	0.171	0.164	5j6hA.pdb.gz	Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.
14	PDB:6e1iA	0.418	0.316	8.012E-11	389	0.163	0.111	6e1iA.pdb.gz
15	PDB:6fgbA	0.497	0.494	1.242E-10	265	0.160	0.158	6fgbA.pdb.gz
16	PDB:6mp0A	0.429	0.323	1.464E-10	388	0.186	0.126	6mp0A.pdb.gz
17	PDB:6d7gA	0.406	0.305	4.889E-10	386	0.148	0.101	6d7gA.pdb.gz
18	PDB:2qriA	0.456	0.325	6.430E-10	398	0.179	0.118	2qriA.pdb.gz
19	PDB:3nwmA	0.425	0.322	9.961E-9	384	0.148	0.102	3nwmA.pdb.gz
20	PDB:3ov6A	0.477	0.354	2.031E-8	376	0.175	0.122	3ov6A.pdb.gz	The 2.5 A structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A1V0E3P2	0.0	544	263	0.996	0.996	A0A1V0E3P2_HUMAN HLA-DMB OS=Homo sapiens OX=9606 GN=HLA-DMB PE=4 SV=1
2	P28068	0.0	544	263	0.996	0.996	DMB_HUMAN HLA class II histocompatibility antigen, DM beta chain OS=Homo sapiens OX=9606 GN=HLA-DMB PE=1 SV=2
3	P70679	9.65e-142	400	261	0.700	0.705	P70679_MOUSE MB2k1 protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
4	P70238	1.50e-141	399	261	0.700	0.705	P70238_MOUSE MB2p protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
5	Q31114	1.61e-141	399	261	0.700	0.705	Q31114_MOUSE MHC class II H2-M beta 2 chain OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
6	B7ZNR4	2.37e-141	399	261	0.700	0.705	B7ZNR4_MOUSE Histocompatibility 2, class II, locus Mb2 OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
7	B7ZNR3	2.98e-141	399	261	0.700	0.705	B7ZNR3_MOUSE Histocompatibility 2, class II, locus Mb2 OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
8	Q31112	4.94e-141	398	261	0.696	0.701	Q31112_MOUSE MHC class II H2-M beta 2 chain OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
9	Q31113	7.57e-141	397	261	0.696	0.701	Q31113_MOUSE MHC class II H2-M beta 2 chain OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
10	P70241	7.65e-141	397	261	0.696	0.701	P70241_MOUSE MB2w5 protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
11	P70239	1.07e-140	397	261	0.696	0.701	P70239_MOUSE MB2r protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
12	Q95602	1.40e-140	397	261	0.696	0.701	Q95602_MOUSE MB2q1 protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
13	Q95552	1.26e-139	394	261	0.692	0.697	Q95552_MOUSE MB2d protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
14	Q31099	1.36e-139	394	261	0.692	0.697	Q31099_MOUSE H2-M beta 2 OS=Mus musculus OX=10090 GN=H2-DMb2 PE=1 SV=2
15	P70240	5.14e-139	393	261	0.688	0.693	P70240_MOUSE MB2w3 protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
16	P35737	9.36e-138	390	261	0.692	0.697	DMB_MOUSE Class II histocompatibility antigen, M beta 1 chain OS=Mus musculus OX=10090 GN=H2-DMb1 PE=2 SV=1
17	Q31101	1.88e-108	313	189	0.536	0.746	Q31101_MOUSE H2-M beta chain (Fragment) OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
18	Q31100	3.70e-108	312	189	0.536	0.746	Q31100_MOUSE H2-M beta chain (Fragment) OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
19	Q7JFR0	4.17e-108	312	189	0.536	0.746	Q7JFR0_MOUSE H2-M beta chain (Fragment) OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
20	Q31098	3.13e-107	310	189	0.532	0.741	Q31098_MOUSE H2-M beta chain (Fragment) OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF07654 C1-set	7e-19	79.3	Immunoglobulin C1-set domain
2	PF08205 C2-set_2	2.2	19.7	CD80-like C2-set immunoglobulin domain
3	PF07679 I-set	10	17.6	Immunoglobulin I-set domain
4	PF00047 ig	1.6e+02	13.9	Immunoglobulin domain
5	PF13895 Ig_2	0.0087	27.7	Immunoglobulin domain
6	PF13927 Ig_3	2.9e-05	35.8	Immunoglobulin domain
7	PF00969 MHC_II_beta	4.7e-23	92.4	Class II histocompatibility antigen, beta domain
8	PF19160 SPARK	91	14.8	SPARK

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9593.ENSGGOP00000018065

Rank	PPI partner	STRING score	Description
1	9593.ENSGGOP00000019648	0.999	Major histocompatibility complex, class II, DM alpha
2	9593.ENSGGOP00000009633	0.996	Major histocompatibility complex, class II, DR alpha
3	9593.ENSGGOP00000001218	0.986	Major histocompatibility complex, class II, DP alpha 1
4	9593.ENSGGOP00000010383	0.976	Major histocompatibility complex, class II, DO alpha
5	9593.ENSGGOP00000024462	0.960	Major histocompatibility complex, class II, DQ alpha 1
6	9593.ENSGGOP00000021208	0.957	Major histocompatibility complex, class II, DR beta 5
7	9593.ENSGGOP00000011421	0.924	CD74 molecule, major histocompatibility complex, class II invariant chain
8	9593.ENSGGOP00000004173	0.855	Major histocompatibility complex, class II, DQ beta 1
9	9593.ENSGGOP00000028181	0.855	Major histocompatibility complex, class II, DQ beta 2
10	9593.ENSGGOP00000003173	0.854	CD4 molecule
11	9593.ENSGGOP00000018186	0.847	CD247 molecule
12	9593.ENSGGOP00000013296	0.787	Major histocompatibility complex, class II, DP beta 1
13	9593.ENSGGOP00000025986	0.759	Uncharacterized protein
14	9593.ENSGGOP00000018138	0.600	Uncharacterized protein
15	9593.ENSGGOP00000021576	0.600	Uncharacterized protein
16	9593.ENSGGOP00000022473	0.600	Uncharacterized protein
17	9593.ENSGGOP00000005721	0.565	Bromodomain containing 2
18	9593.ENSGGOP00000010681	0.565	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity)
19	9593.ENSGGOP00000024036	0.560	Thyroglobulin
20	9593.ENSGGOP00000025112	0.560	Nidogen 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0044877	0.560	protein-containing complex binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0002376	0.994	immune system process
GO:0009987	0.989	cellular process
GO:0019884	0.968	antigen processing and presentation of exogenous antigen
GO:0002478	0.949	antigen processing and presentation of exogenous peptide antigen
GO:0019886	0.937	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0065007	0.915	biological regulation
GO:0050789	0.912	regulation of biological process
GO:0050794	0.895	regulation of cellular process
GO:0048518	0.838	positive regulation of biological process
GO:0002682	0.797	regulation of immune system process
GO:0048522	0.716	positive regulation of cellular process
GO:0002684	0.626	positive regulation of immune system process
GO:0050896	0.591	response to stimulus
GO:0002694	0.557	regulation of leukocyte activation
GO:0048583	0.533	regulation of response to stimulus
GO:0051249	0.461	regulation of lymphocyte activation
GO:0051240	0.445	positive regulation of multicellular organismal process
GO:0002696	0.426	positive regulation of leukocyte activation
GO:0006955	0.423	immune response
GO:0050776	0.423	regulation of immune response
GO:0050778	0.346	positive regulation of immune response
GO:0051084	0.323	'de novo' post-translational protein folding
GO:0051251	0.313	positive regulation of lymphocyte activation

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005768	0.997	endosome
GO:0005773	0.996	vacuole
GO:0098588	0.995	bounding membrane of organelle
GO:0005774	0.988	vacuolar membrane
GO:0012506	0.985	vesicle membrane
GO:0030659	0.984	cytoplasmic vesicle membrane
GO:0005764	0.966	lysosome
GO:0098852	0.965	lytic vacuole membrane
GO:0005765	0.964	lysosomal membrane
GO:0071944	0.955	cell periphery
GO:0032991	0.954	protein-containing complex
GO:0005886	0.954	plasma membrane
GO:0010008	0.950	endosome membrane
GO:0098797	0.896	plasma membrane protein complex
GO:0042611	0.860	MHC protein complex
GO:0005770	0.667	late endosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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